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#438006 Smellicopter Drone Uses Live Moth ...

Research into robotic sensing has, understandably I guess, been very human-centric. Most of us navigate and experience the world visually and in 3D, so robots tend to get covered with things like cameras and lidar. Touch is important to us, as is sound, so robots are getting pretty good with understanding tactile and auditory information, too. Smell, though? In most cases, smell doesn’t convey nearly as much information for us, so while it hasn’t exactly been ignored in robotics, it certainly isn’t the sensing modality of choice in most cases.

Part of the problem with smell sensing is that we just don’t have a good way of doing it, from a technical perspective. This has been a challenge for a long time, and it’s why we either bribe or trick animals like dogs, rats, vultures, and other animals to be our sensing systems for airborne chemicals. If only they’d do exactly what we wanted them to do all the time, this would be fine, but they don’t, so it’s not.

Until we get better at making chemical sensors, leveraging biology is the best we can do, and what would be ideal would be some sort of robot-animal hybrid cyborg thing. We’ve seen some attempts at remote controlled insects, but as it turns out, you can simplify things if you don’t use the entire insect, but instead just find a way to use its sensing system. Enter the Smellicopter.

There’s honestly not too much to say about the drone itself. It’s an open-source drone project called Crazyflie 2.0, with some additional off the shelf sensors for obstacle avoidance and stabilization. The interesting bits are a couple of passive fins that keep the drone pointed into the wind, and then the sensor, called an electroantennogram.

Image: UW

The drone’s sensor, called an electroantennogram, consists of a “single excised antenna” from a Manduca sexta hawkmoth and a custom signal processing circuit.

To make one of these sensors, you just, uh, “harvest” an antenna from a live hawkmoth. Obligingly, the moth antenna is hollow, meaning that you can stick electrodes up it. Whenever the olfactory neurons in the antenna (which is still technically alive even though it’s not attached to the moth anymore) encounter an odor that they’re looking for, they produce an electrical signal that the electrodes pick up. Plug the other ends of the electrodes into a voltage amplifier and filter, run it through an analog to digital converter, and you’ve got a chemical sensor that weighs just 1.5 gram and consumes only 2.7 mW of power. It’s significantly more sensitive than a conventional metal-oxide odor sensor, in a much smaller and more efficient form factor, making it ideal for drones.

To localize an odor, the Smellicopter uses a simple bioinspired approach called crosswind casting, which involves moving laterally left and right and then forward when an odor is detected. Here’s how it works:

The vehicle takes off to a height of 40 cm and then hovers for ten seconds to allow it time to orient upwind. The smellicopter starts casting left and right crosswind. When a volatile chemical is detected, the smellicopter will surge 25 cm upwind, and then resume casting. As long as the wind direction is fairly consistent, this strategy will bring the insect or robot increasingly closer to a singular source with each surge.

Since odors are airborne, they need a bit of a breeze to spread very far, and the Smellicopter won’t be able to detect them unless it’s downwind of the source. But, that’s just how odors work— even if you’re right next to the source, if the wind is blowing from you towards the source rather than the other way around, you might not catch a whiff of it.

Whenever the olfactory neurons in the antenna encounter an odor that they’re looking for, they produce an electrical signal that the electrodes pick up

There are a few other constraints to keep in mind with this sensor as well. First, rather than detecting something useful (like explosives), it’s going to detect the smells of pretty flowers, because moths like pretty flowers. Second, the antenna will literally go dead on you within a couple hours, since it only functions while its tissues are alive and metaphorically kicking. Interestingly, it may be possible to use CRISPR-based genetic modification to breed moths with antennae that do respond to useful smells, which would be a neat trick, and we asked the researchers—Melanie Anderson, a doctoral student of mechanical engineering at the University of Washington, in Seattle; Thomas Daniel, a UW professor of biology; and Sawyer Fuller, a UW assistant professor of mechanical engineering—about this, along with some other burning questions, via email.

IEEE Spectrum, asking the important questions first: So who came up with “Smellicopter”?

Melanie Anderson: Tom Daniel coined the term “Smellicopter”. Another runner up was “OdorRotor”!

In general, how much better are moths at odor localization than robots?

Melanie Anderson: Moths are excellent at odor detection and odor localization and need to be in order to find mates and food. Their antennae are much more sensitive and specialized than any portable man-made odor sensor. We can't ask the moths how exactly they search for odors so well, but being able to have the odor sensitivity of a moth on a flying platform is a big step in that direction.

