Tag Archives: neuroscience

#436911 Scientists Linked Artificial and ...

Posted on March 11, 2020 by Android

Scientists have linked up two silicon-based artificial neurons with a biological one across multiple countries into a fully-functional network. Using standard internet protocols, they established a chain of communication whereby an artificial neuron controls a living, biological one, and passes on the info to another artificial one.

Whoa.

We’ve talked plenty about brain-computer interfaces and novel computer chips that resemble the brain. We’ve covered how those “neuromorphic” chips could link up into tremendously powerful computing entities, using engineered communication nodes called artificial synapses.

As Moore’s law is dying, we even said that neuromorphic computing is one path towards the future of extremely powerful, low energy consumption artificial neural network-based computing—in hardware—that could in theory better link up with the brain. Because the chips “speak” the brain’s language, in theory they could become neuroprosthesis hubs far more advanced and “natural” than anything currently possible.

This month, an international team put all of those ingredients together, turning theory into reality.

The three labs, scattered across Padova, Italy, Zurich, Switzerland, and Southampton, England, collaborated to create a fully self-controlled, hybrid artificial-biological neural network that communicated using biological principles, but over the internet.

The three-neuron network, linked through artificial synapses that emulate the real thing, was able to reproduce a classic neuroscience experiment that’s considered the basis of learning and memory in the brain. In other words, artificial neuron and synapse “chips” have progressed to the point where they can actually use a biological neuron intermediary to form a circuit that, at least partially, behaves like the real thing.

That’s not to say cyborg brains are coming soon. The simulation only recreated a small network that supports excitatory transmission in the hippocampus—a critical region that supports memory—and most brain functions require enormous cross-talk between numerous neurons and circuits. Nevertheless, the study is a jaw-dropping demonstration of how far we’ve come in recreating biological neurons and synapses in artificial hardware.

And perhaps one day, the currently “experimental” neuromorphic hardware will be integrated into broken biological neural circuits as bridges to restore movement, memory, personality, and even a sense of self.

The Artificial Brain Boom
One important thing: this study relies heavily on a decade of research into neuromorphic computing, or the implementation of brain functions inside computer chips.

The best-known example is perhaps IBM’s TrueNorth, which leveraged the brain’s computational principles to build a completely different computer than what we have today. Today’s computers run on a von Neumann architecture, in which memory and processing modules are physically separate. In contrast, the brain’s computing and memory are simultaneously achieved at synapses, small “hubs” on individual neurons that talk to adjacent ones.

Because memory and processing occur on the same site, biological neurons don’t have to shuttle data back and forth between processing and storage compartments, massively reducing processing time and energy use. What’s more, a neuron’s history will also influence how it behaves in the future, increasing flexibility and adaptability compared to computers. With the rise of deep learning, which loosely mimics neural processing as the prima donna of AI, the need to reduce power while boosting speed and flexible learning is becoming ever more tantamount in the AI community.

Neuromorphic computing was partially born out of this need. Most chips utilize special ingredients that change their resistance (or other physical characteristics) to mimic how a neuron might adapt to stimulation. Some chips emulate a whole neuron, that is, how it responds to a history of stimulation—does it get easier or harder to fire? Others imitate synapses themselves, that is, how easily they will pass on the information to another neuron.

Although single neuromorphic chips have proven to be far more efficient and powerful than current computer chips running machine learning algorithms in toy problems, so far few people have tried putting the artificial components together with biological ones in the ultimate test.

That’s what this study did.

A Hybrid Network
Still with me? Let’s talk network.

It’s gonna sound complicated, but remember: learning is the formation of neural networks, and neurons that fire together wire together. To rephrase: when learning, neurons will spontaneously organize into networks so that future instances will re-trigger the entire network. To “wire” together, downstream neurons will become more responsive to their upstream neural partners, so that even a whisper will cause them to activate. In contrast, some types of stimulation will cause the downstream neuron to “chill out” so that only an upstream “shout” will trigger downstream activation.

Both these properties—easier or harder to activate downstream neurons—are essentially how the brain forms connections. The “amping up,” in neuroscience jargon, is long-term potentiation (LTP), whereas the down-tuning is LTD (long-term depression). These two phenomena were first discovered in the rodent hippocampus more than half a century ago, and ever since have been considered as the biological basis of how the brain learns and remembers, and implicated in neurological problems such as addition (seriously, you can’t pass Neuro 101 without learning about LTP and LTD!).

