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#435172 DARPA’s New Project Is Investing ...

When Elon Musk and DARPA both hop aboard the cyborg hypetrain, you know brain-machine interfaces (BMIs) are about to achieve the impossible.

BMIs, already the stuff of science fiction, facilitate crosstalk between biological wetware with external computers, turning human users into literal cyborgs. Yet mind-controlled robotic arms, microelectrode “nerve patches”, or “memory Band-Aids” are still purely experimental medical treatments for those with nervous system impairments.

With the Next-Generation Nonsurgical Neurotechnology (N3) program, DARPA is looking to expand BMIs to the military. This month, the project tapped six academic teams to engineer radically different BMIs to hook up machines to the brains of able-bodied soldiers. The goal is to ditch surgery altogether—while minimizing any biological interventions—to link up brain and machine.

Rather than microelectrodes, which are currently surgically inserted into the brain to hijack neural communication, the project is looking to acoustic signals, electromagnetic waves, nanotechnology, genetically-enhanced neurons, and infrared beams for their next-gen BMIs.

It’s a radical departure from current protocol, with potentially thrilling—or devastating—impact. Wireless BMIs could dramatically boost bodily functions of veterans with neural damage or post-traumatic stress disorder (PTSD), or allow a single soldier to control swarms of AI-enabled drones with his or her mind. Or, similar to the Black Mirror episode Men Against Fire, it could cloud the perception of soldiers, distancing them from the emotional guilt of warfare.

When trickled down to civilian use, these new technologies are poised to revolutionize medical treatment. Or they could galvanize the transhumanist movement with an inconceivably powerful tool that fundamentally alters society—for better or worse.

Here’s what you need to know.

Radical Upgrades
The four-year N3 program focuses on two main aspects: noninvasive and “minutely” invasive neural interfaces to both read and write into the brain.

Because noninvasive technologies sit on the scalp, their sensors and stimulators will likely measure entire networks of neurons, such as those controlling movement. These systems could then allow soldiers to remotely pilot robots in the field—drones, rescue bots, or carriers like Boston Dynamics’ BigDog. The system could even boost multitasking prowess—mind-controlling multiple weapons at once—similar to how able-bodied humans can operate a third robotic arm in addition to their own two.

In contrast, minutely invasive technologies allow scientists to deliver nanotransducers without surgery: for example, an injection of a virus carrying light-sensitive sensors, or other chemical, biotech, or self-assembled nanobots that can reach individual neurons and control their activity independently without damaging sensitive tissue. The proposed use for these technologies isn’t yet well-specified, but as animal experiments have shown, controlling the activity of single neurons at multiple points is sufficient to program artificial memories of fear, desire, and experiences directly into the brain.

“A neural interface that enables fast, effective, and intuitive hands-free interaction with military systems by able-bodied warfighters is the ultimate program goal,” DARPA wrote in its funding brief, released early last year.

The only technologies that will be considered must have a viable path toward eventual use in healthy human subjects.

“Final N3 deliverables will include a complete integrated bidirectional brain-machine interface system,” the project description states. This doesn’t just include hardware, but also new algorithms tailored to these system, demonstrated in a “Department of Defense-relevant application.”

The Tools
Right off the bat, the usual tools of the BMI trade, including microelectrodes, MRI, or transcranial magnetic stimulation (TMS) are off the table. These popular technologies rely on surgery, heavy machinery, or personnel to sit very still—conditions unlikely in the real world.

The six teams will tap into three different kinds of natural phenomena for communication: magnetism, light beams, and acoustic waves.

Dr. Jacob Robinson at Rice University, for example, is combining genetic engineering, infrared laser beams, and nanomagnets for a bidirectional system. The $18 million project, MOANA (Magnetic, Optical and Acoustic Neural Access device) uses viruses to deliver two extra genes into the brain. One encodes a protein that sits on top of neurons and emits infrared light when the cell activates. Red and infrared light can penetrate through the skull. This lets a skull cap, embedded with light emitters and detectors, pick up these signals for subsequent decoding. Ultra-fast and utra-sensitvie photodetectors will further allow the cap to ignore scattered light and tease out relevant signals emanating from targeted portions of the brain, the team explained.

The other new gene helps write commands into the brain. This protein tethers iron nanoparticles to the neurons’ activation mechanism. Using magnetic coils on the headset, the team can then remotely stimulate magnetic super-neurons to fire while leaving others alone. Although the team plans to start in cell cultures and animals, their goal is to eventually transmit a visual image from one person to another. “In four years we hope to demonstrate direct, brain-to-brain communication at the speed of thought and without brain surgery,” said Robinson.

