Tag Archives: 2015

#437769 Q&A: Facebook’s CTO Is at War With ...

Photo: Patricia de Melo Moreira/AFP/Getty Images

Facebook chief technology officer Mike Schroepfer leads the company’s AI and integrity efforts.

Facebook’s challenge is huge. Billions of pieces of content—short and long posts, images, and combinations of the two—are uploaded to the site daily from around the world. And any tiny piece of that—any phrase, image, or video—could contain so-called bad content.

In its early days, Facebook relied on simple computer filters to identify potentially problematic posts by their words, such as those containing profanity. These automatically filtered posts, as well as posts flagged by users as offensive, went to humans for adjudication.

In 2015, Facebook started using artificial intelligence to cull images that contained nudity, illegal goods, and other prohibited content; those images identified as possibly problematic were sent to humans for further review.

By 2016, more offensive photos were reported by Facebook’s AI systems than by Facebook users (and that is still the case).

In 2018, Facebook CEO Mark Zuckerberg made a bold proclamation: He predicted that within five or ten years, Facebook’s AI would not only look for profanity, nudity, and other obvious violations of Facebook’s policies. The tools would also be able to spot bullying, hate speech, and other misuse of the platform, and put an immediate end to them.

Today, automated systems using algorithms developed with AI scan every piece of content between the time when a user completes a post and when it is visible to others on the site—just fractions of a second. In most cases, a violation of Facebook’s standards is clear, and the AI system automatically blocks the post. In other cases, the post goes to human reviewers for a final decision, a workforce that includes 15,000 content reviewers and another 20,000 employees focused on safety and security, operating out of more than 20 facilities around the world.

In the first quarter of this year, Facebook removed or took other action (like appending a warning label) on more than 9.6 million posts involving hate speech, 8.6 million involving child nudity or exploitation, almost 8 million posts involving the sale of drugs, 2.3 million posts involving bullying and harassment, and tens of millions of posts violating other Facebook rules.

Right now, Facebook has more than 1,000 engineers working on further developing and implementing what the company calls “integrity” tools. Using these systems to screen every post that goes up on Facebook, and doing so in milliseconds, is sucking up computing resources. Facebook chief technology officer Mike Schroepfer, who is heading up Facebook’s AI and integrity efforts, spoke with IEEE Spectrum about the team’s progress on building an AI system that detects bad content.

Since that discussion, Facebook’s policies around hate speech have come under increasing scrutiny, with particular attention on divisive posts by political figures. A group of major advertisers in June announced that they would stop advertising on the platform while reviewing the situation, and civil rights groups are putting pressure on others to follow suit until Facebook makes policy changes related to hate speech and groups that promote hate, misinformation, and conspiracies.

Facebook CEO Mark Zuckerberg responded with news that Facebook will widen the category of what it considers hateful content in ads. Now the company prohibits claims that people from a specific race, ethnicity, national origin, religious affiliation, caste, sexual orientation, gender identity, or immigration status are a threat to the physical safety, health, or survival of others. The policy change also aims to better protect immigrants, migrants, refugees, and asylum seekers from ads suggesting these groups are inferior or expressing contempt. Finally, Zuckerberg announced that the company will label some problematic posts by politicians and government officials as content that violates Facebook’s policies.

However, civil rights groups say that’s not enough. And an independent audit released in July also said that Facebook needs to go much further in addressing civil rights concerns and disinformation.

Schroepfer indicated that Facebook’s AI systems are designed to quickly adapt to changes in policy. “I don’t expect considerable technical changes are needed to adjust,” he told Spectrum.

This interview has been edited and condensed for clarity.

IEEE Spectrum: What are the stakes of content moderation? Is this an existential threat to Facebook? And is it critical that you deal well with the issue of election interference this year?

Schroepfer: It’s probably existential; it’s certainly massive. We are devoting a tremendous amount of our attention to it.

The idea that anyone could meddle in an election is deeply disturbing and offensive to all of us here, just as people and citizens of democracies. We don’t want to see that happen anywhere, and certainly not on our watch. So whether it’s important to the company or not, it’s important to us as people. And I feel a similar way on the content-moderation side.

There are not a lot of easy choices here. The only way to prevent people, with certainty, from posting bad things is to not let them post anything. We can take away all voice and just say, “Sorry, the Internet’s too dangerous. No one can use it.” That will certainly get rid of all hate speech online. But I don’t want to end up in that world. And there are variants of that world that various governments are trying to implement, where they get to decide what’s true or not, and you as a person don’t. I don’t want to get there either.

My hope is that we can build a set of tools that make it practical for us to do a good enough job, so that everyone is still excited about the idea that anyone can share what they want, and so that Facebook is a safe and reasonable place for people to operate in.

