Tag Archives: evidence

#435691 Squeezing Rocket Fuel From Moon Rocks

Posted on September 16, 2019 by Android

Illustration: John MacNeill

Engineers and Architects Are Already Designing Lunar Habitats
Squeezing Rocket Fuel From Moon Rocks
Robots Will Navigate the Moon With Maps They Make Themselves
Kim Stanley Robinson Built a Moon Base in His Mind

The most valuable natural resource on the moon may be water. In addition to sustaining lunar colonists, it could also be broken down into its constituent elements—hydrogen and oxygen—and used to make rocket propellant.

Although the ancients called the dark areas on the moon maria (Latin for “seas”), it has long been clear that liquid water can’t exist on the lunar surface, where it would swiftly evaporate. Since the 1960s, though, scientists have hypothesized that the moon indeed harbors water, in the form of ice. Because the moon has a very small axial tilt—just 1.5 degrees—the floors of many polar craters remain in perpetual darkness. Water could thus condense and survive in such polar “cold traps,” where it might one day be mined.

1/5

Water Water Everywhere: Finding rich deposits of ice and extracting it should be possible but will be technically challenging for lunar settlers. Illustration: John MacNeill

2/5

Mapping the Moon: Several lunar missions have produced strong evidence of water ice. A NASA instrument called the Moon Mineralogy Mapper (M3) found indications of water ice on the permanently shadowed floors of some polar craters. However, the measurements suggest that only a small fraction of cold traps contain ice [colored areas], and that the ice is probably mixed with lunar regolith. Data source.

3/5

Rover-Mounted Drill: The most straightforward strategy for extracting water from polar ice deposits uses a rover-mounted drill. Honeybee Robotics has designed a Planetary Volatiles Extractor with a heated auger, which would cause any water ice in the drilled regolith to vaporize. That vapor would then move through a tube to a condenser unit, where it would turn back into ice. Illustration: John MacNeill

4/5

Thermal Mining: A more ambitious scheme for extracting water from the moon is “thermal mining.” Researchers at the Colorado School of Mines have proposed redirecting the sun’s rays , using heliostats mounted on a crater rim. Water trapped in the regolith would turn into vapor that would be collected in a large tent, then vented into refrigerated cold traps, where it would condense as pure water ice. Illustration: John MacNeill

5/5

Compressed-Gas Transport: To produce rocket fuel from water ice would require an electrolyzer to break the water into hydrogen and oxygen, which would then be compressed and stored for later use. In situ production would also require vehicles to transport the processed fuel to rocket pads. Illustration: John MacNeill

Previous
Next Continue reading →

Posted in Human Robots

#435676 Intel’s Neuromorphic System Hits 8 ...

Posted on September 16, 2019 by Android

At the DARPA Electronics Resurgence Initiative Summit today in Detroit, Intel plans to unveil an 8-million-neuron neuromorphic system comprising 64 Loihi research chips—codenamed Pohoiki Beach. Loihi chips are built with an architecture that more closely matches the way the brain works than do chips designed to do deep learning or other forms of AI. For the set of problems that such “spiking neural networks” are particularly good at, Loihi is about 1,000 times as fast as a CPU and 10,000 times as energy efficient. The new 64-Loihi system represents the equivalent of 8-million neurons, but that’s just a step to a 768-chip, 100-million-neuron system that the company plans for the end of 2019.

Intel and its research partners are just beginning to test what massive neural systems like Pohoiki Beach can do, but so far the evidence points to even greater performance and efficiency, says Mike Davies, director of neuromorphic research at Intel.

“We’re quickly accumulating results and data that there are definite benefits… mostly in the domain of efficiency. Virtually every one that we benchmark…we find significant gains in this architecture,” he says.

Going from a single-Loihi to 64 of them is more of a software issue than a hardware one. “We designed scalability into the Loihi chip from the beginning,” says Davies. “The chip has a hierarchical routing interface…which allows us to scale to up to 16,000 chips. So 64 is just the next step.”

