Tag Archives: back

#439693 Agility Robotics’ Digit is Getting ...

Agility Robotics' Digit humanoid has been taking a bit of a break from work during the pandemic. Most of what we've seen from Agility and Digit over the past year and a half has been decidedly research-y. Don't get me wrong, Digit's been busy making humans look bad and not falling over when it really should have done, but remember that Agility's goal is to make Digit into a useful, practical robot. It's not a research platform—as Agility puts it, Digit is intended to “accelerate business productivity and people's pursuit of a more fulfilling life.” As far as I can make out, this is a fancier way of saying that Digit should really be spending its time doing dull repetitive tasks so that humans don't have to, and in a new video posted today, the robot shows how it can help out with boring warehouse tote shuffling.

The highlights here for me are really in the combination of legged mobility and object manipulation. Right at the beginning of the video, you see Digit squatting all the way down, grasping a tote bin, shuffling backwards to get the bin out from under the counter, and then standing again. There's an unfortunate cut there, but the sequence is shown again at 0:44, and you can see how Digit pulls the tote towards itself and then regrasps it before lifting. Clever. And at 1:20, the robot gives a tote that it just placed on a shelf a little nudge with one arm to make sure it's in the right spot.

These are all very small things, but I think of them as highlights because all of the big things seem to be more or less solved in this scenario. Digit has no problem lifting things, walking around, and not mowing over the occasional human, and once that stuff is all sorted, whether the robot is able to effectively work in an environment like this is to some extent reflected in all of these other little human-obvious things that often make the difference between success and failure.
The clear question, though, is why Digit (or, more broadly, any bipedal robot) is the right robot to be doing this kind of job. There are other robots out there already doing tasks like these in warehouses, and they generally have wheeled bases and manipulation systems specifically designed to move totes and do nothing else. If you were to use one of those robots instead of Digit, my guess is that you'd pay less for it, it would be somewhat safer, and it would likely do the job more efficiently. Fundamentally, Digit can't out box-move a box-moving robot. But the critical thing to consider here is that as soon as you run out of boxes to move, Digit can do all kinds of other things thanks to its versatile humanoid design, while your box-moving robot can only sit in the corner and be sad until more boxes show up.
“We did not set out to build a humanoid robot. We set out to solve mobility.”
—Agility CTO Jonathan Hurst
“Digit is very, very flexible automation,” Agility CTO Jonathan Hurst told us when we asked him about this. “The value of what we're doing is in generality, and having a robot that's going be able to work carrying totes for three or four hours, then go unload boxes from trailers for three or four hours, keep up with you if you change your workflow entirely. Many of these spaces are designed specifically around the human form factor, and it's possible for a robot like Digit to do all of these different boring, repetitive jobs. And then when things get complicated, humans are still doing it.”
The value of having a human-like robot in a human environment comes into play as soon as you start thinking about typical warehouse situations that would be trivial for a human to solve but that are impossible for wheeled robots. For example, Hurst says that Digit is capable of using a stool to reach objects on high shelves. You could, of course, design a wheeled robot with an extension system to allow it to reach high shelves, but you're now adding more cost and complexity, and the whole point of a generalist humanoid robot is that in human environments, you just don't have to worry about environmental challenges. Or that's the idea, anyway, but as Hurst explains, the fact that Digit ended up with a mostly humanoid form factor was more like a side effect of designing with specific capabilities in mind:
We did not set out to build a humanoid robot. We set out to solve mobility, and we've been on a methodical path towards understanding physical interaction in the world. Agility started with our robot Cassie, and one of the big problems with Cassie was that we didn't have enough inertia in the robot's body to counteract the leg swinging forward, which is why Digit has an upright torso. We wanted to give ourselves more control authority in the yaw direction with Cassie, so we experimented with putting a tail on the robot, and it turns out that the best tail is a pair of bilaterally symmetrical tails, one on either side.
Our goal was to design a machine that can go where people go while manipulating things in the world, and we ended up with this kind of form factor. It's a very different path for us to have gotten here than the vast majority of humanoid robots, and there's an awful lot of subtlety that is in our machine that is absent in most other machines.IEEE Spectrum: So are you saying that Digit's arms sort of started out as tails to help Cassie with yaw control?
