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#437695 Video Friday: Even Robots Know That You ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

CLAWAR 2020 – August 24-26, 2020 – [Online Conference]
Other Than Human – September 3-10, 2020 – Stockholm, Sweden
ICRES 2020 – September 28-29, 2020 – Taipei, Taiwan
AUVSI EXPONENTIAL 2020 – October 5-8, 2020 – [Online Conference]
IROS 2020 – October 25-29, 2020 – Las Vegas, Nev., USA
CYBATHLON 2020 – November 13-14, 2020 – [Online Event]
ICSR 2020 – November 14-16, 2020 – Golden, Colo., USA
Let us know if you have suggestions for next week, and enjoy today's videos.

From the Robotics and Perception Group at UZH comes Flightmare, a simulation environment for drones that combines a slick rendering engine with a robust physics engine that can run as fast as your system can handle.

Flightmare is composed of two main components: a configurable rendering engine built on Unity and a flexible physics engine for dynamics simulation. Those two components are totally decoupled and can run independently from each other. Flightmare comes with several desirable features: (i) a large multi-modal sensor suite, including an interface to extract the 3D point-cloud of the scene; (ii) an API for reinforcement learning which can simulate hundreds of quadrotors in parallel; and (iii) an integration with a virtual-reality headset for interaction with the simulated environment. Flightmare can be used for various applications, including path-planning, reinforcement learning, visual-inertial odometry, deep learning, human-robot interaction, etc.

[ Flightmare ]

Quadruped robots yelling at people to maintain social distancing is really starting to become a thing, for better or worse.

We introduce a fully autonomous surveillance robot based on a quadruped platform that can promote social distancing in complex urban environments. Specifically, to achieve autonomy, we mount multiple cameras and a 3D LiDAR on the legged robot. The robot then uses an onboard real-time social distancing detection system to track nearby pedestrian groups. Next, the robot uses a crowd-aware navigation algorithm to move freely in highly dynamic scenarios. The robot finally uses a crowd aware routing algorithm to effectively promote social distancing by using human-friendly verbal cues to send suggestions to overcrowded pedestrians.

[ Project ]

Thanks Fan!

The Personal Robotics Group at Oregon State University is looking at UV germicidal irradiation for surface disinfection with a Fetch Manipulator Robot.

Fetch Robot disinfecting dance party woo!

[ Oregon State ]

How could you not take a mask from this robot?

[ Reachy ]

This work presents the design, development and autonomous navigation of the alpha-version of our Resilient Micro Flyer, a new type of collision-tolerant small aerial robot tailored to traversing and searching within highly confined environments including manhole-sized tubes. The robot is particularly lightweight and agile, while it implements a rigid collision-tolerant design which renders it resilient during forcible interaction with the environment. Furthermore, the design of the system is enhanced through passive flaps ensuring smoother and more compliant collision which was identified to be especially useful in very confined settings.

[ ARL ]

Pepper can make maps and autonomously navigate, which is interesting, but not as interesting as its posture when it's wandering around.

Dat backing into the charging dock tho.

[ Pepper ]

RatChair a strategy for displacing big objects by attaching relatively small vibration sources. After learning how several random bursts of vibration affect its pose, an optimization algorithm discovers the optimal sequence of vibration patterns required to (slowly but surely) move the object to a specified position.

This is from 2015, why isn't all of my furniture autonomous yet?!

[ KAIST ]

The new SeaDrone Pro is designed to be the underwater equivalent of a quadrotor. This video is a rendering, but we've been assured that it does actually exist.

[ SeaDrone ]

Thanks Eduardo!

Porous Loops is a lightweight composite facade panel that shows the potential of 3D printing of mineral foams for building scale applications.

[ ETH ]

Thanks Fan!

Here's an interesting idea for a robotic gripper- it's what appears to be a snap bracelet coupled to a pneumatic actuator that allows the snap bracelet to be reset.

