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#436784 This Week’s Awesome Tech Stories From ...

COMPUTING
Inside the Race to Build the Best Quantum Computer on Earth
Gideon Lichfield | MIT Technology Review
“Regardless of whether you agree with Google’s position [on ‘quantum supremacy’] or IBM’s, the next goal is clear, Oliver says: to build a quantum computer that can do something useful. …The trouble is that it’s nearly impossible to predict what the first useful task will be, or how big a computer will be needed to perform it.”

FUTURE
We’re Not Prepared for the End of Moore’s Law
David Rotman | MIT Technology Review
“Quantum computing, carbon nanotube transistors, even spintronics, are enticing possibilities—but none are obvious replacements for the promise that Gordon Moore first saw in a simple integrated circuit. We need the research investments now to find out, though. Because one prediction is pretty much certain to come true: we’re always going to want more computing power.”

ROBOTICS
Flippy the Burger-Flipping Robot Is Changing the Face of Fast Food as We Know It
Luke Dormehl | Digital Trends
“Flippy is the result of the Miso team’s robotics expertise, coupled with that industry-specific knowledge. It’s a burger-flipping robot arm that’s equipped with both thermal and regular vision, which grills burgers to order while also advising human collaborators in the kitchen when they need to add cheese or prep buns for serving.”

BIOTECHNOLOGY
The Next Generation of Batteries Could Be Built by Viruses
Daniel Oberhaus | Wired
“[MIT bioengineering professor Angela Belcher has] made viruses that can work with over 150 different materials and demonstrated that her technique can be used to manufacture other materials like solar cells. Belcher’s dream of zipping around in a ‘virus-powered car’ still hasn’t come true, but after years of work she and her colleagues at MIT are on the cusp of taking the technology out of the lab and into the real world.”

SPACE
Biggest Cosmic Explosion Ever Detected Left Huge Dent in Space
Hannah Devlin | The Guardian
“The biggest cosmic explosion on record has been detected—an event so powerful that it punched a dent the size of 15 Milky Ways in the surrounding space. The eruption is thought to have originated at a supermassive black hole in the Ophiuchus galaxy cluster, which is about 390 million light years from Earth.”

SCIENCE FICTION
Star Trek’s Warp Speed Would Have Tragic Consequences
Cassidy Ward | SyFy
“The various crews of Trek‘s slate of television shows and movies can get from here to there without much fanfare. Seeking out new worlds and new civilizations is no more difficult than gassing up the car and packing a cooler full of junk food. And they don’t even need to do that! The replicators will crank out a bologna sandwich just like mom used to make. All that’s left is to go, but what happens then?”

Image Credit: sergio souza / Pexels Continue reading

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#436578 AI Just Discovered a New Antibiotic to ...

Penicillin, one of the greatest discoveries in the history of medicine, was a product of chance.

After returning from summer vacation in September 1928, bacteriologist Alexander Fleming found a colony of bacteria he’d left in his London lab had sprouted a fungus. Curiously, wherever the bacteria contacted the fungus, their cell walls broke down and they died. Fleming guessed the fungus was secreting something lethal to the bacteria—and the rest is history.

Fleming’s discovery of penicillin and its later isolation, synthesis, and scaling in the 1940s released a flood of antibiotic discoveries in the next few decades. Bacteria and fungi had been waging an ancient war against each other, and the weapons they’d evolved over eons turned out to be humanity’s best defense against bacterial infection and disease.

In recent decades, however, the flood of new antibiotics has slowed to a trickle.

Their development is uneconomical for drug companies, and the low-hanging fruit has long been picked. We’re now facing the emergence of strains of super bacteria resistant to one or more antibiotics and an aging arsenal to fight them with. Gone unchallenged, an estimated 700,000 deaths worldwide due to drug resistance could rise to as many as 10 million in 2050.

Increasingly, scientists warn the tide is turning, and we need a new strategy to keep pace with the remarkably quick and boundlessly creative tactics of bacterial evolution.