Jonathan Hurst: There are many examples like this—we've been going down this path where we find a solution to a problem like yaw control, and it happens to look like it does with animals, but it's also a solution that's optimal in several different ways, like physical interaction and being able to catch the robot when it falls. It's not like it's a compromise between one thing and another thing, it's straight up the right solution for these three different performance design goals.
Looking back, we started by asking, should we put a reaction wheel or a gyro on Cassie for yaw control? Well, that's just wasted mass. We could use a tail, and there are a lot of nice robots with tails, but usually they're for controlling pitch. It's the same with animals; if you look at lizards, they use their tails for mid-air reorienting to land on their feet after they jump. Cassie doesn't need a tail for that, but we only have a couple of small feet on the ground to work with. And if you look at other bipedal animals, every one of them has some other way of getting that yaw authority. If you watch an ostrich run, when it turns, it sticks its wing out to get the control that it needs.
And so all of these things just fall into place, and a bilaterally symmetrical pair of tails is the best way to control yaw in a biped. When you see Digit walking and its arms are swinging, that's not something that we added to make the motion look right. It looks right because it literally is right—it's the physics of mobility. And that's a good sign for us that we're on the right path to getting the performance that we want.
“We're going for general purpose, but starting with some of the easiest use cases.”
—Agility CTO Jonathan Hurst
Spectrum: We've seen Digit demonstrating very impressive mobility skills. Why are we seeing a demo in a semi-constrained warehouse environment instead of somewhere that would more directly leverage Digit's unique advantages?
Jonathan Hurst: It's about finding the earliest, most appropriate, and most valuable use cases. There's a lot to this robot, and we're not going to be just a tote packing robot. We're not building a specialized robot for this one application, but we have a couple of pretty big logistics partners who are interested in the flexibility and the manipulation capabilities of this machine. And yeah, what you're seeing now is the robot on a flattish floor, but it's also not going to be tripped up by a curb, or a step, or, a wire cover, or other things on the ground. You don't have to worry about anything like that. So next, it's an easy transition next to unloading trailers, where it's going to have to be stepping over gaps and up and down things and around boxes on the floor and stuff like that. We're going for general purpose, but starting with some of the easiest use cases.
Damion Shelton, CEO: We're trying to prune down the industry space, to get to something where there's a clear value proposition with a partner and deploying there. We can respect the difficulty of the general purpose use case and work to deploy early and profitably, as opposed to continuing to push for the outdoor applications. The blessing and the curse of the Ford opportunity is that it's super interesting, but also super hard. And so it's very motivating, and it's clear to us that that's where one of the ultimate opportunities is, but it's also far enough away from a deployment timeline that it just doesn't map on to a viable business model.
This is a point that every robotics company runs into sooner or later, where aspirations have to succumb to the reality of selling robots in a long-term sustainable way. It's definitely not a bad thing, it just means that we may have to adjust our expectations accordingly. No matter what kind of flashy cutting-edge capabilities your robot has, if it can't cost effectively do dull or dirty or dangerous stuff, nobody's going to pay you money for it. And cost effective usefulness is, arguably, one of the biggest challenges in bipedal robotics right now. In the past, I've been impressed by Digit's weightlifting skills, or its ability to climb steep and muddy hills. I'll be just as impressed when it starts making money for Agility by doing boring repetitive tasks in warehouses, because that means that Agility will be able to keep working towards those more complex, more exciting things. “It's not general manipulation, and we're not solving the grand challenges of robotics,” says Hurst. “Yet. But we're on our way.” Continue reading

Posted in Human Robots

#439105 This Robot Taught Itself to Walk in a ...

Recently, in a Berkeley lab, a robot called Cassie taught itself to walk, a little like a toddler might. Through trial and error, it learned to move in a simulated world. Then its handlers sent it strolling through a minefield of real-world tests to see how it’d fare.

And, as it turns out, it fared pretty damn well. With no further fine-tuning, the robot—which is basically just a pair of legs—was able to walk in all directions, squat down while walking, right itself when pushed off balance, and adjust to different kinds of surfaces.

It’s the first time a machine learning approach known as reinforcement learning has been so successfully applied in two-legged robots.

This likely isn’t the first robot video you’ve seen, nor the most polished.

For years, the internet has been enthralled by videos of robots doing far more than walking and regaining their balance. All that is table stakes these days. Boston Dynamics, the heavyweight champ of robot videos, regularly releases mind-blowing footage of robots doing parkour, back flips, and complex dance routines. At times, it can seem the world of iRobot is just around the corner.

This sense of awe is well-earned. Boston Dynamics is one of the world’s top makers of advanced robots.

