Tag Archives: computer science
#436578 AI Just Discovered a New Antibiotic to ...
Penicillin, one of the greatest discoveries in the history of medicine, was a product of chance.
After returning from summer vacation in September 1928, bacteriologist Alexander Fleming found a colony of bacteria he’d left in his London lab had sprouted a fungus. Curiously, wherever the bacteria contacted the fungus, their cell walls broke down and they died. Fleming guessed the fungus was secreting something lethal to the bacteria—and the rest is history.
Fleming’s discovery of penicillin and its later isolation, synthesis, and scaling in the 1940s released a flood of antibiotic discoveries in the next few decades. Bacteria and fungi had been waging an ancient war against each other, and the weapons they’d evolved over eons turned out to be humanity’s best defense against bacterial infection and disease.
In recent decades, however, the flood of new antibiotics has slowed to a trickle.
Their development is uneconomical for drug companies, and the low-hanging fruit has long been picked. We’re now facing the emergence of strains of super bacteria resistant to one or more antibiotics and an aging arsenal to fight them with. Gone unchallenged, an estimated 700,000 deaths worldwide due to drug resistance could rise to as many as 10 million in 2050.
Increasingly, scientists warn the tide is turning, and we need a new strategy to keep pace with the remarkably quick and boundlessly creative tactics of bacterial evolution.
But where the golden age of antibiotics was sparked by serendipity, human intelligence, and natural molecular weapons, its sequel may lean on the uncanny eye of artificial intelligence to screen millions of compounds—and even design new ones—in search of the next penicillin.
Hal Discovers a Powerful Antibiotic
In a paper published this week in the journal, Cell, MIT researchers took a step in this direction. The team says their machine learning algorithm discovered a powerful new antibiotic.
Named for the AI in 2001: A Space Odyssey, the antibiotic, halicin, successfully wiped out dozens of bacterial strains, including some of the most dangerous drug-resistant bacteria on the World Health Organization’s most wanted list. The bacteria also failed to develop resistance to E. coli during a month of observation, in stark contrast to existing antibiotic ciprofloxacin.
“In terms of antibiotic discovery, this is absolutely a first,” Regina Barzilay, a senior author on the study and computer science professor at MIT, told The Guardian.
The algorithm that discovered halicin was trained on the molecular features of 2,500 compounds. Nearly half were FDA-approved drugs, and another 800 naturally occurring. The researchers specifically tuned the algorithm to look for molecules with antibiotic properties but whose structures would differ from existing antibiotics (as halicin’s does). Using another machine learning program, they screened the results for those likely to be safe for humans.
Early study suggests halicin attacks the bacteria’s cell membranes, disrupting their ability to produce energy. Protecting the cell membrane from halicin might take more than one or two genetic mutations, which could account for its impressive ability to prevent resistance.
“I think this is one of the more powerful antibiotics that has been discovered to date,” James Collins, an MIT professor of bioengineering and senior author told The Guardian. “It has remarkable activity against a broad range of antibiotic-resistant pathogens.”
Beyond tests in petri-dish bacterial colonies, the team also tested halicin in mice. The antibiotic cleared up infections of a strain of bacteria resistant to all known antibiotics in a day. The team plans further study in partnership with a pharmaceutical company or nonprofit, and they hope to eventually prove it safe and effective for use in humans.
This last bit remains the trickiest step, given the cost of getting a new drug approved. But Collins hopes algorithms like theirs will help. “We could dramatically reduce the cost required to get through clinical trials,” he told the Financial Times.
A Universe of Drugs Awaits
The bigger story may be what happens next.
How many novel antibiotics await discovery, and how far can AI screening take us? The initial 6,000 compounds scanned by Barzilay and Collins’s team is a drop in the bucket.
They’ve already begun digging deeper by setting the algorithm loose on 100 million molecules from an online library of 1.5 billion compounds called the ZINC15 database. This first search took three days and turned up 23 more candidates that, like halicin, differ structurally from existing antibiotics and may be safe for humans. Two of these—which the team will study further—appear to be especially powerful.
Even more ambitiously, Barzilay hopes the approach can find or even design novel antibiotics that kill bad bacteria with alacrity while sparing the good guys. In this way, a round of antibiotics would cure whatever ails you without taking out your whole gut microbiome in the process.