So it’s perhaps especially salient that one of the first artificial-brain hybrid networks recapitulated this classic result.

To visualize: the three-neuron network began in Switzerland, with an artificial neuron with the badass name of “silicon spiking neuron.” That neuron is linked to an artificial synapse, a “memristor” located in the UK, which is then linked to a biological rat neuron cultured in Italy. The rat neuron has a “smart” microelectrode, controlled by the artificial synapse, to stimulate it. This is the artificial-to-biological pathway.

Meanwhile, the rat neuron in Italy also has electrodes that listen in on its electrical signaling. This signaling is passed back to another artificial synapse in the UK, which is then used to control a second artificial neuron back in Switzerland. This is the biological-to-artificial pathway back. As a testimony in how far we’ve come in digitizing neural signaling, all of the biological neural responses are digitized and sent over the internet to control its far-out artificial partner.

Here’s the crux: to demonstrate a functional neural network, just having the biological neuron passively “pass on” electrical stimulation isn’t enough. It has to show the capacity to learn, that is, to be able to mimic the amping up and down-tuning that are LTP and LTD, respectively.

You’ve probably guessed the results: certain stimulation patterns to the first artificial neuron in Switzerland changed how the artificial synapse in the UK operated. This, in turn, changed the stimulation to the biological neuron, so that it either amped up or toned down depending on the input.

Similarly, the response of the biological neuron altered the second artificial synapse, which then controlled the output of the second artificial neuron. Altogether, the biological and artificial components seamlessly linked up, over thousands of miles, into a functional neural circuit.

Cyborg Mind-Meld
So…I’m still picking my jaw up off the floor.

It’s utterly insane seeing a classic neuroscience learning experiment repeated with an integrated network with artificial components. That said, a three-neuron network is far from the thousands of synapses (if not more) needed to truly re-establish a broken neural circuit in the hippocampus, which DARPA has been aiming to do. And LTP/LTD has come under fire recently as the de facto brain mechanism for learning, though so far they remain cemented as neuroscience dogma.

However, this is one of the few studies where you see fields coming together. As Richard Feynman famously said, “What I cannot recreate, I cannot understand.” Even though neuromorphic chips were built on a high-level rather than molecular-level understanding of how neurons work, the study shows that artificial versions can still synapse with their biological counterparts. We’re not just on the right path towards understanding the brain, we’re recreating it, in hardware—if just a little.

While the study doesn’t have immediate use cases, practically it does boost both the neuromorphic computing and neuroprosthetic fields.

“We are very excited with this new development,” said study author Dr. Themis Prodromakis at the University of Southampton. “On one side it sets the basis for a novel scenario that was never encountered during natural evolution, where biological and artificial neurons are linked together and communicate across global networks; laying the foundations for the Internet of Neuro-electronics. On the other hand, it brings new prospects to neuroprosthetic technologies, paving the way towards research into replacing dysfunctional parts of the brain with AI chips.”

Image Credit: Gerd Altmann from Pixabay Continue reading →

Posted in Human Robots

#436488 Tech’s Biggest Leaps From the Last 10 ...

Posted on January 3, 2020 by Android

As we enter our third decade in the 21st century, it seems appropriate to reflect on the ways technology developed and note the breakthroughs that were achieved in the last 10 years.

The 2010s saw IBM’s Watson win a game of Jeopardy, ushering in mainstream awareness of machine learning, along with DeepMind’s AlphaGO becoming the world’s Go champion. It was the decade that industrial tools like drones, 3D printers, genetic sequencing, and virtual reality (VR) all became consumer products. And it was a decade in which some alarming trends related to surveillance, targeted misinformation, and deepfakes came online.

For better or worse, the past decade was a breathtaking era in human history in which the idea of exponential growth in information technologies powered by computation became a mainstream concept.

As I did last year for 2018 only, I’ve asked a collection of experts across the Singularity University faculty to help frame the biggest breakthroughs and moments that gave shape to the past 10 years. I asked them what, in their opinion, was the most important breakthrough in their respective fields over the past decade.

My own answer to this question, focused in the space of augmented and virtual reality, would be the stunning announcement in March of 2014 that Facebook acquired Oculus VR for $2 billion. Although VR technology had been around for a while, it was at this precise moment that VR arrived as a consumer technology platform. Facebook, largely fueled by the singular interest of CEO Mark Zuckerberg, has funded the development of this industry, keeping alive the hope that consumer VR can become a sustainable business. In the meantime, VR has continued to grow in sophistication and usefulness, though it has yet to truly take off as a mainstream concept. That will hopefully be a development for the 2020s.