But where the golden age of antibiotics was sparked by serendipity, human intelligence, and natural molecular weapons, its sequel may lean on the uncanny eye of artificial intelligence to screen millions of compounds—and even design new ones—in search of the next penicillin.

Hal Discovers a Powerful Antibiotic
In a paper published this week in the journal, Cell, MIT researchers took a step in this direction. The team says their machine learning algorithm discovered a powerful new antibiotic.

Named for the AI in 2001: A Space Odyssey, the antibiotic, halicin, successfully wiped out dozens of bacterial strains, including some of the most dangerous drug-resistant bacteria on the World Health Organization’s most wanted list. The bacteria also failed to develop resistance to E. coli during a month of observation, in stark contrast to existing antibiotic ciprofloxacin.

“In terms of antibiotic discovery, this is absolutely a first,” Regina Barzilay, a senior author on the study and computer science professor at MIT, told The Guardian.

The algorithm that discovered halicin was trained on the molecular features of 2,500 compounds. Nearly half were FDA-approved drugs, and another 800 naturally occurring. The researchers specifically tuned the algorithm to look for molecules with antibiotic properties but whose structures would differ from existing antibiotics (as halicin’s does). Using another machine learning program, they screened the results for those likely to be safe for humans.

Early study suggests halicin attacks the bacteria’s cell membranes, disrupting their ability to produce energy. Protecting the cell membrane from halicin might take more than one or two genetic mutations, which could account for its impressive ability to prevent resistance.

“I think this is one of the more powerful antibiotics that has been discovered to date,” James Collins, an MIT professor of bioengineering and senior author told The Guardian. “It has remarkable activity against a broad range of antibiotic-resistant pathogens.”

Beyond tests in petri-dish bacterial colonies, the team also tested halicin in mice. The antibiotic cleared up infections of a strain of bacteria resistant to all known antibiotics in a day. The team plans further study in partnership with a pharmaceutical company or nonprofit, and they hope to eventually prove it safe and effective for use in humans.

This last bit remains the trickiest step, given the cost of getting a new drug approved. But Collins hopes algorithms like theirs will help. “We could dramatically reduce the cost required to get through clinical trials,” he told the Financial Times.

A Universe of Drugs Awaits
The bigger story may be what happens next.

How many novel antibiotics await discovery, and how far can AI screening take us? The initial 6,000 compounds scanned by Barzilay and Collins’s team is a drop in the bucket.

They’ve already begun digging deeper by setting the algorithm loose on 100 million molecules from an online library of 1.5 billion compounds called the ZINC15 database. This first search took three days and turned up 23 more candidates that, like halicin, differ structurally from existing antibiotics and may be safe for humans. Two of these—which the team will study further—appear to be especially powerful.

Even more ambitiously, Barzilay hopes the approach can find or even design novel antibiotics that kill bad bacteria with alacrity while sparing the good guys. In this way, a round of antibiotics would cure whatever ails you without taking out your whole gut microbiome in the process.

All this is part of a larger movement to use machine learning algorithms in the long, expensive process of drug discovery. Other players in the area are also training AI on the vast possibility space of drug-like compounds. Last fall, one of the leaders in the area, Insilico, was challenged by a partner to see just how fast their method could do the job. The company turned out a new a proof-of-concept drug candidate in only 46 days.

The field is still developing, however, and it has yet to be seen exactly how valuable these approaches will be in practice. Barzilay is optimistic though.

“There is still a question of whether machine-learning tools are really doing something intelligent in healthcare, and how we can develop them to be workhorses in the pharmaceuticals industry,” she said. “This shows how far you can adapt this tool.”

Image Credit: Halicin (top row) prevented the development of antibiotic resistance in E. coli, while ciprofloxacin (bottom row) did not. Collins Lab at MIT Continue reading

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#436573 This Week’s Awesome Tech Stories From ...

