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#439077 How Scientists Grew Human Muscles in Pig ...
The little pigs bouncing around the lab looked exceedingly normal. Yet their adorable exterior hid a remarkable secret: each piglet carried two different sets of genes. For now, both sets came from their own species. But one day, one of those sets may be human.
The piglets are chimeras—creatures with intermingled sets of genes, as if multiple entities were seamlessly mashed together. Named after the Greek lion-goat-serpent monsters, chimeras may hold the key to an endless supply of human organs and tissues for transplant. The crux is growing these human parts in another animal—one close enough in size and function to our own.
Last week, a team from the University of Minnesota unveiled two mind-bending chimeras. One was joyous little piglets, each propelled by muscles grown from a different pig. Another was pig embryos, transplanted into surrogate pigs, that developed human muscles for more than 20 days.
The study, led by Drs. Mary and Daniel Garry at the University of Minnesota, had a therapeutic point: engineering a brilliant way to replace muscle loss, especially for the muscles around our skeletons that allow us to move and navigate the world. Trauma and injury, such as from firearm wounds or car crashes, can damage muscle tissue beyond the point of repair. Unfortunately, muscles are also stubborn in that donor tissue from cadavers doesn’t usually “take” at the injury site. For now, there are no effective treatments for severe muscle death, called volumetric muscle loss.
The new human-pig hybrids are designed to tackle this problem. Muscle wasting aside, the study also points to a clever “hack” that increases the amount of human tissue inside a growing pig embryo.
If further improved, the technology could “provide an unlimited supply of organs for transplantation,” said Dr. Mary Garry to Inverse. What’s more, because the human tissue can be sourced from patients themselves, the risk of rejection by the immune system is relatively low—even when grown inside a pig.
“The shortage of organs for heart transplantation, vascular grafting, and skeletal muscle is staggering,” said Garry. Human-animal chimeras could have a “seismic impact” that transforms organ transplantation and helps solve the organ shortage crisis.
That is, if society accepts the idea of a semi-humanoid pig.
Wait…But How?
The new study took a page from previous chimera recipes.
The main ingredients and steps go like this: first, you need an embryo that lacks the ability to develop a tissue or organ. This leaves an “empty slot” of sorts that you can fill with another set of genes—pig, human, or even monkey.
Second, you need to fine-tune the recipe so that the embryos “take” the new genes, incorporating them into their bodies as if they were their own. Third, the new genes activate to instruct the growing embryo to make the necessary tissue or organs without harming the overall animal. Finally, the foreign genes need to stay put, without cells migrating to another body part—say, the brain.
Not exactly straightforward, eh? The piglets are technological wonders that mix cutting-edge gene editing with cloning technologies.
The team went for two chimeras: one with two sets of pig genes, the other with a pig and human mix. Both started with a pig embryo that can’t make its own skeletal muscles (those are the muscles surrounding your bones). Using CRISPR, the gene-editing Swiss Army Knife, they snipped out three genes that are absolutely necessary for those muscles to develop. Like hitting a bullseye with three arrows simultaneously, it’s already a technological feat.
Here’s the really clever part: the muscles around your bones have a slightly different genetic makeup than the ones that line your blood vessels or the ones that pump your heart. While the resulting pig embryos had severe muscle deformities as they developed, their hearts beat as normal. This means the gene editing cut only impacted skeletal muscles.
Then came step two: replacing the missing genes. Using a microneedle, the team injected a fertilized and slightly developed pig egg—called a blastomere—into the embryo. If left on its natural course, a blastomere eventually develops into another embryo. This step “smashes” the two sets of genes together, with the newcomer filling the muscle void. The hybrid embryo was then placed into a surrogate, and roughly four months later, chimeric piglets were born.
Equipped with foreign DNA, the little guys nevertheless seemed totally normal, nosing around the lab and running everywhere without obvious clumsy stumbles. Under the microscope, their “xenomorph” muscles were indistinguishable from run-of-the-mill average muscle tissue—no signs of damage or inflammation, and as stretchy and tough as muscles usually are. What’s more, the foreign DNA seemed to have only developed into muscles, even though they were prevalent across the body. Extensive fishing experiments found no trace of the injected set of genes inside blood vessels or the brain.