Tom Daniel: Our best estimate is that they outperform robotic sensing by at least three orders of magnitude.

How does the localization behavior of the Smellicopter compare to that of a real moth?

Anderson: The cast-and-surge odor search strategy is a simplified version of what we believe the moth (and many other odor searching animals) are doing. It is a reactive strategy that relies on the knowledge that if you detect odor, you can assume that the source is somewhere up-wind of you. When you detect odor, you simply move upwind, and when you lose the odor signal you cast in a cross-wind direction until you regain the signal.

Can you elaborate on the potential for CRISPR to be able to engineer moths for the detection of specific chemicals?

Anderson: CRISPR is already currently being used to modify the odor detection pathways in moth species. It is one of our future efforts to specifically use this to make the antennae sensitive to other chemicals of interest, such as the chemical scent of explosives.

Sawyer Fuller: We think that one of the strengths of using a moth's antenna, in addition to its speed, is that it may provide a path to both high chemical specificity as well as high sensitivity. By expressing a preponderance of only one or a few chemosensors, we are anticipating that a moth antenna will give a strong response only to that chemical. There are several efforts underway in other research groups to make such specific, sensitive chemical detectors. Chemical sensing is an area where biology exceeds man-made systems in terms of efficiency, small size, and sensitivity. So that's why we think that the approach of trying to leverage biological machinery that already exists has some merit.

You mention that the antennae lifespan can be extended for a few days with ice- how feasible do you think this technology is outside of a research context?

Anderson: The antennae can be stored in tiny vials in a standard refrigerator or just with an ice pack to extend their life to about a week. Additionally, the process for attaching the antenna to the electrical circuit is a teachable skill. It is definitely feasible outside of a research context.

Considering the trajectory that sensor development is on, how long do you think that this biological sensor system will outperform conventional alternatives?

Anderson: It's hard to speak toward what will happen in the future, but currently, the moth antenna still stands out among any commercially-available portable sensors.

There have been some experiments with cybernetic insects; what are the advantages and disadvantages of your approach, as opposed to (say) putting some sort of tracking system on a live moth?

Daniel: I was part of a cyber insect team a number of years ago. The challenge of such research is that the animal has natural reactions to attempts to steer or control it.

Anderson: While moths are better at odor tracking than robots currently, the advantage of the drone platform is that we have control over it. We can tell it to constrain the search to a certain area, and return after it finishes searching.

What can you tell us about the health, happiness, and overall wellfare of the moths in your experiments?

Anderson: The moths are cold anesthetized before the antennae are removed. They are then frozen so that they can be used for teaching purposes or in other research efforts.

What are you working on next?

Daniel: The four big efforts are (1) CRISPR modification, (2) experiments aimed at improving the longevity of the antennal preparation, (3) improved measurements of antennal electrical responses to odors combined with machine learning to see if we can classify different odors, and (4) flight in outdoor environments.

Fuller: The moth's antenna sensor gives us a new ability to sense with a much shorter latency than was previously possible with similarly-sized sensors (e.g. semiconductor sensors). What exactly a robot agent should do to best take advantage of this is an open question. In particular, I think the speed may help it to zero in on plume sources in complex environments much more quickly. Think of places like indoor settings with flow down hallways that splits out at doorways, and in industrial settings festooned with pipes and equipment. We know that it is possible to search out and find odors in such scenarios, as anybody who has had to contend with an outbreak of fruit flies can attest. It is also known that these animals respond very quickly to sudden changes in odor that is present in such turbulent, patchy plumes. Since it is hard to reduce such plumes to a simple model, we think that machine learning may provide insights into how to best take advantage of the improved temporal plume information we now have available.

Tom Daniel also points out that the relative simplicity of this project (now that the UW researchers have it all figured out, that is) means that even high school students could potentially get involved in it, even if it’s on a ground robot rather than a drone. All the details are in the paper that was just published in Bioinspiration & Biomimetics. Continue reading

Posted in Human Robots

#438001 How an Israeli Startup Is Using AI to ...

The first baby conceived using in-vitro fertilization (IVF) was born in the UK in 1978. Over 40 years later, the technique has become commonplace, but its success rate is still fairly low at around 22 to 30 percent. A female-founded Israeli startup called Embryonics is setting out to change this by using artificial intelligence to screen embryos.