Spectrum: You joined Facebook in 2008, before AI was part of the company’s toolbox. When did that change? When did you begin to think that AI tools would be useful to Facebook?

Schroepfer: Ten years ago, AI wasn’t commercially practical; the technology just didn’t work very well. In 2012, there was one of those moments that a lot of people point to as the beginning of the current revolution in deep learning and AI. A computer-vision model—a neural network—was trained using what we call supervised training, and it turned out to be better than all the existing models.

Spectrum: How is that training done, and how did computer-vision models come to Facebook?

Image: Facebook

Just Broccoli? Facebook’s image analysis algorithms can tell the difference between marijuana [left] and tempura broccoli [right] better than some humans.

Schroepfer: Say I take a bunch of photos and I have people look at them. If they see a photo of a cat, they put a text label that says cat; if it’s one of a dog, the text label says dog. If you build a big enough data set and feed that to the neural net, it learns how to tell the difference between cats and dogs.

Prior to 2012, it didn’t work very well. And then in 2012, there was this moment where it seemed like, “Oh wow, this technique might work.” And a few years later we were deploying that form of technology to help us detect problematic imagery.

Spectrum: Do your AI systems work equally well on all types of prohibited content?

Schroepfer: Nudity was technically easiest. I don’t need to understand language or culture to understand that this is either a naked human or not. Violence is a much more nuanced problem, so it was harder technically to get it right. And with hate speech, not only do you have to understand the language, it may be very contextual, even tied to recent events. A week before the Christchurch shooting [New Zealand, 2019], saying “I wish you were in the mosque” probably doesn’t mean anything. A week after, that might be a terrible thing to say.

Spectrum: How much progress have you made on hate speech?

Schroepfer: AI, in the first quarter of 2020, proactively detected 88.8 percent of the hate-speech content we removed, up from 80.2 percent in the previous quarter. In the first quarter of 2020, we took action on 9.6 million pieces of content for violating our hate-speech policies.

Image: Facebook

Off Label: Sometimes image analysis isn’t enough to determine whether a picture posted violates the company’s policies. In considering these candy-colored vials of marijuana, for example, the algorithms can look at any accompanying text and, if necessary, comments on the post.

Spectrum: It sounds like you’ve expanded beyond tools that analyze images and are also using AI tools that analyze text.

Schroepfer: AI started off as very siloed. People worked on language, people worked on computer vision, people worked on video. We’ve put these things together—in production, not just as research—into multimodal classifiers.

[Schroepfer shows a photo of a pan of Rice Krispies treats, with text referring to it as a “potent batch”] This is a case in which you have an image, and then you have the text on the post. This looks like Rice Krispies. On its own, this image is fine. You put the text together with it in a bigger model; that can then understand what’s going on. That didn’t work five years ago.

Spectrum: Today, every post that goes up on Facebook is immediately checked by automated systems. Can you explain that process?

Image: Facebook

Bigger Picture: Identifying hate speech is often a matter of context. Either the text or the photo in this post isn’t hateful standing alone, but putting them together tells a different story.

Schroepfer: You upload an image and you write some text underneath it, and the systems look at both the image and the text to try to see which, if any, policies it violates. Those decisions are based on our Community Standards. It will also look at other signals on the posts, like the comments people make.

It happens relatively instantly, though there may be times things happen after the fact. Maybe you uploaded a post that had misinformation in it, and at the time you uploaded it, we didn’t know it was misinformation. The next day we fact-check something and scan again; we may find your post and take it down. As we learn new things, we’re going to go back through and look for violations of what we now know to be a problem. Or, as people comment on your post, we might update our understanding of it. If people are saying, “That’s terrible,” or “That’s mean,” or “That looks fake,” those comments may be an interesting signal.

Spectrum: How is Facebook applying its AI tools to the problem of election interference?

Schroepfer: I would split election interference into two categories. There are times when you’re going after the content, and there are times you’re going after the behavior or the authenticity of the person.

On content, if you’re sharing misinformation, saying, “It’s super Wednesday, not super Tuesday, come vote on Wednesday,” that’s a problem whether you’re an American sitting in California or a foreign actor.

Other times, people create a series of Facebook pages pretending they’re Americans, but they’re really a foreign entity. That is a problem on its own, even if all the content they’re sharing completely meets our Community Standards. The problem there is that you have a foreign government running an information operation.

There, you need different tools. What you’re trying to do is put pieces together, to say, “Wait a second. All of these pages—Martians for Justice, Moonlings for Justice, and Venusians for Justice”—are all run by an administrator with an IP address that’s outside the United States. So they’re all connected, even though they’re pretending to not be connected. That’s a very different problem than me sitting in my office in Menlo Park [Calif.] sharing misinformation.