[ Georgia Tech ]

Graze is developing a commercial robotic lawnmower. They're also doing a sort of crowdfunded investment thing, which probably explains the painfully overproduced nature of the following video:

A couple things about this: the hard part, which the video skips over almost entirely, is the mapping, localization, and understanding where to mow and where not to mow. The pitch deck seems to suggest that this is mostly done through computer vision, a thing that's perhaps easy to do under controlled ideal conditions, but difficult to apply to a world full lawns that are all different. The commercial aspect is interesting because golf courses are likely as standardized as you can get, but the emphasis here on how much money they can make without really addressing any of the technical stuff makes me raise an eyebrow or two.

[ Graze ]

The record & playback X-series arm demo allows the user to record the arm's movements while motors are torqued off. Then, the user may torque the motor's on and watch the movements they just made playback!

[ Interbotix ]

Shadow Robot has a new teleop system for its hand. I'm guessing that it's even trickier to use than it looks.

[ Shadow Robot ]

Quanser Interactive Labs is a collection of virtual hardware-based laboratory activities that supplement traditional or online courses. Same as working with physical systems in the lab, students work with virtual twins of Quanser's most popular plants, develop their mathematical models, implement and simulate the dynamic behavior of these systems, design controllers, and validate them on a high-fidelity 3D real-time virtual models. The virtual systems not only look like the real ones, they also behave, can be manipulated, measured, and controlled like real devices. And finally, when students go to the lab, they can deploy their virtually-validated designs on actual physical equipment.

[ Quanser ]

This video shows robot-assisted heart surgery. It's amazing to watch if you haven't seen this sort of thing before, but be aware that there is a lot of blood.

This video demonstrates a fascinating case of robotic left atrial myxoma excision, narrated by Joel Dunning, Middlesbrough, UK. The Robotic platform provides superior visualisation and enhanced dexterity, through keyhole incisions. Robotic surgery is an integral part of our Minimally Invasive Cardiothoracic Surgery Program.

[ Tristan D. Yan ]

Thanks Fan!

In this talk, we present our work on learning control policies directly in simulation that are deployed onto real drones without any fine tuning. The presentation covers autonomous drone racing, drone acrobatics, and uncertainty estimation in deep networks.

[ RPG ] Continue reading

Posted in Human Robots

#437645 How Robots Became Essential Workers in ...

Photo: Sivaram V/Reuters

A robot, developed by Asimov Robotics to spread awareness about the coronavirus, holds a tray with face masks and sanitizer.

As the coronavirus emergency exploded into a full-blown pandemic in early 2020, forcing countless businesses to shutter, robot-making companies found themselves in an unusual situation: Many saw a surge in orders. Robots don’t need masks, can be easily disinfected, and, of course, they don’t get sick.

An army of automatons has since been deployed all over the world to help with the crisis: They are monitoring patients, sanitizing hospitals, making deliveries, and helping frontline medical workers reduce their exposure to the virus. Not all robots operate autonomously—many, in fact, require direct human supervision, and most are limited to simple, repetitive tasks. But robot makers say the experience they’ve gained during this trial-by-fire deployment will make their future machines smarter and more capable. These photos illustrate how robots are helping us fight this pandemic—and how they might be able to assist with the next one.

DROID TEAM

Photo: Clement Uwiringiyimana/Reuters

A squad of robots serves as the first line of defense against person-to-person transmission at a medical center in Kigali, Rwanda. Patients walking into the facility get their temperature checked by the machines, which are equipped with thermal cameras atop their heads. Developed by UBTech Robotics, in China, the robots also use their distinctive appearance—they resemble characters out of a Star Wars movie—to get people’s attention and remind them to wash their hands and wear masks.

Photo: Clement Uwiringiyimana/Reuters

SAY “AAH”
To speed up COVID-19 testing, a team of Danish doctors and engineers at the University of Southern Denmark and at Lifeline Robotics is developing a fully automated swab robot. It uses computer vision and machine learning to identify the perfect target spot inside the person’s throat; then a robotic arm with a long swab reaches in to collect the sample—all done with a swiftness and consistency that humans can’t match. In this photo, one of the creators, Esben Østergaard, puts his neck on the line to demonstrate that the robot is safe.