IVF consists of fertilizing a woman’s egg with her partner’s or a donor’s sperm outside of her body, creating an embryo that’s then implanted in the uterus. It’s not an easy process in any sense of the word—physically, emotionally, or financially. Insurance rarely covers IVF, and the costs run anywhere from $12,000 to $25,000 per cycle (a cycle takes about a month and includes stimulating a woman’s ovaries to produce eggs, extracting the eggs, inseminating them outside the body, and implanting an embryo).

Women have to give themselves daily hormone shots to stimulate egg production, and these can cause uncomfortable side effects. After so much stress and expense, it’s disheartening to think that the odds of a successful pregnancy are, at best, one in three.

A crucial factor in whether or not an IVF cycle works—that is, whether the embryo implants in the uterus and begins to develop into a healthy fetus—is the quality of the embryo. Doctors examine embryos through a microscope to determine how many cells they contain and whether they appear healthy, and choose the one that looks most viable.

But the human eye can only see so much, even with the help of a microscope; despite embryologists’ efforts to select the “best” embryo, success rates are still relatively low. “Many decisions are based on gut feeling or personal experience,” said Embryonics founder and CEO Yael Gold-Zamir. “Even if you go to the same IVF center, two experts can give you different opinions on the same embryo.”

This is where Embryonics’ technology comes in. They used 8,789 time-lapse videos of developing embryos to train an algorithm that predicts the likelihood of successful embryo implantation. A little less than half of the embryos from the dataset were graded by embryologists, and implantation data was integrated when it was available (as a binary “successful” or “failed” metric).

The algorithm uses geometric deep learning, a technique that takes a traditional convolutional neural network—which filters input data to create maps of its features, and is most commonly used for image recognition—and applies it to more complex data like 3D objects and graphs. Within days after fertilization, the embryo is still at the blastocyst stage, essentially a microscopic clump of just 200-300 cells; the algorithm uses this deep learning technique to spot and identify patterns in embryo development that human embryologists either wouldn’t see at all, or would require massive collation of data to validate.

On top of the embryo videos, Embryonics’ team incorporated patient data and environmental data from the lab into its algorithm, with encouraging results: the company reports that using its algorithm resulted in a 12 percent increase in positive predictive value (identifying embryos that would lead to implantation and healthy pregnancy) and a 29 percent increase in negative predictive value (identifying embyros that would not result in successful pregnancy) when compared to an external panel of embryologists.

TechCrunch reported last week that in a pilot of 11 women who used Embryonics’ algorithm to select their embryos, 6 are enjoying successful pregnancies, while 5 are still awaiting results.

Embryonics wasn’t the first group to think of using AI to screen embryos; a similar algorithm developed in 2019 by researchers at Weill Cornell Medicine was able to classify the quality of a set of embryo images with 97 percent accuracy. But Embryonics will be one of the first to bring this sort of technology to market. The company is waiting to receive approval from European regulatory bodies to be able to sell the software to fertility clinics in Europe.

Its timing is ripe: as more and more women delay having kids due to lifestyle and career-related factors, demand for IVF is growing, and will likely accelerate in coming years.

The company ultimately hopes to bring its product to the US, as well as to expand its work to include using data to improve hormonal stimulation.

Image Credit: Gerd Altmann from Pixabay Continue reading

Posted in Human Robots

#437992 This Week’s Awesome Tech Stories From ...

ARTIFICIAL INTELLIGENCE
This Chinese Lab Is Aiming for Big AI Breakthroughs
Will Knight | Wired
“China produces as many artificial intelligence researchers as the US, but it lags in key fields like machine learning. The government hopes to make up ground. …It set AI researchers the goal of making ‘fundamental breakthroughs by 2025’ and called for the country to be ‘the world’s primary innovation center by 2030.’ BAAI opened a year later, in Zhongguancun, a neighborhood of Beijing designed to replicate US innovation hubs such as Boston and Silicon Valley.”

ENVIRONMENT
What Elon Musk’s $100 Million Carbon Capture Prize Could Mean
James Temple | MIT Technology Review
“[Elon Musk] announced on Twitter that he plans to give away $100 million of [his $180 billion net worth] as a prize for the ‘best carbon capture technology.’ …Another $100 million could certainly help whatever venture, or ventures, clinch Musk’s prize. But it’s a tiny fraction of his wealth and will also only go so far. …Money aside, however, one thing Musk has a particular knack for is generating attention. And this is a space in need of it.”

HEALTH
Synthetic Cornea Helped a Legally Blind Man Regain His Sight
Steve Dent | Engadget
“While the implant doesn’t contain any electronics, it could help more people than any robotic eye. ‘After years of hard work, seeing a colleague implant the CorNeat KPro with ease and witnessing a fellow human being regain his sight the following day was electrifying and emotionally moving, there were a lot of tears in the room,’ said CorNeat Vision co-founder Dr. Gilad Litvin.”