Photo: Tim Herman/Intel Corporation

One of Intel’s Nahuku boards, each of which contains 8 to 32 Intel Loihi neuromorphic chips, shown here interfaced to an Intel Arria 10 FPGA development kit. Intel’s latest neuromorphic system, Pohoiki Beach, is made up of multiple Nahuku boards and contains 64 Loihi chips.

Finding algorithms that run well on an 8-million-neuron system and optimizing those algorithms in software is a considerable effort, he says. Still, the payoff could be huge. Neural networks that are more brain-like, such as Loihi, could be immune to some of the artificial intelligence’s—for lack of a better word—dumbness.

For example, today’s neural networks suffer from something called catastrophic forgetting. If you tried to teach a trained neural network to recognize something new—a new road sign, say—by simply exposing the network to the new input, it would disrupt the network so badly that it would become terrible at recognizing anything. To avoid this, you have to completely retrain the network from the ground up. (DARPA’s Lifelong Learning, or L2M, program is dedicated to solving this problem.)

(Here’s my favorite analogy: Say you coached a basketball team, and you raised the net by 30 centimeters while nobody was looking. The players would miss a bunch at first, but they’d figure things out quickly. If those players were like today’s neural networks, you’d have to pull them off the court and teach them the entire game over again—dribbling, passing, everything.)

Loihi can run networks that might be immune to catastrophic forgetting, meaning it learns a bit more like a human. In fact, there’s evidence through a research collaboration with Thomas Cleland’s group at Cornell University, that Loihi can achieve what’s called one-shot learning. That is, learning a new feature after being exposed to it only once. The Cornell group showed this by abstracting a model of the olfactory system so that it would run on Loihi. When exposed to a new virtual scent, the system not only didn't catastrophically forget everything else it had smelled, it learned to recognize the new scent just from the single exposure.

Loihi might also be able to run feature-extraction algorithms that are immune to the kinds of adversarial attacks that befuddle today’s image recognition systems. Traditional neural networks don’t really understand the features they’re extracting from an image in the way our brains do. “They can be fooled with simplistic attacks like changing individual pixels or adding a screen of noise that wouldn’t fool a human in any way,” Davies explains. But the sparse-coding algorithms Loihi can run work more like the human visual system and so wouldn’t fall for such shenanigans. (Disturbingly, humans are not completely immune to such attacks.)

Photo: Tim Herman/Intel Corporation

A close-up shot of Loihi, Intel’s neuromorphic research chip. Intel’s latest neuromorphic system, Pohoiki Beach, will be comprised of 64 of these Loihi chips.

Researchers have also been using Loihi to improve real-time control for robotic systems. For example, last week at the Telluride Neuromorphic Cognition Engineering Workshop—an event Davies called “summer camp for neuromorphics nerds”—researchers were hard at work using a Loihi-based system to control a foosball table. “It strikes people as crazy,” he says. “But it’s a nice illustration of neuromorphic technology. It’s fast, requires quick response, quick planning, and anticipation. These are what neuromorphic chips are good at.” Continue reading →

Posted in Human Robots

#435520 These Are the Meta-Trends Shaping the ...

Posted on August 20, 2019 by Android

Life is pretty different now than it was 20 years ago, or even 10 years ago. It’s sort of exciting, and sort of scary. And hold onto your hat, because it’s going to keep changing—even faster than it already has been.

The good news is, maybe there won’t be too many big surprises, because the future will be shaped by trends that have already been set in motion. According to Singularity University co-founder and XPRIZE founder Peter Diamandis, a lot of these trends are unstoppable—but they’re also pretty predictable.

At SU’s Global Summit, taking place this week in San Francisco, Diamandis outlined some of the meta-trends he believes are key to how we’ll live our lives and do business in the (not too distant) future.

Increasing Global Abundance
Resources are becoming more abundant all over the world, and fewer people are seeing their lives limited by scarcity. “It’s hard for us to realize this as we see crisis news, but what people have access to is more abundant than ever before,” Diamandis said. Products and services are becoming cheaper and thus available to more people, and having more resources then enables people to create more, thus producing even more resources—and so on.