Photo: University of Southern Denmark

GERM ZAPPER
After six of its doctors became infected with the coronavirus, the Sassarese hospital in Sardinia, Italy, tightened its safety measures. It also brought in the robots. The machines, developed by UVD Robots, use lidar to navigate autonomously. Each bot carries an array of powerful short-wavelength ultraviolet-C lights that destroy the genetic material of viruses and other pathogens after a few minutes of exposure. Now there is a spike in demand for UV-disinfection robots as hospitals worldwide deploy them to sterilize intensive care units and operating theaters.

Photo: UVD Robots

RUNNING ERRANDS

In medical facilities, an ideal role for robots is taking over repetitive chores so that nurses and physicians can spend their time doing more important tasks. At Shenzhen Third People’s Hospital, in China, a robot called Aimbot drives down the hallways, enforcing face-mask and social-distancing rules and spraying disinfectant. At a hospital near Austin, Texas, a humanoid robot developed by Diligent Robotics fetches supplies and brings them to patients’ rooms. It repeats this task day and night, tirelessly, allowing the hospital staff to spend more time interacting with patients.

Photos, left: Diligent Robotics; Right: UBTech Robotics

THE DOCTOR IS IN
Nurses and doctors at Circolo Hospital in Varese, in northern Italy—the country’s hardest-hit region—use robots as their avatars, enabling them to check on their patients around the clock while minimizing exposure and conserving protective equipment. The robots, developed by Chinese firm Sanbot, are equipped with cameras and microphones and can also access patient data like blood oxygen levels. Telepresence robots, originally designed for offices, are becoming an invaluable tool for medical workers treating highly infectious diseases like COVID-19, reducing the risk that they’ll contract the pathogen they’re fighting against.

Photo: Miguel Medina/AFP/Getty Images

HELP FROM ABOVE

Photo: Zipline

Authorities in several countries attempted to use drones to enforce lockdowns and social-distancing rules, but the effectiveness of such measures remains unclear. A better use of drones was for making deliveries. In the United States, startup Zipline deployed its fixed-wing autonomous aircraft to connect two medical facilities 17 kilometers apart. For the staff at the Huntersville Medical Center, in North Carolina, masks, gowns, and gloves literally fell from the skies. The hope is that drones like Zipline’s will one day be able to deliver other kinds of critical materials, transport test samples, and distribute drugs and vaccines.

Photos: Zipline

SPECIAL DELIVERY
It’s not quite a robot takeover, but the streets and sidewalks of dozens of cities around the world have seen a proliferation of hurrying wheeled machines. Delivery robots are now in high demand as online orders continue to skyrocket.

In Hamburg, the six-wheeled robots developed by Starship Technologies navigate using cameras, GPS, and radar to bring groceries to customers.

Photo: Christian Charisius/Picture Alliance/Getty Images

In Medellín, Colombia, a startup called Rappi deployed a fleet of robots, built by Kiwibot, to deliver takeout to people in lockdown.

Photo: Joaquin Sarmiento/AFP/Getty Images

China’s JD.com, one of the country’s largest e-commerce companies, is using 20 robots to transport goods in Changsha, Hunan province; each vehicle has 22 separate compartments, which customers unlock using face authentication.

Photos: TPG/Getty Images

LIFE THROUGH ROBOTS
Robots can’t replace real human interaction, of course, but they can help people feel more connected at a time when meetings and other social activities are mostly on hold.

In Ostend, Belgium, ZoraBots brought one of its waist-high robots, equipped with cameras, microphones, and a screen, to a nursing home, allowing residents like Jozef Gouwy to virtually communicate with loved ones despite a ban on in-person visits.

Photo: Yves Herman/Reuters

In Manila, nearly 200 high school students took turns “teleporting” into a tall wheeled robot, developed by the school’s robotics club, to walk on stage during their graduation ceremony.

Photo: Ezra Acayan/Getty Images

And while Japan’s Chiba Zoological Park was temporarily closed due to the pandemic, the zoo used an autonomous robotic vehicle called RakuRo, equipped with 360-degree cameras, to offer virtual tours to children quarantined at home.

Photo: Tomohiro Ohsumi/Getty Images

SENTRY ROBOTS
Offices, stores, and medical centers are adopting robots as enforcers of a new coronavirus code.