But they still have to meticulously hand program and choreograph the movements of the robots in their videos. This is a powerful approach, and the Boston Dynamics team has done incredible things with it.

In real-world situations, however, robots need to be robust and resilient. They need to regularly deal with the unexpected, and no amount of choreography will do. Which is how, it’s hoped, machine learning can help.

Reinforcement learning has been most famously exploited by Alphabet’s DeepMind to train algorithms that thrash humans at some the most difficult games. Simplistically, it’s modeled on the way we learn. Touch the stove, get burned, don’t touch the damn thing again; say please, get a jelly bean, politely ask for another.

In Cassie’s case, the Berkeley team used reinforcement learning to train an algorithm to walk in a simulation. It’s not the first AI to learn to walk in this manner. But going from simulation to the real world doesn’t always translate.

Subtle differences between the two can (literally) trip up a fledgling robot as it tries out its sim skills for the first time.

To overcome this challenge, the researchers used two simulations instead of one. The first simulation, an open source training environment called MuJoCo, was where the algorithm drew upon a large library of possible movements and, through trial and error, learned to apply them. The second simulation, called Matlab SimMechanics, served as a low-stakes testing ground that more precisely matched real-world conditions.

Once the algorithm was good enough, it graduated to Cassie.

And amazingly, it didn’t need further polishing. Said another way, when it was born into the physical world—it knew how to walk just fine. In addition, it was also quite robust. The researchers write that two motors in Cassie’s knee malfunctioned during the experiment, but the robot was able to adjust and keep on trucking.

Other labs have been hard at work applying machine learning to robotics.

Last year Google used reinforcement learning to train a (simpler) four-legged robot. And OpenAI has used it with robotic arms. Boston Dynamics, too, will likely explore ways to augment their robots with machine learning. New approaches—like this one aimed at training multi-skilled robots or this one offering continuous learning beyond training—may also move the dial. It’s early yet, however, and there’s no telling when machine learning will exceed more traditional methods.

And in the meantime, Boston Dynamics bots are testing the commercial waters.

Still, robotics researchers, who were not part of the Berkeley team, think the approach is promising. Edward Johns, head of Imperial College London’s Robot Learning Lab, told MIT Technology Review, “This is one of the most successful examples I have seen.”

The Berkeley team hopes to build on that success by trying out “more dynamic and agile behaviors.” So, might a self-taught parkour-Cassie be headed our way? We’ll see.

Image Credit: University of California Berkeley Hybrid Robotics via YouTube Continue reading

Posted in Human Robots

#439089 Ingenuity’s Chief Pilot Explains How ...

On April 11, the Mars helicopter Ingenuity will take to the skies of Mars for the first time. It will do so fully autonomously, out of necessity—the time delay between Ingenuity’s pilots at the Jet Propulsion Laboratory and Jezero Crater on Mars makes manual or even supervisory control impossible. So the best that the folks at JPL can do is practice as much as they can in simulation, and then hope that the helicopter can handle everything on its own.

Here on Earth, simulation is a critical tool for many robotics applications, because it doesn’t rely on access to expensive hardware, is non-destructive, and can be run in parallel and at faster-than-real-time speeds to focus on solving specific problems. Once you think you’ve gotten everything figured out in simulation, you can always give it a try on the real robot and see how close you came. If it works in real life, great! And if not, well, you can tweak some stuff in the simulation and try again.

For the Mars helicopter, simulation is much more important, and much higher stakes. Testing the Mars helicopter under conditions matching what it’ll find on Mars is not physically possible on Earth. JPL has flown engineering models in Martian atmospheric conditions, and they’ve used an actuated tether to mimic Mars gravity, but there’s just no way to know what it’ll be like flying on Mars until they’ve actually flown on Mars. With that in mind, the Ingenuity team has been relying heavily on simulation, since that’s one of the best tools they have to prepare for their Martian flights. We talk with Ingenuity’s Chief Pilot, Håvard Grip, to learn how it all works.

Ingenuity Facts:
Body Size: a box of tissues

Brains: Qualcomm Snapdragon 801

Weight: 1.8 kilograms

Propulsion: Two 1.2m carbon fiber rotors

Navigation sensors: VGA camera, laser altimeter, inclinometer

Ingenuity is scheduled to make its first flight no earlier than April 11. Before liftoff, the Ingenuity team will conduct a variety of pre-flight checks, including verifying the responsiveness of the control system and spinning the blades up to full speed (2,537 rpm) without lifting off. If everything looks good, the first flight will consist of a 1 meter per second climb to 3 meters, 30 seconds of hover at 3 meters while rotating in place a bit, and then a descent to landing. If Ingenuity pulls this off, that will have made its entire mission a success. There will be more flights over the next few weeks, but all it takes is one to prove that autonomous helicopter flight on Mars is possible.