A Better Human-Pig Hybrid
Confident in their recipe, the team next repeated the experiment with human cells, with a twist. Instead of using controversial human embryonic stem cells, which are obtained from aborted fetuses, they relied on induced pluripotent stem cells (iPSCs). These are skin cells that have been reverted back into a stem cell state.
Unlike previous attempts at making human chimeras, the team then scoured the genetic landscape of how pig and human embryos develop to find any genetic “brakes” that could derail the process. One gene, TP53, stood out, which was then promptly eliminated with CRISPR.
This approach provides a way for future studies to similarly increase the efficiency of interspecies chimeras, the team said.
The human-pig embryos were then carefully grown inside surrogate pigs for less than a month, and extensively analyzed. By day 20, the hybrids had already grown detectable human skeletal muscle. Similar to the pig-pig chimeras, the team didn’t detect any signs that the human genes had sprouted cells that would eventually become neurons or other non-muscle cells.
For now, human-animal chimeras are not allowed to grow to term, in part to stem the theoretical possibility of engineering humanoid hybrid animals (shudder). However, a sentient human-pig chimera is something that the team specifically addressed. Through multiple experiments, they found no trace of human genes in the embryos’ brain stem cells 20 and 27 days into development. Similarly, human donor genes were absent in cells that would become the hybrid embryos’ reproductive cells.
Despite bioethical quandaries and legal restrictions, human-animal chimeras have taken off, both as a source of insight into human brain development and a well of personalized organs and tissues for transplant. In 2019, Japan lifted its ban on developing human brain cells inside animal embryos, as well as the term limit—to global controversy. There’s also the question of animal welfare, given that hybrid clones will essentially become involuntary organ donors.
As the debates rage on, scientists are nevertheless pushing the limits of human-animal chimeras, while treading as carefully as possible.
“Our data…support the feasibility of the generation of these interspecies chimeras, which will serve as a model for translational research or, one day, as a source for xenotransplantation,” the team said.
Image Credit: Christopher Carson on Unsplash Continue reading
Posted in Human Robots
#439042 How Scientists Used Ultrasound to Read ...
Thanks to neural implants, mind reading is no longer science fiction.
As I’m writing this sentence, a tiny chip with arrays of electrodes could sit on my brain, listening in on the crackling of my neurons firing as my hands dance across the keyboard. Sophisticated algorithms could then decode these electrical signals in real time. My brain’s inner language to plan and move my fingers could then be used to guide a robotic hand to do the same. Mind-to-machine control, voilà!
Yet as the name implies, even the most advanced neural implant has a problem: it’s an implant. For electrodes to reliably read the brain’s electrical chatter, they need to pierce through the its protective membrane and into brain tissue. Danger of infection aside, over time, damage accumulates around the electrodes, distorting their signals or even rendering them unusable.
Now, researchers from Caltech have paved a way to read the brain without any physical contact. Key to their device is a relatively new superstar in neuroscience: functional ultrasound, which uses sound waves to capture activity in the brain.
In monkeys, the technology could reliably predict their eye movement and hand gestures after just a single trial—without the usual lengthy training process needed to decode a movement. If adopted by humans, the new mind-reading tech represents a triple triumph: it requires minimal surgery and minimal learning, but yields maximal resolution for brain decoding. For people who are paralyzed, it could be a paradigm shift in how they control their prosthetics.
“We pushed the limits of ultrasound neuroimaging and were thrilled that it could predict movement,” said study author Dr. Sumner Norman.
To Dr. Krishna Shenoy at Stanford, who was not involved, the study will finally put ultrasound “on the map as a brain-machine interface technique. Adding to this toolkit is spectacular,” he said.
Breaking the Sound Barrier
Using sound to decode brain activity might seem preposterous, but ultrasound has had quite the run in medicine. You’ve probably heard of its most common use: taking photos of a fetus in pregnancy. The technique uses a transducer, which emits ultrasound pulses into the body and finds boundaries in tissue structure by analyzing the sound waves that bounce back.
