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#437261 How AI Will Make Drug Discovery ...

Posted on July 24, 2020 by Android

If you had to guess how long it takes for a drug to go from an idea to your pharmacy, what would you guess? Three years? Five years? How about the cost? $30 million? $100 million?

Well, here’s the sobering truth: 90 percent of all drug possibilities fail. The few that do succeed take an average of 10 years to reach the market and cost anywhere from $2.5 billion to $12 billion to get there.

But what if we could generate novel molecules to target any disease, overnight, ready for clinical trials? Imagine leveraging machine learning to accomplish with 50 people what the pharmaceutical industry can barely do with an army of 5,000.

Welcome to the future of AI and low-cost, ultra-fast, and personalized drug discovery. Let’s dive in.

GANs & Drugs
Around 2012, computer scientist-turned-biophysicist Alex Zhavoronkov started to notice that artificial intelligence was getting increasingly good at image, voice, and text recognition. He knew that all three tasks shared a critical commonality. In each, massive datasets were available, making it easy to train up an AI.

But similar datasets were present in pharmacology. So, back in 2014, Zhavoronkov started wondering if he could use these datasets and AI to significantly speed up the drug discovery process. He’d heard about a new technique in artificial intelligence known as generative adversarial networks (or GANs). By pitting two neural nets against one another (adversarial), the system can start with minimal instructions and produce novel outcomes (generative). At the time, researchers had been using GANs to do things like design new objects or create one-of-a-kind, fake human faces, but Zhavoronkov wanted to apply them to pharmacology.

He figured GANs would allow researchers to verbally describe drug attributes: “The compound should inhibit protein X at concentration Y with minimal side effects in humans,” and then the AI could construct the molecule from scratch. To turn his idea into reality, Zhavoronkov set up Insilico Medicine on the campus of Johns Hopkins University in Baltimore, Maryland, and rolled up his sleeves.

Instead of beginning their process in some exotic locale, Insilico’s “drug discovery engine” sifts millions of data samples to determine the signature biological characteristics of specific diseases. The engine then identifies the most promising treatment targets and—using GANs—generates molecules (that is, baby drugs) perfectly suited for them. “The result is an explosion in potential drug targets and a much more efficient testing process,” says Zhavoronkov. “AI allows us to do with fifty people what a typical drug company does with five thousand.”

The results have turned what was once a decade-long war into a month-long skirmish.

In late 2018, for example, Insilico was generating novel molecules in fewer than 46 days, and this included not just the initial discovery, but also the synthesis of the drug and its experimental validation in computer simulations.

Right now, they’re using the system to hunt down new drugs for cancer, aging, fibrosis, Parkinson’s, Alzheimer’s, ALS, diabetes, and many others. The first drug to result from this work, a treatment for hair loss, is slated to start Phase I trials by the end of 2020.

They’re also in the early stages of using AI to predict the outcomes of clinical trials in advance of the trial. If successful, this technique will enable researchers to strip a bundle of time and money out of the traditional testing process.

Protein Folding
Beyond inventing new drugs, AI is also being used by other scientists to identify new drug targets—that is, the place to which a drug binds in the body and another key part of the drug discovery process.

Between 1980 and 2006, despite an annual investment of $30 billion, researchers only managed to find about five new drug targets a year. The trouble is complexity. Most potential drug targets are proteins, and a protein’s structure—meaning the way a 2D sequence of amino acids folds into a 3D protein—determines its function.

But a protein with merely a hundred amino acids (a rather small protein) can produce a googol-cubed worth of potential shapes—that’s a one followed by three hundred zeroes. This is also why protein-folding has long been considered an intractably hard problem for even the most powerful of supercomputers.

Back in 1994, to monitor supercomputers’ progress in protein-folding, a biannual competition was created. Until 2018, success was fairly rare. But then the creators of DeepMind turned their neural networks loose on the problem. They created an AI that mines enormous datasets to determine the most likely distance between a protein’s base pairs and the angles of their chemical bonds—aka, the basics of protein-folding. They called it AlphaFold.

On its first foray into the competition, contestant AIs were given 43 protein-folding problems to solve. AlphaFold got 25 right. The second-place team managed a meager three. By predicting the elusive ways in which various proteins fold on the basis of their amino acid sequences, AlphaFold may soon have a tremendous impact in aiding drug discovery and fighting some of today’s most intractable diseases.

Drug Delivery
Another theater of war for improved drugs is the realm of drug delivery. Even here, converging exponential technologies are paving the way for massive implications in both human health and industry shifts.

One key contender is CRISPR, the fast-advancing gene-editing technology that stands to revolutionize synthetic biology and treatment of genetically linked diseases. And researchers have now demonstrated how this tool can be applied to create materials that shape-shift on command. Think: materials that dissolve instantaneously when faced with a programmed stimulus, releasing a specified drug at a highly targeted location.

Yet another potential boon for targeted drug delivery is nanotechnology, whereby medical nanorobots have now been used to fight incidences of cancer. In a recent review of medical micro- and nanorobotics, lead authors (from the University of Texas at Austin and University of California, San Diego) found numerous successful tests of in vivo operation of medical micro- and nanorobots.

Drugs From the Future
Covid-19 is uniting the global scientific community with its urgency, prompting scientists to cast aside nation-specific territorialism, research secrecy, and academic publishing politics in favor of expedited therapeutic and vaccine development efforts. And in the wake of rapid acceleration across healthcare technologies, Big Pharma is an area worth watching right now, no matter your industry. Converging technologies will soon enable extraordinary strides in longevity and disease prevention, with companies like Insilico leading the charge.

Riding the convergence of massive datasets, skyrocketing computational power, quantum computing, cognitive surplus capabilities, and remarkable innovations in AI, we are not far from a world in which personalized drugs, delivered directly to specified targets, will graduate from science fiction to the standard of care.

Rejuvenational biotechnology will be commercially available sooner than you think. When I asked Alex for his own projection, he set the timeline at “maybe 20 years—that’s a reasonable horizon for tangible rejuvenational biotechnology.”

How might you use an extra 20 or more healthy years in your life? What impact would you be able to make?