All this is part of a larger movement to use machine learning algorithms in the long, expensive process of drug discovery. Other players in the area are also training AI on the vast possibility space of drug-like compounds. Last fall, one of the leaders in the area, Insilico, was challenged by a partner to see just how fast their method could do the job. The company turned out a new a proof-of-concept drug candidate in only 46 days.
The field is still developing, however, and it has yet to be seen exactly how valuable these approaches will be in practice. Barzilay is optimistic though.
“There is still a question of whether machine-learning tools are really doing something intelligent in healthcare, and how we can develop them to be workhorses in the pharmaceuticals industry,” she said. “This shows how far you can adapt this tool.”
Image Credit: Halicin (top row) prevented the development of antibiotic resistance in E. coli, while ciprofloxacin (bottom row) did not. Collins Lab at MIT Continue reading
Posted in Human Robots
#436200 AI and the Future of Work: The Economic ...
This week at MIT, academics and industry officials compared notes, studies, and predictions about AI and the future of work. During the discussions, an insurance company executive shared details about one AI program that rolled out at his firm earlier this year. A chatbot the company introduced, the executive said, now handles 150,000 calls per month.
Later in the day, a panelist—David Fanning, founder of PBS’s Frontline—remarked that this statistic is emblematic of broader fears he saw when reporting a new Frontline documentary about AI. “People are scared,” Fanning said of the public’s AI anxiety.
Fanning was part of a daylong symposium about AI’s economic consequences—good, bad, and otherwise—convened by MIT’s Task Force on the Work of the Future.
“Dig into every industry, and you’ll find AI changing the nature of work,” said Daniela Rus, director of MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL). She cited recent McKinsey research that found 45 percent of the work people are paid to do today can be automated with currently available technologies. Those activities, McKinsey found, represent some US $2 trillion in wages.
However, the threat of automation—whether by AI or other technologies—isn’t as new as technologists on America’s coasts seem to believe, said panelist Fred Goff, CEO of Jobcase, Inc.
“If you live in Detroit or Toledo, where I come from, technology has been displacing jobs for the last half-century,” Goff said. “I don’t think that most people in this country have the increased anxiety that the coasts do, because they’ve been living this.”
Goff added that the challenge AI poses for the workforce is not, as he put it, “getting coal miners to code.” Rather, he said, as AI automates some jobs, it will also open opportunities for “reskilling” that may have nothing to do with AI or automation. He touted trade schools—teaching skills like welding, plumbing, and electrical work—and certification programs for sales industry software packages like Salesforce.
On the other hand, a documentarian who reported another recent program on AI—Krishna Andavolu, senior correspondent for Vice Media—said “reskilling” may not be an easy answer.
“People in rooms like this … don’t realize that a lot of people don’t want to work that much,” Andavolu said. “They’re not driven by passion for their career, they’re driven by passion for life. We’re telling a lot of these workers that they need to reskill. But to a lot of people that sounds like, ‘I’ve got to work twice as hard for what I have now.’ That sounds scary. We underestimate that at our peril.”
Part of the problem with “reskilling,” Andavolu said, is that some high-growth industries involve caregiving for seniors and in medical facilities—roles which are traditionally considered “feminized” careers. Destigmatizing these jobs, and increasing the pay to match the salaries of displaced jobs like long-haul truck drivers, is another challenge.
Daron Acemoglu, MIT Institute Professor of Economics, faulted the comparably slim funding of academic research into AI.
“There is nothing preordained about the progress of technology,” he said. Computers, the Internet, antibiotics, and sensors all grew out of government and academic research programs. What he called the “blue-sky thinking” of non-corporate AI research can also develop applications that are not purely focused on maximizing profits.
American companies, Acemoglu said, get tax breaks for capital R&D—but not for developing new technologies for their employees. “We turn around and [tell companies], ‘Use your technologies to empower workers,’” he said. “But why should they do that? Hiring workers is expensive in many ways. And we’re subsidizing capital.”
Said Sarita Gupta, director of the Ford Foundation’s Future of Work(ers) Program, “Low and middle income workers have for over 30 years been experiencing stagnant and declining pay, shrinking benefits, and less power on the job. Now technology is brilliant at enabling scale. But the question we sit with is—how do we make sure that we’re not scaling these longstanding problems?”
Andrew McAfee, co-director of MIT’s Initiative on the Digital Economy, said AI may not reduce the number of jobs available in the workplace today. But the quality of those jobs is another story. He cited the Dutch economist Jan Tinbergen who decades ago said that “Inequality is a race between technology and education.”