Roughly a decade ago, neuroscientists realized they could adapt the tech for brain scanning. Rather than directly measuring the brain’s electrical chatter, it looks at a proxy—blood flow. When certain brain regions or circuits are active, the brain requires much more energy, which is provided by increased blood flow. In this way, functional ultrasound works similarly to functional MRI, but at a far higher resolution—roughly ten times, the authors said. Plus, people don’t have to lie very still in an expensive, claustrophobic magnet.
“A key question in this work was: If we have a technique like functional ultrasound that gives us high-resolution images of the brain’s blood flow dynamics in space and over time, is there enough information from that imaging to decode something useful about behavior?” said study author Dr. Mikhail Shapiro.
There’s plenty of reasons for doubt. As the new kid on the block, functional ultrasound has some known drawbacks. A major one: it gives a far less direct signal than electrodes. Previous studies show that, with multiple measurements, it can provide a rough picture of brain activity. But is that enough detail to guide a robotic prosthesis?
One-Trial Wonder
The new study put functional ultrasound to the ultimate test: could it reliably detect movement intention in monkeys? Because their brains are the most similar to ours, rhesus macaque monkeys are often the critical step before a brain-machine interface technology is adapted for humans.
The team first inserted small ultrasound transducers into the skulls of two rhesus monkeys. While it sounds intense, the surgery doesn’t penetrate the brain or its protective membrane; it’s only on the skull. Compared to electrodes, this means the brain itself isn’t physically harmed.
The device is linked to a computer, which controls the direction of sound waves and captures signals from the brain. For this study, the team aimed the pulses at the posterior parietal cortex, a part of the “motor” aspect of the brain, which plans movement. If right now you’re thinking about scrolling down this page, that’s the brain region already activated, before your fingers actually perform the movement.
Then came the tests. The first looked at eye movements—something pretty necessary before planning actual body movements without tripping all over the place. Here, the monkeys learned to focus on a central dot on a computer screen. A second dot, either left or right, then flashed. The monkeys’ task was to flicker their eyes to the most recent dot. It’s something that seems easy for us, but requires sophisticated brain computation.
The second task was more straightforward. Rather than just moving their eyes to the second target dot, the monkeys learned to grab and manipulate a joystick to move a cursor to that target.
Using brain imaging to decode the mind and control movement. Image Credit: S. Norman, Caltech
As the monkeys learned, so did the device. Ultrasound data capturing brain activity was fed into a sophisticated machine learning algorithm to guess the monkeys’ intentions. Here’s the kicker: once trained, using data from just a single trial, the algorithm was able to correctly predict the monkeys’ actual eye movement—whether left or right—with roughly 78 percent accuracy. The accuracy for correctly maneuvering the joystick was even higher, at nearly 90 percent.
That’s crazy accurate, and very much needed for a mind-controlled prosthetic. If you’re using a mind-controlled cursor or limb, the last thing you’d want is to have to imagine the movement multiple times before you actually click the web button, grab the door handle, or move your robotic leg.
Even more impressive is the resolution. Sound waves seem omnipresent, but with focused ultrasound, it’s possible to measure brain activity at a resolution of 100 microns—roughly 10 neurons in the brain.
A Cyborg Future?
Before you start worrying about scientists blasting your brain with sound waves to hack your mind, don’t worry. The new tech still requires skull surgery, meaning that a small chunk of skull needs to be removed. However, the brain itself is spared. This means that compared to electrodes, ultrasound could offer less damage and potentially a far longer mind reading than anything currently possible.
There are downsides. Focused ultrasound is far younger than any electrode-based neural implants, and can’t yet reliably decode 360-degree movement or fine finger movements. For now, the tech requires a wire to link the device to a computer, which is off-putting to many people and will prevent widespread adoption. Add to that the inherent downside of focused ultrasound, which lags behind electrical recordings by roughly two seconds.
