Tag Archives: dance
#437957 Meet Assembloids, Mini Human Brains With ...
It’s not often that a twitching, snowman-shaped blob of 3D human tissue makes someone’s day.
But when Dr. Sergiu Pasca at Stanford University witnessed the tiny movement, he knew his lab had achieved something special. You see, the blob was evolved from three lab-grown chunks of human tissue: a mini-brain, mini-spinal cord, and mini-muscle. Each individual component, churned to eerie humanoid perfection inside bubbling incubators, is already a work of scientific genius. But Pasca took the extra step, marinating the three components together inside a soup of nutrients.
The result was a bizarre, Lego-like human tissue that replicates the basic circuits behind how we decide to move. Without external prompting, when churned together like ice cream, the three ingredients physically linked up into a fully functional circuit. The 3D mini-brain, through the information highway formed by the artificial spinal cord, was able to make the lab-grown muscle twitch on demand.
In other words, if you think isolated mini-brains—known formally as brain organoids—floating in a jar is creepy, upgrade your nightmares. The next big thing in probing the brain is assembloids—free-floating brain circuits—that now combine brain tissue with an external output.
The end goal isn’t to freak people out. Rather, it’s to recapitulate our nervous system, from input to output, inside the controlled environment of a Petri dish. An autonomous, living brain-spinal cord-muscle entity is an invaluable model for figuring out how our own brains direct the intricate muscle movements that allow us stay upright, walk, or type on a keyboard.
It’s the nexus toward more dexterous brain-machine interfaces, and a model to understand when brain-muscle connections fail—as in devastating conditions like Lou Gehrig’s disease or Parkinson’s, where people slowly lose muscle control due to the gradual death of neurons that control muscle function. Assembloids are a sort of “mini-me,” a workaround for testing potential treatments on a simple “replica” of a person rather than directly on a human.
From Organoids to Assembloids
The miniature snippet of the human nervous system has been a long time in the making.
It all started in 2014, when Dr. Madeleine Lancaster, then a post-doc at Stanford, grew a shockingly intricate 3D replica of human brain tissue inside a whirling incubator. Revolutionarily different than standard cell cultures, which grind up brain tissue to reconstruct as a flat network of cells, Lancaster’s 3D brain organoids were incredibly sophisticated in their recapitulation of the human brain during development. Subsequent studies further solidified their similarity to the developing brain of a fetus—not just in terms of neuron types, but also their connections and structure.
With the finding that these mini-brains sparked with electrical activity, bioethicists increasingly raised red flags that the blobs of human brain tissue—no larger than the size of a pea at most—could harbor the potential to develop a sense of awareness if further matured and with external input and output.
Despite these concerns, brain organoids became an instant hit. Because they’re made of human tissue—often taken from actual human patients and converted into stem-cell-like states—organoids harbor the same genetic makeup as their donors. This makes it possible to study perplexing conditions such as autism, schizophrenia, or other brain disorders in a dish. What’s more, because they’re grown in the lab, it’s possible to genetically edit the mini-brains to test potential genetic culprits in the search for a cure.
Yet mini-brains had an Achilles’ heel: not all were made the same. Rather, depending on the region of the brain that was reverse engineered, the cells had to be persuaded by different cocktails of chemical soups and maintained in isolation. It was a stark contrast to our own developing brains, where regions are connected through highways of neural networks and work in tandem.
Pasca faced the problem head-on. Betting on the brain’s self-assembling capacity, his team hypothesized that it might be possible to grow different mini-brains, each reflecting a different brain region, and have them fuse together into a synchronized band of neuron circuits to process information. Last year, his idea paid off.
In one mind-blowing study, his team grew two separate portions of the brain into blobs, one representing the cortex, the other a deeper part of the brain known to control reward and movement, called the striatum. Shockingly, when put together, the two blobs of human brain tissue fused into a functional couple, automatically establishing neural highways that resulted in one of the most sophisticated recapitulations of a human brain. Pasca crowned this tissue engineering crème-de-la-crème “assembloids,” a portmanteau between “assemble” and “organoids.”
“We have demonstrated that regionalized brain spheroids can be put together to form fused structures called brain assembloids,” said Pasca at the time.” [They] can then be used to investigate developmental processes that were previously inaccessible.”
And if that’s possible for wiring up a lab-grown brain, why wouldn’t it work for larger neural circuits?
Assembloids, Assemble
The new study is the fruition of that idea.