McAfee said, ultimately, the time to solve the economic problems AI poses for workers in the United States is when the U.S. economy is doing well—like right now.
“We do have the wind at our backs,” said Elisabeth Reynolds, executive director of MIT’s Task Force on the Work of the Future.
“We have some breathing room right now,” McAfee agreed. “Economic growth has been pretty good. Unemployment is pretty low. Interest rates are very, very low. We might not have that war chest in the future.” Continue reading
Posted in Human Robots
#436174 How Selfish Are You? It Matters for ...
Our personalities impact almost everything we do, from the career path we choose to the way we interact with others to how we spend our free time.
But what about the way we drive—could personality be used to predict whether a driver will cut someone off, speed, or, say, zoom through a yellow light instead of braking?
There must be something to the idea that those of us who are more mild-mannered are likely to drive a little differently than the more assertive among us. At least, that’s what a team from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) is betting on.
“Working with and around humans means figuring out their intentions to better understand their behavior,” said graduate student Wilko Schwarting, lead author on the paper published this week in Proceedings of the National Academy of Sciences. “People’s tendencies to be collaborative or competitive often spills over into how they behave as drivers. In this paper we sought to understand if this was something we could actually quantify.”
The team is building a model that classifies drivers according to how selfish or selfless they are, then uses that classification to help predict how drivers will behave on the road. Ideally, the system will help improve safety for self-driving cars by integrating a degree of ‘humanity’ into how their software perceives its surroundings; right now, human drivers and their cars are just another object, not much different than a tree or a sign.
But unlike trees and signs, humans have behavioral patterns and motivations. For greater success on roads that are still dominated by us mercurial humans, the CSAIL team believes, driverless cars should take our personalities into account.
How Selfish Are You?
About how important is your own well-being to you vs. the well-being of other people? It’s a hard question to answer without specifying who the other people are; your answer would likely differ if we’re talking about your friends, loved ones, strangers, or people you actively dislike.
In social psychology, social value orientation (SVO) refers to people’s preferences for allocating resources between themselves and others. The two broad categories people can fall into are pro-social (people who are more cooperative, and expect cooperation from others) and pro-self (pretty self-explanatory: “Me first!”).
Based on drivers’ behavior in two different road scenarios—merging and making a left turn—the CSAIL team’s model classified drivers as pro-social or egoistic. Slowing down to let someone merge into your lane in front of you would earn you a pro-social classification, while cutting someone off or not slowing down to allow a left turn would make you egoistic.
On the Road
The system then uses these classifications to model and predict drivers’ behavior. The team demonstrated that using their model, errors in predicting the behavior of other cars were reduced by 25 percent.
In a left-turn simulation, for example, their car would wait when an approaching car had an egoistic driver, but go ahead and make the turn when the other driver was prosocial. Similarly, if a self-driving car is trying to merge into the left lane and it’s identified the drivers in that lane as egoistic, it will assume they won’t slow down to let it in, and will wait to merge behind them. If, on the other hand, the self-driving car knows that the human drivers in the left lane are prosocial, it will attempt to merge between them since they’re likely to let it in.
So how does this all translate to better safety?
It’s essentially a starting point for imbuing driverless cars with some of the abilities and instincts that are innate to humans. If you’re driving down the highway and you see a car swerving outside its lane, you’ll probably distance yourself from that car because you know it’s more likely to cause an accident. Our senses take in information we can immediately interpret and act on, and this includes predictions about what might happen based on observations of what just happened. Our observations can clue us in to a driver’s personality (the swerver must be careless) or simply to the circumstances of a given moment (the swerver was texting).
But right now, self-driving cars assume all human drivers behave the same way, and they have no mechanism for incorporating observations about behavioral differences between drivers into their decisions.
“Creating more human-like behavior in autonomous vehicles (AVs) is fundamental for the safety of passengers and surrounding vehicles, since behaving in a predictable manner enables humans to understand and appropriately respond to the AV’s actions,” said Schwarting.
Though it may feel a bit unsettling to think of an algorithm lumping you into a category and driving accordingly around you, maybe it’s less unsettling than thinking of self-driving cars as pre-programmed, oblivious robots unable to adapt to different driving styles.
The team’s next step is to apply their model to pedestrians, bikes, and other agents frequently found in driving environments. They also plan to look into other robotic systems acting among people, like household robots, and integrating social value orientation into their algorithms.
Image Credit: Image by Free-Photos from Pixabay Continue reading
Posted in Human Robots