I’m not going to go into lots of technical detail, because this is an area of adversarial nature. The fundamental problem you’re trying to solve is that there’s one entity coordinating the activity of a bunch of things that look like they’re not all one thing. So this is a series of Instagram accounts, or a series of Facebook pages, or a series of WhatsApp accounts, and they’re pretending to be totally different things. We’re looking for signals that these things are related in some way. And we’re looking through the graph [what Facebook calls its map of relationships between users] to understand the properties of this network.

Spectrum: What cutting-edge AI tools and methods have you been working on lately?

Schroepfer: Supervised learning, with humans setting up the instruction process for the AI systems, is amazingly effective. But it has a very obvious flaw: the speed at which you can develop these things is limited by how fast you can curate the data sets. If you’re dealing in a problem domain where things change rapidly, you have to rebuild a new data set and retrain the whole thing.

Self-supervision is inspired by the way people learn, by the way kids explore the world around them. To get computers to do it themselves, we take a bunch of raw data and build a way for the computer to construct its own tests. For language, you scan a bunch of Web pages, and the computer builds a test where it takes a sentence, eliminates one of the words, and figures out how to predict what word belongs there. And because it created the test, it actually knows the answer. I can use as much raw text as I can find and store because it’s processing everything itself and doesn’t require us to sit down and build the information set. In the last two years there has been a revolution in language understanding as a result of AI self-supervised learning.

Spectrum: What else are you excited about?

Schroepfer: What we’ve been working on over the last few years is multilingual understanding. Usually, when I’m trying to figure out, say, whether something is hate speech or not I have to go through the whole process of training the model in every language. I have to do that one time for every language. When you make a post, the first thing we have to figure out is what language your post is in. “Ah, that’s Spanish. So send it to the Spanish hate-speech model.”

We’ve started to build a multilingual model—one box where you can feed in text in 40 different languages and it determines whether it’s hate speech or not. This is way more effective and easier to deploy.

To geek out for a second, just the idea that you can build a model that understands a concept in multiple languages at once is crazy cool. And it not only works for hate speech, it works for a variety of things.

When we started working on this multilingual model years ago, it performed worse than every single individual model. Now, it not only works as well as the English model, but when you get to the languages where you don’t have enough data, it’s so much better. This rapid progress is very exciting.

Spectrum: How do you move new AI tools from your research labs into operational use?

Schroepfer: Engineers trying to make the next breakthrough will often say, “Cool, I’ve got a new thing and it achieved state-of-the-art results on machine translation.” And we say, “Great. How long does it take to run in production?” They say, “Well, it takes 10 seconds for every sentence to run on a CPU.” And we say, “It’ll eat our whole data center if we deploy that.” So we take that state-of-the-art model and we make it 10 or a hundred or a thousand times more efficient, maybe at the cost of a little bit of accuracy. So it’s not as good as the state-of-the-art version, but it’s something we can actually put into our data centers and run in production.

Spectrum: What’s the role of the humans in the loop? Is it true that Facebook currently employs 35,000 moderators?

Schroepfer: Yes. Right now our goal is not to reduce that. Our goal is to do a better job catching bad content. People often think that the end state will be a fully automated system. I don’t see that world coming anytime soon.

As automated systems get more sophisticated, they take more and more of the grunt work away, freeing up the humans to work on the really gnarly stuff where you have to spend an hour researching.

We also use AI to give our human moderators power tools. Say I spot this new meme that is telling everyone to vote on Wednesday rather than Tuesday. I have a tool in front of me that says, “Find variants of that throughout the system. Find every photo with the same text, find every video that mentions this thing and kill it in one shot.” Rather than, I found this one picture, but then a bunch of other people upload that misinformation in different forms.

Another important aspect of AI is that anything I can do to prevent a person from having to look at terrible things is time well spent. Whether it’s a person employed by us as a moderator or a user of our services, looking at these things is a terrible experience. If I can build systems that take the worst of the worst, the really graphic violence, and deal with that in an automated fashion, that’s worth a lot to me. Continue reading

Posted in Human Robots

#437695 Video Friday: Even Robots Know That You ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

CLAWAR 2020 – August 24-26, 2020 – [Online Conference]
Other Than Human – September 3-10, 2020 – Stockholm, Sweden
ICRES 2020 – September 28-29, 2020 – Taipei, Taiwan
AUVSI EXPONENTIAL 2020 – October 5-8, 2020 – [Online Conference]
IROS 2020 – October 25-29, 2020 – Las Vegas, Nev., USA
CYBATHLON 2020 – November 13-14, 2020 – [Online Event]
ICSR 2020 – November 14-16, 2020 – Golden, Colo., USA
Let us know if you have suggestions for next week, and enjoy today's videos.