Need evidence? The proportion of the world’s population living in extreme poverty is currently lower than it’s ever been. The average human life expectancy is longer than it’s ever been. The costs of day-to-day needs like food, energy, transportation, and communications are on a downward trend.

Take energy. In most of the world, though its costs are decreasing, it’s still a fairly precious commodity; we turn off our lights and our air conditioners when we don’t need them (ideally, both to save money and to avoid wastefulness). But the cost of solar energy has plummeted, and the storage capacity of batteries is improving, and solar technology is steadily getting more efficient. Bids for new solar power plants in the past few years have broken each other’s records for lowest cost per kilowatt hour.

“We’re not far from a penny per kilowatt hour for energy from the sun,” Diamandis said. “And if you’ve got energy, you’ve got water.” Desalination, for one, will be much more widely feasible once the cost of the energy needed for it drops.

Knowledge is perhaps the most crucial resource that’s going from scarce to abundant. All the world’s knowledge is now at the fingertips of anyone who has a mobile phone and an internet connection—and the number of people connected is only going to grow. “Everyone is being connected at gigabit connection speeds, and this will be transformative,” Diamandis said. “We’re heading towards a world where anyone can know anything at any time.”

Increasing Capital Abundance
It’s not just goods, services, and knowledge that are becoming more plentiful. Money is, too—particularly money for business. “There’s more and more capital available to invest in companies,” Diamandis said. As a result, more people are getting the chance to bring their world-changing ideas to life.

Venture capital investments reached a new record of $130 billion in 2018, up from $84 billion in 2017—and that’s just in the US. Globally, VC funding grew 21 percent from 2017 to a total of $207 billion in 2018.

Through crowdfunding, any person in any part of the world can present their idea and ask for funding. That funding can come in the form of a loan, an equity investment, a reward, or an advanced purchase of the proposed product or service. “Crowdfunding means it doesn’t matter where you live, if you have a great idea you can get it funded by people from all over the world,” Diamandis said.

All this is making a difference; the number of unicorns—privately-held startups valued at over $1 billion—currently stands at an astounding 360.

One of the reasons why the world is getting better, Diamandis believes, is because entrepreneurs are trying more crazy ideas—not ideas that are reasonable or predictable or linear, but ideas that seem absurd at first, then eventually end up changing the world.

Everyone and Everything, Connected
As already noted, knowledge is becoming abundant thanks to the proliferation of mobile phones and wireless internet; everyone’s getting connected. In the next decade or sooner, connectivity will reach every person in the world. 5G is being tested and offered for the first time this year, and companies like Google, SpaceX, OneWeb, and Amazon are racing to develop global satellite internet constellations, whether by launching 12,000 satellites, as SpaceX’s Starlink is doing, or by floating giant balloons into the stratosphere like Google’s Project Loon.

“We’re about to reach a period of time in the next four to six years where we’re going from half the world’s people being connected to the whole world being connected,” Diamandis said. “What happens when 4.2 billion new minds come online? They’re all going to want to create, discover, consume, and invent.”

And it doesn’t stop at connecting people. Things are becoming more connected too. “By 2020 there will be over 20 billion connected devices and more than one trillion sensors,” Diamandis said. By 2030, those projections go up to 500 billion and 100 trillion. Think about it: there’s home devices like refrigerators, TVs, dishwashers, digital assistants, and even toasters. There’s city infrastructure, from stoplights to cameras to public transportation like buses or bike sharing. It’s all getting smart and connected.

Soon we’ll be adding autonomous cars to the mix, and an unimaginable glut of data to go with them. Every turn, every stop, every acceleration will be a data point. Some cars already collect over 25 gigabytes of data per hour, Diamandis said, and car data is projected to generate $750 billion of revenue by 2030.

“You’re going to start asking questions that were never askable before, because the data is now there to be mined,” he said.