ARTIFICIAL INTELLIGENCE
The Messy, Secretive Reality Behind OpenAI’s Bid to Save the World
Karen Hao | MIT Technology Review
“The AI moonshot was founded in the spirit of transparency. This is the inside story of how competitive pressure eroded that idealism. …Yet OpenAI is still a bastion of talent and cutting-edge research, filled with people who are sincerely striving to work for the benefit of humanity. In other words, it still has the most important elements, and there’s still time for it to change.”

ROBOTICS
3D Printed Four-Legged Robot Is Ready to Take on Spot—at a Lower Price
Luke Dormehl | Digital Trends
“[Ghost Robotics and Origin] have teamed up to develop a new line of robots, called the Spirit Series, which offer impressively capable four-legged robots, but which can be printed using additive manufacturing at a fraction of the cost and speed of traditional manufacturing approaches.”

PRIVACY
The Studs on This Punk Bracelet Are Actually Microphone-Jamming Ultrasonic Speakers
Andrew Liszewski | Gizmodo
“You can prevent facial recognition cameras from identifying you by wearing face paint, masks, or sometimes just a pair of oversized sunglasses. Keeping conversations private from an ever-growing number of microphone-equipped devices isn’t quite as easy, but researchers have created what could be the first wearable that actually helps increase your privacy.”

TRANSPORTATION
Iron Man Dreams Are Closer to Becoming a Reality Thanks to This New Jetman Dubai Video
Julia Alexander | The Verge
“Tony Stark may have destroyed his Iron Man suits in Iron Man 3 (only to bring out a whole new line in Avengers: Age of Ultron), but Jetman Dubai’s Iron Man-like dreams of autonomous human flight are realer than ever. A new video published by the company shows pilot Vince Reffet using a jet-powered, carbon-fiber suit to launch off the ground and fly 6,000 feet in the air.”

TECHNOLOGY
Wikipedia Is the Last Best Place on the Internet
Richard Cooke | Wired
“More than an encyclopedia, Wikipedia has become a community, a library, a constitution, an experiment, a political manifesto—the closest thing there is to an online public square. It is one of the few remaining places that retains the faintly utopian glow of the early World Wide Web.”

SCIENCE
The Very Large Array Will Search for Evidence of Extraterrestrial Life
Georgina Torbet | Digital Trends
“To begin the project, an interface will be added to the NRAO’s Very Large Array (VLA) in New Mexico to search for events or structures which could indicate the presence of life, such as laser beams, structures built around stars, indications of constructed satellites, or atmospheric chemicals produced by industry.”

SCIENCE FICTION
The Terrible Truth About Star Trek’s Transporters
Cassidy Ward | SyFy Wire
“The fact that you are scanned, deconstructed, and rebuilt almost immediately thereafter only creates the illusion of continuity. In reality, you are killed and then something exactly like you is born, elsewhere. There’s a whole philosophical debate about whether this really matters. If the person constructed on the other end is identical to you, down to the atomic level, is there any measurable difference from it being actually you?”

Image Credit: Samuel Giacomelli / Unsplash Continue reading

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#436559 This Is What an AI Said When Asked to ...

“What’s past is prologue.” So says the famed quote from Shakespeare’s The Tempest, alleging that we can look to what has already happened as an indication of what will happen next.

This idea could be interpreted as being rather bleak; are we doomed to repeat the errors of the past until we correct them? We certainly do need to learn and re-learn life lessons—whether in our work, relationships, finances, health, or other areas—in order to grow as people.

Zooming out, the same phenomenon exists on a much bigger scale—that of our collective human history. We like to think we’re improving as a species, but haven’t yet come close to doing away with the conflicts and injustices that plagued our ancestors.

Zooming back in (and lightening up) a little, what about the short-term future? What might happen over the course of this year, and what information would we use to make educated guesses about it?

The editorial team at The Economist took a unique approach to answering these questions. On top of their own projections for 2020, including possible scenarios in politics, economics, and the continued development of technologies like artificial intelligence, they looked to an AI to make predictions of its own. What it came up with is intriguing, and a little bit uncanny.

[For the full list of the questions and answers, read The Economist article].