At Fortis Hospital in Bangalore, India, a robot called Mitra uses a thermal camera to perform a preliminary screening of patients.

Photo: Manjunath Kiran/AFP/Getty Images

In Tunisia, the police use a tanklike robot to patrol the streets of its capital city, Tunis, verifying that citizens have permission to go out during curfew hours.

Photo: Khaled Nasraoui/Picture Alliance/Getty Images

And in Singapore, the Bishan-Ang Moh Kio Park unleashed a Spot robot dog, developed by Boston Dynamics, to search for social-distancing violators. Spot won’t bark at them but will rather play a recorded message reminding park-goers to keep their distance.

Photo: Roslan Rahman/AFP/Getty Images

This article appears in the October 2020 print issue as “How Robots Became Essential Workers.” Continue reading

Posted in Human Robots

#437628 Video Friday: An In-Depth Look at Mesmer ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here’s what we have so far (send us your events!):

AUVSI EXPONENTIAL 2020 – October 5-8, 2020 – [Online]
IROS 2020 – October 25-29, 2020 – [Online]
ROS World 2020 – November 12, 2020 – [Online]
CYBATHLON 2020 – November 13-14, 2020 – [Online]
ICSR 2020 – November 14-16, 2020 – Golden, Colo., USA
Let us know if you have suggestions for next week, and enjoy today’s videos.

Bear Robotics, a robotics and artificial intelligence company, and SoftBank Robotics Group, a leading robotics manufacturer and solutions provider, have collaborated to bring a new robot named Servi to the food service and hospitality field.

[ Bear Robotics ]

A literal in-depth look at Engineered Arts’ Mesmer android.

[ Engineered Arts ]

Is your robot running ROS? Is it connected to the Internet? Are you actually in control of it right now? Are you sure?

I appreciate how the researchers admitted to finding two of their own robots as part of the scan, a Baxter and a drone.

[ Brown ]

Smile Robotics describes this as “(possibly) world’s first full-autonomous clear-up-the-table robot.”

We’re not qualified to make a judgement on the world firstness, but personally I hate clearing tables, so this robot has my vote.

Smile Robotics founder and CEO Takashi Ogura, along with chief engineer Mitsutaka Kabasawa and engineer Kazuya Kobayashi, are former Google roboticists. Ogura also worked at SCHAFT. Smile says its robot uses ROS and is controlled by a framework written mainly in Rust, adding: “We are hiring Rustacean Roboticists!”

[ Smile Robotics ]

We’re not entirely sure why, but Panasonic has released plans for an Internet of Things system for hamsters.

We devised a recipe for a “small animal healthcare device” that can measure the weight and activity of small animals, the temperature and humidity of the breeding environment, and manage their health. This healthcare device visualizes the health status and breeding environment of small animals and manages their health to promote early detection of diseases. While imagining the scene where a healthcare device is actually used for an important small animal that we treat with affection, we hope to help overcome the current difficult situation through manufacturing.

[ Panasonic ] via [ RobotStart ]

Researchers at Yale have developed a robotic fabric, a breakthrough that could lead to such innovations as adaptive clothing, self-deploying shelters, or lightweight shape-changing machinery.

The researchers focused on processing functional materials into fiber-form so they could be integrated into fabrics while retaining its advantageous properties. For example, they made variable stiffness fibers out of an epoxy embedded with particles of Field’s metal, an alloy that liquifies at relatively low temperatures. When cool, the particles are solid metal and make the material stiffer; when warm, the particles melt into liquid and make the material softer.

[ Yale ]

In collaboration with Armasuisse and SBB, RSL demonstrated the use of a teleoperated Menzi Muck M545 to clean up a rock slide in Central Switzerland. The machine can be operated from a teloperation platform with visual and motion feedback. The walking excavator features an active chassis that can adapt to uneven terrain.

[ ETHZ RSL ]

An international team of JKU researchers is continuing to develop their vision for robots made out of soft materials. A new article in the journal “Communications Materials” demonstrates just how these kinds of soft machines react using weak magnetic fields to move very quickly. A triangle-shaped robot can roll itself in air at high speed and walk forward when exposed to an alternating in-plane square wave magnetic field (3.5 mT, 1.5 Hz). The diameter of the robot is 18 mm with a thickness of 80 µm. A six-arm robot can grab, transport, and release non-magnetic objects such as a polyurethane foam cube controlled by a permanent magnet.