Increasing Human Intelligence
Indeed, we’ll have data on everything we could possibly want data on. We’ll also soon have what Diamandis calls just-in-time education, where 5G combined with artificial intelligence and augmented reality will allow you to learn something in the moment you need it. “It’s not going and studying, it’s where your AR glasses show you how to do an emergency surgery, or fix something, or program something,” he said.

We’re also at the beginning of massive investments in research working towards connecting our brains to the cloud. “Right now, everything we think, feel, hear, or learn is confined in our synaptic connections,” Diamandis said. What will it look like when that’s no longer the case? Companies like Kernel, Neuralink, Open Water, Facebook, Google, and IBM are all investing billions of dollars into brain-machine interface research.

Increasing Human Longevity
One of the most important problems we’ll use our newfound intelligence to solve is that of our own health and mortality, making 100 years old the new 60—then eventually, 120 or 150.

“Our bodies were never evolved to live past age 30,” Diamandis said. “You’d go into puberty at age 13 and have a baby, and by the time you were 26 your baby was having a baby.”

Seeing how drastically our lifespans have changed over time makes you wonder what aging even is; is it natural, or is it a disease? Many companies are treating it as one, and using technologies like senolytics, CRISPR, and stem cell therapy to try to cure it. Scaffolds of human organs can now be 3D printed then populated with the recipient’s own stem cells so that their bodies won’t reject the transplant. Companies are testing small-molecule pharmaceuticals that can stop various forms of cancer.

“We don’t truly know what’s going on inside our bodies—but we can,” Diamandis said. “We’re going to be able to track our bodies and find disease at stage zero.”

Chins Up
The world is far from perfect—that’s not hard to see. What’s less obvious but just as true is that we’re living in an amazing time. More people are coming together, and they have more access to information, and that information moves faster, than ever before.

“I don’t think any of us understand how fast the world is changing,” Diamandis said. “Most people are fearful about the future. But we should be excited about the tools we now have to solve the world’s problems.”

Image Credit: spainter_vfx / Shutterstock.com Continue reading →

Posted in Human Robots

#435167 A Closer Look at the Robots Helping Us ...

Posted on June 5, 2019 by Android

Buck Rogers had Twiki. Luke Skywalker palled around with C-3PO and R2-D2. And astronauts aboard the International Space Station (ISS) now have their own robotic companions in space—Astrobee.

A pair of the cube-shaped robots were launched to the ISS during an April re-supply mission and are currently being commissioned for use on the space station. The free-flying space robots, dubbed Bumble and Honey, are the latest generation of robotic machines to join the human crew on the ISS.

Exploration of the solar system and beyond will require autonomous machines that can assist humans with numerous tasks—or go where we cannot. NASA has said repeatedly that robots will be instrumental in future space missions to the moon, Mars, and even to the icy moon Europa.

The Astrobee robots will specifically test robotic capabilities in zero gravity, replacing the SPHERES (Synchronized Position Hold, Engage, Reorient, Experimental Satellite) robots that have been on the ISS for more than a decade to test various technologies ranging from communications to navigation.

The 18-sided robots, each about the size of a volleyball or an oversized Dungeons and Dragons die, use CO2-based cold-gas thrusters for movement and a series of ultrasonic beacons for orientation. The Astrobee robots, on the other hand, can propel themselves autonomously around the interior of the ISS using electric fans and six cameras.

The modular design of the Astrobee robots means they are highly plug-and-play, capable of being reconfigured with different hardware modules. The robots’ software is also open-source, encouraging scientists and programmers to develop and test new algorithms and features.

And, yes, the Astrobee robots will be busy as bees once they are fully commissioned this fall, with experiments planned to begin next year. Scientists hope to learn more about how robots can assist space crews and perform caretaking duties on spacecraft.

Robots Working Together
The Astrobee robots are expected to be joined by a familiar “face” on the ISS later this year—the humanoid robot Robonaut.

Robonaut, also known as R2, was the first US-built robot on the ISS. It joined the crew back in 2011 without legs, which were added in 2014. However, the installation never entirely worked, as R2 experienced power failures that eventually led to its return to Earth last year to fix the problem. If all goes as planned, the space station’s first humanoid robot will return to the ISS to lend a hand to the astronauts and the new robotic arrivals.