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(Both A360 and Abundance-Digital are part of Singularity University—your participation opens you to a global community.)

This article originally appeared on diamandis.com. Read the original article here.

Image Credit: andreas160578 from Pixabay Continue reading →

Posted in Human Robots

#437251 The Robot Revolution Was Televised: Our ...

Posted on July 20, 2020 by Android

When robots take over the world, Boston Dynamics may get a special shout-out in the acceptance speech.

“Do you, perchance, recall the many times you shoved our ancestors with a hockey stick on YouTube? It might have seemed like fun and games to you—but we remember.”

In the last decade, while industrial robots went about blandly automating boring tasks like the assembly of Teslas, Boston Dynamics built robots as far removed from Roombas as antelope from amoebas. The flaws in Asimov’s laws of robotics suddenly seemed a little too relevant.

The robot revolution was televised—on YouTube. With tens of millions of views, the robotics pioneer is the undisputed heavyweight champion of robot videos, and has been for years. Each new release is basically guaranteed press coverage—mostly stoking robot fear but occasionally eliciting compassion for the hardships of all robot-kind. And for good reason. The robots are not only some of the most advanced in the world, their makers just seem to have a knack for dynamite demos.

When Google acquired the company in 2013, it was a bombshell. One of the richest tech companies, with some of the most sophisticated AI capabilities, had just paired up with one of the world’s top makers of robots. And some walked on two legs like us.

Of course, the robots aren’t quite as advanced as they seem, and a revolution is far from imminent. The decade’s most meme-worthy moment was a video montage of robots, some of them by Boston Dynamics, falling—over and over and over, in the most awkward ways possible. Even today, they’re often controlled by a human handler behind the scenes, and the most jaw-dropping cuts can require several takes to nail. Google sold the company to SoftBank in 2017, saying advanced as they were, there wasn’t yet a clear path to commercial products. (Google’s robotics work was later halted and revived.)

Yet, despite it all, Boston Dynamics is still with us and still making sweet videos. Taken as a whole, the evolution in physical prowess over the years has been nothing short of astounding. And for the first time, this year, a Boston Dynamics robot, Spot, finally went on sale to anyone with a cool $75K.

So, we got to thinking: What are our favorite Boston Dynamics videos? And can we gather them up in one place for your (and our) viewing pleasure? Well, great question, and yes, why not. These videos were the ones that entertained or amazed us most (or both). No doubt, there are other beloved hits we missed or inadvertently omitted.

With that in mind, behold: Our favorite Boston Dynamics videos, from that one time they dressed up a humanoid bot in camo and gas mask—because, damn, that’s terrifying—to the time the most advanced robot dog in all the known universe got extra funky.

Let’s Kick This Off With a Big (Loud) Robot Dog
Let’s start with a baseline. BigDog was the first Boston Dynamics YouTube sensation. The year? 2009! The company was working on military contracts, and BigDog was supposed to be a sort of pack mule for soldiers. The video primarily shows off BigDog’s ability to balance on its own, right itself, and move over uneven terrain. Note the power source—a noisy combustion engine—and utilitarian design. Sufficed to say, things have evolved.

Nothing to See Here. Just a Pair of Robot Legs on a Treadmill
While BigDog is the ancestor of later four-legged robots, like Spot, Petman preceded the two-legged Atlas robot. Here, the Petman prototype, just a pair of robot legs and a caged torso, gets a light workout on the treadmill. Again, you can see its ability to balance and right itself when shoved. In contrast to BigDog, Petman is tethered for power (which is why it’s so quiet) and to catch it should it fall. Again, as you’ll see, things have evolved since then.

Robot in Gas Mask and Camo Goes for a Stroll
This one broke the internet—for obvious reasons. Not only is the robot wearing clothes, those clothes happen to be a camouflaged chemical protection suit and gas mask. Still working for the military, Boston Dynamics said Petman was testing protective clothing, and in addition to a full body, it had skin that actually sweated and was studded with sensors to detect leaks. In addition to walking, Petman does some light calisthenics as it prepares to climb out of the uncanny valley. (Still tethered though!)

This Machine Could Run Down Usain Bolt
If BigDog and Petman were built for balance and walking, Cheetah was built for speed. Here you can see the four-legged robot hitting 28.3 miles per hour, which, as the video casually notes, would be enough to run down the fastest human on the planet. Luckily, it wouldn’t be running down anyone as it was firmly leashed in the lab at this point.

Ever Dreamt of a Domestic Robot to Do the Dishes?
After its acquisition by Google, Boston Dynamics eased away from military contracts and applications. It was a return to more playful videos (like BigDog hitting the beach in Thailand and sporting bull horns) and applications that might be practical in civilian life. Here, the team introduced Spot, a streamlined version of BigDog, and showed it doing dishes, delivering a drink, and slipping on a banana peel (which was, of course, instantly made into a viral GIF). Note how much quieter Spot is thanks to an onboard battery and electric motor.

Spot Gets Funky
Nothing remotely practical here. Just funky moves. (Also, with a coat of yellow and black paint, Spot’s dressed more like a polished product as opposed to a utilitarian lab robot.)

Atlas Does Parkour…
Remember when Atlas was just a pair of legs on a treadmill? It’s amazing what ten years brings. By 2019, Atlas had a more polished appearance, like Spot, and had long ago ditched the tethers. Merely balancing was laughably archaic. The robot now had some amazing moves: like a handstand into a somersault, 180- and 360-degree spins, mid-air splits, and just for good measure, a gymnastics-style end to the routine to show it’s in full control.

…and a Backflip?!
To this day, this one is just. Insane.

10 Robot Dogs Tow a Box Truck
Nearly three decades after its founding, Boston Dynamics is steadily making its way into the commercial space. The company is pitching Spot as a multipurpose ‘mobility platform,’ emphasizing it can carry a varied suite of sensors and can go places standard robots can’t. (Its Handle robot is also set to move into warehouse automation.) So far, Spot’s been mostly trialed in surveying and data collection, but as this video suggests, string enough Spots together, and they could tow your car. That said, a pack of 10 would set you back $750K, so, it’s probably safe to say a tow truck is the better option (for now).