From the Robotics and Perception Group at UZH comes Flightmare, a simulation environment for drones that combines a slick rendering engine with a robust physics engine that can run as fast as your system can handle.

Flightmare is composed of two main components: a configurable rendering engine built on Unity and a flexible physics engine for dynamics simulation. Those two components are totally decoupled and can run independently from each other. Flightmare comes with several desirable features: (i) a large multi-modal sensor suite, including an interface to extract the 3D point-cloud of the scene; (ii) an API for reinforcement learning which can simulate hundreds of quadrotors in parallel; and (iii) an integration with a virtual-reality headset for interaction with the simulated environment. Flightmare can be used for various applications, including path-planning, reinforcement learning, visual-inertial odometry, deep learning, human-robot interaction, etc.

[ Flightmare ]

Quadruped robots yelling at people to maintain social distancing is really starting to become a thing, for better or worse.

We introduce a fully autonomous surveillance robot based on a quadruped platform that can promote social distancing in complex urban environments. Specifically, to achieve autonomy, we mount multiple cameras and a 3D LiDAR on the legged robot. The robot then uses an onboard real-time social distancing detection system to track nearby pedestrian groups. Next, the robot uses a crowd-aware navigation algorithm to move freely in highly dynamic scenarios. The robot finally uses a crowd aware routing algorithm to effectively promote social distancing by using human-friendly verbal cues to send suggestions to overcrowded pedestrians.

[ Project ]

Thanks Fan!

The Personal Robotics Group at Oregon State University is looking at UV germicidal irradiation for surface disinfection with a Fetch Manipulator Robot.

Fetch Robot disinfecting dance party woo!

[ Oregon State ]

How could you not take a mask from this robot?

[ Reachy ]

This work presents the design, development and autonomous navigation of the alpha-version of our Resilient Micro Flyer, a new type of collision-tolerant small aerial robot tailored to traversing and searching within highly confined environments including manhole-sized tubes. The robot is particularly lightweight and agile, while it implements a rigid collision-tolerant design which renders it resilient during forcible interaction with the environment. Furthermore, the design of the system is enhanced through passive flaps ensuring smoother and more compliant collision which was identified to be especially useful in very confined settings.

[ ARL ]

Pepper can make maps and autonomously navigate, which is interesting, but not as interesting as its posture when it's wandering around.

Dat backing into the charging dock tho.

[ Pepper ]

RatChair a strategy for displacing big objects by attaching relatively small vibration sources. After learning how several random bursts of vibration affect its pose, an optimization algorithm discovers the optimal sequence of vibration patterns required to (slowly but surely) move the object to a specified position.

This is from 2015, why isn't all of my furniture autonomous yet?!

[ KAIST ]

The new SeaDrone Pro is designed to be the underwater equivalent of a quadrotor. This video is a rendering, but we've been assured that it does actually exist.

[ SeaDrone ]

Thanks Eduardo!

Porous Loops is a lightweight composite facade panel that shows the potential of 3D printing of mineral foams for building scale applications.

[ ETH ]

Thanks Fan!

Here's an interesting idea for a robotic gripper- it's what appears to be a snap bracelet coupled to a pneumatic actuator that allows the snap bracelet to be reset.

[ Georgia Tech ]

Graze is developing a commercial robotic lawnmower. They're also doing a sort of crowdfunded investment thing, which probably explains the painfully overproduced nature of the following video:

A couple things about this: the hard part, which the video skips over almost entirely, is the mapping, localization, and understanding where to mow and where not to mow. The pitch deck seems to suggest that this is mostly done through computer vision, a thing that's perhaps easy to do under controlled ideal conditions, but difficult to apply to a world full lawns that are all different. The commercial aspect is interesting because golf courses are likely as standardized as you can get, but the emphasis here on how much money they can make without really addressing any of the technical stuff makes me raise an eyebrow or two.

[ Graze ]

The record & playback X-series arm demo allows the user to record the arm's movements while motors are torqued off. Then, the user may torque the motor's on and watch the movements they just made playback!

[ Interbotix ]

Shadow Robot has a new teleop system for its hand. I'm guessing that it's even trickier to use than it looks.

[ Shadow Robot ]

Quanser Interactive Labs is a collection of virtual hardware-based laboratory activities that supplement traditional or online courses. Same as working with physical systems in the lab, students work with virtual twins of Quanser's most popular plants, develop their mathematical models, implement and simulate the dynamic behavior of these systems, design controllers, and validate them on a high-fidelity 3D real-time virtual models. The virtual systems not only look like the real ones, they also behave, can be manipulated, measured, and controlled like real devices. And finally, when students go to the lab, they can deploy their virtually-validated designs on actual physical equipment.