Okay but tell me more about that cute sheep.

[ JKU ]

Interbotix has this “research level robotic crawler,” which both looks mean and runs ROS, a dangerous combination.

And here’s how it all came together:

[ Interbotix ]

I guess if you call them “loitering missile systems” rather than “drones that blow things up” people are less likely to get upset?

[ AeroVironment ]

In this video, we show a planner for a master dual-arm robot to manipulate tethered tools with an assistant dual-arm robot’s help. The assistant robot provides assistance to the master robot by manipulating the tool cable and avoiding collisions. The provided assistance allows the master robot to perform tool placements on the robot workspace table to regrasp the tool, which would typically fail since the tool cable tension may change the tool positions. It also allows the master robot to perform tool handovers, which would normally cause entanglements or collisions with the cable and the environment without the assistance.

[ Harada Lab ]

This video shows a flexible and robust robotic system for autonomous drawing on 3D surfaces. The system takes 2D drawing strokes and a 3D target surface (mesh or point clouds) as input. It maps the 2D strokes onto the 3D surface and generates a robot motion to draw the mapped strokes using visual recognition, grasp pose reasoning, and motion planning.

[ Harada Lab ]

Weekly mobility test. This time the Warthog takes on a fallen tree. Will it cross it? The answer is in the video!

And the answer is: kinda?

[ NORLAB ]

One of the advantages of walking machines is their ability to apply forces in all directions and of various magnitudes to the environment. Many of the multi-legged robots are equipped with point contact feet as these simplify the design and control of the robot. The iStruct project focuses on the development of a foot that allows extensive contact with the environment.

[ DFKI ]

An urgent medical transport was simulated in NASA’s second Systems Integration and Operationalization (SIO) demonstration Sept. 28 with partner Bell Textron Inc. Bell used the remotely-piloted APT 70 to conduct a flight representing an urgent medical transport mission. It is envisioned in the future that an operational APT 70 could provide rapid medical transport for blood, organs, and perishable medical supplies (payload up to 70 pounds). The APT 70 is estimated to move three times as fast as ground transportation.

Always a little suspicious when the video just shows the drone flying, and sitting on the ground, but not that tricky transition between those two states.

[ NASA ]

A Lockheed Martin Robotics Seminar on “Socially Assistive Mobile Robots,” by Yi Guo from Stevens Institute of Technology.

The use of autonomous mobile robots in human environments is on the rise. Assistive robots have been seen in real-world environments, such as robot guides in airports, robot polices in public parks, and patrolling robots in supermarkets. In this talk, I will first present current research activities conducted in the Robotics and Automation Laboratory at Stevens. I’ll then focus on robot-assisted pedestrian regulation, where pedestrian flows are regulated and optimized through passive human-robot interaction.

[ UMD ]

This week’s CMU RI Seminar is by CMU’s Zachary Manchester, on “The World’s Tiniest Space Program.”

The aerospace industry has experienced a dramatic shift over the last decade: Flying a spacecraft has gone from something only national governments and large defense contractors could afford to something a small startup can accomplish on a shoestring budget. A virtuous cycle has developed where lower costs have led to more launches and the growth of new markets for space-based data. However, many barriers remain. This talk will focus on driving these trends to their ultimate limit by harnessing advances in electronics, planning, and control to build spacecraft that cost less than a new smartphone and can be deployed in large numbers.

[ CMU RI ] Continue reading

Posted in Human Robots

#437224 This Week’s Awesome Tech Stories From ...

VIRTUAL REALITY
How Holographic Tech Is Shrinking VR Displays to the Size of Sunglasses
Kyle Orland | Ars Technica
“…researchers at Facebook Reality Labs are using holographic film to create a prototype VR display that looks less like ski goggles and more like lightweight sunglasses. With a total thickness less than 9mm—and without significant compromises on field of view or resolution—these displays could one day make today’s bulky VR headset designs completely obsolete.”