Below is a decade in review across the technology areas that are giving shape to our modern world, as described by the SU community of experts.

Digital Biology
Dr. Tiffany Vora | Faculty Director and Vice Chair, Digital Biology and Medicine, Singularity University

In my mind, this decade of astounding breakthroughs in the life sciences and medicine rests on the achievement of the $1,000 human genome in 2016. More-than-exponentially falling costs of DNA sequencing have driven advances in medicine, agriculture, ecology, genome editing, synthetic biology, the battle against climate change, and our fundamental understanding of life and its breathtaking connections. The “digital” revolution in DNA constituted an important model for harnessing other types of biological information, from personalized bio data to massive datasets spanning populations and species.

Crucially, by aggressively driving down the cost of such analyses, researchers and entrepreneurs democratized access to the source code of life—with attendant financial, cultural, and ethical consequences. Exciting, but take heed: Veritas Genetics spearheaded a $600 genome in 2019, only to have to shutter USA operations due to a money trail tangled with the trade war with China. Stay tuned through the early 2020s to see the pricing of DNA sequencing fall even further … and to experience the many ways that cheaper, faster harvesting of biological data will enrich your daily life.

Cryptocurrency
Alex Gladstein | Chief Strategy Officer, Human Rights Foundation

The past decade has seen Bitcoin go from just an idea on an obscure online message board to a global financial network carrying more than 100 billion dollars in value. And we’re just getting started. One recent defining moment in the cryptocurrency space has been a stunning trend underway in Venezuela, where today, the daily dollar-denominated value of Bitcoin traded now far exceeds the daily dollar-denominated value traded on the Caracas Stock Exchange. It’s just one country, but it’s a significant country, and a paradigm shift.

Governments and corporations are following Bitcoin’s success too, and are looking to launch their own digital currencies. China will launch its “DC/EP” project in the coming months, and Facebook is trying to kickstart its Libra project. There are technical and regulatory uncertainties for both, but one thing is for certain: the era of digital currency has arrived.

Business Strategy and Entrepreneurship
Pascal Finnette | Chair, Entrepreneurship and Open Innovation, Singularity University

For me, without a doubt, the most interesting and quite possibly ground-shifting development in the fields of entrepreneurship and corporate innovation in the last ten years is the rapid maturing of customer-driven product development frameworks such as Lean Startup, and its subsequent adoption by corporates for their own innovation purposes.

Tools and frameworks like the Business Model Canvas, agile (software) development and the aforementioned Lean Startup methodology fundamentally shifted the way we think and go about building products, services, and companies, with many of these tools bursting onto the startup scene in the late 2000s and early 2010s.

As these tools matured they found mass adoption not only in startups around the world, but incumbent companies who eagerly adopted them to increase their own innovation velocity and success.

Energy
Ramez Naam | Co-Chair, Energy and Environment, Singularity University

The 2010s were the decade that saw clean electricity, energy storage, and electric vehicles break through price and performance barriers around the world. Solar, wind, batteries, and EVs started this decade as technologies that had to be subsidized. That was the first phase of their existence. Now they’re entering their third, most disruptive phase, where shifting to clean energy and mobility is cheaper than continuing to use existing coal, gas, or oil infrastructure.

Consider that at the start of 2010, there was no place on earth where building new solar or wind was cheaper than building new coal or gas power generation. By 2015, in some of the sunniest and windiest places on earth, solar and wind had entered their second phase, where they were cost-competitive for new power. And then, in 2018 and 2019, we started to see the edge of the third phase, as building new solar and wind, in some parts of the world, was cheaper than operating existing coal or gas power plants.

Food Technology
Liz Specht, Ph. D | Associate Director of Science & Technology, The Good Food Institute

The arrival of mainstream plant-based meat is easily the food tech advance of the decade. Meat analogs have, of course, been around forever. But only in the last decade have companies like Beyond Meat and Impossible Foods decided to cut animals out of the process and build no-compromise meat directly from plants.

Plant-based meat is already transforming the fast-food industry. For example, the introduction of the Impossible Whopper led Burger King to their most profitable quarter in many years. But the global food industry as a whole is shifting as well. Tyson, JBS, Nestle, Cargill, and many others are all embracing plant-based meat.