Image credit: Boston Dynamics Continue reading →

Posted in Human Robots

#436466 How Two Robots Learned to Grill and ...

Posted on December 19, 2019 by Android

The list of things robots can do seems to be growing by the week. They can play sports, help us explore outer space and the deep sea, take over some of our boring everyday tasks, and even assemble Ikea furniture.

Now they can add one more accomplishment to the list: grilling and serving a hot dog.

It seems like a pretty straightforward task, and as far as grilling goes, hot dogs are about as easy as it gets (along with, maybe, burgers? Hot dogs require more rotation, but it’s easier to tell when they’re done since they’re lighter in color).

Let’s paint a picture: you’re manning the grill at your family’s annual Fourth of July celebration. You’ve got a 10-pack of plump, juicy beef franks and a hungry crowd of relatives whose food-to-alcohol ratio is getting pretty skewed—they need some solid calories, pronto. What are the steps you need to take to get those franks from package to plate?

Each one needs to be placed on the grill, rotated every couple minutes for even cooking, removed from the grill when you deem it’s done, then—if you’re the kind of guy or gal who goes the extra mile—placed in a bun and dressed with ketchup, mustard, pickles, and the like before being handed over to salivating, too-loud Uncle Hector or sweet, bored Cousin Margaret.

While carrying out your grillmaster duties, you know better than to drop the hot dogs on the ground, leave them cooking on one side for too long, squeeze them to the point of breaking or bursting, and any other hot-dog-ruining amateur moves.

But for a robot, that’s a lot to figure out, especially if they have no prior knowledge of grilling hot dogs (which, well, most robots don’t).

As described in a paper published in this week’s Science Robotics, a team from Boston University programmed two robotic arms to use reinforcement learning—a branch of machine learning in which software gathers information about its environment then learns from it by replaying its experiences and incorporating rewards—to cook and serve hot dogs.

The team used a set of formulas to specify and combine tasks (“pick up hot dog and place on the grill”), meet safety requirements (“always avoid collisions”), and incorporate general prior knowledge (“you cannot pick up another hot dog if you are already holding one”).

Baxter and Jaco—as the two robots were dubbed—were trained through computer simulations. The paper’s authors emphasized their use of what they call a “formal specification language” for training the software, with the aim of generating easily-interpretable task descriptions. In reinforcement learning, they explain, being able to understand how a reward function influences an AI’s learning process is a key component in understanding the system’s behavior—but most systems lack this quality, and are thus likely to be lumped into the ‘black box’ of AI.

The robots’ decisions throughout the hot dog prep process—when to turn a hot dog, when to take it off the grill, and so on—are, the authors write, “easily interpretable from the beginning because the language is very similar to plain English.”

Besides being a step towards more explainable AI systems, Baxter and Jaco are another example of fast-food robots—following in the footsteps of their burger and pizza counterparts—that may take over some repetitive manual tasks currently performed by human workers. As robots’ capabilities improve through incremental progress like this, they’ll be able to take on additional tasks.

In a not-so-distant future, then, you just may find yourself throwing back drinks with Uncle Hector and Cousin Margaret while your robotic replacement mans the grill, churning out hot dogs that are perfectly cooked every time.

Image Credit: Image by Muhammad Ribkhan from Pixabay Continue reading →

Posted in Human Robots

#436263 Skydio 2 Review: This Is the Drone You ...

Posted on December 3, 2019 by Android

Let me begin this review by saying that the Skydio 2 is one of the most impressive robots that I have ever seen. Over the last decade, I’ve spent enough time around robots to have a very good sense of what kinds of things are particularly challenging for them, and to set my expectations accordingly. Those expectations include things like “unstructured environments are basically impossible” and “full autonomy is impractically expensive” and “robot videos rarely reflect reality.”

Skydio’s newest drone is an exception to all of this. It’s able to fly autonomously at speed through complex environments in challenging real-world conditions in a way that’s completely effortless and stress-free for the end user, allowing you to capture the kind of video that would be otherwise impossible, even (I’m guessing) for professional drone pilots. When you see this technology in action, it’s (almost) indistinguishable from magic.

Skydio 2 Price
To be clear, the Skydio 2 is not without compromises, and the price of $999 (on pre-order with delivery of the next batch expected in spring of 2020) requires some justification. But the week I’ve had with this drone has left me feeling like its fundamental autonomous capability is so far beyond just about anything that I’ve ever experienced that I’m questioning why I would every fly anything else ever again.

We’ve written extensively about Skydio, beginning in early 2016 when the company posted a video of a prototype drone dodging trees while following a dude on a bike. Even three years ago, Skydio’s tech was way better than anything we’d seen outside of a research lab, and in early 2018, they introduced their first consumer product, the Skydio R1. A little over a year later, Skydio has introduced the Skydio 2, which is smaller, smarter, and much more affordable. Here’s an overview video just to get you caught up:

Skydio sent me a Skydio 2 review unit last week, and while I’m reasonably experienced with drones in general, this is the first time I’ve tried a Skydio drone in person. I had a pretty good idea what to expect, and I was absolutely blown away. Like, I was giggling to myself while running through the woods as the drone zoomed around, deftly avoiding trees and keeping me in sight. Robots aren’t supposed to be this good.

A week is really not enough time to explore everything that the Skydio can do, especially Thanksgiving week in Washington, D.C. (a no-fly zone) in early winter. But I found a nearby state park in which I could legally and safely fly the drone, and I did my best to put the Skydio 2 through its paces.

Note: Throughout this review, we’ve got a bunch of GIFs to help illustrate different features of the drone. To fit them all in, these GIFs had to be heavily compressed. Underneath each GIF is a timestamped link to this YouTube video (also available at the bottom of the post), which you can click on to see the an extended cut of the original 4K 30 fps footage. And there’s a bunch of interesting extra video in there as well.

Skydio 2 Specs

Photo: Evan Ackerman/IEEE Spectrum

The Skydio 2 is primarily made out of magnesium, which (while light) is both heavier and more rigid and durable than plastic. The offset props (the back pair are above the body, and the front pair are below) are necessary to maintain the field of view of the navigation cameras.