[ Quanser ]

This video shows robot-assisted heart surgery. It's amazing to watch if you haven't seen this sort of thing before, but be aware that there is a lot of blood.

This video demonstrates a fascinating case of robotic left atrial myxoma excision, narrated by Joel Dunning, Middlesbrough, UK. The Robotic platform provides superior visualisation and enhanced dexterity, through keyhole incisions. Robotic surgery is an integral part of our Minimally Invasive Cardiothoracic Surgery Program.

[ Tristan D. Yan ]

Thanks Fan!

In this talk, we present our work on learning control policies directly in simulation that are deployed onto real drones without any fine tuning. The presentation covers autonomous drone racing, drone acrobatics, and uncertainty estimation in deep networks.

[ RPG ] Continue reading

Posted in Human Robots

#437395 Microsoft Had a Crazy Idea to Put ...

A little over two years ago, a shipping container-sized cylinder bearing Microsoft’s name and logo was lowered onto the ocean floor off the northern coast of Scotland. Inside were 864 servers, and their submersion was part of the second phase of the software giant’s Project Natick. Launched in 2015, the project’s purpose is to determine the feasibility of underwater data centers powered by offshore renewable energy.

A couple months ago, the deep-sea servers were brought back up to the surface so engineers could inspect them and evaluate how they’d performed while under water.

But wait—why were they there in the first place?

As bizarre as it seems to sink hundreds of servers into the ocean, there are actually several very good reasons to do so. According to the UN, about 40 percent of the world’s population lives within 60 miles of an ocean. As internet connectivity expands to cover most of the globe in the next few years, millions more people will come online, and a lot more servers will be needed to manage the increased demand and data they’ll generate.

In densely-populated cities real estate is expensive and can be hard to find. But know where there’s lots of cheap, empty space? At the bottom of the ocean. This locale also carries the added benefit of being really cold (depending where we’re talking, that is; if you’re looking off the coast of, say, Mumbai or Abu Dhabi, the waters are warmer).

Servers generate a lot of heat, and datacenters use most of their electricity for cooling. Keeping not just the temperature but also the humidity level constant is important for optimal functioning of the servers; neither of these vary much 100 feet under water.

Finally, installing data centers on the ocean floor is, surprisingly, much faster than building them on land. Microsoft claims its server-holding cylinders will take less than 90 days to go from factory ship to operation, as compared to the average two years it takes to get a terrestrial data center up and running.

Microsoft’s Special Projects team operated the underwater data center for two years, and it took a full day to dredge it up and bring it to the surface. One of the first things researchers did was to insert test tubes into the container to take samples of the air inside; they’ll use it to try to determine how gases released from the equipment may have impacted the servers’ operating environment.

The container was filled with dry nitrogen upon deployment, which seems to have made for a much better environment than the oxygen that land-bound servers are normally surrounded by; the failure rate of the servers in the water was just one-eighth that of Microsoft’s typical rate for its servers on land. The team thinks the nitrogen atmosphere was helpful because it’s less corrosive than oxygen. The fact that no humans entered the container for the entirety of its operations helped, too (no moving around of components or having to turn on lights or adjust the temperature).

Ben Cutler, a project manager in Microsoft’s Special Projects research group who leads Project Natick, believes the results of this phase of the project are sufficient to show that underwater data centers are worth pursuing. “We are now at the point of trying to harness what we have done as opposed to feeling the need to go and prove out some more,” he said.

Cutler envisions putting underwater datacenters near offshore wind farms to power them sustainably. The data centers of the future will require less human involvement, instead being managed and run primarily by technologies like robotics and AI. In this kind of “lights-out” datacenter, the servers would be swapped out about once every five years, with any that fail before then being taken offline.

The final step in this phase of Project Natick is to recycle all the components used for the underwater data center, including the steel pressure vessel, heat exchangers, and the servers themselves—and restoring the sea bed where the cylinder rested back to its original condition.

If Cutler’s optimism is a portent of things to come, it may not be long before the ocean floor is dotted with sustainable datacenters to feed our ever-increasing reliance on our phones and the internet.

Image Credit: Microsoft Continue reading

Posted in Human Robots

#437276 Cars Will Soon Be Able to Sense and ...

Imagine you’re on your daily commute to work, driving along a crowded highway while trying to resist looking at your phone. You’re already a little stressed out because you didn’t sleep well, woke up late, and have an important meeting in a couple hours, but you just don’t feel like your best self.