Other projects in N3 are just are ambitious.

The Carnegie Mellon team, for example, plans to use ultrasound waves to pinpoint light interaction in targeted brain regions, which can then be measured through a wearable “hat.” To write into the brain, they propose a flexible, wearable electrical mini-generator that counterbalances the noisy effect of the skull and scalp to target specific neural groups.

Similarly, a group at Johns Hopkins is also measuring light path changes in the brain to correlate them with regional brain activity to “read” wetware commands.

The Teledyne Scientific & Imaging group, in contrast, is turning to tiny light-powered “magnetometers” to detect small, localized magnetic fields that neurons generate when they fire, and match these signals to brain output.

The nonprofit Battelle team gets even fancier with their ”BrainSTORMS” nanotransducers: magnetic nanoparticles wrapped in a piezoelectric shell. The shell can convert electrical signals from neurons into magnetic ones and vice-versa. This allows external transceivers to wirelessly pick up the transformed signals and stimulate the brain through a bidirectional highway.

The magnetometers can be delivered into the brain through a nasal spray or other non-invasive methods, and magnetically guided towards targeted brain regions. When no longer needed, they can once again be steered out of the brain and into the bloodstream, where the body can excrete them without harm.

Four-Year Miracle
Mind-blown? Yeah, same. However, the challenges facing the teams are enormous.

DARPA’s stated goal is to hook up at least 16 sites in the brain with the BMI, with a lag of less than 50 milliseconds—on the scale of average human visual perception. That’s crazy high resolution for devices sitting outside the brain, both in space and time. Brain tissue, blood vessels, and the scalp and skull are all barriers that scatter and dissipate neural signals. All six teams will need to figure out the least computationally-intensive ways to fish out relevant brain signals from background noise, and triangulate them to the appropriate brain region to decipher intent.

In the long run, four years and an average $20 million per project isn’t much to potentially transform our relationship with machines—for better or worse. DARPA, to its credit, is keenly aware of potential misuse of remote brain control. The program is under the guidance of a panel of external advisors with expertise in bioethical issues. And although DARPA’s focus is on enabling able-bodied soldiers to better tackle combat challenges, it’s hard to argue that wireless, non-invasive BMIs will also benefit those most in need: veterans and other people with debilitating nerve damage. To this end, the program is heavily engaging the FDA to ensure it meets safety and efficacy regulations for human use.

Will we be there in just four years? I’m skeptical. But these electrical, optical, acoustic, magnetic, and genetic BMIs, as crazy as they sound, seem inevitable.

“DARPA is preparing for a future in which a combination of unmanned systems, AI, and cyber operations may cause conflicts to play out on timelines that are too short for humans to effectively manage with current technology alone,” said Al Emondi, the N3 program manager.

The question is, now that we know what’s in store, how should the rest of us prepare?

Image Credit: With permission from DARPA N3 project. Continue reading

Posted in Human Robots

#435152 The Futuristic Tech Disrupting Real ...

In the wake of the housing market collapse of 2008, one entrepreneur decided to dive right into the failing real estate industry. But this time, he didn’t buy any real estate to begin with. Instead, Glenn Sanford decided to launch the first-ever cloud-based real estate brokerage, eXp Realty.

Contracting virtual platform VirBELA to build out the company’s mega-campus in VR, eXp Realty demonstrates the power of a dematerialized workspace, throwing out hefty overhead costs and fundamentally redefining what ‘real estate’ really means. Ten years later, eXp Realty has an army of 14,000 agents across all 50 US states, 3 Canadian provinces, and 400 MLS market areas… all without a single physical office.

But VR is just one of many exponential technologies converging to revolutionize real estate and construction. As floating cities and driverless cars spread out your living options, AI and VR are together cutting out the middleman.

Already, the global construction industry is projected to surpass $12.9 trillion in 2022, and the total value of the US housing market alone grew to $33.3 trillion last year. Both vital for our daily lives, these industries will continue to explode in value, posing countless possibilities for disruption.

In this blog, I’ll be discussing the following trends:

New prime real estate locations;
Disintermediation of the real estate broker and search;
Materials science and 3D printing in construction.

Let’s dive in!

Location Location Location
Until today, location has been the name of the game when it comes to hunting down the best real estate. But constraints on land often drive up costs while limiting options, and urbanization is only exacerbating the problem.

Beyond the world of virtual real estate, two primary mechanisms are driving the creation of new locations.

(1) Floating Cities

Offshore habitation hubs, floating cities have long been conceived as a solution to rising sea levels, skyrocketing urban populations, and threatened ecosystems. In success, they will soon unlock an abundance of prime real estate, whether for scenic living, commerce, education, or recreation.