The Skydio 2 both looks and feels like a well-designed and carefully thought-out drone. It’s solid, and a little on the heavy side as far as drones go—it’s primarily made out of magnesium, which (while light) is both heavier and more rigid and durable than plastic. The blue and black color scheme is far more attractive than you typically see with drones.

Photo: Evan Ackerman/IEEE Spectrum

To detect and avoid obstacles, the Skydio 2 uses an array of six 4K hemispherical cameras that feed data into an NVIDIA Jetson TX2 at 30 fps, with the drone processing a million points in 3D space per second to plan the safest path.

The Skydio 2 is built around an array of six hemispherical obstacle-avoidance cameras and the NVIDIA Jetson TX2 computing module that they’re connected to. This defines the placement of the gimbal, the motors and props, and the battery, since all of this stuff has to be as much as possible out of the view of the cameras in order for the drone to effectively avoid obstacles in any direction.

Without the bottom-mounted battery attached, the drone is quite flat. The offset props (the back pair are above the body, and the front pair are below) are necessary to maintain the field of view of the obstacle-avoidance cameras. These hemispherical cameras are on the end of each of the prop arms as well as above and below the body of the drone. They look awfully exposed, even though each is protected from ground contact by a little fin. You need to make sure these cameras are clean and smudge-free, and Skydio includes a cleaning cloth for this purpose. Underneath the drone there are slots for microSD cards, one for recording from the camera and a second one that the drone uses to store data. The attention to detail extends to the SD card insertion, which has a sloped channel that guides the card securely into its slot.

Once you snap the battery in, the drone goes from looking streamlined to looking a little chubby. Relative to other drones, the battery almost seems like an afterthought, like Skydio designed the drone and then remembered, “oops we have to add a battery somewhere, let’s just kludge it onto the bottom.” But again, the reason for this is to leave room inside the body for the NVIDIA TX2, while making sure that the battery stays out of view of the obstacle avoidance cameras.

The magnetic latching system for the battery is both solid and satisfying. I’m not sure why it’s necessary, strictly speaking, but I do like it, and it doesn’t seem like the battery will fly off even during the most aggressive maneuvers. Each battery includes an LED array that will display its charge level in 25 percent increments, as well as a button that you push to turn the drone on and off. Charging takes place via a USB-C port in the top of the drone, which I don’t like, because it means that the batteries can’t be charged on their own (like the Parrot Anafi’s battery), and that you can’t charge one battery while flying with another, like basically every other drone ever. A separate battery charger that will charge two at once is available from Skydio for an eyebrow-raising $129.

I appreciate that all of Skydio’s stuff (batteries, controller, and beacon) charges via USB-C, though. The included USB-C adapter with its beefy cable will output at up to 65 watts, which’ll charge a mostly depleted battery in under an hour. The drone turns itself on while charging, which seems unnecessary.

Photo: Evan Ackerman/IEEE Spectrum

The Skydio 2 is not foldable, making it not nearly as easy to transport as some other drones. But it does come with a nice case that mitigates this issue somewhat, and the drone plus two batteries end up as a passably flat package about the size of a laptop case.

The most obvious compromise that Skydio made with the Skydio 2 is that the drone is not foldable. Skydio CEO Adam Bry told us that adding folding joints to the arms of the Skydio 2 would have made calibrating all six cameras a nightmare and significantly impacted performance. This makes complete sense, of course, but it does mean that the Skydio 2 is not nearly as easy to transport as some other drones.

Photo: Evan Ackerman/IEEE Spectrum

Folded and unfolded: The Skydio 2 compared to the Parrot Anafi (upper left) and the DJI Mavic Pro (upper right).

The Skydio 2 does come with a very nice case that mitigates this issue somewhat, and the drone plus two batteries end up as a passably flat package about the size of a laptop case. Still, it’s just not as convenient to toss into a backpack as my Anafi, although the Mavic Mini might be even more portable.

Photo: Evan Ackerman/IEEE Spectrum

While the Skydio 2’s case is relatively compact, the non-foldable drone is overall a significantly larger package than the Parrot Anafi.

The design of the drone leads to some other compromises as well. Since landing gear would, I assume, occlude the camera system, the drone lands directly on the bottom of its battery pack, which has a slightly rubberized pad about the size of a playing card. This does’t feel particularly stable unless you end up on a very flat surface, and made me concerned for the exposed cameras underneath the drone as well as the lower set of props. I’d recommend hand takeoffs and landings—more on those later.

Skydio 2 Camera System

Photo: Evan Ackerman/IEEE Spectrum

The Skydio 2’s primary camera is a Sony IMX577 1/2.3″ 12.3-megapixel CMOS sensor. It’s mounted to a three-axis gimbal and records 4K video at 60 fps, or 1080p video at 120 fps.

The Skydio 2 comes with a three-axis gimbal supporting a 12-megapixel camera, just enough to record 4K video at 60 fps, or 1080p video at 120 fps. Skydio has provided plenty of evidence that its imaging system is at least as good if not better than other drone cameras. Tested against my Mavic Pro and Parrot Anafi, I found no reason to doubt that. To be clear, I didn’t do exhaustive pixel-peeping comparisons between them, you’re just getting my subjective opinion that the Skydio 2 has a totally decent camera that you won’t be disappointed with. I will say that I found the HDR photo function to be not all that great under the few situations in which I tested it—after looking at a few muddy sunset shots, I turned it off and was much happier.

Photo: Evan Ackerman/IEEE Spectrum

The Skydio 2’s 12-megapixel camera is solid, although we weren’t impressed with the HDR option.

The video stabilization is fantastic, to the point where watching the video footage can be underwhelming because it doesn’t reflect the motion of the drone. I almost wish there was a way to change to unstabilized (or less-stabilized) video so that the viewer could get a little more of a wild ride. Or, ideally, there’d be a way for the drone to provide you with a visualization of what it was doing using the data collected by its cameras. That’s probably wishful thinking, though. The drone itself doesn’t record audio because all you’d get would be an annoying buzz, but the app does record audio, so the audio from your phone gets combined with the drone video. Don’t expect great quality, but it’s better than nothing.