Suddenly another car cuts you off, coming way too close to your front bumper as it changes lanes. Your already-simmering emotions leap into overdrive, and you lay on the horn and shout curses no one can hear.

Except someone—or, rather, something—can hear: your car. Hearing your angry words, aggressive tone, and raised voice, and seeing your furrowed brow, the onboard computer goes into “soothe” mode, as it’s been programmed to do when it detects that you’re angry. It plays relaxing music at just the right volume, releases a puff of light lavender-scented essential oil, and maybe even says some meditative quotes to calm you down.

What do you think—creepy? Helpful? Awesome? Weird? Would you actually calm down, or get even more angry that a car is telling you what to do?

Scenarios like this (maybe without the lavender oil part) may not be imaginary for much longer, especially if companies working to integrate emotion-reading artificial intelligence into new cars have their way. And it wouldn’t just be a matter of your car soothing you when you’re upset—depending what sort of regulations are enacted, the car’s sensors, camera, and microphone could collect all kinds of data about you and sell it to third parties.

Computers and Feelings
Just as AI systems can be trained to tell the difference between a picture of a dog and one of a cat, they can learn to differentiate between an angry tone of voice or facial expression and a happy one. In fact, there’s a whole branch of machine intelligence devoted to creating systems that can recognize and react to human emotions; it’s called affective computing.

Emotion-reading AIs learn what different emotions look and sound like from large sets of labeled data; “smile = happy,” “tears = sad,” “shouting = angry,” and so on. The most sophisticated systems can likely even pick up on the micro-expressions that flash across our faces before we consciously have a chance to control them, as detailed by Daniel Goleman in his groundbreaking book Emotional Intelligence.

Affective computing company Affectiva, a spinoff from MIT Media Lab, says its algorithms are trained on 5,313,751 face videos (videos of people’s faces as they do an activity, have a conversation, or react to stimuli) representing about 2 billion facial frames. Fascinatingly, Affectiva claims its software can even account for cultural differences in emotional expression (for example, it’s more normalized in Western cultures to be very emotionally expressive, whereas Asian cultures tend to favor stoicism and politeness), as well as gender differences.

But Why?
As reported in Motherboard, companies like Affectiva, Cerence, Xperi, and Eyeris have plans in the works to partner with automakers and install emotion-reading AI systems in new cars. Regulations passed last year in Europe and a bill just introduced this month in the US senate are helping make the idea of “driver monitoring” less weird, mainly by emphasizing the safety benefits of preemptive warning systems for tired or distracted drivers (remember that part in the beginning about sneaking glances at your phone? Yeah, that).

Drowsiness and distraction can’t really be called emotions, though—so why are they being lumped under an umbrella that has a lot of other implications, including what many may consider an eerily Big Brother-esque violation of privacy?

Our emotions, in fact, are among the most private things about us, since we are the only ones who know their true nature. We’ve developed the ability to hide and disguise our emotions, and this can be a useful skill at work, in relationships, and in scenarios that require negotiation or putting on a game face.

And I don’t know about you, but I’ve had more than one good cry in my car. It’s kind of the perfect place for it; private, secluded, soundproof.

Putting systems into cars that can recognize and collect data about our emotions under the guise of preventing accidents due to the state of mind of being distracted or the physical state of being sleepy, then, seems a bit like a bait and switch.

A Highway to Privacy Invasion?
European regulations will help keep driver data from being used for any purpose other than ensuring a safer ride. But the US is lagging behind on the privacy front, with car companies largely free from any enforceable laws that would keep them from using driver data as they please.

Affectiva lists the following as use cases for occupant monitoring in cars: personalizing content recommendations, providing alternate route recommendations, adapting environmental conditions like lighting and heating, and understanding user frustration with virtual assistants and designing those assistants to be emotion-aware so that they’re less frustrating.

Our phones already do the first two (though, granted, we’re not supposed to look at them while we drive—but most cars now let you use bluetooth to display your phone’s content on the dashboard), and the third is simply a matter of reaching a hand out to turn a dial or press a button. The last seems like a solution for a problem that wouldn’t exist without said… solution.

Despite how unnecessary and unsettling it may seem, though, emotion-reading AI isn’t going away, in cars or other products and services where it might provide value.

Besides automotive AI, Affectiva also makes software for clients in the advertising space. With consent, the built-in camera on users’ laptops records them while they watch ads, gauging their emotional response, what kind of marketing is most likely to engage them, and how likely they are to buy a given product. Emotion-recognition tech is also being used or considered for use in mental health applications, call centers, fraud monitoring, and education, among others.