All that aside, however, the tech is just tiptoeing into a future where minds and machines seamlessly connect. Ultrasound can penetrate the skull, though not yet at the resolution needed for imaging and decoding brain activity. The team is already working with human volunteers with traumatic brain injuries, who had to have a piece of their skulls removed, to see how well ultrasound works for reading their minds.
“What’s most exciting is that functional ultrasound is a young technique with huge potential. This is just our first step in bringing high performance, less invasive brain-machine interface to more people,” said Norman.
Image Credit: Free-Photos / Pixabay Continue reading
Posted in Human Robots
#438982 Quantum Computing and Reinforcement ...
Deep reinforcement learning is having a superstar moment.
Powering smarter robots. Simulating human neural networks. Trouncing physicians at medical diagnoses and crushing humanity’s best gamers at Go and Atari. While far from achieving the flexible, quick thinking that comes naturally to humans, this powerful machine learning idea seems unstoppable as a harbinger of better thinking machines.
Except there’s a massive roadblock: they take forever to run. Because the concept behind these algorithms is based on trial and error, a reinforcement learning AI “agent” only learns after being rewarded for its correct decisions. For complex problems, the time it takes an AI agent to try and fail to learn a solution can quickly become untenable.
But what if you could try multiple solutions at once?
This week, an international collaboration led by Dr. Philip Walther at the University of Vienna took the “classic” concept of reinforcement learning and gave it a quantum spin. They designed a hybrid AI that relies on both quantum and run-of-the-mill classic computing, and showed that—thanks to quantum quirkiness—it could simultaneously screen a handful of different ways to solve a problem.
The result is a reinforcement learning AI that learned over 60 percent faster than its non-quantum-enabled peers. This is one of the first tests that shows adding quantum computing can speed up the actual learning process of an AI agent, the authors explained.
Although only challenged with a “toy problem” in the study, the hybrid AI, once scaled, could impact real-world problems such as building an efficient quantum internet. The setup “could readily be integrated within future large-scale quantum communication networks,” the authors wrote.
The Bottleneck
Learning from trial and error comes intuitively to our brains.
Say you’re trying to navigate a new convoluted campground without a map. The goal is to get from the communal bathroom back to your campsite. Dead ends and confusing loops abound. We tackle the problem by deciding to turn either left or right at every branch in the road. One will get us closer to the goal; the other leads to a half hour of walking in circles. Eventually, our brain chemistry rewards correct decisions, so we gradually learn the correct route. (If you’re wondering…yeah, true story.)
Reinforcement learning AI agents operate in a similar trial-and-error way. As a problem becomes more complex, the number—and time—of each trial also skyrockets.
“Even in a moderately realistic environment, it may simply take too long to rationally respond to a given situation,” explained study author Dr. Hans Briegel at the Universität Innsbruck in Austria, who previously led efforts to speed up AI decision-making using quantum mechanics. If there’s pressure that allows “only a certain time for a response, an agent may then be unable to cope with the situation and to learn at all,” he wrote.
Many attempts have tried speeding up reinforcement learning. Giving the AI agent a short-term “memory.” Tapping into neuromorphic computing, which better resembles the brain. In 2014, Briegel and colleagues showed that a “quantum brain” of sorts can help propel an AI agent’s decision-making process after learning. But speeding up the learning process itself has eluded our best attempts.
The Hybrid AI
The new study went straight for that previously untenable jugular.
The team’s key insight was to tap into the best of both worlds—quantum and classical computing. Rather than building an entire reinforcement learning system using quantum mechanics, they turned to a hybrid approach that could prove to be more practical. Here, the AI agent uses quantum weirdness as it’s trying out new approaches—the “trial” in trial and error. The system then passes the baton to a classical computer to give the AI its reward—or not—based on its performance.
At the heart of the quantum “trial” process is a quirk called superposition. Stay with me. Our computers are powered by electrons, which can represent only two states—0 or 1. Quantum mechanics is far weirder, in that photons (particles of light) can simultaneously be both 0 and 1, with a slightly different probability of “leaning towards” one or the other.