Augmented and Virtual Reality
Jody Medich | CEO, Superhuman-x

The breakthrough moment for augmented and virtual reality came in 2013 when Palmer Lucky took apart an Android smartphone and added optic lenses to make the first version of the Oculus Rift. Prior to that moment, we struggled with miniaturizing the components needed to develop low-latency head-worn devices. But thanks to the smartphone race started in 2006 with the iPhone, we finally had a suite of sensors, chips, displays, and computing power small enough to put on the head.

What will the next 10 years bring? Look for AR/VR to explode in a big way. We are right on the cusp of that tipping point when the tech is finally “good enough” for our linear expectations. Given all it can do today, we can’t even picture what’s possible. Just as today we can’t function without our phones, by 2029 we’ll feel lost without some AR/VR product. It will be the way we interact with computing, smart objects, and AI. Tim Cook, Apple CEO, predicts it will replace all of today’s computing devices. I can’t wait.

Philosophy of Technology
Alix Rübsaam | Faculty Fellow, Singularity University, Philosophy of Technology/Ethics of AI

The last decade has seen a significant shift in our general attitude towards the algorithms that we now know dictate much of our surroundings. Looking back at the beginning of the decade, it seems we were blissfully unaware of how the data we freely and willingly surrendered would feed the algorithms that would come to shape every aspect of our daily lives: the news we consume, the products we purchase, the opinions we hold, etc.

If I were to isolate a single publication that contributed greatly to the shift in public discourse on algorithms, it would have to be Cathy O’Neil’s Weapons of Math Destruction from 2016. It remains a comprehensive, readable, and highly informative insight into how algorithms dictate our finances, our jobs, where we go to school, or if we can get health insurance. Its publication represents a pivotal moment when the general public started to question whether we should be OK with outsourcing decision making to these opaque systems.

The ubiquity of ethical guidelines for AI and algorithms published just in the last year (perhaps most comprehensively by the AI Now Institute) fully demonstrates the shift in public opinion of this decade.

Data Science
Ola Kowalewski | Faculty Fellow, Singularity University, Data Innovation

In the last decade we entered the era of internet and smartphone ubiquity. The number of internet users doubled, with nearly 60 percent of the global population connected online and now over 35 percent of the globe owns a smartphone. With billions of people in a state of constant connectedness and therefore in a state of constant surveillance, the companies that have built the tech infrastructure and information pipelines have dominated the global economy. This shift from tech companies being the underdogs to arguably the world’s major powers sets the landscape we enter for the next decade.

Global Grand Challenges
Darlene Damm | Vice Chair, Faculty, Global Grand Challenges, Singularity University

The biggest breakthrough over the last decade in social impact and technology is that the social impact sector switched from seeing technology as something problematic to avoid, to one of the most effective ways to create social change. We now see people using exponential technologies to solve all sorts of social challenges in areas ranging from disaster response to hunger to shelter.

The world’s leading social organizations, such as UNICEF and the World Food Programme, have launched their own venture funds and accelerators, and the United Nations recently declared that digitization is revolutionizing global development.

Digital Biology
Raymond McCauley | Chair, Digital Biology, Singularity University, Co-Founder & Chief Architect, BioCurious; Principal, Exponential Biosciences

CRISPR is bringing about a revolution in genetic engineering. It’s obvious, and it’s huge. What may not be so obvious is the widespread adoption of genetic testing. And this may have an even longer-lasting effect. It’s used to test new babies, to solve medical mysteries, and to catch serial killers. Thanks to holiday ads from 23andMe and Ancestry.com, it’s everywhere. Testing your DNA is now a common over-the-counter product. People are using it to set their diet, to pick drugs, and even for dating (or at least picking healthy mates).

And we’re just in the early stages. Further down the line, doing large-scale studies on more people, with more data, will lead to the use of polygenic risk scores to help us rank our genetic potential for everything from getting cancer to being a genius. Can you imagine what it would be like for parents to pick new babies, GATTACA-style, to get the smartest kids? You don’t have to; it’s already happening.

Artificial Intelligence
Neil Jacobstein | Chair, Artificial Intelligence and Robotics, Singularity University

The convergence of exponentially improved computing power, the deep learning algorithm, and access to massive data resulted in a series of AI breakthroughs over the past decade. These included: vastly improved accuracy in identifying images, making self driving cars practical, beating several world champions in Go, and identifying gender, smoking status, and age from retinal fundus photographs.