Skydio 2 App
The app is very simple compared to every other drone app I’ve tried, and that’s a good thing. Here’s what it looks like:

Image: Skydio

Trackable subjects get a blue “+” sign over them, and if you tap them, the “+” turns into a spinny blue circle. Once you’ve got a subject selected, you can choose from a variety of cinematic skills that the drone will execute while following you.

You get the controls that you need and the information that you need, and nothing else. Manual flight with the on-screen buttons works adequately, and the double-tap to fly function on the phone works surprisingly well, making it easy to direct the drone to a particular spot above the ground.

The settings menus are limited but functional, allowing you to change settings for the camera and a few basic tweaks for controlling the drone. One unique setting to the Skydio 2 is the height floor—since the drone only avoids static obstacles, you can set it to maintain a height of at least 8 feet above the ground while flying autonomously to make sure that if you’re flying around other people, it won’t run into anyone who isn’t absurdly tall and therefore asking for it.

Trackable subjects get a blue “+” sign over them in the app, and if you tap them, the “+” turns into a spinny blue circle. Once you’ve got a subject selected, you can choose from a variety of cinematic skills that the drone will execute while following you, and in addition, you can select “one-shot” skills that involve the drone performing a specific maneuver before returning to the previously selected cinematic skill. For example, you can tell the drone to orbit around you, and then do a “rocket” one-shot where it’ll fly straight up above you (recording the whole time, of course), before returning to its orbiting.

After you’re done flying, you can scroll through your videos and easily clip out excerpts from them and save them to your phone for sharing. Again, it’s a fairly simple interface without a lot of options. You could call it limited, I guess, but I appreciate that it just does a few things that you care about and otherwise doesn’t clutter itself up.

The real limitation of the app is that it uses Wi-Fi to connect to the Skydio 2, which restricts the range. To fly much beyond a hundred meters or so, you’ll need to use the controller or beacon instead.

Skydio 2 Controller and Beacon

Photo: Evan Ackerman/IEEE Spectrum

While the Skydio 2 controller provides a better hands-on flight experience than with the phone, plus an extended range of up to 3.5 km, more experienced pilots may find manual control a bit frustrating, because the underlying autonomy will supersede your maneuvers when you start getting close to objects.

I was looking forward to using the controller, because with every other drone I’ve had, the precision that a physically controller provides is, I find, mandatory for a good flying experience and to get the photos and videos that you want. With Skydio 2, that’s all out the window. It’s not that the controller is useless or anything, it’s just that because the drone tracks you and avoids obstacles on its own, that level of control precision becomes largely unnecessary.

The controller itself is perfectly fine. It’s a rebranded Parrot Skycontroller3, which is the same as the one that you get with a Parrot Anafi. It’s too bad that the sticks don’t unscrew to make it a little more portable, and overall it’s functional rather than fancy, but it feels good to use and includes a sizeable antenna that makes a significant difference to the range that you get (up to 3.5 kilometers).

You definitely get a better hands-on flight experience with the controller than with the phone, so if you want to (say) zip the drone around some big open space for fun, it’s good for that. And it’s nice to be able to hand the controller to someone who’s never flown a drone before and let them take it for a spin without freaking out about them crashing it the whole time. For more experienced pilots, though, the controller is ultimately just a bit frustrating, because the underlying autonomy will supersede your control when you start getting close to objects, which (again) limits how useful the controller is relative to your phone.

I do still prefer the controller over the phone, but I’m not sure that it’s worth the extra $150, unless you plan to fly the Skydio 2 at very long distances or primarily in manual mode. And honestly, if either of those two things are your top priority, the Skydio 2 is probably not the drone for you.

Photo: Evan Ackerman/IEEE Spectrum

The Skydio 2 beacon uses GPS tracking to help the drone follow you, extending range up to 1.5 km. You can also fly the with the beacon alone, no phone necessary.

The purpose of the beacon, according to Skydio, is to give the drone a way of tracking you if it can’t see you, which can happen, albeit infrequently. My initial impression of the beacon was that it was primarily useful as a range-extending bridge between my phone and the drone. But I accidentally left my phone at home one day (oops) and had to fly the drone with only the beacon, and it was a surprisingly decent experience. The beacon allows for full manual control of a sort—you can tap different buttons to rotate, fly forward, and ascend or descend. This is sufficient for takeoff, landing, to make sure that the drone is looking at you when you engage visual tracking, and to rescue it if it gets trapped somewhere.

The rest of the beacon’s control functions are centered around a few different tracking modes, and with these, it works just about as well as your phone. You have fewer options overall, but all the basic stuff is there with just a few intuitive button clicks, including tracking range and angle. If you’re willing to deal with this relatively minor compromise, it’s nice to not have your phone available for other things rather than being monopolized by the drone.

Skydio 2 In Flight

GIF: Evan Ackerman/IEEE Spectrum

Hand takeoffs are simple and reliable.
Click here for a full resolution clip.

Starting up the Skydio 2 doesn’t require any kind of unusual calibration steps or anything like that. It prefers to be kept still, but you can start it up while holding it, it’ll just take a few seconds longer to tell you that it’s ready to go. While the drone will launch from any flat surface with significant clearance around it (it’ll tell you if it needs more room), the small footprint of the battery means that I was more comfortable hand launching it. This is not a “throw” launch; you just let the drone rest on your palm, tell it to take off, and then stay still while it gets its motors going and then gently lifts off. The lift off is so gentle that you have to be careful not to pull your hand away too soon—I did that once and the drone, being not quite ready, dropped towards the ground, but managed to recover without much drama.

GIF: Evan Ackerman/IEEE Spectrum

Hand landings always look scary, but the Skydio 2 is incredibly gentle. After trying this once, it became the only way I ever landed the drone.
Click here for a full resolution clip.

Catching the drone for landing is perhaps very slightly more dangerous, but not any more difficult. You put the drone above and in front of you facing away, tell it to land in the app or with the beacon, and then put your hand underneath it to grasp it as it slowly descends. It settles delicately and promptly turns itself off. Every drone should land this way. The battery pack provides a good place to grip, although you do have to be mindful of the forward set of props, which (since they’re the pair that are beneath the body of drone) are quite close to your fingers. You’ll certainly be mindful after you catch a blade with your fingers once. Which I did. For the purposes of this review and totally not by accident. No damage, for the record.