In particular, NASA is interested in how the two different robotic platforms can complement each other, with an eye toward outfitting the agency’s proposed lunar orbital space station with various robots that can supplement a human crew.

“We don’t have definite plans for what would happen on the Gateway yet, but there’s a general recognition that intra-vehicular robots are important for space stations,” Astrobee technical lead Trey Smith in the NASA Intelligent Robotics Group told IEEE Spectrum. “And so, it would not be surprising to see a mobile manipulator like Robonaut, and a free flyer like Astrobee, on the Gateway.”

While the focus on R2 has been to test its capabilities in zero gravity and to use it for mundane or dangerous tasks in space, the technology enabling the humanoid robot has proven to be equally useful on Earth.

For example, R2 has amazing dexterity for a robot, with sensors, actuators, and tendons comparable to the nerves, muscles, and tendons in a human hand. Based on that design, engineers are working on a robotic glove that can help factory workers, for instance, do their jobs better while reducing the risk of repetitive injuries. R2 has also inspired development of a robotic exoskeleton for both astronauts in space and paraplegics on Earth.

Working Hard on Soft Robotics
While innovative and technologically sophisticated, Astrobee and Robonaut are typical robots in that neither one would do well in a limbo contest. In other words, most robots are limited in their flexibility and agility based on current hardware and materials.

A subfield of robotics known as soft robotics involves developing robots with highly pliant materials that mimic biological organisms in how they move. Scientists at NASA’s Langley Research Center are investigating how soft robots could help with future space exploration.

Specifically, the researchers are looking at a series of properties to understand how actuators—components responsible for moving a robotic part, such as Robonaut’s hand—can be built and used in space.

The team first 3D prints a mold and then pours a flexible material like silicone into the mold. Air bladders or chambers in the actuator expand and compress using just air.

Some of the first applications of soft robotics sound more tool-like than R2-D2-like. For example, two soft robots could connect to produce a temporary shelter for astronauts on the moon or serve as an impromptu wind shield during one of Mars’ infamous dust storms.

The idea is to use soft robots in situations that are “dangerous, dirty, or dull,” according to Jack Fitzpatrick, a NASA intern working on the soft robotics project at Langley.

Working on Mars
Of course, space robots aren’t only designed to assist humans. In many instances, they are the only option to explore even relatively close celestial bodies like Mars. Four American-made robotic rovers have been used to investigate the fourth planet from the sun since 1997.

Opportunity is perhaps the most famous, covering about 25 miles of terrain across Mars over 15 years. A dust storm knocked it out of commission last year, with NASA officially ending the mission in February.

However, the biggest and baddest of the Mars rovers, Curiosity, is still crawling across the Martian surface, sending back valuable data since 2012. The car-size robot carries 17 cameras, a laser to vaporize rocks for study, and a drill to collect samples. It is on the hunt for signs of biological life.

The next year or two could see a virtual traffic jam of robots to Mars. NASA’s Mars 2020 Rover is next in line to visit the Red Planet, sporting scientific gadgets like an X-ray fluorescence spectrometer for chemical analyses and ground-penetrating radar to see below the Martian surface.

This diagram shows the instrument payload for the Mars 2020 mission. Image Credit: NASA.
Meanwhile, the Europeans have teamed with the Russians on a rover called Rosalind Franklin, named after a famed British chemist, that will drill down into the Martian ground for evidence of past or present life as soon as 2021.

The Chinese are also preparing to begin searching for life on Mars using robots as soon as next year, as part of the country’s Mars Global Remote Sensing Orbiter and Small Rover program. The mission is scheduled to be the first in a series of launches that would culminate with bringing samples back from Mars to Earth.

Perhaps there is no more famous utterance in the universe of science fiction as “to boldly go where no one has gone before.” However, the fact is that human exploration of the solar system and beyond will only be possible with robots of different sizes, shapes, and sophistication.