Combined, these breakthroughs convinced researchers and investors that after 50+ years of research and development, AI was ready for prime-time applications. Now, virtually every field of human endeavor is being revolutionized by machine learning. We still have a long way to go to achieve human-level intelligence and beyond, but the pace of worldwide improvement is blistering.

Hod Lipson | Professor of Engineering and Data Science, Columbia University

The biggest moment in AI in the past decade (and in its entire history, in my humble opinion) was midnight, Pacific time, September 30, 2012: the moment when machines finally opened their eyes. It was the moment when deep learning took off, breaking stagnant decades of machine blindness, when AI couldn’t reliably tell apart even a cat from a dog. That seemingly trivial accomplishment—a task any one-year-old child can do—has had a ripple effect on AI applications from driverless cars to health diagnostics. And this is just the beginning of what is sure to be a Cambrian explosion of AI.

Neuroscience
Divya Chander | Chair, Neuroscience, Singularity University

If the 2000s were the decade of brain mapping, then the 2010s were the decade of brain writing. Optogenetics, a technique for precisely mapping and controlling neurons and neural circuits using genetically-directed light, saw incredible growth in the 2010s.

Also in the last 10 years, neuromodulation, or the ability to rewire the brain using both invasive and non-invasive interfaces and energy, has exploded in use and form. For instance, the Braingate consortium showed us how electrode arrays implanted into the motor cortex could be used by paralyzed people to use their thoughts to direct a robotic arm. These technologies, alone or in combination with robotics, exoskeletons, and flexible, implantable, electronics also make possible a future of human augmentation.

Image Credit: Image by Jorge Guillen from Pixabay Continue reading →

Posted in Human Robots

#435423 Moving Beyond Mind-Controlled Limbs to ...

Posted on July 31, 2019 by Android

Brain-machine interface enthusiasts often gush about “closing the loop.” It’s for good reason. On the implant level, it means engineering smarter probes that only activate when they detect faulty electrical signals in brain circuits. Elon Musk’s Neuralink—among other players—are readily pursuing these bi-directional implants that both measure and zap the brain.

But to scientists laboring to restore functionality to paralyzed patients or amputees, “closing the loop” has broader connotations. Building smart mind-controlled robotic limbs isn’t enough; the next frontier is restoring sensation in offline body parts. To truly meld biology with machine, the robotic appendage has to “feel one” with the body.

This month, two studies from Science Robotics describe complementary ways forward. In one, scientists from the University of Utah paired a state-of-the-art robotic arm—the DEKA LUKE—with electrically stimulating remaining nerves above the attachment point. Using artificial zaps to mimic the skin’s natural response patterns to touch, the team dramatically increased the patient’s ability to identify objects. Without much training, he could easily discriminate between the small and large and the soft and hard while blindfolded and wearing headphones.

In another, a team based at the National University of Singapore took inspiration from our largest organ, the skin. Mimicking the neural architecture of biological skin, the engineered “electronic skin” not only senses temperature, pressure, and humidity, but continues to function even when scraped or otherwise damaged. Thanks to artificial nerves that transmit signals far faster than our biological ones, the flexible e-skin shoots electrical data 1,000 times quicker than human nerves.

Together, the studies marry neuroscience and robotics. Representing the latest push towards closing the loop, they show that integrating biological sensibilities with robotic efficiency isn’t impossible (super-human touch, anyone?). But more immediately—and more importantly—they’re beacons of hope for patients who hope to regain their sense of touch.

For one of the participants, a late middle-aged man with speckled white hair who lost his forearm 13 years ago, superpowers, cyborgs, or razzle-dazzle brain implants are the last thing on his mind. After a barrage of emotionally-neutral scientific tests, he grasped his wife’s hand and felt her warmth for the first time in over a decade. His face lit up in a blinding smile.

That’s what scientists are working towards.

Biomimetic Feedback
The human skin is a marvelous thing. Not only does it rapidly detect a multitude of sensations—pressure, temperature, itch, pain, humidity—its wiring “binds” disparate signals together into a sensory fingerprint that helps the brain identify what it’s feeling at any moment. Thanks to over 45 miles of nerves that connect the skin, muscles, and brain, you can pick up a half-full coffee cup, knowing that it’s hot and sloshing, while staring at your computer screen. Unfortunately, this complexity is also why restoring sensation is so hard.