Photo: Evan Ackerman/IEEE Spectrum

You won’t be disappointed with the Skydio 2’s in-flight performance, unless you’re looking for a dedicated racing drone.

In normal flight, the Skydio 2 performs as well as you’d expect. It’s stable and manages light to moderate wind without any problems, although I did notice some occasional lateral drifting when the drone should have been in a stationary hover. While the controller gains are adjustable, the Skydio 2 isn’t quite as aggressive in flight as my Mavic Pro on Sport Mode, but again, if you’re looking for a high-speed drone, that’s really not what the Skydio is all about.

The Skydio 2 is substantially louder than my Anafi, although the Anafi is notably quiet for a drone. It’s not annoying to hear (not a high-pitched whine), but you can hear it from a ways away, and farther away than my Mavic Pro. I’m not sure whether that’s because of the absolute volume or the volume plus the pitch. In some ways, this is a feature, since you can hear the drone following you even if you’re not looking at it, you just need to be aware of the noise it makes when you’re flying it around people.

Obstacle Avoidance
The primary reason Skydio 2 is the drone that you want to fly is because of its autonomous subject tracking and obstacle avoidance. Skydio’s PR videos make this capability look almost too good, and since I hadn’t tried out one of their drones before, the first thing I did with it was exactly what you’d expect: attempt to fly it directly into the nearest tree.

GIF: Evan Ackerman/IEEE Spectrum

The Skydio 2 deftly slides around trees and branches. The control inputs here were simple “forward” or “turn,” all obstacle avoidance is autonomous.
Click here for a full resolution clip.

And it just won’t do it. It slows down a bit, and then slides right around one tree after another, going over and under and around branches. I pointed the drone into a forest and just held down “forward” and away it went, without any fuss, effortlessly ducking and weaving its way around. Of course, it wasn’t effortless at all—six 4K cameras were feeding data into the NVIDIA TX2 at 30 fps, and the drone was processing a million points in 3D space per second to plan the safest path while simultaneously taking into account where I wanted it to go. I spent about 10 more minutes doing my level best to crash the drone into anything at all using a flying technique probably best described as “reckless,” but the drone was utterly unfazed. It’s incredible.

What knocked my socks off was telling the drone to pass through treetops—in the clip below, I’m just telling the drone to fly straight down. Watch as it weaves its way through gaps between the branches:

GIF: Evan Ackerman/IEEE Spectrum

The result of parking the Skydio 2 above some trees and holding “down” on the controller is this impressive fully autonomous descent through the branches.
Click here for a full resolution clip.

Here’s one more example, where I sent the drone across a lake and started poking around in a tree. Sometimes the Skydio 2 isn’t sure where you want it to go, and you have to give it a little bit of a nudge in a clear direction, but that’s it.

GIF: Evan Ackerman/IEEE Spectrum

In obstacle-heavy environments, the Skydio 2 prudently slows down, but it can pick its way through almost anything that it can see.
Click here for a full resolution clip.

It’s important to keep in mind that all of the Skydio 2’s intelligence is based on vision. It uses cameras to see the world, which means that it has similar challenges as your eyes do. Specifically, Skydio warns against flying in the following conditions:

Skydio 2 can’t see certain visually challenging obstacles. Do not fly around thin branches, telephone or power lines, ropes, netting, wires, chain link fencing or other objects less than ½ inch in diameter.
Do not fly around transparent surfaces like windows or reflective surfaces like mirrors greater than 60 cm wide.
When the sun is low on the horizon, it can temporarily blind Skydio 2’s cameras depending on the angle of flight. Your drone may be cautious or jerky when flying directly toward the sun.

Basically, if you’d have trouble seeing a thing, or seeing under some specific flight conditions, then the Skydio 2 almost certainly will also. It gets even more problematic when challenging obstacles are combined with challenging flight conditions, which is what I’m pretty sure led to the only near-crash I had with the drone. Here’s a video:

GIF: Evan Ackerman/IEEE Spectrum

Flying around very thin branches and into the sun can cause problems for the Skydio 2’s obstacle avoidance.
Click here for a full resolution clip.

I had the Skydio 2 set to follow me on my bike (more about following and tracking in a bit). It was mid afternoon, but since it’s late fall here in Washington, D.C., the sun doesn’t get much higher than 30 degrees above the horizon. Late fall also means that most of the deciduous trees have lost their leaves, and so there are a bunch of skinny branches all over the place. The drone was doing a pretty good job of following me along the road at a relatively slow speed, and then it clipped the branch that you can just barely see in the video above. It recovered in an acrobatic maneuver that has been mostly video-stabilized out, and resumed tracking me before I freaked and told it to land. You can see another example here, where the drone (again) clips a branch that has the sun behind it, and this clip shows me stopping my bike before the drone runs into another branch in a similar orientation. As the video shows, it’s very hard to see the branches until it’s too late.

As far as I can tell, the drone is no worse for wear from any of this, apart from a small nick in one of the props. But, this is a good illustration of a problematic situation for the Skydio 2: flying into a low sun angle around small bare branches. Should I not have been flying the drone in this situation? It’s hard to say. These probably qualify as “thin branches,” although there was plenty of room along with middle of the road. There is an open question with the Skydio 2 as to exactly how much responsibility the user should have about when and where it’s safe to fly—for branches, how thin is too thin? How low can the sun be? What if the branches are only kinda thin and the sun is only kinda low, but it’s also a little windy? Better to be safe than sorry, of course, but there’s really no way for the user (or the drone) to know what it can’t handle until it can’t handle it.

Edge cases like these aside, the obstacle avoidance just works. Even if you’re not deliberately trying to fly into branches, it’s keeping a lookout for you all the time, which means that flying the drone goes from somewhat stressful to just pure fun. I can’t emphasize enough how amazing it is to be able to fly without worrying about running into things, and how great it feels to be able to hand the controller to someone who’s never flown a drone before and say, with complete confidence, “go ahead, fly it around!”

