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#437573 Micro-robot with chemically encoded ...
A team of researchers from the University of Chemistry and Technology Prague, Yonsei University and the Brno University of Technology has developed a micro-robot with chemically encoded intelligence that can remove hormonal pollutants from a solution. They have published their results in Nature Machine Intelligence. Dongdong Jin and Li Zhang with the Chinese University of Hong Kong and Multiscale Medical Robotics Center, respectively, have published a News and Views piece in the same issue outlining the state of micro-robot research and describe the work done by the researchers with this new effort. Continue reading
Posted in Human Robots
#437471 How Giving Robots a Hybrid, Human-Like ...
Squeezing a lot of computing power into robots without using up too much space or energy is a constant battle for their designers. But a new approach that mimics the structure of the human brain could provide a workaround.
The capabilities of most of today’s mobile robots are fairly rudimentary, but giving them the smarts to do their jobs is still a serious challenge. Controlling a body in a dynamic environment takes a surprising amount of processing power, which requires both real estate for chips and considerable amounts of energy to power them.
As robots get more complex and capable, those demands are only going to increase. Today’s most powerful AI systems run in massive data centers across far more chips than can realistically fit inside a machine on the move. And the slow death of Moore’s Law suggests we can’t rely on conventional processors getting significantly more efficient or compact anytime soon.
That prompted a team from the University of Southern California to resurrect an idea from more than 40 years ago: mimicking the human brain’s division of labor between two complimentary structures. While the cerebrum is responsible for higher cognitive functions like vision, hearing, and thinking, the cerebellum integrates sensory data and governs movement, balance, and posture.
When the idea was first proposed the technology didn’t exist to make it a reality, but in a paper recently published in Science Robotics, the researchers describe a hybrid system that combines analog circuits that control motion and digital circuits that govern perception and decision-making in an inverted pendulum robot.
“Through this cooperation of the cerebrum and the cerebellum, the robot can conduct multiple tasks simultaneously with a much shorter latency and lower power consumption,” write the researchers.
The type of robot the researchers were experimenting with looks essentially like a pole balancing on a pair of wheels. They have a broad range of applications, from hoverboards to warehouse logistics—Boston Dynamics’ recently-unveiled Handle robot operates on the same principles. Keeping them stable is notoriously tough, but the new approach managed to significantly improve all digital control approaches by radically improving the speed and efficiency of computations.
Key to bringing the idea alive was the recent emergence of memristors—electrical components whose resistance relies on previous input, which allows them to combine computing and memory in one place in a way similar to how biological neurons operate.
The researchers used memristors to build an analog circuit that runs an algorithm responsible for integrating data from the robot’s accelerometer and gyroscope, which is crucial for detecting the angle and velocity of its body, and another that controls its motion. One key advantage of this setup is that the signals from the sensors are analog, so it does away with the need for extra circuitry to convert them into digital signals, saving both space and power.
More importantly, though, the analog system is an order of magnitude faster and more energy-efficient than a standard all-digital system, the authors report. This not only lets them slash the power requirements, but also lets them cut the processing loop from 3,000 microseconds to just 6. That significantly improves the robot’s stability, with it taking just one second to settle into a steady state compared to more than three seconds using the digital-only platform.
At the minute this is just a proof of concept. The robot the researchers have built is small and rudimentary, and the algorithms being run on the analog circuit are fairly basic. But the principle is a promising one, and there is currently a huge amount of R&D going into neuromorphic and memristor-based analog computing hardware.
As often turns out to be the case, it seems like we can’t go too far wrong by mimicking the best model of computation we have found so far: our own brains.
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Posted in Human Robots
#437429 Insects found to use natural wing ...
A team of researchers from the University of California, the University of North Carolina at Chapel Hill and Pacific Northwest National Laboratory has found that insects use natural oscillations to stabilize their flight. In their study, published in the journal Science Robotics, the researchers used what they describe as “a type of calculus” (chronological calculus) to better understand the factors that are involved in keeping flapping winged insects aloft. Matěj Karásek, with Delft University of Technology has published a Focus piece in the same journal issue describing the work done by the team on this new effort. Continue reading
Posted in Human Robots
#437261 How AI Will Make Drug Discovery ...
If you had to guess how long it takes for a drug to go from an idea to your pharmacy, what would you guess? Three years? Five years? How about the cost? $30 million? $100 million?
Well, here’s the sobering truth: 90 percent of all drug possibilities fail. The few that do succeed take an average of 10 years to reach the market and cost anywhere from $2.5 billion to $12 billion to get there.
But what if we could generate novel molecules to target any disease, overnight, ready for clinical trials? Imagine leveraging machine learning to accomplish with 50 people what the pharmaceutical industry can barely do with an army of 5,000.
Welcome to the future of AI and low-cost, ultra-fast, and personalized drug discovery. Let’s dive in.
GANs & Drugs
Around 2012, computer scientist-turned-biophysicist Alex Zhavoronkov started to notice that artificial intelligence was getting increasingly good at image, voice, and text recognition. He knew that all three tasks shared a critical commonality. In each, massive datasets were available, making it easy to train up an AI.