TRANSPORTATION
Stock Surge Makes Tesla the World’s Most Valuable Automaker
Timothy B. Lee | Ars Technica
“It’s a remarkable milestone for a company that sells far fewer cars than its leading rivals. …But Wall Street is apparently very optimistic about Tesla’s prospects for future growth and profits. Many experts expect a global shift to battery electric vehicles over the next decade or two, and Tesla is leading that revolution.”

FUTURE OF FOOD
These Plant-Based Steaks Come Out of a 3D Printer
Adele Peters | Fast Company
“The startup, launched by cofounders who met while developing digital printers at HP, created custom 3D printers that aim to replicate meat by printing layers of what they call ‘alt-muscle,’ ‘alt-fat,’ and ‘alt-blood,’ forming a complex 3D model.”

AUTOMATION
The US Air Force Is Turning Old F-16s Into AI-Powered Fighters
Amit Katwala | Wired UK
“Maverick’s days are numbered. The long-awaited sequel to Top Gun is due to hit cinemas in December, but the virtuoso fighter pilots at its heart could soon be a thing of the past. The trustworthy wingman will soon be replaced by artificial intelligence, built into a drone, or an existing fighter jet with no one in the cockpit.”

ROBOTICS
NASA Wants to Build a Steam-Powered Hopping Robot to Explore Icy Worlds
Georgina Torbet | Digital Trends
“A bouncing, ball-like robot that’s powered by steam sounds like something out of a steampunk fantasy, but it could be the ideal way to explore some of the distant, icy environments of our solar system. …This round robot would be the size of a soccer ball, with instruments held in the center of a metal cage, and it would use steam-powered thrusters to make jumps from one area of terrain to the next.”

FUTURE
Could Teleporting Ever Work?
Daniel Kolitz | Gizmodo
“Have the major airlines spent decades suppressing teleportation research? Have a number of renowned scientists in the field of teleportation studies disappeared under mysterious circumstances? Is there a cork board at the FBI linking Delta Airlines, shady foreign security firms, and dozens of murdered research professors? …No. None of that is the case. Which begs the question: why doesn’t teleportation exist yet?”

ENERGY
Nuclear ‘Power Balls’ Could Make Meltdowns a Thing of the Past
Daniel Oberhaus | Wired
“Not only will these reactors be smaller and more efficient than current nuclear power plants, but their designers claim they’ll be virtually meltdown-proof. Their secret? Millions of submillimeter-size grains of uranium individually wrapped in protective shells. It’s called triso fuel, and it’s like a radioactive gobstopper.”

TECHNOLOGY
A Plan to Redesign the Internet Could Make Apps That No One Controls
Will Douglas Heaven | MIT Techology Review
“[John Perry] Barlow’s ‘home of Mind’ is ruled today by the likes of Google, Facebook, Amazon, Alibaba, Tencent, and Baidu—a small handful of the biggest companies on earth. Yet listening to the mix of computer scientists and tech investors speak at an online event on June 30 hosted by the Dfinity Foundation…it is clear that a desire for revolution is brewing.”

IMPACT
To Save the World, the UN Is Turning It Into a Computer Simulation
Will Bedingfield | Wired
“The UN has now announced its new secret recipe to achieve [its 17 sustainable development goals or SDGs]: a computer simulation called Policy Priority Inference (PPI). …PPI is a budgeting software—it simulates a government and its bureaucrats as they allocate money on projects that might move a country closer to an SDG.”

Image credit: Benjamin Suter / Unsplash Continue reading

Posted in Human Robots

#437209 A Renaissance of Genomics and Drugs Is ...

The causes of aging are extremely complex and unclear. But with longevity clinical trials increasing, more answers—and questions—are emerging than ever before.

With the dramatic demonetization of genome reading and editing over the past decade, and Big Pharma, startups, and the FDA starting to face aging as a disease, we are starting to turn those answers into practical ways to extend our healthspan.

In this article, I’ll explore how genome sequencing and editing, along with new classes of anti-aging drugs, are augmenting our biology to further extend our healthy lives.

Genome Sequencing and Editing
Your genome is the software that runs your body. A sequence of 3.2 billion letters makes you “you.” These base pairs of A’s, T’s, C’s, and G’s determine your hair color, your height, your personality, your propensity for disease, your lifespan, and so on.