Image Credit: NASA. Continue reading →

Posted in Human Robots

#434792 Extending Human Longevity With ...

Posted on March 28, 2019 by Android

Lizards can regrow entire limbs. Flatworms, starfish, and sea cucumbers regrow entire bodies. Sharks constantly replace lost teeth, often growing over 20,000 teeth throughout their lifetimes. How can we translate these near-superpowers to humans?

The answer: through the cutting-edge innovations of regenerative medicine.

While big data and artificial intelligence transform how we practice medicine and invent new treatments, regenerative medicine is about replenishing, replacing, and rejuvenating our physical bodies.

In Part 5 of this blog series on Longevity and Vitality, I detail three of the regenerative technologies working together to fully augment our vital human organs.

Replenish: Stem cells, the regenerative engine of the body
Replace: Organ regeneration and bioprinting
Rejuvenate: Young blood and parabiosis

Let’s dive in.

Replenish: Stem Cells – The Regenerative Engine of the Body
Stem cells are undifferentiated cells that can transform into specialized cells such as heart, neurons, liver, lung, skin and so on, and can also divide to produce more stem cells.

In a child or young adult, these stem cells are in large supply, acting as a built-in repair system. They are often summoned to the site of damage or inflammation to repair and restore normal function.

But as we age, our supply of stem cells begins to diminish as much as 100- to 10,000-fold in different tissues and organs. In addition, stem cells undergo genetic mutations, which reduce their quality and effectiveness at renovating and repairing your body.

Imagine your stem cells as a team of repairmen in your newly constructed mansion. When the mansion is new and the repairmen are young, they can fix everything perfectly. But as the repairmen age and reduce in number, your mansion eventually goes into disrepair and finally crumbles.

What if you could restore and rejuvenate your stem cell population?

One option to accomplish this restoration and rejuvenation is to extract and concentrate your own autologous adult stem cells from places like your adipose (or fat) tissue or bone marrow.

These stem cells, however, are fewer in number and have undergone mutations (depending on your age) from their original ‘software code.’ Many scientists and physicians now prefer an alternative source, obtaining stem cells from the placenta or umbilical cord, the leftovers of birth.

These stem cells, available in large supply and expressing the undamaged software of a newborn, can be injected into joints or administered intravenously to rejuvenate and revitalize.

Think of these stem cells as chemical factories generating vital growth factors that can help to reduce inflammation, fight autoimmune disease, increase muscle mass, repair joints, and even revitalize skin and grow hair.

Over the last decade, the number of publications per year on stem cell-related research has increased 40x, and the stem cell market is expected to increase to $297 billion by 2022.

Rising research and development initiatives to develop therapeutic options for chronic diseases and growing demand for regenerative treatment options are the most significant drivers of this budding industry.

Biologists led by Kohji Nishida at Osaka University in Japan have discovered a new way to nurture and grow the tissues that make up the human eyeball. The scientists are able to grow retinas, corneas, the eye’s lens, and more, using only a small sample of adult skin.

In a Stanford study, seven of 18 stroke victims who agreed to stem cell treatments showed remarkable motor function improvements. This treatment could work for other neurodegenerative conditions such as Alzheimer’s, Parkinson’s, and ALS.

Doctors from the USC Neurorestoration Center and Keck Medicine of USC injected stem cells into the damaged cervical spine of a recently paralyzed 21-year-old man. Three months later, he showed dramatic improvement in sensation and movement of both arms.

In 2019, doctors in the U.K. cured a patient with HIV for the second time ever thanks to the efficacy of stem cells. After giving the cancer patient (who also had HIV) an allogeneic haematopoietic (e.g. blood) stem cell treatment for his Hodgkin’s lymphoma, the patient went into long-term HIV remission—18 months and counting at the time of the study’s publication.

Replace: Organ Regeneration and 3D Printing
Every 10 minutes, someone is added to the US organ transplant waiting list, totaling over 113,000 people waiting for replacement organs as of January 2019.