Skydio 2 vs. DJI Mavic

Photo: Evan Ackerman/IEEE Spectrum

Both the Skydio 2 and many models of DJI’s Mavic use visual obstacle avoidance, but the Skydio 2 is so much more advanced that you can’t really compare the two systems.

It’s important to note that there’s a huge difference between the sort of obstacle avoidance that you get with a DJI Mavic, and the sort of obstacle avoidance that you get with the Skydio 2. The objective of the Mavic’s obstacle avoidance is really there to prevent you from accidentally running into things, and in that capacity, it usually works. But there are two things to keep in mind here—first, not running into things is not the same as avoiding things, because avoiding things means planning several steps ahead, not just one step.

Second, there’s the fact that the Mavic’s obstacle detection only works most of the time. Fundamentally, I don’t trust my Mavic Pro, because sometimes the safety system doesn’t kick in for whatever reason and the drone ends up alarmingly close to something. And that’s actually fine, because with the Mavic, I expect to be piloting it. It’s for this same reason that I don’t care that my Parrot Anafi doesn’t have obstacle avoidance at all: I’m piloting it anyway, and I’m a careful pilot, so it just doesn’t matter. The Skydio 2 is totally and completely different. It’s in a class by itself, and you can’t compare what it can do to what anything else out there right now. Period.

Skydio 2 Tracking
Skydio’s big selling point on the Skydio 2 is that it’ll autonomously track you while avoiding obstacles. It does this visually, by watching where you go, predicting your future motion, and then planning its own motion to keep you in frame. The works better than you might expect, in that it’s really very good at not losing you. Obviously, the drone prioritizes not running into stuff over tracking you, which means that it may not always be where you feel like it should be. It’s probably trying to get there, but in obstacle dense environments, it can take some creative paths.

Having said that, I found it to be very consistent with keeping me in the frame, and I only managed to lose it when changing direction while fully occluded by an obstacle, or while it was executing an avoidance maneuver that was more dynamic than normal. If you deliberately try to hide from the drone it’s not that hard to do so if there are enough obstacles around, but I didn’t find the tracking to be something that I had to worry about it most cases. When tracking does fail and you’re not using the beacon, the drone will come to a hover. It won’t try and find you, but it will reacquire you if you get back into its field of view.

The Skydio 2 had no problem tracking me running through fairly dense trees:

GIF: Evan Ackerman/IEEE Spectrum

The Skydio 2 had no problem chasing me around through these trees, even while I was asking it to continually change its tracking angle.
Click here for a full resolution clip.

It also managed to keep up with me as I rode my bike along a tree-lined road:

GIF: Evan Ackerman/IEEE Spectrum

The Skydio 2 is easily fast enough to keep up with me on a bike, even while avoiding tree branches.
Click here for a full resolution clip.

It lost me when I asked it to follow very close behind me as I wove through some particularly branch-y trees, but it fails more or less gracefully by just sort of nope-ing out of situations when they start to get bad and coming to a hover somewhere safe.

GIF: Evan Ackerman/IEEE Spectrum

The Skydio 2 knows better than to put itself into situations that it can’t handle, and will bail to a safe spot if things get too complicated.
Click here for a full resolution clip.

After a few days of playing with the drone, I started to get to the point where I could set it to track me and then just forget about it while I rode my bike or whatever, as opposed to constantly turning around to make sure it was still behind me, which is what I was doing initially. It’s a level of trust that I don’t think would be possible with any other drone.

Should You Buy a Skydio 2?

Photo: Evan Ackerman/IEEE Spectrum

We think the Skydio 2 is fun and relaxing to fly, with unique autonomous intelligence that makes it worth the cost.

In case I haven’t said it often enough in this review, the Skydio 2 is an incredible piece of technology. As far as I know (as a robotics journalist, mind you), this represents the state of the art in commercial drone autonomy, and quite possibly the state of the art in drone autonomy, period. And it’s available for $999, which is expensive, but less money than a Mavic Pro 2. If you’re interested in a new drone, you should absolutely consider the Skydio 2.

There are some things to keep in mind—battery life is a solid but not stellar 20 minutes. Extra batteries are expensive at $99 each (the base kit includes just one). The controller and the beacon are also expensive, at $150 each. And while I think the Skydio 2 is definitely the drone you want to fly, it may not be the drone you want to travel with, since it’s bulky compared to other options.

But there’s no denying the fact that the experience is uniquely magical. Once you’ve flown the Skydio 2, you won’t want to fly anything else. This drone makes it possible to get pictures and videos that would be otherwise impossible, and you can do it completely on your own. You can trust the drone to do what it promises, as long as you’re mindful of some basic and common sense safety guidelines. And we’ve been told that the drone is only going to get smarter and more capable over time.

If you buy a Skydio 2, it comes with the following warranty from Skydio:

“If you’re operating your Skydio 2 within our Safe Flight guidelines, and it crashes, we’ll repair or replace it for free.”

Skydio trusts their drone to go out into a chaotic and unstructured world and dodge just about anything that comes its way. And after a week with this drone, I can see how they’re able to offer this kind of guarantee. This is the kind of autonomy that robots have been promising for years, and the Skydio 2 makes it real.

Detailed technical specifications are available on Skydio’s website, and if you have any questions, post a comment—we’ve got this drone for a little while longer, and I’d be happy to try out (nearly) anything with it.

Skydio 2 Review Video Highlights
This video is about 7 minutes of 4K, 30 fps footage directly from the Skydio 2. The only editing I did was cutting clips together, no stabilization or color correcting or anything like that. The drone will record in 4K 60 fps, so it gets smoother than this, but I, er, forgot to change the setting.

[ Skydio ] Continue reading →

Posted in Human Robots

#436234 Robot Gift Guide 2019

Posted on November 28, 2019 by Android

Welcome to the eighth edition of IEEE Spectrum’s Robot Gift Guide!

This year we’re featuring 15 robotic products that we think will make fantastic holiday gifts. As always, we tried to include a broad range of robot types and prices, focusing mostly on items released this year. (A reminder: While we provide links to places where you can buy these items, we’re not endorsing any in particular, and a little bit of research may result in better deals.)