One pioneering model is that of Oceanix City, designed by Danish architect Bjarke Ingels and a host of other domain experts. Intended to adapt organically over time, Oceanix would consist of a galaxy of mass-produced, hexagonal floating modules, built as satellite “cities” off coastal urban centers and sustained by renewable energies.

While individual 4.5-acre platforms would each sustain 300 people, these hexagonal modules are designed to link into 75-acre tessellations sustaining up to 10,000 residents. Each anchored to the ocean floor using biorock, Oceanix cities are slated to be closed-loop systems, as external resources are continuously supplied by automated drone networks.

Electric boats or flying cars might zoom you to work, city-embedded water capture technologies would provide your water, and while vertical and outdoor farming supply your family meal, share economies would dominate goods provision.

AERIAL: Located in calm, sheltered waters, near coastal megacities, OCEANIX City will be an adaptable, sustainable, scalable, and affordable solution for human life on the ocean. Image Credit: OCEANIX/BIG-Bjarke Ingels Group.
Joined by countless government officials whose islands risk submersion at the hands of sea level rise, the UN is now getting on board. And just this year, seasteading is exiting the realm of science fiction and testing practical waters.

As French Polynesia seeks out robust solutions to sea level rise, their government has now joined forces with the San Francisco-based Seasteading Institute. With a newly designated special economic zone and 100 acres of beachfront, this joint Floating Island Project could even see up to a dozen inhabitable structures by 2020. And what better to fund the $60 million project than the team’s upcoming ICO?

But aside from creating new locations, autonomous vehicles (AVs) and flying cars are turning previously low-demand land into the prime real estate of tomorrow.

(2) Autonomous Electric Vehicles and Flying Cars

Today, the value of a location is a function of its proximity to your workplace, your city’s central business district, the best schools, or your closest friends.

But what happens when driverless cars desensitize you to distance, or Hyperloop and flying cars decimate your commute time? Historically, every time new transit methods have hit the mainstream, tolerance for distance has opened up right alongside them, further catalyzing city spread.

And just as Hyperloop and the Boring Company aim to make your commute immaterial, autonomous vehicle (AV) ridesharing services will spread out cities in two ways: (1) by drastically reducing parking spaces needed (vertical parking decks = more prime real estate); and (2) by untethering you from the steering wheel. Want an extra two hours of sleep on the way to work? Schedule a sleeper AV and nap on your route to the office. Need a car-turned-mobile-office? No problem.

Meanwhile, aerial taxis (i.e. flying cars) will allow you to escape ground congestion entirely, delivering you from bedroom to boardroom at decimated time scales.

Already working with regulators, Uber Elevate has staked ambitious plans for its UberAIR airborne taxi project. By 2023, Uber anticipates rolling out flying drones in its two first pilot cities, Los Angeles and Dallas. Flying between rooftop skyports, drones would carry passengers at a height of 1,000 to 2,000 feet at speeds between 100 to 200 mph. And while costs per ride are anticipated to resemble those of an Uber Black based on mileage, prices are projected to soon drop to those of an UberX.

But the true economic feat boils down to this: if I were to commute 50 to 100 kilometers, I could get two or three times the house for the same price. (Not to mention the extra living space offered up by my now-unneeded garage.)

All of a sudden, virtual reality, broadband, AVs, or high-speed vehicles are going to change where we live and where we work. So rather than living in a crowded, dense urban core for access to jobs and entertainment, our future of personalized, autonomous, low-cost transport opens the luxury of rural areas to all without compromising the benefits of a short commute.

Once these drivers multiply your real estate options, how will you select your next home?

Disintermediation: Say Bye to Your Broker
In a future of continuous and personalized preference-tracking, why hire a human agent who knows less about your needs and desires than a personal AI?

Just as disintermediation is cutting out bankers and insurance agents, so too is it closing in on real estate brokers. Over the next decade, as AI becomes your agent, VR will serve as your medium.

To paint a more vivid picture of how this will look, over 98 percent of your home search will be conducted from the comfort of your couch through next-generation VR headgear.

Once you’ve verbalized your primary desires for home location, finishings, size, etc. to your personal AI, it will offer you top picks, tour-able 24/7, with optional assistance by a virtual guide and constantly updated data. As a seller, this means potential buyers from two miles, or two continents, away.

Throughout each immersive VR tour, advanced eye-tracking software and a permissioned machine learning algorithm follow your gaze, further learn your likes and dislikes, and intelligently recommend other homes or commercial residences to visit.

