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#436526 Not Bot, Not Beast: Scientists Create ...

A remarkable combination of artificial intelligence (AI) and biology has produced the world’s first “living robots.”

This week, a research team of roboticists and scientists published their recipe for making a new lifeform called xenobots from stem cells. The term “xeno” comes from the frog cells (Xenopus laevis) used to make them.

One of the researchers described the creation as “neither a traditional robot nor a known species of animal,” but a “new class of artifact: a living, programmable organism.”

Xenobots are less than 1 millimeter long and made of 500-1,000 living cells. They have various simple shapes, including some with squat “legs.” They can propel themselves in linear or circular directions, join together to act collectively, and move small objects. Using their own cellular energy, they can live up to 10 days.

While these “reconfigurable biomachines” could vastly improve human, animal, and environmental health, they raise legal and ethical concerns.

Strange New ‘Creature’
To make xenobots, the research team used a supercomputer to test thousands of random designs of simple living things that could perform certain tasks.

The computer was programmed with an AI “evolutionary algorithm” to predict which organisms would likely display useful tasks, such as moving towards a target.

After the selection of the most promising designs, the scientists attempted to replicate the virtual models with frog skin or heart cells, which were manually joined using microsurgery tools. The heart cells in these bespoke assemblies contract and relax, giving the organisms motion.

The creation of xenobots is groundbreaking. Despite being described as “programmable living robots,” they are actually completely organic and made of living tissue. The term “robot” has been used because xenobots can be configured into different forms and shapes, and “programmed” to target certain objects, which they then unwittingly seek. They can also repair themselves after being damaged.

Possible Applications
Xenobots may have great value. Some speculate they could be used to clean our polluted oceans by collecting microplastics. Similarly, they may be used to enter confined or dangerous areas to scavenge toxins or radioactive materials. Xenobots designed with carefully shaped “pouches” might be able to carry drugs into human bodies.

Future versions may be built from a patient’s own cells to repair tissue or target cancers. Being biodegradable, xenobots would have an edge on technologies made of plastic or metal.

Further development of biological “robots” could accelerate our understanding of living and robotic systems. Life is incredibly complex, so manipulating living things could reveal some of life’s mysteries—and improve our use of AI.

Legal and Ethical Questions
Conversely, xenobots raise legal and ethical concerns. In the same way they could help target cancers, they could also be used to hijack life functions for malevolent purposes.

Some argue artificially making living things is unnatural, hubristic, or involves “playing God.” A more compelling concern is that of unintended or malicious use, as we have seen with technologies in fields including nuclear physics, chemistry, biology and AI. For instance, xenobots might be used for hostile biological purposes prohibited under international law.

More advanced future xenobots, especially ones that live longer and reproduce, could potentially “malfunction” and go rogue, and out-compete other species.

For complex tasks, xenobots may need sensory and nervous systems, possibly resulting in their sentience. A sentient programmed organism would raise additional ethical questions. Last year, the revival of a disembodied pig brain elicited concerns about different species’ suffering.

Managing Risks
The xenobot’s creators have rightly acknowledged the need for discussion around the ethics of their creation. The 2018 scandal over using CRISPR (which allows the introduction of genes into an organism) may provide an instructive lesson here. While the experiment’s goal was to reduce the susceptibility of twin baby girls to HIV-AIDS, associated risks caused ethical dismay. The scientist in question is in prison.

When CRISPR became widely available, some experts called for a moratorium on heritable genome editing. Others argued the benefits outweighed the risks.

While each new technology should be considered impartially and based on its merits, giving life to xenobots raises certain significant questions:

Should xenobots have biological kill-switches in case they go rogue?
Who should decide who can access and control them?
What if “homemade” xenobots become possible? Should there be a moratorium until regulatory frameworks are established? How much regulation is required?

Lessons learned in the past from advances in other areas of science could help manage future risks, while reaping the possible benefits.

Long Road Here, Long Road Ahead
The creation of xenobots had various biological and robotic precedents. Genetic engineering has created genetically modified mice that become fluorescent in UV light.

Designer microbes can produce drugs and food ingredients that may eventually replace animal agriculture. In 2012, scientists created an artificial jellyfish called a “medusoid” from rat cells.

Robotics is also flourishing. Nanobots can monitor people’s blood sugar levels and may eventually be able to clear clogged arteries. Robots can incorporate living matter, which we witnessed when engineers and biologists created a sting-ray robot powered by light-activated cells.

In the coming years, we are sure to see more creations like xenobots that evoke both wonder and due concern. And when we do, it is important we remain both open-minded and critical.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Image Credit: Photo by Joel Filipe on Unsplash Continue reading

Posted in Human Robots

#436123 A Path Towards Reasonable Autonomous ...