This noncommittal oddity is part of what makes quantum computing so powerful. Take our reinforcement learning example of navigating a new campsite. In our classic world, we—and our AI—need to decide between turning left or right at an intersection. In a quantum setup, however, the AI can (in a sense) turn left and right at the same time. So when searching for the correct path back to home base, the quantum system has a leg up in that it can simultaneously explore multiple routes, making it far faster than conventional, consecutive trail and error.
“As a consequence, an agent that can explore its environment in superposition will learn significantly faster than its classical counterpart,” said Briegel.
It’s not all theory. To test out their idea, the team turned to a programmable chip called a nanophotonic processor. Think of it as a CPU-like computer chip, but it processes particles of light—photons—rather than electricity. These light-powered chips have been a long time in the making. Back in 2017, for example, a team from MIT built a fully optical neural network into an optical chip to bolster deep learning.
The chips aren’t all that exotic. Nanophotonic processors act kind of like our eyeglasses, which can carry out complex calculations that transform light that passes through them. In the glasses case, they let people see better. For a light-based computer chip, it allows computation. Rather than using electrical cables, the chips use “wave guides” to shuttle photons and perform calculations based on their interactions.
The “error” or “reward” part of the new hardware comes from a classical computer. The nanophotonic processor is coupled to a traditional computer, where the latter provides the quantum circuit with feedback—that is, whether to reward a solution or not. This setup, the team explains, allows them to more objectively judge any speed-ups in learning in real time.
In this way, a hybrid reinforcement learning agent alternates between quantum and classical computing, trying out ideas in wibbly-wobbly “multiverse” land while obtaining feedback in grounded, classic physics “normality.”
A Quantum Boost
In simulations using 10,000 AI agents and actual experimental data from 165 trials, the hybrid approach, when challenged with a more complex problem, showed a clear leg up.
The key word is “complex.” The team found that if an AI agent has a high chance of figuring out the solution anyway—as for a simple problem—then classical computing works pretty well. The quantum advantage blossoms when the task becomes more complex or difficult, allowing quantum mechanics to fully flex its superposition muscles. For these problems, the hybrid AI was 63 percent faster at learning a solution compared to traditional reinforcement learning, decreasing its learning effort from 270 guesses to 100.
Now that scientists have shown a quantum boost for reinforcement learning speeds, the race for next-generation computing is even more lit. Photonics hardware required for long-range light-based communications is rapidly shrinking, while improving signal quality. The partial-quantum setup could “aid specifically in problems where frequent search is needed, for example, network routing problems” that’s prevalent for a smooth-running internet, the authors wrote. With a quantum boost, reinforcement learning may be able to tackle far more complex problems—those in the real world—than currently possible.
“We are just at the beginning of understanding the possibilities of quantum artificial intelligence,” said lead author Walther.
Image Credit: Oleg Gamulinskiy from Pixabay Continue reading
Posted in Human Robots
#438785 Video Friday: A Blimp For Your Cat
Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):
HRI 2021 – March 8-11, 2021 – [Online Conference]
RoboSoft 2021 – April 12-16, 2021 – [Online Conference]
ICRA 2021 – May 30-5, 2021 – Xi'an, China
Let us know if you have suggestions for next week, and enjoy today's videos.
Shiny robotic cat toy blimp!
I am pretty sure this is Google Translate getting things wrong, but the About page mentions that the blimp will “take you to your destination after appearing in the death of God.”
[ NTT DoCoMo ] via [ RobotStart ]
If you have yet to see this real-time video of Perseverance landing on Mars, drop everything and watch it.
During the press conference, someone commented that this is the first time anyone on the team who designed and built this system has ever seen it in operation, since it could only be tested at the component scale on Earth. This landing system has blown my mind since Curiosity.
Here's a better look at where Percy ended up:
[ NASA ]
The fact that Digit can just walk up and down wet, slippery, muddy hills without breaking a sweat is (still) astonishing.
[ Agility Robotics ]
SkyMul wants drones to take over the task of tying rebar, which looks like just the sort of thing we'd rather robots be doing so that we don't have to:
The tech certainly looks promising, and SkyMul says that they're looking for some additional support to bring things to the pilot stage.