Curious as to what the living room might look like with a fresh coat of blue paint and a white carpet? No problem! VR programs will be able to modify rendered environments instantly, changing countless variables, from furniture materials to even the sun’s orientation. Keen to input your own furniture into a VR-rendered home? Advanced AIs could one day compile all your existing furniture, electronics, clothing, decorations, and even books, virtually organizing them across any accommodating new space.

As 3D scanning technologies make extraordinary headway, VR renditions will only grow cheaper and higher resolution. One company called Immersive Media (disclosure: I’m an investor and advisor) has a platform for 360-degree video capture and distribution, and is already exploring real estate 360-degree video.

Smaller firms like Studio 216, Vieweet, Arch Virtual, ArX Solutions, and Rubicon Media can similarly capture and render models of various properties for clients and investors to view and explore. In essence, VR real estate platforms will allow you to explore any home for sale, do the remodel, and determine if it truly is the house of your dreams.

Once you’re ready to make a bid, your AI will even help estimate a bid, process and submit your offer. Real estate companies like Zillow, Trulia, Move, Redfin, ZipRealty (acquired by Realogy in 2014) and many others have already invested millions in machine learning applications to make search, valuation, consulting, and property management easier, faster, and much more accurate.

But what happens if the home you desire most means starting from scratch with new construction?

New Methods and Materials for Construction
For thousands of years, we’ve been constrained by the construction materials of nature. We built bricks from naturally abundant clay and shale, used tree limbs as our rooftops and beams, and mastered incredible structures in ancient Rome with the use of cement.

But construction is now on the cusp of a materials science revolution. Today, I’d like to focus on three key materials:

Upcycled Materials

Imagine if you could turn the world’s greatest waste products into their most essential building blocks. Thanks to UCLA researchers at CO2NCRETE, we can already do this with carbon emissions.

Today, concrete produces about five percent of all greenhouse gas (GHG) emissions. But what if concrete could instead conserve greenhouse emissions? CO2NCRETE engineers capture carbon from smokestacks and combine it with lime to create a new type of cement. The lab’s 3D printers then shape the upcycled concrete to build entirely new structures. Once conquered at scale, upcycled concrete will turn a former polluter into a future conserver.

Or what if we wanted to print new residences from local soil at hand? Marking an extraordinary convergence between robotics and 3D printing, the Institute of Advanced Architecture of Catalonia (IAAC) is already working on a solution.

In a major feat for low-cost construction in remote zones, IAAC has found a way to convert almost any soil into a building material with three times the tensile strength of industrial clay. Offering myriad benefits, including natural insulation, low GHG emissions, fire protection, air circulation, and thermal mediation, IAAC’s new 3D printed native soil can build houses on-site for as little as $1,000.

Nanomaterials

Nano- and micro-materials are ushering in a new era of smart, super-strong, and self-charging buildings. While carbon nanotubes dramatically increase the strength-to-weight ratio of skyscrapers, revolutionizing their structural flexibility, nanomaterials don’t stop here.

Several research teams are pioneering silicon nanoparticles to capture everyday light flowing through our windows. Little solar cells at the edges of windows then harvest this energy for ready use. Researchers at the US National Renewable Energy Lab have developed similar smart windows. Turning into solar panels when bathed in sunlight, these thermochromic windows will power our buildings, changing color as they do.

Self-Healing Infrastructure

The American Society of Civil Engineers estimates that the US needs to spend roughly $4.5 trillion to fix nationwide roads, bridges, dams, and common infrastructure by 2025. But what if infrastructure could fix itself?

Enter self-healing concrete. Engineers at Delft University have developed bio-concrete that can repair its own cracks. As head researcher Henk Jonkers explains, “What makes this limestone-producing bacteria so special is that they are able to survive in concrete for more than 200 years and come into play when the concrete is damaged. […] If cracks appear as a result of pressure on the concrete, the concrete will heal these cracks itself.”

But bio-concrete is only the beginning of self-healing technologies. As futurist architecture firms start printing plastic and carbon-fiber houses like the stunner seen below (using Branch Technologies’ 3D printing technology), engineers have begun tackling self-healing plastic.

And in a bid to go smart, burgeoning construction projects have started embedding sensors for preemptive detection. Beyond materials and sensors, however, construction methods are fast colliding into robotics and 3D printing.

While some startups and research institutes have leveraged robot swarm construction (namely, Harvard’s robotic termite-like swarm of programmed constructors), others have taken to large-scale autonomous robots.