Until recently, it’s been very difficult to rapidly and cheaply “read” these letters—and even more difficult to understand what they mean. Since 2001, the cost to sequence a whole human genome has plummeted exponentially, outpacing Moore’s Law threefold. From an initial cost of $3.7 billion, it dropped to $10 million in 2006, and to $1,500 in 2015.

Today, the cost of genome sequencing has dropped below $600, and according to Illumina, the world’s leading sequencing company, the process will soon cost about $100 and take about an hour to complete.

This represents one of the most powerful and transformative technology revolutions in healthcare. When we understand your genome, we’ll be able to understand how to optimize “you.”

We’ll know the perfect foods, the perfect drugs, the perfect exercise regimen, and the perfect supplements, just for you.
We’ll understand what microbiome types, or gut flora, are ideal for you (more on this in a later article).
We’ll accurately predict how specific sedatives and medicines will impact you.
We’ll learn which diseases and illnesses you’re most likely to develop and, more importantly, how to best prevent them from developing in the first place (rather than trying to cure them after the fact).

CRISPR Gene Editing
In addition to reading the human genome, scientists can now edit a genome using a naturally occurring biological system discovered in 1987 called CRISPR/Cas9.

Short for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9, the editing system was adapted from a naturally-occurring defense system found in bacteria.

Here’s how it works. The bacteria capture snippets of DNA from invading viruses (or bacteriophage) and use them to create DNA segments known as CRISPR arrays. The CRISPR arrays allow the bacteria to “remember” the viruses (or closely related ones), and defend against future invasions. If the viruses attack again, the bacteria produce RNA segments from the CRISPR arrays to target the viruses’ DNA. The bacteria then use Cas9 to cut the DNA apart, which disables the virus.

Most importantly, CRISPR is cheap, quick, easy to use, and more accurate than all previous gene editing methods. As a result, CRISPR/Cas9 has swept through labs around the world as the way to edit a genome. A short search in the literature will show an exponential rise in the number of CRISPR-related publications and patents.

2018: Filled With CRISPR Breakthroughs
Early results are impressive. Researchers have used CRISPR to genetically engineer cocaine resistance into mice, reverse the gene defect causing Duchenne muscular dystrophy (DMD) in dogs, and reduce genetic deafness in mice.

Already this year, CRISPR-edited immune cells have been shown to successfully kill cancer cells in human patients. Researchers have discovered ways to activate CRISPR with light and use the gene-editing technology to better understand Alzheimer’s disease progression.

With great power comes great responsibility, and the opportunity for moral and ethical dilemmas. In 2015, Chinese scientists sparked global controversy when they first edited human embryo cells in the lab with the goal of modifying genes that would make the child resistant to smallpox, HIV, and cholera. Three years later, in November 2018, researcher He Jiankui informed the world that the first set of CRISPR-engineered female twins had been delivered.

To accomplish his goal, Jiankui deleted a region of a receptor on the surface of white blood cells known as CCR5, introducing a rare, natural genetic variation that makes it more difficult for HIV to infect its favorite target, white blood cells. Because Jiankui forged ethical review documents and misled doctors in the process, he was sentenced to three years in prison and fined $429,000 last December.

Coupled with significant ethical conversations necessary for progress, CRISPR will soon provide us the tools to eliminate diseases, create hardier offspring, produce new environmentally resistant crops, and even wipe out pathogens.

Senolytics, Nutraceuticals, and Pharmaceuticals
Over the arc of your life, the cells in your body divide until they reach what is known as the Hayflick limit, or the number of times a normal human cell population will divide before cell division stops, which is typically about 50 divisions.

What normally follows next is programmed cell death or destruction by the immune system. A very small fraction of cells, however, become senescent cells and evade this fate to linger indefinitely. These lingering cells secrete a potent mix of molecules that triggers chronic inflammation, damages the surrounding tissue structures, and changes the behavior of nearby cells for the worse. Senescent cells appear to be one of the root causes of aging, causing everything from fibrosis and blood vessel calcification to localized inflammatory conditions such as osteoarthritis to diminished lung function.