BIOTECH
MIT Develops Method for Lab-Grown Plants That May Eventually Lead to Alternatives to Forestry and Farming
Darrell Etherington | TechCrunch
“If the work of these researchers can eventually be used to create a way to produce lab-grown wood for use in construction and fabrication in a way that’s scalable and efficient, then there’s tremendous potential in terms of reducing the impact on forestry globally. Eventually, the team even theorizes you could coax the growth of plant-based materials into specific target shapes, so you could also do some of the manufacturing in the lab, by growing a wood table directly for instance.”

AUTOMATION
FAA Approves First Fully Automated Commercial Drone Flights
Andy Pasztor and Katy Stech Ferek | The Wall Street Journal
“US aviation regulators have approved the first fully automated commercial drone flights, granting a small Massachusetts-based company permission to operate drones without hands-on piloting or direct observation by human controllers or observers. …The company’s Scout drones operate under predetermined flight programs and use acoustic technology to detect and avoid drones, birds, and other obstacles.”

SPACE
China’s Surging Private Space Industry Is Out to Challenge the US
Neel V. Patel | MIT Technology Review
“[The Ceres-1] was a commercial rocket—only the second from a Chinese company ever to go into space. And the launch happened less than three years after the company was founded. The achievement is a milestone for China’s fledgling—but rapidly growing—private space industry, an increasingly critical part of the country’s quest to dethrone the US as the world’s preeminent space power.”

CRYPTOCURRENCY
Janet Yellen Will Consider Limiting Use of Cryptocurrency
Timothy B. Lee | Ars Technica
“Cryptocurrencies could come under renewed regulatory scrutiny over the next four years if Janet Yellen, Joe Biden’s pick to lead the Treasury Department, gets her way. During Yellen’s Tuesday confirmation hearing before the Senate Finance Committee, Sen. Maggie Hassan (D-N.H.) asked Yellen about the use of cryptocurrency by terrorists and other criminals. ‘Cryptocurrencies are a particular concern,’ Yellen responded. ‘I think many are used—at least in a transactions sense—mainly for illicit financing.’i”

SCIENCE
Secret Ingredient Found to Power Supernovas
Thomas Lewton | Quanta
“…Only in the last few years, with the growth of supercomputers, have theorists had enough computing power to model massive stars with the complexity needed to achieve explosions. …These new simulations are giving researchers a better understanding of exactly how supernovas have shaped the universe we see today.”

Image Credit: Ricardo Gomez Angel / Unsplash Continue reading

Posted in Human Robots

#437982 Superintelligent AI May Be Impossible to ...

It may be theoretically impossible for humans to control a superintelligent AI, a new study finds. Worse still, the research also quashes any hope for detecting such an unstoppable AI when it’s on the verge of being created.

Slightly less grim is the timetable. By at least one estimate, many decades lie ahead before any such existential computational reckoning could be in the cards for humanity.

Alongside news of AI besting humans at games such as chess, Go and Jeopardy have come fears that superintelligent machines smarter than the best human minds might one day run amok. “The question about whether superintelligence could be controlled if created is quite old,” says study lead author Manuel Alfonseca, a computer scientist at the Autonomous University of Madrid. “It goes back at least to Asimov’s First Law of Robotics, in the 1940s.”

The Three Laws of Robotics, first introduced in Isaac Asimov's 1942 short story “Runaround,” are as follows:

A robot may not injure a human being or, through inaction, allow a human being to come to harm.
A robot must obey the orders given it by human beings except where such orders would conflict with the First Law.
A robot must protect its own existence as long as such protection does not conflict with the First or Second Laws.

In 2014, philosopher Nick Bostrom, director of the Future of Humanity Institute at the University of Oxford, not only explored ways in which a superintelligent AI could destroy us but also investigated potential control strategies for such a machine—and the reasons they might not work.

Bostrom outlined two possible types of solutions of this “control problem.” One is to control what the AI can do, such as keeping it from connecting to the Internet, and the other is to control what it wants to do, such as teaching it rules and values so it would act in the best interests of humanity. The problem with the former is that Bostrom thought a supersmart machine could probably break free from any bonds we could make. With the latter, he essentially feared that humans might not be smart enough to train a superintelligent AI.