One such example involves Fastbrick Robotics. After multiple iterations, the company’s Hadrian X end-to-end bricklaying robot can now autonomously build a fully livable, 180-square meter home in under 3 days. Using a laser-guided robotic attachment, the all-in-one brick-loaded truck simply drives to a construction site and directs blocks through its robotic arm in accordance with a 3D model.

Layhead. Image Credit: Fastbrick Robotics.
Meeting verified building standards, Hadrian and similar solutions hold massive promise in the long term, deployable across post-conflict refugee sites and regions recovering from natural catastrophes.

Imagine the implications. Eliminating human safety concerns and unlocking any environment, autonomous builder robots could collaboratively build massive structures in space or deep underwater habitats.

Final Thoughts
Where, how, and what we live in form a vital pillar of our everyday lives. The concept of “home” is unlikely to disappear anytime soon. At the same time, real estate and construction are two of the biggest playgrounds for technological convergence, each on the verge of revolutionary disruption.

As underlying shifts in transportation, land reclamation, and the definition of “space” (real vs. virtual) take hold, the real estate market is about to explode in value, spreading out urban centers on unprecedented scales and unlocking vast new prime “property.”

Meanwhile, converging advancements in AI and VR are fundamentally disrupting the way we design, build, and explore new residences. Just as mirror worlds create immersive, virtual real estate economies, VR tours and AI agents are absorbing both sides of the coin to entirely obliterate the middleman.

And as materials science breakthroughs meet new modes of construction, the only limits to tomorrow’s structures are those of our own imagination.

Join Me
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Image Credit: OCEANIX/BIG-Bjarke Ingels Group. Continue reading

Posted in Human Robots

#434755 This Week’s Awesome Stories From ...

ARTIFICIAL INTELLIGENCE
DeepMind and Google: The Battle to Control Artificial Intelligence
Hal Hodson | 1843
“Hassabis thought DeepMind would be a hybrid: it would have the drive of a startup, the brains of the greatest universities, and the deep pockets of one of the world’s most valuable companies. Every element was in place to hasten the arrival of AGI and solve the causes of human misery.”

ROBOTICS
Robot Valets Are Now Parking Cars in One of France’s Busiest Airports
James Vincent | The Verge
“Stanley Robotics say its system uses space much more efficiently than humans, fitting 50 percent more cars into the same area. This is thanks in part to the robots’ precision driving, but also because the system keeps track of when customers will return. This means the robots can park cars three or four deep, but then dig out the right vehicle ready for its owner’s return.”

COMPUTING
Quantum Computing Should Supercharge This Machine-Learning Technique
Will Knight | MIT Technology Review
“Quantum computing and artificial intelligence are both hyped ridiculously. But it seems a combination of the two may indeed combine to open up new possibilities.”

BIOTECH
Scientists Reawaken Cells From a 28,000-Year-Old Mammoth
Becky Ferreira | Motherboard
“Yuka the woolly mammoth died a long time ago, but scientists gave her cells a short second life in mouse egg cells.”

ETHICS
CRISPR Experts Are Calling for a Global Moratorium on Heritable Gene Editing
Niall Firth | MIT Technology Review
“We still don’t know what the majority of our genes do, so the risks of unintended consequences or so-called off-target effects—good or bad—are huge. …Changes in a genome might have unforeseen outcomes in future generations as well. ‘Attempting to reshape the species on the basis of our current state of knowledge would be hubris,’ the letter reads.”

GENETICS
Unleash the Full Potential of the Human Genome Project
Paul Glimcher | The Hill
“So how do the risks embedded in our genes become the diseases, the so-called phenotypes, we seek to cure or prevent? …It is not just nature, but also nurture, which leads to disease. This is something that we have known for centuries, but which we seem to have conveniently forgotten in our rush to embrace the technology of genetics. In 1990 the only thing we could measure comprehensively was genetics, so we did it. But why did we stop there?”

Image Credit: Fernanda Marin / Unsplash Continue reading

Posted in Human Robots

#434658 The Next Data-Driven Healthtech ...

Increasing your healthspan (i.e. making 100 years old the new 60) will depend to a large degree on artificial intelligence. And, as we saw in last week’s blog, healthcare AI systems are extremely data-hungry.

Fortunately, a slew of new sensors and data acquisition methods—including over 122 million wearables shipped in 2018—are bursting onto the scene to meet the massive demand for medical data.

From ubiquitous biosensors, to the mobile healthcare revolution, to the transformative power of the Health Nucleus, converging exponential technologies are fundamentally transforming our approach to healthcare.

In Part 4 of this blog series on Longevity & Vitality, I expand on how we’re acquiring the data to fuel today’s AI healthcare revolution.