Countless more people in need of ‘spare parts’ never make it onto the waiting list. And on average, 20 people die each day while waiting for a transplant.

As a result, 35 percent of all US deaths (~900,000 people) could be prevented or delayed with access to organ replacements.

The excessive demand for donated organs will only intensify as technologies like self-driving cars make the world safer, given that many organ donors result from auto and motorcycle accidents. Safer vehicles mean less accidents and donations.

Clearly, replacement and regenerative medicine represent a massive opportunity.

Organ Entrepreneurs
Enter United Therapeutics CEO, Dr. Martine Rothblatt. A one-time aerospace entrepreneur (she was the founder of Sirius Satellite Radio), Rothblatt changed careers in the 1990s after her daughter developed a rare lung disease.

Her moonshot today is to create an industry of replacement organs. With an initial focus on diseases of the lung, Rothblatt set out to create replacement lungs. To accomplish this goal, her company United Therapeutics has pursued a number of technologies in parallel.

3D Printing Lungs
In 2017, United teamed up with one of the world’s largest 3D printing companies, 3D Systems, to build a collagen bioprinter and is paying another company, 3Scan, to slice up lungs and create detailed maps of their interior.

This 3D Systems bioprinter now operates according to a method called stereolithography. A UV laser flickers through a shallow pool of collagen doped with photosensitive molecules. Wherever the laser lingers, the collagen cures and becomes solid.

Gradually, the object being printed is lowered and new layers are added. The printer can currently lay down collagen at a resolution of around 20 micrometers, but will need to achieve resolution of a micrometer in size to make the lung functional.

Once a collagen lung scaffold has been printed, the next step is to infuse it with human cells, a process called recellularization.

The goal here is to use stem cells that grow on scaffolding and differentiate, ultimately providing the proper functionality. Early evidence indicates this approach can work.

In 2018, Harvard University experimental surgeon Harald Ott reported that he pumped billions of human cells (from umbilical cords and diced lungs) into a pig lung stripped of its own cells. When Ott’s team reconnected it to a pig’s circulation, the resulting organ showed rudimentary function.

Humanizing Pig Lungs
Another of Rothblatt’s organ manufacturing strategies is called xenotransplantation, the idea of transplanting an animal’s organs into humans who need a replacement.

Given the fact that adult pig organs are similar in size and shape to those of humans, United Therapeutics has focused on genetically engineering pigs to allow humans to use their organs. “It’s actually not rocket science,” said Rothblatt in her 2015 TED talk. “It’s editing one gene after another.”

To accomplish this goal, United Therapeutics made a series of investments in companies such as Revivicor Inc. and Synthetic Genomics Inc., and signed large funding agreements with the University of Maryland, University of Alabama, and New York Presbyterian/Columbia University Medical Center to create xenotransplantation programs for new hearts, kidneys, and lungs, respectively. Rothblatt hopes to see human translation in three to four years.

In preparation for that day, United Therapeutics owns a 132-acre property in Research Triangle Park and built a 275,000-square-foot medical laboratory that will ultimately have the capability to annually produce up to 1,000 sets of healthy pig lungs—known as xenolungs—from genetically engineered pigs.

Lung Ex Vivo Perfusion Systems
Beyond 3D printing and genetically engineering pig lungs, Rothblatt has already begun implementing a third near-term approach to improve the supply of lungs across the US.

Only about 30 percent of potential donor lungs meet transplant criteria in the first place; of those, only about 85 percent of those are usable once they arrive at the surgery center. As a result, nearly 75 percent of possible lungs never make it to the recipient in need.

What if these lungs could be rejuvenated? This concept informs Dr. Rothblatt’s next approach.

In 2016, United Therapeutics invested $41.8 million in TransMedics Inc., an Andover, Massachusetts company that develops ex vivo perfusion systems for donor lungs, hearts, and kidneys.

The XVIVO Perfusion System takes marginal-quality lungs that initially failed to meet transplantation standard-of-care criteria and perfuses and ventilates them at normothermic conditions, providing an opportunity for surgeons to reassess transplant suitability.