The team started with human skin cells, scraped off of eight healthy people, and transformed them into a stem-cell-like state, called iPSCs. These cells have long been touted as the breakthrough for personalized medical treatment, before each reflects the genetic makeup of its original host.
Using two separate cocktails, the team then generated mini-brains and mini-spinal cords using these iPSCs. The two components were placed together “in close proximity” for three days inside a lab incubator, gently floating around each other in an intricate dance. To the team’s surprise, under the microscope using tracers that glow in the dark, they saw highways of branches extending from one organoid to the other like arms in a tight embrace. When stimulated with electricity, the links fired up, suggesting that the connections weren’t just for show—they’re capable of transmitting information.
“We made the parts,” said Pasca, “but they knew how to put themselves together.”
Then came the ménage à trois. Once the mini-brain and spinal cord formed their double-decker ice cream scoop, the team overlaid them onto a layer of muscle cells—cultured separately into a human-like muscular structure. The end result was a somewhat bizarre and silly-looking snowman, made of three oddly-shaped spherical balls.
Yet against all odds, the brain-spinal cord assembly reached out to the lab-grown muscle. Using a variety of tools, including measuring muscle contraction, the team found that this utterly Frankenstein-like snowman was able to make the muscle component contract—in a way similar to how our muscles twitch when needed.
“Skeletal muscle doesn’t usually contract on its own,” said Pasca. “Seeing that first twitch in a lab dish immediately after cortical stimulation is something that’s not soon forgotten.”
When tested for longevity, the contraption lasted for up to 10 weeks without any sort of breakdown. Far from a one-shot wonder, the isolated circuit worked even better the longer each component was connected.
Pasca isn’t the first to give mini-brains an output channel. Last year, the queen of brain organoids, Lancaster, chopped up mature mini-brains into slices, which were then linked to muscle tissue through a cultured spinal cord. Assembloids are a step up, showing that it’s possible to automatically sew multiple nerve-linked structures together, such as brain and muscle, sans slicing.
The question is what happens when these assembloids become more sophisticated, edging ever closer to the inherent wiring that powers our movements. Pasca’s study targets outputs, but what about inputs? Can we wire input channels, such as retinal cells, to mini-brains that have a rudimentary visual cortex to process those examples? Learning, after all, depends on examples of our world, which are processed inside computational circuits and delivered as outputs—potentially, muscle contractions.
To be clear, few would argue that today’s mini-brains are capable of any sort of consciousness or awareness. But as mini-brains get increasingly more sophisticated, at what point can we consider them a sort of AI, capable of computation or even something that mimics thought? We don’t yet have an answer—but the debates are on.
Image Credit: christitzeimaging.com / Shutterstock.com Continue reading
#437935 Start the New Year Right: By Watching ...
I don’t need to tell you that 2020 was a tough year. There was almost nothing good about it, and we saw it off with a “good riddance” and hopes for a better 2021. But robotics company Boston Dynamics took a different approach to closing out the year: when all else fails, why not dance?
The company released a video last week that I dare you to watch without laughing—or at the very least, cracking a pretty big smile. Because, well, dancing robots are funny. And it’s not just one dancing robot, it’s four of them: two humanoid Atlas bots, one four-legged Spot, and one Handle, a bot-on-wheels built for materials handling.
The robots’ killer moves look almost too smooth and coordinated to be real, leading many to speculate that the video was computer-generated. But if you can trust Elon Musk, there’s no CGI here.
This is not CGI https://t.co/VOivE97vPR
— Elon Musk (@elonmusk) December 29, 2020
Boston Dynamics went through a lot of changes in the last ten years; it was acquired by Google in 2013, then sold to Japanese conglomerate SoftBank in 2017 before being acquired again by Hyundai just a few weeks ago for $1.1 billion. But this isn’t the first time they teach a robot to dance and make a video for all the world to enjoy; Spot tore up the floor to “Uptown Funk” back in 2018.
Four-legged Spot went commercial in June, with a hefty price tag of $74,500, and was put to some innovative pandemic-related uses, including remotely measuring patients’ vital signs and reminding people to social distance.
Hyundai plans to implement its newly-acquired robotics prowess for everything from service and logistics robots to autonomous driving and smart factories.