Last month, we spoke with Mars Helicopter Operations Lead Tim Canham about Ingenuity’s hardware, software, and autonomy, but we wanted to know more about how the Ingenuity team has been using simulation for everything from vehicle design to flight planning. To answer our questions, we talked with JPL’s Håvard Grip, who led the development of Ingenuity’s navigation and flight control systems. Grip also has the title of Ingenuity Chief Pilot, which is pretty awesome. He summarizes this role as “operating the flight control system to make the helicopter do what we want it to do.”

IEEE Spectrum: Can you tell me about the simulation environment that JPL uses for Ingenuity’s flight planning?

Håvard Grip: We developed a Mars helicopter simulation ourselves at JPL, based on a multi-body simulation framework that’s also developed at JPL, called DARTS/DSHELL. That's a system that has been in development at JPL for about 30 years now, and it's been used in a number of missions. And so we took that multibody simulation framework, and based on it we built our own Mars helicopter simulation, put together our own rotor model, our own aerodynamics models, and everything else that's needed in order to simulate a helicopter. We also had a lot of help from the rotorcraft experts at NASA Ames and NASA Langley.

Image: NASA/JPL

Ingenuity in JPL’s flight simulator.

Without being able to test on Mars, how much validation are you able to do of what you’re seeing in simulation?

We can do a fair amount, but it requires a lot of planning. When we made our first real prototype (with a full-size rotor that looked like what we were thinking of putting on Mars) we first spent a lot of time designing it and using simulation tools to guide that design, and when we were sufficiently confident that we were close enough, and that we understood enough about it, then we actually built the thing and designed a whole suite of tests in a vacuum chamber where where we could replicate Mars atmospheric conditions. And those tests were before we tried to fly the helicopter—they were specifically targeted at what we call system identification, which has to do with figuring out what the true properties, the true dynamics of a system are, compared to what we assumed in our models. So then we got to see how well our models did, and in the places where they needed adjustment, we could go back and do that.

The simulation work that we really started after that very first initial lift test, that’s what allowed us to unlock all of the secrets to building a helicopter that can fly on Mars.
—Håvard Grip, Ingenuity Chief Pilot

We did a lot of this kind of testing. It was a big campaign, in several stages. But there are of course things that you can't fully replicate, and you do depend on simulation to tie things together. For example, we can't truly replicate Martian gravity on Earth. We can replicate the atmosphere, but not the gravity, and so we have to do various things when we fly—either make the helicopter very light, or we have to help it a little bit by pulling up on it with a string to offload some of the weight. These things don't fully replicate what it will be like on Mars. We also can't simultaneously replicate the Mars aerodynamic environment and the physical and visual surroundings that the helicopter will be flying in. These are places where simulation tools definitely come in handy, with the ability to do full flight tests from A to B, with the helicopter taking off from the ground, running the flight software that it will be running on board, simulating the images that the navigation camera takes of the ground below as it flies, feeding that back into the flight software, and then controlling it.

To what extent can simulation really compensate for the kinds of physical testing that you can’t do on Earth?

It gives you a few different possibilities. We can take certain tests on Earth where we replicate key elements of the environment, like the atmosphere or the visual surroundings for example, and you can validate your simulation on those parameters that you can test on Earth. Then, you can combine those things in simulation, which gives you the ability to set up arbitrary scenarios and do lots and lots of tests. We can Monte Carlo things, we can do a flight a thousand times in a row, with small perturbations of various parameters and tease out what our sensitivities are to those things. And those are the kinds of things that you can't do with physical tests, both because you can't fully replicate the environment and also because of the resources that would be required to do the same thing a thousand times in a row.

Because there are limits to the physical testing we can do on Earth, there are elements where we know there's more uncertainty. On those aspects where the uncertainty is high, we tried to build in enough margin that we can handle a range of things. And simulation gives you the ability to then maybe play with those parameters, and put them at their outer limits, and test them beyond where the real parameters are going to be to make sure that you have robustness even in those extreme cases.

How do you make sure you’re not relying on simulation too much, especially since in some ways it’s your only option?