In this blog, I’ll explore:

How the Health Nucleus is transforming “sick care” to healthcare
Sensors, wearables, and nanobots
The advent of mobile health

Let’s dive in.

Health Nucleus: Transforming ‘Sick Care’ to Healthcare
Much of today’s healthcare system is actually sick care. Most of us assume that we’re perfectly healthy, with nothing going on inside our bodies, until the day we travel to the hospital writhing in pain only to discover a serious or life-threatening condition.

Chances are that your ailment didn’t materialize that morning; rather, it’s been growing or developing for some time. You simply weren’t aware of it. At that point, once you’re diagnosed as “sick,” our medical system engages to take care of you.

What if, instead of this retrospective and reactive approach, you were constantly monitored, so that you could know the moment anything was out of whack?

Better yet, what if you more closely monitored those aspects of your body that your gene sequence predicted might cause you difficulty? Think: your heart, your kidneys, your breasts. Such a system becomes personalized, predictive, and possibly preventative.

This is the mission of the Health Nucleus platform built by Human Longevity, Inc. (HLI). While not continuous—that will come later, with the next generation of wearable and implantable sensors—the Health Nucleus was designed to ‘digitize’ you once per year to help you determine whether anything is going on inside your body that requires immediate attention.

The Health Nucleus visit provides you with the following tests during a half-day visit:

Whole genome sequencing (30x coverage)
Whole body (non-contrast) MRI
Brain magnetic resonance imaging/angiography (MRI/MRA)
CT (computed tomography) of the heart and lungs
Coronary artery calcium scoring
Electrocardiogram
Echocardiogram
Continuous cardiac monitoring
Clinical laboratory tests and metabolomics

In late 2018, HLI published the results of the first 1,190 clients through the Health Nucleus. The results were eye-opening—especially since these patients were all financially well-off, and already had access to the best doctors.

Following are the physiological and genomic findings in these clients who self-selected to undergo evaluation at HLI’s Health Nucleus.

Physiological Findings [TG]

Two percent had previously unknown tumors detected by MRI
2.5 percent had previously undetected aneurysms detected by MRI
Eight percent had cardiac arrhythmia found on cardiac rhythm monitoring, not previously known
Nine percent had moderate-severe coronary artery disease risk, not previously known
16 percent discovered previously unknown cardiac structure/function abnormalities
30 percent had elevated liver fat, not previously known

Genomic Findings [TG]

24 percent of clients uncovered a rare (unknown) genetic mutation found on WGS
63 percent of clients had a rare genetic mutation with a corresponding phenotypic finding

In summary, HLI’s published results found that 14.4 percent of clients had significant findings that are actionable, requiring immediate or near-term follow-up and intervention.

Long-term value findings were found in 40 percent of the clients we screened. Long-term clinical findings include discoveries that require medical attention or monitoring but are not immediately life-threatening.

The bottom line: most people truly don’t know their actual state of health. The ability to take a fully digital deep dive into your health status at least once per year will enable you to detect disease at stage zero or stage one, when it is most curable.

Sensors, Wearables, and Nanobots
Wearables, connected devices, and quantified self apps will allow us to continuously collect enormous amounts of useful health information.

Wearables like the Quanttus wristband and Vital Connect can transmit your electrocardiogram data, vital signs, posture, and stress levels anywhere on the planet.

In April 2017, we were proud to grant $2.5 million in prize money to the winning team in the Qualcomm Tricorder XPRIZE, Final Frontier Medical Devices.

Using a group of noninvasive sensors that collect data on vital signs, body chemistry, and biological functions, Final Frontier integrates this data in their powerful, AI-based DxtER diagnostic engine for rapid, high-precision assessments.

Their engine combines learnings from clinical emergency medicine and data analysis from actual patients.

Google is developing a full range of internal and external sensors (e.g. smart contact lenses) that can monitor the wearer’s vitals, ranging from blood sugar levels to blood chemistry.

In September 2018, Apple announced its Series 4 Apple Watch, including an FDA-approved mobile, on-the-fly ECG. Granted its first FDA approval, Apple appears to be moving deeper into the sensing healthcare market.

Further, Apple is reportedly now developing sensors that can non-invasively monitor blood sugar levels in real time for diabetic treatment. IoT-connected sensors are also entering the world of prescription drugs.

Last year, the FDA approved the first sensor-embedded pill, Abilify MyCite. This new class of digital pills can now communicate medication data to a user-controlled app, to which doctors may be granted access for remote monitoring.

Perhaps what is most impressive about the next generation of wearables and implantables is the density of sensors, processing, networking, and battery capability that we can now cheaply and compactly integrate.