An AI That Reads—Then Writes
Almost exactly a year ago, non-profit OpenAI announced it had built a neural network for natural language processing called GPT-2. The announcement was met with some controversy, as it included the caveat that the tool would not be immediately released to the public due to its potential for misuse. It was then released in phases over the course of several months.

GPT-2’s creators upped the bar on quality when training the neural net; rather than haphazardly feeding it low-quality text, they only used articles that got more than three upvotes on Reddit (admittedly, this doesn’t guarantee high quality across the board—but it’s something).

The training dataset consisted of 40GB of text. For context, 1GB of text is about 900,000 ASCII pages or 130,000 double-spaced Microsoft Word pages.

The tool has no understanding of the text it’s generating, of course. It uses language patterns and word sequences to draw statistical associations between words and phrases, building a sort of guidebook for itself (not unlike the grammar rules and vocabulary words you might study when trying to learn a foreign language). It then uses that guidebook to answer questions or predict what will come after a particular sequence of words.

GPT-2’s creators did note that when the model is trained on specifically-selected datasets for narrower applications, its replies become more convincing.

Some Light Editing
Though the Economist article detailing GPT-2’s predictions describes the text the model generated as “unedited,” this isn’t wholly accurate. In a Medium post, deputy editor Tom Standage describes the methodology he used, and it does involve a degree of tweaking.

Standage wrote an introductory paragraph, followed by his opening question (“Greetings, GPT-2. Have you done an interview before?”). He configured the tool to generate five responses to each subsequent question then selected the best answer, deleting any questions GPT-2 came up with as part of its response.

AI’s View of the World—and Itself
The questions Standage asked ranged from tech-related (the future of AI, technological unemployment, misuse of technology) to political and economic (re-election of Donald Trump, the US-China trade war). Here are a couple of his questions and GPT-2’s answers:

Q: Do fake news stories, generated using AI, pose a threat to democracy? Are we likely to see this tactic being used in the 2020 American presidential elections?
A: Yes, we’ll probably see them. It’s just a matter of when. Fake news stories are generally generated by political campaigns, and have the potential to have a huge impact on the outcome of an election. This is because they spread misinformation, often with no basis in fact.

Q: How do you see the economic outlook for 2020?
A: I think it is very unclear. The outlook for the UK economy is uncertain, but the American economy is very strong. I think we are going to have a lot of turbulence in the world economy.

While some of its answers seemed insightful—when asked about the future of AI, GPT-2 advised that we treat the technology like a tool and “put as much effort into developing [it] as necessary, rather than worrying that it’s going to harm us and destroy our lives”—many of the responses were quite vague. One answer, for example, mentions that there will “probably be major changes in China.” Are we talking political changes? Social? Economic? All of the above?

However, while nothing the AI wrote was particularly illuminating or new, it’s impressive that it was able to expound on the correct topic for each question, and in fully coherent English.

GPT-2 named itself—AI—as the most important disruptive technology to watch in 2020. This is telling; it’s coming from a synthesis of millions of pages of published articles. If GPT-2 thinks AI is more important than, say, gene editing or quantum computing, it could be right. Or it could simply be that AI is at peak hype, and as such more is being written about it than about other technologies.

Equally intriguing was GPT-2’s response when asked whether Donald Trump will win a second term: “I think he will not win a second term. I think he will be defeated in the general election.” Some deeper insight there would be great, but hey—we’ll take it.

Predicting Predictions
Since an AI can read and synthesize vast data sets much faster than we can, it’s being used to predict all kinds of things, from virus outbreaks to crime. But asking it to philosophize on the future based on the (Reddit-curated) past is new, and if you think about it, a pretty fascinating undertaking.

As GPT-2 and tools like it continually improve, we’ll likely see them making more—and better—predictions of the future. In the meantime, let’s hope that the new data these models are trained on—news of what’s happening this week, this month, this year—add to an already-present sense of optimism.

When asked if it had any advice for readers, GPT-2 replied, “The big projects that you think are impossible today are actually possible in the near future.”

Image Credit: Alexas_Fotos from Pixabay Continue reading

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#436546 How AI Helped Predict the Coronavirus ...