It’s about anchoring it in real data, and we’ve done a lot of that with our physical testing. I think what you’re referring to is making your simulation too perfect, and we’re careful to model the things that matter. For example, the simulated sensors that we use have realistic levels of simulated noise and bias in them, the navigation camera images have realistic levels of degradation, we have realistic disturbances from wind gusts. If you don’t properly account for those things, then you’re missing important details. So, we try to be as accurate as we can, and to capture that by overbounding in areas where we have a high degree of uncertainty.

What kinds of simulated challenges have you put the Mars helicopter through, and how do you decide how far to push those challenges?

One example is that we can simulate going over rougher terrain. We can push that, and see how far we can go and still have the helicopter behave the way that we want it to. Or we can inject levels of noise that maybe the real sensors don't see, but you want to just see how far you can push things and make sure that it's still robust.

Where we put the limits on this and what we consider to be realistic is often a challenge. We consider this on a case by case basis—if you have a sensor that you're dealing with, you try to do testing with it to characterize it and understand its performance as much as possible, and you build a level of confidence in it that allows you to find the proper balance.

When it comes to things like terrain roughness, it's a little bit of a different thing, because we're actually picking where we're flying the helicopter. We have made that choice, and we know what the terrain looks like around us, so we don’t have to wonder about that anymore.

Image: NASA/JPL-Caltech/University of Arizona

Satellite image of the Ingenuity flight area.

The way that we’re trying to approach this operationally is that we should be done with the engineering at this point. We’re not depending on going back and resimulating things, other than a few checks here and there.

Are there any examples of things you learned as part of the simulation process that resulted in changes to the hardware or mission?

You know, it’s been a journey. One of the early things that we discovered as part of modeling the helicopter was that the rotor dynamics were quite different for a helicopter on Mars, in particular with respect to how the rotor responds to the up and down bending of the blades because they’re not perfectly rigid. That motion is a very important influence on the overall flight dynamics of the helicopter, and what we discovered as we started modeling was that this motion is damped much less on Mars. Under-damped oscillatory things like that, you kind of figure might pose a control issue, and that is the case here: if you just naively design it as you might a helicopter on Earth, without taking this into account, you could have a system where the response to control inputs becomes very sluggish. So that required changes to the vehicle design from some of the very early concepts, and it led us to make a rotor that’s extremely light and rigid.

The design cycle for the Mars helicopter—it’s not like we could just build something and take it out to the back yard and try it and then come back and tweak it if it doesn’t work. It’s a much bigger effort to build something and develop a test program where you have to use a vacuum chamber to test it. So you really want to get as close as possible up front, on your first iteration, and not have to go back to the drawing board on the basic things.

So how close were you able to get on your first iteration of the helicopter design?

[This video shows] a very early demo which was done more or less just assuming that things were going to behave as they would on Earth, and that we’d be able to fly in a Martian atmosphere just spinning the rotor faster and having a very light helicopter. We were basically just trying to demonstrate that we could produce enough lift. You can see the helicopter hopping around, with someone trying to joystick it, but it turned out to be very hard to control. This was prior to doing any of the modeling that I talked about earlier. But once we started seriously focusing on the modeling and simulation, we then went on to build a prototype vehicle which had a full-size rotor that’s very close to the rotor that will be flying on Mars. One difference is that prototype had cyclic control only on the lower rotor, and later we added cyclic control on the upper rotor as well, and that decision was informed in large part by the work we did in simulation—we’d put in the kinds of disturbances that we thought we might see on Mars, and decided that we needed to have the extra control authority.

How much room do you think there is for improvement in simulation, and how could that help you in the future?

The tools that we have were definitely sufficient for doing the job that we needed to do in terms of building a helicopter that can fly on Mars. But simulation is a compute-intensive thing, and so I think there’s definitely room for higher fidelity simulation if you have the compute power to do so. For a future Mars helicopter, you could get some benefits by more closely coupling together high-fidelity aerodynamic models with larger multi-body models, and doing that in a fast way, where you can iterate quickly. There’s certainly more potential for optimizing things.

Photo: NASA/JPL-Caltech

Ingenuity preparing for flight.

Watching Ingenuity’s first flight take place will likely be much like watching the Perseverance landing—we’ll be able to follow along with the Ingenuity team while they send commands to the helicopter and receive data back, although the time delay will mean that any kind of direct control won’t be possible. If everything goes the way it’s supposed to, there will hopefully be some preliminary telemetry from Ingenuity saying so, but it sounds like we’ll likely have to wait until April 12 before we get pictures or video of the flight itself.