In a 2015 TED talk, Affectiva co-founder Rana El-Kaliouby told her audience that we’re living in a world increasingly devoid of emotion, and her goal was to bring emotions back into our digital experiences. Soon they’ll be in our cars, too; whether the benefits will outweigh the costs remains to be seen.

Image Credit: Free-Photos from Pixabay Continue reading

Posted in Human Robots

#437209 A Renaissance of Genomics and Drugs Is ...

The causes of aging are extremely complex and unclear. But with longevity clinical trials increasing, more answers—and questions—are emerging than ever before.

With the dramatic demonetization of genome reading and editing over the past decade, and Big Pharma, startups, and the FDA starting to face aging as a disease, we are starting to turn those answers into practical ways to extend our healthspan.

In this article, I’ll explore how genome sequencing and editing, along with new classes of anti-aging drugs, are augmenting our biology to further extend our healthy lives.

Genome Sequencing and Editing
Your genome is the software that runs your body. A sequence of 3.2 billion letters makes you “you.” These base pairs of A’s, T’s, C’s, and G’s determine your hair color, your height, your personality, your propensity for disease, your lifespan, and so on.

Until recently, it’s been very difficult to rapidly and cheaply “read” these letters—and even more difficult to understand what they mean. Since 2001, the cost to sequence a whole human genome has plummeted exponentially, outpacing Moore’s Law threefold. From an initial cost of $3.7 billion, it dropped to $10 million in 2006, and to $1,500 in 2015.

Today, the cost of genome sequencing has dropped below $600, and according to Illumina, the world’s leading sequencing company, the process will soon cost about $100 and take about an hour to complete.

This represents one of the most powerful and transformative technology revolutions in healthcare. When we understand your genome, we’ll be able to understand how to optimize “you.”

We’ll know the perfect foods, the perfect drugs, the perfect exercise regimen, and the perfect supplements, just for you.
We’ll understand what microbiome types, or gut flora, are ideal for you (more on this in a later article).
We’ll accurately predict how specific sedatives and medicines will impact you.
We’ll learn which diseases and illnesses you’re most likely to develop and, more importantly, how to best prevent them from developing in the first place (rather than trying to cure them after the fact).

CRISPR Gene Editing
In addition to reading the human genome, scientists can now edit a genome using a naturally occurring biological system discovered in 1987 called CRISPR/Cas9.

Short for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9, the editing system was adapted from a naturally-occurring defense system found in bacteria.

Here’s how it works. The bacteria capture snippets of DNA from invading viruses (or bacteriophage) and use them to create DNA segments known as CRISPR arrays. The CRISPR arrays allow the bacteria to “remember” the viruses (or closely related ones), and defend against future invasions. If the viruses attack again, the bacteria produce RNA segments from the CRISPR arrays to target the viruses’ DNA. The bacteria then use Cas9 to cut the DNA apart, which disables the virus.

Most importantly, CRISPR is cheap, quick, easy to use, and more accurate than all previous gene editing methods. As a result, CRISPR/Cas9 has swept through labs around the world as the way to edit a genome. A short search in the literature will show an exponential rise in the number of CRISPR-related publications and patents.

2018: Filled With CRISPR Breakthroughs
Early results are impressive. Researchers have used CRISPR to genetically engineer cocaine resistance into mice, reverse the gene defect causing Duchenne muscular dystrophy (DMD) in dogs, and reduce genetic deafness in mice.

Already this year, CRISPR-edited immune cells have been shown to successfully kill cancer cells in human patients. Researchers have discovered ways to activate CRISPR with light and use the gene-editing technology to better understand Alzheimer’s disease progression.

With great power comes great responsibility, and the opportunity for moral and ethical dilemmas. In 2015, Chinese scientists sparked global controversy when they first edited human embryo cells in the lab with the goal of modifying genes that would make the child resistant to smallpox, HIV, and cholera. Three years later, in November 2018, researcher He Jiankui informed the world that the first set of CRISPR-engineered female twins had been delivered.

To accomplish his goal, Jiankui deleted a region of a receptor on the surface of white blood cells known as CCR5, introducing a rare, natural genetic variation that makes it more difficult for HIV to infect its favorite target, white blood cells. Because Jiankui forged ethical review documents and misled doctors in the process, he was sentenced to three years in prison and fined $429,000 last December.

Coupled with significant ethical conversations necessary for progress, CRISPR will soon provide us the tools to eliminate diseases, create hardier offspring, produce new environmentally resistant crops, and even wipe out pathogens.

Senolytics, Nutraceuticals, and Pharmaceuticals
Over the arc of your life, the cells in your body divide until they reach what is known as the Hayflick limit, or the number of times a normal human cell population will divide before cell division stops, which is typically about 50 divisions.