Now Alfonseca and his colleagues suggest it may be impossible to control a superintelligent AI, due to fundamental limits inherent to computing itself. They detailed their findings this month in the Journal of Artificial Intelligence Research.

The researchers suggested that any algorithm that sought to ensure a superintelligent AI cannot harm people had to first simulate the machine’s behavior to predict the potential consequences of its actions. This containment algorithm then would need to halt the supersmart machine if it might indeed do harm.

However, the scientists said it was impossible for any containment algorithm to simulate the AI’s behavior and predict with absolute certainty whether its actions might lead to harm. The algorithm could fail to correctly simulate the AI’s behavior or accurately predict the consequences of the AI’s actions and not recognize such failures.

“Asimov’s first law of robotics has been proved to be incomputable,” Alfonseca says, “and therefore unfeasible.”

We may not even know if we have created a superintelligent machine, the researchers say. This is a consequence of Rice’s theorem, which essentially states that one cannot in general figure anything out about what a computer program might output just by looking at the program, Alfonseca explains.

On the other hand, there’s no need to spruce up the guest room for our future robot overlords quite yet. Three important caveats to the research still leave plenty of uncertainty to the group’s predictions.

First, Alfonseca estimates AI’s moment of truth remains, he says, “At least two centuries in the future.”

Second, he says researchers do not know if so-called artificial general intelligence, also known as strong AI, is theoretically even feasible. “That is, a machine as intelligent as we are in an ample variety of fields,” Alfonseca explains.

Last, Alfonseca says, “We have not proved that superintelligences can never be controlled—only that they can’t always be controlled.”

Although it may not be possible to control a superintelligent artificial general intelligence, it should be possible to control a superintelligent narrow AI—one specialized for certain functions instead of being capable of a broad range of tasks like humans. “We already have superintelligences of this type,” Alfonseca says. “For instance, we have machines that can compute mathematics much faster than we can. This is [narrow] superintelligence, isn’t it?” Continue reading

Posted in Human Robots

#437957 Meet Assembloids, Mini Human Brains With ...

It’s not often that a twitching, snowman-shaped blob of 3D human tissue makes someone’s day.

But when Dr. Sergiu Pasca at Stanford University witnessed the tiny movement, he knew his lab had achieved something special. You see, the blob was evolved from three lab-grown chunks of human tissue: a mini-brain, mini-spinal cord, and mini-muscle. Each individual component, churned to eerie humanoid perfection inside bubbling incubators, is already a work of scientific genius. But Pasca took the extra step, marinating the three components together inside a soup of nutrients.

The result was a bizarre, Lego-like human tissue that replicates the basic circuits behind how we decide to move. Without external prompting, when churned together like ice cream, the three ingredients physically linked up into a fully functional circuit. The 3D mini-brain, through the information highway formed by the artificial spinal cord, was able to make the lab-grown muscle twitch on demand.

In other words, if you think isolated mini-brains—known formally as brain organoids—floating in a jar is creepy, upgrade your nightmares. The next big thing in probing the brain is assembloids—free-floating brain circuits—that now combine brain tissue with an external output.

The end goal isn’t to freak people out. Rather, it’s to recapitulate our nervous system, from input to output, inside the controlled environment of a Petri dish. An autonomous, living brain-spinal cord-muscle entity is an invaluable model for figuring out how our own brains direct the intricate muscle movements that allow us stay upright, walk, or type on a keyboard.

It’s the nexus toward more dexterous brain-machine interfaces, and a model to understand when brain-muscle connections fail—as in devastating conditions like Lou Gehrig’s disease or Parkinson’s, where people slowly lose muscle control due to the gradual death of neurons that control muscle function. Assembloids are a sort of “mini-me,” a workaround for testing potential treatments on a simple “replica” of a person rather than directly on a human.

From Organoids to Assembloids
The miniature snippet of the human nervous system has been a long time in the making.

It all started in 2014, when Dr. Madeleine Lancaster, then a post-doc at Stanford, grew a shockingly intricate 3D replica of human brain tissue inside a whirling incubator. Revolutionarily different than standard cell cultures, which grind up brain tissue to reconstruct as a flat network of cells, Lancaster’s 3D brain organoids were incredibly sophisticated in their recapitulation of the human brain during development. Subsequent studies further solidified their similarity to the developing brain of a fetus—not just in terms of neuron types, but also their connections and structure.

With the finding that these mini-brains sparked with electrical activity, bioethicists increasingly raised red flags that the blobs of human brain tissue—no larger than the size of a pea at most—could harbor the potential to develop a sense of awareness if further matured and with external input and output.