Because Mars doesn’t care what time it is on Earth, the flight will actually be taking place very early on April 12, with the JPL Mission Control livestream starting at 3:30 a.m. EDT (12:30 a.m. PDT). Details are here. Continue reading

Posted in Human Robots

#439077 How Scientists Grew Human Muscles in Pig ...

The little pigs bouncing around the lab looked exceedingly normal. Yet their adorable exterior hid a remarkable secret: each piglet carried two different sets of genes. For now, both sets came from their own species. But one day, one of those sets may be human.

The piglets are chimeras—creatures with intermingled sets of genes, as if multiple entities were seamlessly mashed together. Named after the Greek lion-goat-serpent monsters, chimeras may hold the key to an endless supply of human organs and tissues for transplant. The crux is growing these human parts in another animal—one close enough in size and function to our own.

Last week, a team from the University of Minnesota unveiled two mind-bending chimeras. One was joyous little piglets, each propelled by muscles grown from a different pig. Another was pig embryos, transplanted into surrogate pigs, that developed human muscles for more than 20 days.

The study, led by Drs. Mary and Daniel Garry at the University of Minnesota, had a therapeutic point: engineering a brilliant way to replace muscle loss, especially for the muscles around our skeletons that allow us to move and navigate the world. Trauma and injury, such as from firearm wounds or car crashes, can damage muscle tissue beyond the point of repair. Unfortunately, muscles are also stubborn in that donor tissue from cadavers doesn’t usually “take” at the injury site. For now, there are no effective treatments for severe muscle death, called volumetric muscle loss.

The new human-pig hybrids are designed to tackle this problem. Muscle wasting aside, the study also points to a clever “hack” that increases the amount of human tissue inside a growing pig embryo.

If further improved, the technology could “provide an unlimited supply of organs for transplantation,” said Dr. Mary Garry to Inverse. What’s more, because the human tissue can be sourced from patients themselves, the risk of rejection by the immune system is relatively low—even when grown inside a pig.

“The shortage of organs for heart transplantation, vascular grafting, and skeletal muscle is staggering,” said Garry. Human-animal chimeras could have a “seismic impact” that transforms organ transplantation and helps solve the organ shortage crisis.

That is, if society accepts the idea of a semi-humanoid pig.

Wait…But How?
The new study took a page from previous chimera recipes.

The main ingredients and steps go like this: first, you need an embryo that lacks the ability to develop a tissue or organ. This leaves an “empty slot” of sorts that you can fill with another set of genes—pig, human, or even monkey.

Second, you need to fine-tune the recipe so that the embryos “take” the new genes, incorporating them into their bodies as if they were their own. Third, the new genes activate to instruct the growing embryo to make the necessary tissue or organs without harming the overall animal. Finally, the foreign genes need to stay put, without cells migrating to another body part—say, the brain.

Not exactly straightforward, eh? The piglets are technological wonders that mix cutting-edge gene editing with cloning technologies.

The team went for two chimeras: one with two sets of pig genes, the other with a pig and human mix. Both started with a pig embryo that can’t make its own skeletal muscles (those are the muscles surrounding your bones). Using CRISPR, the gene-editing Swiss Army Knife, they snipped out three genes that are absolutely necessary for those muscles to develop. Like hitting a bullseye with three arrows simultaneously, it’s already a technological feat.

Here’s the really clever part: the muscles around your bones have a slightly different genetic makeup than the ones that line your blood vessels or the ones that pump your heart. While the resulting pig embryos had severe muscle deformities as they developed, their hearts beat as normal. This means the gene editing cut only impacted skeletal muscles.

Then came step two: replacing the missing genes. Using a microneedle, the team injected a fertilized and slightly developed pig egg—called a blastomere—into the embryo. If left on its natural course, a blastomere eventually develops into another embryo. This step “smashes” the two sets of genes together, with the newcomer filling the muscle void. The hybrid embryo was then placed into a surrogate, and roughly four months later, chimeric piglets were born.

Equipped with foreign DNA, the little guys nevertheless seemed totally normal, nosing around the lab and running everywhere without obvious clumsy stumbles. Under the microscope, their “xenomorph” muscles were indistinguishable from run-of-the-mill average muscle tissue—no signs of damage or inflammation, and as stretchy and tough as muscles usually are. What’s more, the foreign DNA seemed to have only developed into muscles, even though they were prevalent across the body. Extensive fishing experiments found no trace of the injected set of genes inside blood vessels or the brain.