What normally follows next is programmed cell death or destruction by the immune system. A very small fraction of cells, however, become senescent cells and evade this fate to linger indefinitely. These lingering cells secrete a potent mix of molecules that triggers chronic inflammation, damages the surrounding tissue structures, and changes the behavior of nearby cells for the worse. Senescent cells appear to be one of the root causes of aging, causing everything from fibrosis and blood vessel calcification to localized inflammatory conditions such as osteoarthritis to diminished lung function.

Fortunately, both the scientific and entrepreneurial communities have begun to work on senolytic therapies, moving the technology for selectively destroying senescent cells out of the laboratory and into a half-dozen startup companies.

Prominent companies in the field include the following:

Unity Biotechnology is developing senolytic medicines to selectively eliminate senescent cells with an initial focus on delivering localized therapy in osteoarthritis, ophthalmology, and pulmonary disease.

Oisin Biotechnologies is pioneering a programmable gene therapy that can destroy cells based on their internal biochemistry.

SIWA Therapeutics is working on an immunotherapy approach to the problem of senescent cells.

In recent years, researchers have identified or designed a handful of senolytic compounds that can curb aging by regulating senescent cells. Two of these drugs that have gained mainstay research traction are rapamycin and metformin.

(1) Rapamycin

Originally extracted from bacteria found on Easter Island, rapamycin acts on the m-TOR (mechanistic target of rapamycin) pathway to selectively block a key protein that facilitates cell division. Currently, rapamycin derivatives are widely used for immunosuppression in organ and bone marrow transplants. Research now suggests that use results in prolonged lifespan and enhanced cognitive and immune function.

PureTech Health subsidiary resTORbio (which went public in 2018) is working on a rapamycin-based drug intended to enhance immunity and reduce infection. Their clinical-stage RTB101 drug works by inhibiting part of the mTOR pathway.

Results of the drug’s recent clinical trial include decreased incidence of infection, improved influenza vaccination response, and a 30.6 percent decrease in respiratory tract infection.

Impressive, to say the least.

(2) Metformin

Metformin is a widely-used generic drug for mitigating liver sugar production in Type 2 diabetes patients. Researchers have found that metformin also reduces oxidative stress and inflammation, which otherwise increase as we age. There is strong evidence that metformin can augment cellular regeneration and dramatically mitigate cellular senescence by reducing both oxidative stress and inflammation.

Over 100 studies registered on ClinicalTrials.gov are currently following up on strong evidence of metformin’s protective effect against cancer.

(3) Nutraceuticals and NAD+

Beyond cellular senescence, certain critical nutrients and proteins tend to decline as a function of age. Nutraceuticals combat aging by supplementing and replenishing these declining nutrient levels.

NAD+ exists in every cell, participating in every process from DNA repair to creating the energy vital for cellular processes. It’s been shown that NAD+ levels decline as we age.

The Elysium Health Basis supplement aims to elevate NAD+ levels in the body to extend one’s lifespan. Elysium’s first clinical study reports that Basis increases NAD+ levels consistently by a sustained 40 percent.

Conclusion
These are just a taste of the tremendous momentum that longevity and aging technology has right now. As artificial intelligence and quantum computing transform how we decode our DNA and how we discover drugs, genetics and pharmaceuticals will become truly personalized.

The next article in this series will demonstrate how artificial intelligence is converging with genetics and pharmaceuticals to transform how we approach longevity, aging, and vitality.

We are edging closer toward a dramatically extended healthspan—where 100 is the new 60. What will you create, where will you explore, and how will you spend your time if you are able to add an additional 40 healthy years to your life?

Join Me
(1) A360 Executive Mastermind: If you’re an exponentially and abundance-minded entrepreneur who would like coaching directly from me, consider joining my Abundance 360 Mastermind, a highly selective community of 360 CEOs and entrepreneurs who I coach for 3 days every January in Beverly Hills, Ca. Through A360, I provide my members with context and clarity about how converging exponential technologies will transform every industry. I’m committed to running A360 for the course of an ongoing 25-year journey as a “countdown to the Singularity.”

If you’d like to learn more and consider joining our 2021 membership, apply here.

(2) Abundance-Digital Online Community: I’ve also created a Digital/Online community of bold, abundance-minded entrepreneurs called Abundance-Digital. Abundance-Digital is Singularity University’s ‘onramp’ for exponential entrepreneurs—those who want to get involved and play at a higher level. Click here to learn more.

(Both A360 and Abundance-Digital are part of Singularity University—your participation opens you to a global community.)

This article originally appeared on diamandis.com. Read the original article here.

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