Take the second-generation OURA ring, for example, which focuses on sleep measurement and management.

The OURA ring looks like a slightly thick wedding band, yet contains an impressive array of sensors and capabilities, including:

Two infrared LED
One infrared sensor
Three temperature sensors
One accelerometer
A six-axis gyro
A curved battery with a seven-day life
The memory, processing, and transmission capability required to connect with your smartphone

Disrupting Medical Imaging Hardware
In 2018, we saw lab breakthroughs that will drive the cost of an ultrasound sensor to below $100, in a packaging smaller than most bandages, powered by a smartphone. Dramatically disrupting ultrasound is just the beginning.

Nanobots and Nanonetworks
While wearables have long been able to track and transmit our steps, heart rate, and other health data, smart nanobots and ingestible sensors will soon be able to monitor countless new parameters and even help diagnose disease.

Some of the most exciting breakthroughs in smart nanotechnology from the past year include:

Researchers from the École Polytechnique Fédérale de Lausanne (EPFL) and the Swiss Federal Institute of Technology in Zurich (ETH Zurich) demonstrated artificial microrobots that can swim and navigate through different fluids, independent of additional sensors, electronics, or power transmission.

Researchers at the University of Chicago proposed specific arrangements of DNA-based molecular logic gates to capture the information contained in the temporal portion of our cells’ communication mechanisms. Accessing the otherwise-lost time-dependent information of these cellular signals is akin to knowing the tune of a song, rather than solely the lyrics.

MIT researchers built micron-scale robots able to sense, record, and store information about their environment. These tiny robots, about 100 micrometers in diameter (approximately the size of a human egg cell), can also carry out pre-programmed computational tasks.

Engineers at University of California, San Diego developed ultrasound-powered nanorobots that swim efficiently through your blood, removing harmful bacteria and the toxins they produce.

But it doesn’t stop there.

As nanosensor and nanonetworking capabilities develop, these tiny bots may soon communicate with each other, enabling the targeted delivery of drugs and autonomous corrective action.

Mobile Health
The OURA ring and the Series 4 Apple Watch are just the tip of the spear when it comes to our future of mobile health. This field, predicted to become a $102 billion market by 2022, puts an on-demand virtual doctor in your back pocket.

Step aside, WebMD.

In true exponential technology fashion, mobile device penetration has increased dramatically, while image recognition error rates and sensor costs have sharply declined.

As a result, AI-powered medical chatbots are flooding the market; diagnostic apps can identify anything from a rash to diabetic retinopathy; and with the advent of global connectivity, mHealth platforms enable real-time health data collection, transmission, and remote diagnosis by medical professionals.

Already available to residents across North London, Babylon Health offers immediate medical advice through AI-powered chatbots and video consultations with doctors via its app.

Babylon now aims to build up its AI for advanced diagnostics and even prescription. Others, like Woebot, take on mental health, using cognitive behavioral therapy in communications over Facebook messenger with patients suffering from depression.

In addition to phone apps and add-ons that test for fertility or autism, the now-FDA-approved Clarius L7 Linear Array Ultrasound Scanner can connect directly to iOS and Android devices and perform wireless ultrasounds at a moment’s notice.

Next, Healthy.io, an Israeli startup, uses your smartphone and computer vision to analyze traditional urine test strips—all you need to do is take a few photos.

With mHealth platforms like ClickMedix, which connects remotely-located patients to medical providers through real-time health data collection and transmission, what’s to stop us from delivering needed treatments through drone delivery or robotic telesurgery?

Welcome to the age of smartphone-as-a-medical-device.

Conclusion
With these DIY data collection and diagnostic tools, we save on transportation costs (time and money), and time bottlenecks.

No longer will you need to wait for your urine or blood results to go through the current information chain: samples will be sent to the lab, analyzed by a technician, results interpreted by your doctor, and only then relayed to you.

Just like the “sage-on-the-stage” issue with today’s education system, healthcare has a “doctor-on-the-dais” problem. Current medical procedures are too complicated and expensive for a layperson to perform and analyze on their own.

The coming abundance of healthcare data promises to transform how we approach healthcare, putting the power of exponential technologies in the patient’s hands and revolutionizing how we live.

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#434256 Singularity Hub’s Top Articles of the ...

2018 was a big year for science and technology. The first gene-edited babies were born, as were the first cloned monkeys. SpaceX successfully launched the Falcon Heavy, and NASA’s InSight lander placed a seismometer on Mars. Bitcoin’s value plummeted, as did the cost of renewable energy. The world’s biggest neuromorphic supercomputer was switched on, and quantum communication made significant progress.