A Better Human-Pig Hybrid
Confident in their recipe, the team next repeated the experiment with human cells, with a twist. Instead of using controversial human embryonic stem cells, which are obtained from aborted fetuses, they relied on induced pluripotent stem cells (iPSCs). These are skin cells that have been reverted back into a stem cell state.

Unlike previous attempts at making human chimeras, the team then scoured the genetic landscape of how pig and human embryos develop to find any genetic “brakes” that could derail the process. One gene, TP53, stood out, which was then promptly eliminated with CRISPR.

This approach provides a way for future studies to similarly increase the efficiency of interspecies chimeras, the team said.

The human-pig embryos were then carefully grown inside surrogate pigs for less than a month, and extensively analyzed. By day 20, the hybrids had already grown detectable human skeletal muscle. Similar to the pig-pig chimeras, the team didn’t detect any signs that the human genes had sprouted cells that would eventually become neurons or other non-muscle cells.

For now, human-animal chimeras are not allowed to grow to term, in part to stem the theoretical possibility of engineering humanoid hybrid animals (shudder). However, a sentient human-pig chimera is something that the team specifically addressed. Through multiple experiments, they found no trace of human genes in the embryos’ brain stem cells 20 and 27 days into development. Similarly, human donor genes were absent in cells that would become the hybrid embryos’ reproductive cells.

Despite bioethical quandaries and legal restrictions, human-animal chimeras have taken off, both as a source of insight into human brain development and a well of personalized organs and tissues for transplant. In 2019, Japan lifted its ban on developing human brain cells inside animal embryos, as well as the term limit—to global controversy. There’s also the question of animal welfare, given that hybrid clones will essentially become involuntary organ donors.

As the debates rage on, scientists are nevertheless pushing the limits of human-animal chimeras, while treading as carefully as possible.

“Our data…support the feasibility of the generation of these interspecies chimeras, which will serve as a model for translational research or, one day, as a source for xenotransplantation,” the team said.

Image Credit: Christopher Carson on Unsplash Continue reading

Posted in Human Robots

#439066 Video Friday: Festo’s BionicSwift

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

RoboSoft 2021 – April 12-16, 2021 – [Online Conference]
ICRA 2021 – May 30-5, 2021 – Xi'an, China
DARPA SubT Finals – September 21-23, 2021 – Louisville, KY, USA
WeRobot 2021 – September 23-25, 2021 – Coral Gables, FL, USA
Let us know if you have suggestions for next week, and enjoy today's videos.

Festo's Bionic Learning Network for 2021 presents a flock of BionicSwifts.

To execute the flight maneuvers as true to life as possible, the wings are modeled on the plumage of birds. The individual lamellae are made of an ultralight, flexible but very robust foam and lie on top of each other like shingles. Connected to a carbon quill, they are attached to the actual hand and arm wings as in the natural model.

During the wing upstroke, the individual lamellae fan out so that air can flow through the wing. This means that the birds need less force to pull the wing up. During the downstroke, the lamellae close up so that the birds can generate more power to fly. Due to this close-to-nature replica of the wings, the BionicSwifts have a better flight profile than previous wing-beating drives.

[ Festo ]

While we've seen a wide variety of COVID-motivated disinfecting robots, they're usually using either ultraviolet light or a chemical fog. This isn't the way that humans clean—we wipe stuff down, which gets rid of surface dirt and disinfects at the same time. Fraunhofer has been working on a mobile manipulator that can clean in the same ways that we do.

It's quite the technical challenge, but it has the potential to be both more efficient and more effective.

[ Fraunhofer ]

In recent years, robots have gained artificial vision, touch, and even smell. “Researchers have been giving robots human-like perception,” says MIT Associate Professor Fadel Adib. In a new paper, Adib’s team is pushing the technology a step further. “We’re trying to give robots superhuman perception,” he says. The researchers have developed a robot that uses radio waves, which can pass through walls, to sense occluded objects. The robot, called RF-Grasp, combines this powerful sensing with more traditional computer vision to locate and grasp items that might otherwise be blocked from view.

[ MIT ]

Ingenuity is now scheduled to fly on April 11.

[ JPL ]

The legendary Zenta is back after a two year YouTube hiatus with “a kind of freaky furry hexapod bunny creature.”