The sensory electrode array implanted in the participant’s arm. Image Credit: George et al., Sci. Robot. 4, eaax2352 (2019)..
However, complex neural patterns can also be a source of inspiration. Previous cyborg arms are often paired with so-called “standard” sensory algorithms to induce a basic sense of touch in the missing limb. Here, electrodes zap residual nerves with intensities proportional to the contact force: the harder the grip, the stronger the electrical feedback. Although seemingly logical, that’s not how our skin works. Every time the skin touches or leaves an object, its nerves shoot strong bursts of activity to the brain; while in full contact, the signal is much lower. The resulting electrical strength curve resembles a “U.”

The LUKE hand. Image Credit: George et al., Sci. Robot. 4, eaax2352 (2019).
The team decided to directly compare standard algorithms with one that better mimics the skin’s natural response. They fitted a volunteer with a robotic LUKE arm and implanted an array of electrodes into his forearm—right above the amputation—to stimulate the remaining nerves. When the team activated different combinations of electrodes, the man reported sensations of vibration, pressure, tapping, or a sort of “tightening” in his missing hand. Some combinations of zaps also made him feel as if he were moving the robotic arm’s joints.

In all, the team was able to carefully map nearly 120 sensations to different locations on the phantom hand, which they then overlapped with contact sensors embedded in the LUKE arm. For example, when the patient touched something with his robotic index finger, the relevant electrodes sent signals that made him feel as if he were brushing something with his own missing index fingertip.

Standard sensory feedback already helped: even with simple electrical stimulation, the man could tell apart size (golf versus lacrosse ball) and texture (foam versus plastic) while blindfolded and wearing noise-canceling headphones. But when the team implemented two types of neuromimetic feedback—electrical zaps that resembled the skin’s natural response—his performance dramatically improved. He was able to identify objects much faster and more accurately under their guidance. Outside the lab, he also found it easier to cook, feed, and dress himself. He could even text on his phone and complete routine chores that were previously too difficult, such as stuffing an insert into a pillowcase, hammering a nail, or eating hard-to-grab foods like eggs and grapes.

The study shows that the brain more readily accepts biologically-inspired electrical patterns, making it a relatively easy—but enormously powerful—upgrade that seamlessly integrates the robotic arms with the host. “The functional and emotional benefits…are likely to be further enhanced with long-term use, and efforts are underway to develop a portable take-home system,” the team said.

E-Skin Revolution: Asynchronous Coded Electronic Skin (ACES)
Flexible electronic skins also aren’t new, but the second team presented an upgrade in both speed and durability while retaining multiplexed sensory capabilities.

Starting from a combination of rubber, plastic, and silicon, the team embedded over 200 sensors onto the e-skin, each capable of discerning contact, pressure, temperature, and humidity. They then looked to the skin’s nervous system for inspiration. Our skin is embedded with a dense array of nerve endings that individually transmit different types of sensations, which are integrated inside hubs called ganglia. Compared to having every single nerve ending directly ping data to the brain, this “gather, process, and transmit” architecture rapidly speeds things up.

The team tapped into this biological architecture. Rather than pairing each sensor with a dedicated receiver, ACES sends all sensory data to a single receiver—an artificial ganglion. This setup lets the e-skin’s wiring work as a whole system, as opposed to individual electrodes. Every sensor transmits its data using a characteristic pulse, which allows it to be uniquely identified by the receiver.

The gains were immediate. First was speed. Normally, sensory data from multiple individual electrodes need to be periodically combined into a map of pressure points. Here, data from thousands of distributed sensors can independently go to a single receiver for further processing, massively increasing efficiency—the new e-skin’s transmission rate is roughly 1,000 times faster than that of human skin.

Second was redundancy. Because data from individual sensors are aggregated, the system still functioned even when any individual receptors are damaged, making it far more resilient than previous attempts. Finally, the setup could easily scale up. Although the team only tested the idea with 240 sensors, theoretically the system should work with up to 10,000.

The team is now exploring ways to combine their invention with other material layers to make it water-resistant and self-repairable. As you might’ve guessed, an immediate application is to give robots something similar to complex touch. A sensory upgrade not only lets robots more easily manipulate tools, doorknobs, and other objects in hectic real-world environments, it could also make it easier for machines to work collaboratively with humans in the future (hey Wall-E, care to pass the salt?).

Dexterous robots aside, the team also envisions engineering better prosthetics. When coated onto cyborg limbs, for example, ACES may give them a better sense of touch that begins to rival the human skin—or perhaps even exceed it.