But similar datasets were present in pharmacology. So, back in 2014, Zhavoronkov started wondering if he could use these datasets and AI to significantly speed up the drug discovery process. He’d heard about a new technique in artificial intelligence known as generative adversarial networks (or GANs). By pitting two neural nets against one another (adversarial), the system can start with minimal instructions and produce novel outcomes (generative). At the time, researchers had been using GANs to do things like design new objects or create one-of-a-kind, fake human faces, but Zhavoronkov wanted to apply them to pharmacology.
He figured GANs would allow researchers to verbally describe drug attributes: “The compound should inhibit protein X at concentration Y with minimal side effects in humans,” and then the AI could construct the molecule from scratch. To turn his idea into reality, Zhavoronkov set up Insilico Medicine on the campus of Johns Hopkins University in Baltimore, Maryland, and rolled up his sleeves.
Instead of beginning their process in some exotic locale, Insilico’s “drug discovery engine” sifts millions of data samples to determine the signature biological characteristics of specific diseases. The engine then identifies the most promising treatment targets and—using GANs—generates molecules (that is, baby drugs) perfectly suited for them. “The result is an explosion in potential drug targets and a much more efficient testing process,” says Zhavoronkov. “AI allows us to do with fifty people what a typical drug company does with five thousand.”
The results have turned what was once a decade-long war into a month-long skirmish.
In late 2018, for example, Insilico was generating novel molecules in fewer than 46 days, and this included not just the initial discovery, but also the synthesis of the drug and its experimental validation in computer simulations.
Right now, they’re using the system to hunt down new drugs for cancer, aging, fibrosis, Parkinson’s, Alzheimer’s, ALS, diabetes, and many others. The first drug to result from this work, a treatment for hair loss, is slated to start Phase I trials by the end of 2020.
They’re also in the early stages of using AI to predict the outcomes of clinical trials in advance of the trial. If successful, this technique will enable researchers to strip a bundle of time and money out of the traditional testing process.
Protein Folding
Beyond inventing new drugs, AI is also being used by other scientists to identify new drug targets—that is, the place to which a drug binds in the body and another key part of the drug discovery process.
Between 1980 and 2006, despite an annual investment of $30 billion, researchers only managed to find about five new drug targets a year. The trouble is complexity. Most potential drug targets are proteins, and a protein’s structure—meaning the way a 2D sequence of amino acids folds into a 3D protein—determines its function.
But a protein with merely a hundred amino acids (a rather small protein) can produce a googol-cubed worth of potential shapes—that’s a one followed by three hundred zeroes. This is also why protein-folding has long been considered an intractably hard problem for even the most powerful of supercomputers.
Back in 1994, to monitor supercomputers’ progress in protein-folding, a biannual competition was created. Until 2018, success was fairly rare. But then the creators of DeepMind turned their neural networks loose on the problem. They created an AI that mines enormous datasets to determine the most likely distance between a protein’s base pairs and the angles of their chemical bonds—aka, the basics of protein-folding. They called it AlphaFold.
On its first foray into the competition, contestant AIs were given 43 protein-folding problems to solve. AlphaFold got 25 right. The second-place team managed a meager three. By predicting the elusive ways in which various proteins fold on the basis of their amino acid sequences, AlphaFold may soon have a tremendous impact in aiding drug discovery and fighting some of today’s most intractable diseases.
Drug Delivery
Another theater of war for improved drugs is the realm of drug delivery. Even here, converging exponential technologies are paving the way for massive implications in both human health and industry shifts.
One key contender is CRISPR, the fast-advancing gene-editing technology that stands to revolutionize synthetic biology and treatment of genetically linked diseases. And researchers have now demonstrated how this tool can be applied to create materials that shape-shift on command. Think: materials that dissolve instantaneously when faced with a programmed stimulus, releasing a specified drug at a highly targeted location.
Yet another potential boon for targeted drug delivery is nanotechnology, whereby medical nanorobots have now been used to fight incidences of cancer. In a recent review of medical micro- and nanorobotics, lead authors (from the University of Texas at Austin and University of California, San Diego) found numerous successful tests of in vivo operation of medical micro- and nanorobots.
Drugs From the Future
Covid-19 is uniting the global scientific community with its urgency, prompting scientists to cast aside nation-specific territorialism, research secrecy, and academic publishing politics in favor of expedited therapeutic and vaccine development efforts. And in the wake of rapid acceleration across healthcare technologies, Big Pharma is an area worth watching right now, no matter your industry. Converging technologies will soon enable extraordinary strides in longevity and disease prevention, with companies like Insilico leading the charge.
Riding the convergence of massive datasets, skyrocketing computational power, quantum computing, cognitive surplus capabilities, and remarkable innovations in AI, we are not far from a world in which personalized drugs, delivered directly to specified targets, will graduate from science fiction to the standard of care.
Rejuvenational biotechnology will be commercially available sooner than you think. When I asked Alex for his own projection, he set the timeline at “maybe 20 years—that’s a reasonable horizon for tangible rejuvenational biotechnology.”
How might you use an extra 20 or more healthy years in your life? What impact would you be able to make?
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This article originally appeared on diamandis.com. Read the original article here.
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Posted in Human Robots