[ Zenta ]

It is with great pride and excitement that the South Australia Police announce a new expansion to their kennel by introducing three new Police Dog (PD) recruits. These dogs have been purposely targeted to bring a whole new range of dog operational capabilities known as the ‘small area urban search and guided evacuation’ dogs. Police have been working closely with specialist vets and dog trainers to ascertain if the lightweight dogs could be transported safely by drones and released into hard-to-access areas where at the moment the larger PDs just simply cannot get in due to their size.

[ SA Police ]

SoftBank may not have Spot cheerleading robots for their baseball team anymore, but they've more than made up for it with a full century of Peppers. And one dude doing the robot.

[ SoftBank ]

MAB Robotics is a Polish company developing walking robots for inspection, and here's a prototype they've been working on.

[ MAB Robotics ]

Thanks Jakub!

DoraNose: Smell your way to a better tomorrow.

[ Dorabot ]

Our robots need to learn how to cope with their new neighbors, and we have just the solution for this, the egg detector! Using cutting-edge AI, it provides incredible precision in detecting a vast variety of eggs. We have deployed this new feature on Boston Dynamics Spot, one of our fleet's robots. It can now detect eggs with its cameras and avoid them on his autonomous missions.

[ Energy Robotics ]

When dropping a squishy robot from an airplane 1,000 feet up, make sure that you land as close to people's cars as you can.

Now do it from orbit!

[ Squishy Robotics ]

An autonomous robot that is able to physically guide humans through narrow and cluttered spaces could be a big boon to the visually-impaired. Most prior robotic guiding systems are based on wheeled platforms with large bases with actuated rigid guiding canes. The large bases and the actuated arms limit these prior approaches from operating in narrow and cluttered environments. We propose a method that introduces a quadrupedal robot with a leash to enable the robot-guiding-human system to change its intrinsic dimension (by letting the leash go slack) in order to fit into narrow spaces.

[ Hybrid Robotics ]

How to prove that your drone is waterproof.

[ UNL ]

Well this ought to be pretty good once it gets out of simulation.

[ Hybrid Robotics ]

MIDAS is Aurora’s AI-enabled, multi-rotor sUAV outfitted with optical sensors and a customized payload that can defeat multiple small UAVs per flight with low-collateral effects.

[ Aurora ]

The robots​ of the DFKI have the advantage of being able to reach extreme environments: they can be used for decontamination purposes in high-risk areas or inspect and maintain underwater​ structures, for which they are tested in the North Sea near Heligoland​.

[ DFKI ]

After years of trying, 60 Minutes cameras finally get a peek inside the workshop at Boston Dynamics, where robots move in ways once only thought possible in movies. Anderson Cooper reports.

[ 60 Minutes ]

In 2007, Noel Sharky stated that “we are sleepwalking into a brave new world where robots decide who, where and when to kill.” Since then thousands of AI and robotics researchers have joined his calls to regulate “killer robots.” But sometime this year, Turkey will deploy fully autonomous home-built kamikaze drones on its border with Syria. What are the ethical choices we need to consider? Will we end up in an episode of Black Mirror? Or is the UN listening to calls and starting the process of regulating this space? Prof. Toby Walsh will discuss this important issue, consider where we are at and where we need to go.

[ ICRA 2020 ]

In the second session of HAI's spring conference, artists and technologists discussed how technology can enhance creativity, reimagine meaning, and support racial and social justice. The conference, called “Intelligence Augmentation: AI Empowering People to Solve Global Challenges,” took place on 25 March 2021.

[ Stanford HAI ]

This spring 2021 GRASP SFI comes from Monroe Kennedy III at Stanford University, on “Considerations for Human-Robot Collaboration.”

The field of robotics has evolved over the past few decades. We’ve seen robots progress from the automation of repetitive tasks in manufacturing to the autonomy of mobilizing in unstructured environments to the cooperation of swarm robots that are centralized or decentralized. These abilities have required advances in robotic hardware, modeling, and artificial intelligence. The next frontier is robots collaborating in complex tasks with human teammates, in environments traditionally configured for humans. While solutions to this challenge must utilize all the advances of robotics, the human element adds a unique aspect that must be addressed. Collaborating with a human teammate means that the robot must have a contextual understanding of the task as well as all participant’s roles. We will discuss what constitutes an effective teammate and how we can capture this behavior in a robotic collaborator.

[ UPenn ] Continue reading

Posted in Human Robots