Regardless, efforts that adapt the functionality of the human nervous system to machines are finally paying off, and more are sure to come. Neuromimetic ideas may very well be the link that finally closes the loop.

Image Credit: Dan Hixson/University of Utah College of Engineering.. Continue reading →

Posted in Human Robots

#435313 This Week’s Awesome Stories From ...

Posted on July 27, 2019 by Android

ARTIFICIAL INTELLIGENCE
Microsoft Invests $1 Billion in OpenAI to Pursue Holy Grail of Artificial Intelligence
James Vincent | The Verge
“i‘The creation of AGI will be the most important technological development in human history, with the potential to shape the trajectory of humanity,’ said [OpenAI cofounder] Sam Altman. ‘Our mission is to ensure that AGI technology benefits all of humanity, and we’re working with Microsoft to build the supercomputing foundation on which we’ll build AGI.’i”

ROBOTICS
UPS Wants to Go Full-Scale With Its Drone Deliveries
Eric Adams | Wired
“If UPS gets its way, it’ll be known for vehicles other than its famous brown vans. The delivery giant is working to become the first commercial entity authorized by the Federal Aviation Administration to use autonomous delivery drones without any of the current restrictions that have governed the aerial testing it has done to date.”

SYNTHETIC BIOLOGY
Scientists Can Finally Build Feedback Circuits in Cells
Megan Molteni | Wired
“Network a few LOCKR-bound molecules together, and you’ve got a circuit that can control a cell’s functions the same way a PID computer program automatically adjusts the pitch of a plane. With the right key, you can make cells glow or blow themselves apart. You can send things to the cell’s trash heap or zoom them to another cellular zip code.”

ENERGY
Carbon Nanotubes Could Increase Solar Efficiency to 80 Percent
David Grossman | Popular Mechanics
“Obviously, that sort of efficiency rating is unheard of in the world of solar panels. But even though a proof of concept is a long way from being used in the real world, any further developments in the nanotubes could bolster solar panels in ways we haven’t seen yet.”

FUTURE
What Technology Is Most Likely to Become Obsolete During Your Lifetime?
Daniel Kolitz | Gizmodo
“Old technology seldom just goes away. Whiteboards and LED screens join chalk blackboards, but don’t eliminate them. Landline phones get scarce, but not phones. …And the technologies that seem to be the most outclassed may come back as a the cult objects of aficionados—the vinyl record, for example. All this is to say that no one can tell us what will be obsolete in fifty years, but probably a lot less will be obsolete than we think.”

NEUROSCIENCE
The Human Brain Project Hasn’t Lived Up to Its Promise
Ed Yong | The Atlantic
“The HBP, then, is in a very odd position, criticized for being simultaneously too grandiose and too narrow. None of the skeptics I spoke with was dismissing the idea of simulating parts of the brain, but all of them felt that such efforts should be driven by actual research questions. …Countless such projects could have been funded with the money channeled into the HBP, which explains much of the furor around the project.”

Image Credit: Aron Van de Pol / Unsplash Continue reading →

Posted in Human Robots

#435308 Brain-Machine Interfaces Are Getting ...

Posted on July 26, 2019 by Android

Elon Musk grabbed a lot of attention with his July 16 announcement that his company Neuralink plans to implant electrodes into the brains of people with paralysis by next year. Their first goal is to create assistive technology to help people who can’t move or are unable to communicate.

If you haven’t been paying attention, brain-machine interfaces (BMIs) that allow people to control robotic arms with their thoughts might sound like science fiction. But science and engineering efforts have already turned it into reality.

In a few research labs around the world, scientists and physicians have been implanting devices into the brains of people who have lost the ability to control their arms or hands for over a decade. In our own research group at the University of Pittsburgh, we’ve enabled people with paralyzed arms and hands to control robotic arms that allow them to grasp and move objects with relative ease. They can even experience touch-like sensations from their own hand when the robot grasps objects.

At its core, a BMI is pretty straightforward. In your brain, microscopic cells called neurons are sending signals back and forth to each other all the time. Everything you think, do and feel as you interact with the world around you is the result of the activity of these 80 billion or so neurons.

If you implant a tiny wire very close to one of these neurons, you can record the electrical activity it generates and send it to a computer. Record enough of these signals from the right area of the brain and it becomes possible to control computers, robots, or anything else you might want, simply by thinking about moving. But doing this comes with tremendous technical challenges, especially if you want to record from hundreds or thousands of neurons.