Rejuvenate Young Blood and Parabiosis
In HBO’s parody of the Bay Area tech community, Silicon Valley, one of the episodes (Season 4, Episode 5) is named “The Blood Boy.”

In this installment, tech billionaire Gavin Belson (Matt Ross) is meeting with Richard Hendricks (Thomas Middleditch) and his team, speaking about the future of the decentralized internet. A young, muscled twenty-something disrupts the meeting when he rolls in a transfusion stand and silently hooks an intravenous connection between himself and Belson.

Belson then introduces the newcomer as his “transfusion associate” and begins to explain the science of parabiosis: “Regular transfusions of the blood of a younger physically fit donor can significantly retard the aging process.”

While the sitcom is fiction, that science has merit, and the scenario portrayed in the episode is already happening today.

On the first point, research at Stanford and Harvard has demonstrated that older animals, when transfused with the blood of young animals, experience regeneration across many tissues and organs.

The opposite is also true: young animals, when transfused with the blood of older animals, experience accelerated aging. But capitalizing on this virtual fountain of youth has been tricky.

Ambrosia
One company, a San Francisco-based startup called Ambrosia, recently commenced one of the trials on parabiosis. Their protocol is simple: Healthy participants aged 35 and older get a transfusion of blood plasma from donors under 25, and researchers monitor their blood over the next two years for molecular indicators of health and aging.

Ambrosia’s founder Jesse Karmazin became interested in launching a company around parabiosis after seeing impressive data from animals and studies conducted abroad in humans: In one trial after another, subjects experience a reversal of aging symptoms across every major organ system. “The effects seem to be almost permanent,” he said. “It’s almost like there’s a resetting of gene expression.”

Infusing your own cord blood stem cells as you age may have tremendous longevity benefits. Following an FDA press release in February 2019, Ambrosia halted its consumer-facing treatment after several months of operation.

Understandably, the FDA raised concerns about the practice of parabiosis because to date, there is a marked lack of clinical data to support the treatment’s effectiveness.

Elevian
On the other end of the reputability spectrum is a startup called Elevian, spun out of Harvard University. Elevian is approaching longevity with a careful, scientifically validated strategy. (Full Disclosure: I am both an advisor to and investor in Elevian.)

CEO Mark Allen, MD, is joined by a dozen MDs and Ph.Ds out of Harvard. Elevian’s scientific founders started the company after identifying specific circulating factors that may be responsible for the “young blood” effect.

One example: A naturally occurring molecule known as “growth differentiation factor 11,” or GDF11, when injected into aged mice, reproduces many of the regenerative effects of young blood, regenerating heart, brain, muscles, lungs, and kidneys.

More specifically, GDF11 supplementation reduces age-related cardiac hypertrophy, accelerates skeletal muscle repair, improves exercise capacity, improves brain function and cerebral blood flow, and improves metabolism.

Elevian is developing a number of therapeutics that regulate GDF11 and other circulating factors. The goal is to restore our body’s natural regenerative capacity, which Elevian believes can address some of the root causes of age-associated disease with the promise of reversing or preventing many aging-related diseases and extending the healthy lifespan.

Conclusion
In 1992, futurist Leland Kaiser coined the term “regenerative medicine”:

“A new branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems.”

Since then, the powerful regenerative medicine industry has grown exponentially, and this rapid growth is anticipated to continue.

A dramatic extension of the human healthspan is just over the horizon. Soon, we’ll all have the regenerative superpowers previously relegated to a handful of animals and comic books.

What new opportunities open up when anybody, anywhere, and at anytime can regenerate, replenish, and replace entire organs and metabolic systems on command?

Join Me
Abundance-Digital Online Community: I’ve created a Digital/Online community of bold, abundance-minded entrepreneurs called Abundance-Digital. Abundance-Digital is my ‘onramp’ for exponential entrepreneurs – those who want to get involved and play at a higher level. Click here to learn more.

Image Credit: Giovanni Cancemi / Shutterstock.com Continue reading →

Posted in Human Robots