As 2018 draws to a close and we start anticipating the developments that will happen in 2019, here’s a look back at our ten most-read articles of the year.

This 3D Printed House Goes Up in a Day for Under $10,000
Vanessa Bates Ramirez | 3/18/18
“ICON and New Story’s vision is one of 3D printed houses acting as a safe, affordable housing alternative for people in need. New Story has already built over 800 homes in Haiti, El Salvador, Bolivia, and Mexico, partnering with the communities they serve to hire local labor and purchase local materials rather than shipping everything in from abroad.”

Machines Teaching Each Other Could Be the Biggest Exponential Trend in AI
Aaron Frank | 1/21/18
“Data is the fuel of machine learning, but even for machines, some data is hard to get—it may be risky, slow, rare, or expensive. In those cases, machines can share experiences or create synthetic experiences for each other to augment or replace data. It turns out that this is not a minor effect, it actually is self-amplifying, and therefore exponential.”

Low-Cost Soft Robot Muscles Can Lift 200 Times Their Weight and Self-Heal
Edd Gent | 1/11/18
“Now researchers at the University of Colorado Boulder have built a series of low-cost artificial muscles—as little as 10 cents per device—using soft plastic pouches filled with electrically insulating liquids that contract with the force and speed of mammalian skeletal muscles when a voltage is applied to them.”

These Are the Most Exciting Industries and Jobs of the Future
Raya Bidshahri | 1/29/18
“Technological trends are giving rise to what many thought leaders refer to as the “imagination economy.” This is defined as “an economy where intuitive and creative thinking create economic value, after logical and rational thinking have been outsourced to other economies.” Unsurprisingly, humans continue to outdo machines when it comes to innovating and pushing intellectual, imaginative, and creative boundaries, making jobs involving these skills the hardest to automate.”

Inside a $1 Billion Real Estate Company Operating Entirely in VR
Aaron Frank | 4/8/18
“Incredibly, this growth is largely the result of eXp Realty’s use of an online virtual world similar to Second Life. That means every employee, contractor, and the thousands of agents who work at the company show up to work—team meetings, training seminars, onboarding sessions—all inside a virtual reality campus.To be clear, this is a traditional real estate brokerage helping people buy and sell physical homes—but they use a virtual world as their corporate offices.”

How Fast Is AI Progressing? Stanford’s New Report Card for Artificial Intelligence
Thomas Hornigold | 1/18/18
“Progress in AI over the next few years is far more likely to resemble a gradual rising tide—as more and more tasks can be turned into algorithms and accomplished by software—rather than the tsunami of a sudden intelligence explosion or general intelligence breakthrough. Perhaps measuring the ability of an AI system to learn and adapt to the work routines of humans in office-based tasks could be possible.”

When Will We Finally Achieve True Artificial Intelligence?
Thomas Hornigold | 1/1/18
“The issue with trying to predict the exact date of human-level AI is that we don’t know how far is left to go. This is unlike Moore’s Law. Moore’s Law, the doubling of processing power roughly every couple of years, makes a very concrete prediction about a very specific phenomenon. We understand roughly how to get there—improved engineering of silicon wafers—and we know we’re not at the fundamental limits of our current approach. You cannot say the same about artificial intelligence.”

IBM’s New Computer Is the Size of a Grain of Salt and Costs Less Than 10 Cents
Edd Gent | 3/26/18
“Costing less than 10 cents to manufacture, the company envisions the device being embedded into products as they move around the supply chain. The computer’s sensing, processing, and communicating capabilities mean it could effectively turn every item in the supply chain into an Internet of Things device, producing highly granular supply chain data that could streamline business operations.”

Why the Rise of Self-Driving Vehicles Will Actually Increase Car Ownership
Melba Kurman and Hod Lipson / 2/14/18
“When people predict the demise of car ownership, they are overlooking the reality that the new autonomous automotive industry is not going to be just a re-hash of today’s car industry with driverless vehicles. Instead, the automotive industry of the future will be selling what could be considered an entirely new product: a wide variety of intelligent, self-guiding transportation robots. When cars become a widely used type of transportation robot, they will be cheap, ubiquitous, and versatile.”

A Model for the Future of Education
Peter Diamandis | 9/12/18
“I imagine a relatively near-term future in which robotics and artificial intelligence will allow any of us, from ages 8 to 108, to easily and quickly find answers, create products, or accomplish tasks, all simply by expressing our desires. From ‘mind to manufactured in moments.’ In short, we’ll be able to do and create almost whatever we want. In this future, what attributes will be most critical for our children to learn to become successful in their adult lives? What’s most important for educating our children today?”

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