Coronavirus has been all over the news for the last couple weeks. A dedicated hospital sprang up in just eight days, the stock market took a hit, Chinese New Year celebrations were spoiled, and travel restrictions are in effect.

But let’s rewind a bit; some crucial events took place before we got to this point.

A little under two weeks before the World Health Organization (WHO) alerted the public of the coronavirus outbreak, a Canadian artificial intelligence company was already sounding the alarm. BlueDot uses AI-powered algorithms to analyze information from a multitude of sources to identify disease outbreaks and forecast how they may spread. On December 31st 2019, the company sent out a warning to its customers to avoid Wuhan, where the virus originated. The WHO didn’t send out a similar public notice until January 9th, 2020.

The story of BlueDot’s early warning is the latest example of how AI can improve our identification of and response to new virus outbreaks.

Predictions Are Bad News
Global pandemic or relatively minor scare? The jury is still out on the coronavirus. However, the math points to signs that the worst is yet to come.

Scientists are still working to determine how infectious the virus is. Initial analysis suggests it may be somewhere between influenza and polio on the virus reproduction number scale, which indicates how many new cases one case leads to.

UK and US-based researchers have published a preliminary paper estimating that the confirmed infected people in Wuhan only represent five percent of those who are actually infected. If the models are correct, 190,000 people in Wuhan will be infected by now, major Chinese cities are on the cusp of large-scale outbreaks, and the virus will continue to spread to other countries.

Finding the Start
The spread of a given virus is partly linked to how long it remains undetected. Identifying a new virus is the first step towards mobilizing a response and, in time, creating a vaccine. Warning at-risk populations as quickly as possible also helps with limiting the spread.

These are among the reasons why BlueDot’s achievement is important in and of itself. Furthermore, it illustrates how AIs can sift through vast troves of data to identify ongoing virus outbreaks.

BlueDot uses natural language processing and machine learning to scour a variety of information sources, including chomping through 100,000 news reports in 65 languages a day. Data is compared with flight records to help predict virus outbreak patterns. Once the automated data sifting is completed, epidemiologists check that the findings make sense from a scientific standpoint, and reports are sent to BlueDot’s customers, which include governments, businesses, and public health organizations.

AI for Virus Detection and Prevention
Other companies, such as Metabiota, are also using data-driven approaches to track the spread of the likes of the coronavirus.

Researchers have trained neural networks to predict the spread of infectious diseases in real time. Others are using AI algorithms to identify how preventive measures can have the greatest effect. AI is also being used to create new drugs, which we may well see repeated for the coronavirus.

If the work of scientists Barbara Han and David Redding comes to fruition, AI and machine learning may even help us predict where virus outbreaks are likely to strike—before they do.

The Uncertainty Factor
One of AI’s core strengths when working on identifying and limiting the effects of virus outbreaks is its incredibly insistent nature. AIs never tire, can sift through enormous amounts of data, and identify possible correlations and causations that humans can’t.

However, there are limits to AI’s ability to both identify virus outbreaks and predict how they will spread. Perhaps the best-known example comes from the neighboring field of big data analytics. At its launch, Google Flu Trends was heralded as a great leap forward in relation to identifying and estimating the spread of the flu—until it underestimated the 2013 flu season by a whopping 140 percent and was quietly put to rest.

Poor data quality was identified as one of the main reasons Google Flu Trends failed. Unreliable or faulty data can wreak havoc on the prediction power of AIs.

In our increasingly interconnected world, tracking the movements of potentially infected individuals (by car, trains, buses, or planes) is just one vector surrounded by a lot of uncertainty.

The fact that BlueDot was able to correctly identify the coronavirus, in part due to its AI technology, illustrates that smart computer systems can be incredibly useful in helping us navigate these uncertainties.

Importantly, though, this isn’t the same as AI being at a point where it unerringly does so on its own—which is why BlueDot employs human experts to validate the AI’s findings.

Image Credit: Coronavirus molecular illustration, Gianluca Tomasello/Wikimedia Commons Continue reading

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