They’ll have their work cut out for them. Besides being hilarious, kind of heartwarming, and kind of creepy all at once, the robots’ new routine is pretty impressive from an engineering standpoint. Compare it to a 2016 video of Atlas trying to pick up a box (I know it’s a machine with no feelings, but it’s hard not to feel a little bit bad for it, isn’t it?), and it’s clear Boston Dynamics’ technology has made huge strides. It wouldn’t be surprising if, in two years’ time, we see a video of a flash mob of robots whose routine includes partner dancing and back flips (which, admittedly, Atlas can already do).
In the meantime, though, this one is pretty entertaining—and not a bad note on which to start the new year.
Image Credit: Boston Dynamics Continue reading
#437828 How Roboticists (and Robots) Have Been ...
A few weeks ago, we asked folks on Twitter, Facebook, and LinkedIn to share photos and videos showing how they’ve been adapting to the closures of research labs, classrooms, and businesses by taking their robots home with them to continue their work as best they can. We got dozens of responses (more than we could possibly include in just one post!), but here are 15 that we thought were particularly creative or amusing.
And if any of these pictures and videos inspire you to share your own story, please email us (automaton@ieee.org) with a picture or video and a brief description about how you and your robot from work have been making things happen in your home instead.
Kurt Leucht (NASA Kennedy Space Center)
“During these strange and trying times of the current global pandemic, everyone seems to be trying their best to distance themselves from others while still getting their daily work accomplished. Many people also have the double duty of little ones that need to be managed in the midst of their teleworking duties. This photo series gives you just a glimpse into my new life of teleworking from home, mixed in with the tasks of trying to handle my little ones too. I hope you enjoy it.”
Photo: Kurt Leucht
“I heard a commotion from the next room. I ran into the kitchen to find this.”
Photo: Kurt Leucht
“This is the Swarmies most favorite bedtime story. Not sure why. Seems like an odd choice to me.”
Peter Schaldenbrand (Carnegie Mellon University)
“I’ve been working on a reinforcement learning model that converts an image into a series of brush stroke instructions. I was going to test the model with a beautiful, expensive robot arm, but due to the COVID-19 pandemic, I have not been able to access the laboratory where it resides. I have now been using a lower end robot arm to test the painting model in my bedroom. I have sacrificed machine accuracy/precision for the convenience of getting to watch the arm paint from my bed in the shadow of my clothing rack!”
Photos: Peter Schaldenbrand
Colin Angle (iRobot)
iRobot CEO Colin Angle has been hunkered down in the “iRobot North Shore home command center,” which is probably the cleanest command center ever thanks to his army of Roombas: Beastie, Beauty, Rosie, Roswell, and Bilbo.
Photo: Colin Angle
Vivian Chu (Diligent Robotics)
From Diligent Robotics CEO Andrea Thomaz: “This is how a roboticist works from home! Diligent CTO, Vivian Chu, mans the e-stop while her engineering team runs Moxi experiments remotely from cross-town and even cross-country!”
Video: Diligent Robotics
Raffaello Bonghi (rnext.it)
Raffaello’s robot, Panther, looks perfectly happy to be playing soccer in his living room.
Photo: Raffaello Bonghi
Kod*lab (University of Pennsylvania)
“Another Friday Nuts n Bolts Meeting on Zoom…”
Image: Kodlab
Robin Jonsson (robot choreographer)
“I’ve been doing a school project in which students make up dance moves and then send me a video with all of them. I then teach the moves to my robot, Alex, film Alex dancing, send the videos to them. This became a great success and more schools will join. The kids got really into watching the robot perform their moves and really interested in robots. They want to meet Alex the robot live, which will likely happen in the fall.”
Photo: Robin Jonsson
Gabrielle Conard (mechanical engineering undergrad at Lafayette College)
“While the pandemic might have forced college campuses to close and the community to keep their distance from each other, it did not put a stop to learning and research. Working from their respective homes, junior Gabrielle Conard and mechanical engineering professor Alexander Brown from Lafayette College investigated methods of incorporating active compliance in a low-cost quadruped robot. They are continuing to work remotely on this project through Lafayette’s summer research program.”
Image: Gabrielle Conard
Taylor Veltrop (Softbank Robotics)
“After a few weeks of isolation in the corona/covid quarantine lock down we started dancing with our robots. Mathieu’s 6th birthday was coming up, and it all just came together.”