Fortunately, both the scientific and entrepreneurial communities have begun to work on senolytic therapies, moving the technology for selectively destroying senescent cells out of the laboratory and into a half-dozen startup companies.

Prominent companies in the field include the following:

Unity Biotechnology is developing senolytic medicines to selectively eliminate senescent cells with an initial focus on delivering localized therapy in osteoarthritis, ophthalmology, and pulmonary disease.

Oisin Biotechnologies is pioneering a programmable gene therapy that can destroy cells based on their internal biochemistry.

SIWA Therapeutics is working on an immunotherapy approach to the problem of senescent cells.

In recent years, researchers have identified or designed a handful of senolytic compounds that can curb aging by regulating senescent cells. Two of these drugs that have gained mainstay research traction are rapamycin and metformin.

(1) Rapamycin

Originally extracted from bacteria found on Easter Island, rapamycin acts on the m-TOR (mechanistic target of rapamycin) pathway to selectively block a key protein that facilitates cell division. Currently, rapamycin derivatives are widely used for immunosuppression in organ and bone marrow transplants. Research now suggests that use results in prolonged lifespan and enhanced cognitive and immune function.

PureTech Health subsidiary resTORbio (which went public in 2018) is working on a rapamycin-based drug intended to enhance immunity and reduce infection. Their clinical-stage RTB101 drug works by inhibiting part of the mTOR pathway.

Results of the drug’s recent clinical trial include decreased incidence of infection, improved influenza vaccination response, and a 30.6 percent decrease in respiratory tract infection.

Impressive, to say the least.

(2) Metformin

Metformin is a widely-used generic drug for mitigating liver sugar production in Type 2 diabetes patients. Researchers have found that metformin also reduces oxidative stress and inflammation, which otherwise increase as we age. There is strong evidence that metformin can augment cellular regeneration and dramatically mitigate cellular senescence by reducing both oxidative stress and inflammation.

Over 100 studies registered on ClinicalTrials.gov are currently following up on strong evidence of metformin’s protective effect against cancer.

(3) Nutraceuticals and NAD+

Beyond cellular senescence, certain critical nutrients and proteins tend to decline as a function of age. Nutraceuticals combat aging by supplementing and replenishing these declining nutrient levels.

NAD+ exists in every cell, participating in every process from DNA repair to creating the energy vital for cellular processes. It’s been shown that NAD+ levels decline as we age.

The Elysium Health Basis supplement aims to elevate NAD+ levels in the body to extend one’s lifespan. Elysium’s first clinical study reports that Basis increases NAD+ levels consistently by a sustained 40 percent.

Conclusion
These are just a taste of the tremendous momentum that longevity and aging technology has right now. As artificial intelligence and quantum computing transform how we decode our DNA and how we discover drugs, genetics and pharmaceuticals will become truly personalized.

The next article in this series will demonstrate how artificial intelligence is converging with genetics and pharmaceuticals to transform how we approach longevity, aging, and vitality.

We are edging closer toward a dramatically extended healthspan—where 100 is the new 60. What will you create, where will you explore, and how will you spend your time if you are able to add an additional 40 healthy years to your life?

Join Me
(1) A360 Executive Mastermind: If you’re an exponentially and abundance-minded entrepreneur who would like coaching directly from me, consider joining my Abundance 360 Mastermind, a highly selective community of 360 CEOs and entrepreneurs who I coach for 3 days every January in Beverly Hills, Ca. Through A360, I provide my members with context and clarity about how converging exponential technologies will transform every industry. I’m committed to running A360 for the course of an ongoing 25-year journey as a “countdown to the Singularity.”

If you’d like to learn more and consider joining our 2021 membership, apply here.

(2) Abundance-Digital Online Community: I’ve also created a Digital/Online community of bold, abundance-minded entrepreneurs called Abundance-Digital. Abundance-Digital is Singularity University’s ‘onramp’ for exponential entrepreneurs—those who want to get involved and play at a higher level. Click here to learn more.

(Both A360 and Abundance-Digital are part of Singularity University—your participation opens you to a global community.)

This article originally appeared on diamandis.com. Read the original article here.

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