Despite these concerns, brain organoids became an instant hit. Because they’re made of human tissue—often taken from actual human patients and converted into stem-cell-like states—organoids harbor the same genetic makeup as their donors. This makes it possible to study perplexing conditions such as autism, schizophrenia, or other brain disorders in a dish. What’s more, because they’re grown in the lab, it’s possible to genetically edit the mini-brains to test potential genetic culprits in the search for a cure.

Yet mini-brains had an Achilles’ heel: not all were made the same. Rather, depending on the region of the brain that was reverse engineered, the cells had to be persuaded by different cocktails of chemical soups and maintained in isolation. It was a stark contrast to our own developing brains, where regions are connected through highways of neural networks and work in tandem.

Pasca faced the problem head-on. Betting on the brain’s self-assembling capacity, his team hypothesized that it might be possible to grow different mini-brains, each reflecting a different brain region, and have them fuse together into a synchronized band of neuron circuits to process information. Last year, his idea paid off.

In one mind-blowing study, his team grew two separate portions of the brain into blobs, one representing the cortex, the other a deeper part of the brain known to control reward and movement, called the striatum. Shockingly, when put together, the two blobs of human brain tissue fused into a functional couple, automatically establishing neural highways that resulted in one of the most sophisticated recapitulations of a human brain. Pasca crowned this tissue engineering crème-de-la-crème “assembloids,” a portmanteau between “assemble” and “organoids.”

“We have demonstrated that regionalized brain spheroids can be put together to form fused structures called brain assembloids,” said Pasca at the time.” [They] can then be used to investigate developmental processes that were previously inaccessible.”

And if that’s possible for wiring up a lab-grown brain, why wouldn’t it work for larger neural circuits?

Assembloids, Assemble
The new study is the fruition of that idea.

The team started with human skin cells, scraped off of eight healthy people, and transformed them into a stem-cell-like state, called iPSCs. These cells have long been touted as the breakthrough for personalized medical treatment, before each reflects the genetic makeup of its original host.

Using two separate cocktails, the team then generated mini-brains and mini-spinal cords using these iPSCs. The two components were placed together “in close proximity” for three days inside a lab incubator, gently floating around each other in an intricate dance. To the team’s surprise, under the microscope using tracers that glow in the dark, they saw highways of branches extending from one organoid to the other like arms in a tight embrace. When stimulated with electricity, the links fired up, suggesting that the connections weren’t just for show—they’re capable of transmitting information.

“We made the parts,” said Pasca, “but they knew how to put themselves together.”

Then came the ménage à trois. Once the mini-brain and spinal cord formed their double-decker ice cream scoop, the team overlaid them onto a layer of muscle cells—cultured separately into a human-like muscular structure. The end result was a somewhat bizarre and silly-looking snowman, made of three oddly-shaped spherical balls.

Yet against all odds, the brain-spinal cord assembly reached out to the lab-grown muscle. Using a variety of tools, including measuring muscle contraction, the team found that this utterly Frankenstein-like snowman was able to make the muscle component contract—in a way similar to how our muscles twitch when needed.

“Skeletal muscle doesn’t usually contract on its own,” said Pasca. “Seeing that first twitch in a lab dish immediately after cortical stimulation is something that’s not soon forgotten.”

When tested for longevity, the contraption lasted for up to 10 weeks without any sort of breakdown. Far from a one-shot wonder, the isolated circuit worked even better the longer each component was connected.

Pasca isn’t the first to give mini-brains an output channel. Last year, the queen of brain organoids, Lancaster, chopped up mature mini-brains into slices, which were then linked to muscle tissue through a cultured spinal cord. Assembloids are a step up, showing that it’s possible to automatically sew multiple nerve-linked structures together, such as brain and muscle, sans slicing.

The question is what happens when these assembloids become more sophisticated, edging ever closer to the inherent wiring that powers our movements. Pasca’s study targets outputs, but what about inputs? Can we wire input channels, such as retinal cells, to mini-brains that have a rudimentary visual cortex to process those examples? Learning, after all, depends on examples of our world, which are processed inside computational circuits and delivered as outputs—potentially, muscle contractions.

To be clear, few would argue that today’s mini-brains are capable of any sort of consciousness or awareness. But as mini-brains get increasingly more sophisticated, at what point can we consider them a sort of AI, capable of computation or even something that mimics thought? We don’t yet have an answer—but the debates are on.

Image Credit: christitzeimaging.com / Shutterstock.com Continue reading

Posted in Human Robots