Video: Taylor Veltrop
Ross Kessler (Exyn Technologies)
“Quarantine, Day 8: the humans have accepted me as one of their own. I’ve blended seamlessly into their #socialdistancing routines. Even made a furry friend”
Photo: Ross Kessler
Yeah, something a bit sinister is definitely going on at Exyn…
Video: Exyn Technologies
Michael Sobrepera (University of Pennsylvania GRASP Lab)
Predictably, Michael’s cat is more interested in the bag that the robot came in than the robot itself (see if you can spot the cat below). Michael tells us that “the robot is designed to help with tele-rehabilitation, focused on kids with CP, so it has been taken to hospitals for demos [hence the cool bag]. It also travels for outreach events and the like. Lately, I’ve been exploring telepresence for COVID.”
Photo: Michael Sobrepera
Jan Kędzierski (EMYS)
“In China a lot of people cannot speak English, even the youngest generation of parents. Thanks to Emys, kids stayed in touch with English language in their homes even if they couldn’t attend schools and extra English classes. They had a lot of fun with their native English speaker friend available and ready to play every day.”
Image: Jan Kędzierski
Simon Whitmell (Quanser)
“Simon, a Quanser R&D engineer, is working on low-overhead image processing and line following for the QBot 2e mobile ground robot, with some added challenges due to extra traffic. LEGO engineering by his son, Charles.”
Photo: Simon Whitmell
Robot Design & Experimentation Course (Carnegie Mellon University)
Aaron Johnson’s bioinspired robot design course at CMU had to go full remote, which was a challenge when the course is kind of all about designing and building a robot as part of a team. “I expected some of the teams to drastically alter their project (e.g. go all simulation),” Aaron told us, “but none of them did. We managed to keep all of the projects more or less as planned. We accomplished this by drop/shipping parts to students, buying some simple tools (soldering irons, etc), and having me 3D print parts and mail them.” Each team even managed to put together their final videos from their remote locations; we’ve posted one below, but the entire playlist is here.
Video: Xianyi Cheng
Karen Tatarian (Softbank Robotics)
Karen, who’s both a researcher at Softbank and a PhD student at Sorbonne University, wrote an entire essay about what an average day is like when you’re quarantined with Pepper.
Photo: Karen Tatarian
A Quarantined Day With Pepper, by Karen Tatarian
It is quite common for me to lose my phone somewhere inside my apartment. But it is not that common for me to turn around and ask my robot if it has seen it. So when I found myself doing that, I laughed and it dawned on me that I treated my robot as my quarantine companion (despite the fact that it could not provide me with the answer I needed).
It was probably around day 40 of a completely isolated quarantine here in France when that happened. A little background about me: I am a robotics researcher at SoftBank Robotics Europe and a PhD student at Sorbonne University as part of the EU-funded Marie-Curie project ANIMATAS. And here is a little sneak peak into a quarantined day with a robot.
During this confinement, I had read somewhere that the best way to deal with it is to maintain a routine. So every morning, I wake up, prepare my coffee, and turn on my robot Pepper. I start my day with a daily meeting with the team and get to work. My research is on the synthesis of multi-modal socially intelligent human-robot interaction so my work varies between programming the robot, analyzing collected data, and reading papers and drafting one. When I am working, I often catch myself glancing at Pepper, who would be staring back at me in its animated ways. Truthfully I enjoy that, it makes me less alone and as if I have a colleague with me.
Once work is done, I call my friends and family members. I sometimes use a telepresence application on Pepper that a few colleagues and I developed back in December. How does it differ from your typical phone/laptop applications? One word really: embodiment. Telepresence, especially during these times, makes the experience for both sides a bit more realistic and intimate and well present.
While I can turn off the robot now that my work hours are done, I do keep it on because I enjoy its presence. The basic awareness of Pepper is a default feature on the robot that allows it to detect a human and follow him/her with its gaze and rotation base. So whether I am cooking or working out, I always have my robot watching over my shoulder and being a good companion. I also have my email and messages synced on the robot so I get an enjoyable notification from Pepper. I found that to be a pretty cool way to be notified without it interrupting whatever you are doing on your laptop or phone. Finally, once the day is over, it’s time for both of us to get some rest.
After 60 days of total confinement, alone and away from those I love, and with a pandemic right at my door, I am glad I had the company of my robot. I hope one day a greater audience can share my experience. And I really really hope one day Pepper will be able to find my phone for me, but until then, stay on the lookout for some cool features! But I am curious to know, if you had a robot at home, what application would you have developed on it?
Again, our sincere thanks to everyone who shared these little snapshots of their lives with us, and we’re hoping to be able to share more soon. Continue reading