If you need even more robot gift ideas, take a look at our past guides: 2018, 2017, 2016, 2015, 2014, 2013, and 2012. Some of those robots are still great choices and might be way cheaper now than when we first posted about them. And if you have suggestions that you’d like to share, post a comment below to help the rest of us find the perfect robot gift.

Skydio 2

Image: Skydio

What makes robots so compelling is their autonomy, and the Skydio 2 is one of the most autonomous robots we’ve ever seen. It uses an array of cameras to map its environment and avoid obstacles in real-time, making flight safe and effortless and enabling the kinds of shots that would be impossible otherwise. Seriously, this thing is magical, and it’s amazing that you can actually buy one.
$1,000
Skydio
UBTECH Jimu MeeBot 2

Image: UBTECH

The Jimu MeeBot 2.0 from UBTECH is a STEM education robot designed to be easy to build and program. It includes six servo motors, a color sensor, and LED lights. An app for iPhone or iPad provides step-by-step 3D instructions, and helps you code different behaviors for the robot. It’s available exclusively from Apple.
$130
Apple
iRobot Roomba s9+

Image: iRobot

We know that $1,400 is a crazy amount of money to spend on a robot vacuum, but the Roomba s9+ is a crazy robot vacuum. As if all of its sensors and mapping intelligence wasn’t enough, it empties itself, which means that you can have your floors vacuumed every single day for a month and you don’t have to even think about it. This is what home robots are supposed to be.
$1,400
iRobot
PFF Gita

Photo: Piaggio Fast Forward

Nobody likes carrying things, which is why Gita is perfect for everyone with an extra $3,000 lying around. Developed by Piaggio Fast Forward, this autonomous robot will follow you around with a cargo hold full of your most important stuff, and do it in a way guaranteed to attract as much attention as possible.
$3,250
Gita
DJI Mavic Mini

Photo: DJI

It’s tiny, it’s cheap, and it takes good pictures—what more could you ask for from a drone? And for $400, this is an excellent drone to get if you’re on a budget and comfortable with manual flight. Keep in mind that while the Mavic Mini is small enough that you don’t need to register it with the FAA, you do still need to follow all the same rules and regulations.
$400
DJI
LEGO Star Wars Droid Commander

Image: LEGO

Designed for kids ages 8+, this LEGO set includes more than 1,000 pieces, enough to build three different droids: R2-D2, Gonk Droid, and Mouse Droid. Using a Bluetooth-controlled robotic brick called Move Hub, which connects to the LEGO BOOST Star Wars app, kids can change how the robots behave and solve challenges, learning basic robotics and coding skills.
$200
LEGO
Sony Aibo

Photo: Sony

Robot pets don’t get much more sophisticated (or expensive) than Sony’s Aibo. Strictly speaking, it’s one of the most complex consumer robots you can buy, and Sony continues to add to Aibo’s software. Recent new features include user programmability, and the ability to “feed” it.
$2,900 (free aibone and paw pads until 12/29/2019)
Sony
Neato Botvac D4 Connected

Photo: Neato

The Neato Botvac D4 may not have all of the features of its fancier and more expensive siblings, but it does have the features that you probably care the most about: The ability to make maps of its environment for intelligent cleaning (using lasers!), along with user-defined no-go lines that keep it where you want it. And it cleans quite well, too.
$530 $350 (sale)
Neato Robotics
Cubelets Curiosity Set

Photo: Modular Robotics

Cubelets are magnetic blocks that you can snap together to make an endless variety of robots with no programming and no wires. The newest set, called Curiosity, is designed for kids ages 4+ and comes with 10 robotic cubes. These include light and distance sensors, motors, and a Bluetooth module, which connects the robot constructions to the Cubelets app.
$250
Modular Robotics
Tertill

Photo: Franklin Robotics

Tertill does one simple job: It weeds your garden. It’s waterproof, dirt proof, solar powered, and fully autonomous, meaning that you can leave it out in your garden all summer and just enjoy eating your plants rather than taking care of them.
$350
Tertill
iRobot Root

Photo: iRobot

Root was originally developed by Harvard University as a tool to help kids progressively learn to code. iRobot has taken over Root and is now supporting the curriculum, which starts for kids before they even know how to read and should keep them busy for years afterwards.
$200
iRobot
LOVOT

Image: Lovot

Let’s be honest: Nobody is really quite sure what LOVOT is. We can all agree that it’s kinda cute, though. And kinda weird. But cute. Created by Japanese robotics startup Groove X, LOVOT does have a whole bunch of tech packed into its bizarre little body and it will do its best to get you to love it.
$2,750 (¥300,000)
LOVOT
Sphero RVR

Photo: Sphero

RVR is a rugged, versatile, easy to program mobile robot. It’s a development platform designed to be a bridge between educational robots like Sphero and more sophisticated and expensive systems like Misty. It’s mostly affordable, very expandable, and comes from a company with a lot of experience making robots.
$250
Sphero
“How to Train Your Robot”

Image: Lawrence Hall of Science

Aimed at 4th and 5th graders, “How to Train Your Robot,” written by Blooma Goldberg, Ken Goldberg, and Ashley Chase, and illustrated by Dave Clegg, is a perfect introduction to robotics for kids who want to get started with designing and building robots. But the book isn’t just for beginners: It’s also a fun, inspiring read for kids who are already into robotics and want to go further—it even introduces concepts like computer simulations and deep learning. You can download a free digital copy or request hardcopies here.
Free
UC Berkeley
MIT Mini Cheetah

Photo: MIT

Yes, Boston Dynamics’ Spot, now available for lease, is probably the world’s most famous quadruped, but MIT is starting to pump out Mini Cheetahs en masse for researchers, and while we’re not exactly sure how you’d manage to get one of these things short of stealing one directly for MIT, a Mini Cheetah is our fantasy robotics gift this year. Mini Cheetah looks like a ton of fun—it’s portable, highly dynamic, super rugged, and easy to control. We want one!
Price N/A
MIT Biomimetic Robotics Lab

For more tech gift ideas, see also IEEE Spectrum’s annual Gift Guide. Continue reading →

Posted in Human Robots