[ SkyMul ]
Thanks Eohan!
Flatcat is a pet-like, playful robot that reacts to touch. Flatcat feels everything exactly: Cuddle with it, romp around with it, or just watch it do weird things of its own accord. We are sure that flatcat will amaze you, like us, and caress your soul.
I don't totally understand it, but I want it anyway.
[ Flatcat ]
Thanks Oswald!
This is how I would have a romantic dinner date if I couldn't get together in person. Herman the UR3 and an OptiTrack system let me remotely make a romantic meal!
[ Dave's Armoury ]
Here, we propose a novel design of deformable propellers inspired by dragonfly wings. The structure of these propellers includes a flexible segment similar to the nodus on a dragonfly wing. This flexible segment can bend, twist and even fold upon collision, absorbing force upon impact and protecting the propeller from damage.
[ Paper ]
Thanks Van!
In the 1970s, The CIA created the world's first miniaturized unmanned aerial vehicle, or UAV, which was intended to be a clandestine listening device. The Insectothopter was never deployed operationally, but was still revolutionary for its time.
It may never have been deployed (not that they'll admit to, anyway), but it was definitely operational and could fly controllably.
[ CIA ]
Research labs are starting to get Digits, which means we're going to get a much better idea of what its limitations are.
[ Ohio State ]
This video shows the latest achievements for LOLA walking on undetected uneven terrain. The robot is technically blind, not using any camera-based or prior information on the terrain.
[ TUM ]
We define “robotic contact juggling” to be the purposeful control of the motion of a three-dimensional smooth object as it rolls freely on a motion-controlled robot manipulator, or “hand.” While specific examples of robotic contact juggling have been studied before, in this paper we provide the first general formulation and solution method for the case of an arbitrary smooth object in single-point rolling contact on an arbitrary smooth hand.
[ Paper ]
Thanks Fan!
A couple of new cobots from ABB, designed to work safely around humans.
[ ABB ]
Thanks Fan!
It's worth watching at least a little bit of Adam Savage testing Spot's new arm, because we get to see Spot try, fail, and eventually succeed at an autonomous door-opening behavior at the 10 minute mark.
[ Tested ]
SVR discusses diversity with guest speakers Dr. Michelle Johnson from the GRASP Lab at UPenn; Dr Ariel Anders from Women in Robotics and first technical hire at Robust.ai; Alka Roy from The Responsible Innovation Project; and Kenechukwu C. Mbanesi and Kenya Andrews from Black in Robotics. The discussion here is moderated by Dr. Ken Goldberg—artist, roboticist and Director of the CITRIS People and Robots Lab—and Andra Keay from Silicon Valley Robotics.
[ SVR ]
RAS presents a Soft Robotics Debate on Bioinspired vs. Biohybrid Design.
In this debate, we will bring together experts in Bioinspiration and Biohybrid design to discuss the necessary steps to make more competent soft robots. We will try to answer whether bioinspired research should focus more on developing new bioinspired material and structures or on the integration of living and artificial structures in biohybrid designs.
[ RAS SoRo ]
IFRR presents a Colloquium on Human Robot Interaction.
Across many application domains, robots are expected to work in human environments, side by side with people. The users will vary substantially in background, training, physical and cognitive abilities, and readiness to adopt technology. Robotic products are expected to not only be intuitive, easy to use, and responsive to the needs and states of their users, but they must also be designed with these differences in mind, making human-robot interaction (HRI) a key area of research.
[ IFRR ]
Vijay Kumar, Nemirovsky Family Dean and Professor at Penn Engineering, gives an introduction to ENIAC day and David Patterson, Pardee Professor of Computer Science, Emeritus at the University of California at Berkeley, speaks about the legacy of the ENIAC and its impact on computer architecture today. This video is comprised of lectures one and two of nine total lectures in the ENIAC Day series.
There are more interesting ENIAC videos at the link below, but we'll highlight this particular one, about the women of the ENIAC, also known as the First Programmers.
[ ENIAC Day ] Continue reading
Posted in Human Robots