What Neuralink Is Bringing to the Table
Elon Musk founded Neuralink in 2017, aiming to address these challenges and raise the bar for implanted neural interfaces.

Perhaps the most impressive aspect of Neuralink’s system is the breadth and depth of their approach. Building a BMI is inherently interdisciplinary, requiring expertise in electrode design and microfabrication, implantable materials, surgical methods, electronics, packaging, neuroscience, algorithms, medicine, regulatory issues, and more. Neuralink has created a team that spans most, if not all, of these areas.

With all of this expertise, Neuralink is undoubtedly moving the field forward, and improving their technology rapidly. Individually, many of the components of their system represent significant progress along predictable paths. For example, their electrodes, that they call threads, are very small and flexible; many researchers have tried to harness those properties to minimize the chance the brain’s immune response would reject the electrodes after insertion. Neuralink has also developed high-performance miniature electronics, another focus area for labs working on BMIs.

Often overlooked in academic settings, however, is how an entire system would be efficiently implanted in a brain.

Neuralink’s BMI requires brain surgery. This is because implanted electrodes that are in intimate contact with neurons will always outperform non-invasive electrodes where neurons are far away from the electrodes sitting outside the skull. So, a critical question becomes how to minimize the surgical challenges around getting the device into a brain.

Maybe the most impressive aspect of Neuralink’s announcement was that they created a 3,000-electrode neural interface where electrodes could be implanted at a rate of between 30 and 200 per minute. Each thread of electrodes is implanted by a sophisticated surgical robot that essentially acts like a sewing machine. This all happens while specifically avoiding blood vessels that blanket the surface of the brain. The robotics and imaging that enable this feat, with tight integration to the entire device, is striking.

Neuralink has thought through the challenge of developing a clinically viable BMI from beginning to end in a way that few groups have done, though they acknowledge that many challenges remain as they work towards getting this technology into human patients in the clinic.

Figuring Out What More Electrodes Gets You
The quest for implantable devices with thousands of electrodes is not only the domain of private companies. DARPA, the NIH BRAIN Initiative, and international consortiums are working on neurotechnologies for recording and stimulating in the brain with goals of tens of thousands of electrodes. But what might scientists do with the information from 1,000, 3,000, or maybe even 100,000 neurons?

At some level, devices with more electrodes might not actually be necessary to have a meaningful impact in people’s lives. Effective control of computers for access and communication, of robotic limbs to grasp and move objects as well as of paralyzed muscles is already happening—in people. And it has been for a number of years.

Since the 1990s, the Utah Array, which has just 100 electrodes and is manufactured by Blackrock Microsystems, has been a critical device in neuroscience and clinical research. This electrode array is FDA-cleared for temporary neural recording. Several research groups, including our own, have implanted Utah Arrays in people that lasted multiple years.

Currently, the biggest constraints are related to connectors, electronics, and system-level engineering, not the implanted electrode itself—although increasing the electrodes’ lifespan to more than five years would represent a significant advance. As those technical capabilities improve, it might turn out that the ability to accurately control computers and robots is limited more by scientists’ understanding of what the neurons are saying—that is, the neural code—than by the number of electrodes on the device.

Even the most capable implanted system, and maybe the most capable devices researchers can reasonably imagine, might fall short of the goal of actually augmenting skilled human performance. Nevertheless, Neuralink’s goal of creating better BMIs has the potential to improve the lives of people who can’t move or are unable to communicate. Right now, Musk’s vision of using BMIs to meld physical brains and intelligence with artificial ones is no more than a dream.

So, what does the future look like for Neuralink and other groups creating implantable BMIs? Devices with more electrodes that last longer and are connected to smaller and more powerful wireless electronics are essential. Better devices themselves, however, are insufficient. Continued public and private investment in companies and academic research labs, as well as innovative ways for these groups to work together to share technologies and data, will be necessary to truly advance scientists’ understanding of the brain and deliver on the promise of BMIs to improve peoples’ lives.

While researchers need to keep the future societal implications of advanced neurotechnologies in mind—there’s an essential role for ethicists and regulation—BMIs could be truly transformative as they help more people overcome limitations caused by injury or disease in the brain and body.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Image Credit: UPMC/Pitt Health Sciences, / CC BY-NC-ND Continue reading →

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