Editor’s Note: The debate on autonomous weapons systems has been escalating over the past several years as the underlying technologies evolve to the point where their deployment in a military context seems inevitable. IEEE Spectrum has published a variety of perspectives on this issue. In summary, while there is a compelling argument to be made that autonomous weapons are inherently unethical and should be banned, there is also a compelling argument to be made that autonomous weapons could potentially make conflicts less harmful, especially to non-combatants. Despite an increasing amount of international attention (including from the United Nations), progress towards consensus, much less regulatory action, has been slow. The following workshop paper on autonomous weapons systems policy is remarkable because it was authored by a group of experts with very different (and in some cases divergent) views on the issue. Even so, they were able to reach consensus on a roadmap that all agreed was worth considering. It’s collaborations like this that could be the best way to establish a reasonable path forward on such a contentious issue, and with the permission of the authors, we’re excited to be able to share this paper (originally posted on Georgia Tech’s Mobile Robot Lab website) with you in its entirety.

Autonomous Weapon Systems: A Roadmapping Exercise
Over the past several years, there has been growing awareness and discussion surrounding the possibility of future lethal autonomous weapon systems that could fundamentally alter humanity’s relationship with violence in war. Lethal autonomous weapons present a host of legal, ethical, moral, and strategic challenges. At the same time, artificial intelligence (AI) technology could be used in ways that improve compliance with the laws of war and reduce non-combatant harm. Since 2014, states have come together annually at the United Nations to discuss lethal autonomous weapons systems1. Additionally, a growing number of individuals and non-governmental organizations have become active in discussions surrounding autonomous weapons, contributing to a rapidly expanding intellectual field working to better understand these issues. While a wide range of regulatory options have been proposed for dealing with the challenge of lethal autonomous weapons, ranging from a preemptive, legally binding international treaty to reinforcing compliance with existing laws of war, there is as yet no international consensus on a way forward.

The lack of an international policy consensus, whether codified in a formal document or otherwise, poses real risks. States could fall victim to a security dilemma in which they deploy untested or unsafe weapons that pose risks to civilians or international stability. Widespread proliferation could enable illicit uses by terrorists, criminals, or rogue states. Alternatively, a lack of guidance on which uses of autonomy are acceptable could stifle valuable research that could reduce the risk of non-combatant harm.

International debate thus far has predominantly centered around whether or not states should adopt a preemptive, legally-binding treaty that would ban lethal autonomous weapons before they can be built. Some of the authors of this document have called for such a treaty and would heartily support it, if states were to adopt it. Other authors of this document have argued an overly expansive treaty would foreclose the possibility of using AI to mitigate civilian harm. Options for international action are not binary, however, and there are a range of policy options that states should consider between adopting a comprehensive treaty or doing nothing.

The purpose of this paper is to explore the possibility of a middle road. If a roadmap could garner sufficient stakeholder support to have significant beneficial impact, then what elements could it contain? The exercise whose results are presented below was not to identify recommendations that the authors each prefer individually (the authors hold a broad spectrum of views), but instead to identify those components of a roadmap that the authors are all willing to entertain2. We, the authors, invite policymakers to consider these components as they weigh possible actions to address concerns surrounding autonomous weapons3.

Summary of Issues Surrounding Autonomous Weapons

There are a variety of issues that autonomous weapons raise, which might lend themselves to different approaches. A non-exhaustive list of issues includes:

The potential for beneficial uses of AI and autonomy that could improve precision and reliability in the use of force and reduce non-combatant harm.
Uncertainty about the path of future technology and the likelihood of autonomous weapons being used in compliance with the laws of war, or international humanitarian law (IHL), in different settings and on various timelines.
A desire for some degree of human involvement in the use of force. This has been expressed repeatedly in UN discussions on lethal autonomous weapon systems in different ways.
Particular risks surrounding lethal autonomous weapons specifically targeting personnel as opposed to vehicles or materiel.
Risks regarding international stability.
Risk of proliferation to terrorists, criminals, or rogue states.
Risk that autonomous systems that have been verified to be acceptable can be made unacceptable through software changes.
The potential for autonomous weapons to be used as scalable weapons enabling a small number of individuals to inflict very large-scale casualties at low cost, either intentionally or accidentally.

Summary of Components

A time-limited moratorium on the development, deployment, transfer, and use of anti-personnel lethal autonomous weapon systems4. Such a moratorium could include exceptions for certain classes of weapons.
Define guiding principles for human involvement in the use of force.
Develop protocols and/or technological means to mitigate the risk of unintentional escalation due to autonomous systems.
Develop strategies for preventing proliferation to illicit uses, such as by criminals, terrorists, or rogue states.
Conduct research to improve technologies and human-machine systems to reduce non-combatant harm and ensure IHL compliance in the use of future weapons.

Component 1:

States should consider adopting a five-year, renewable moratorium on the development, deployment, transfer, and use of anti-personnel lethal autonomous weapon systems. Anti-personnel lethal autonomous weapon systems are defined as weapons systems that, once activated, can select and engage dismounted human targets without further intervention by a human operator, possibly excluding systems such as:

Fixed-point defensive systems with human supervisory control to defend human-occupied bases or installations
Limited, proportional, automated counter-fire systems that return fire in order to provide immediate, local defense of humans
Time-limited pursuit deterrent munitions or systems
Autonomous weapon systems with size above a specified explosive weight limit that select as targets hand-held weapons, such as rifles, machine guns, anti-tank weapons, or man-portable air defense systems, provided there is adequate protection for non-combatants and ensuring IHL compliance5

The moratorium would not apply to:

Anti-vehicle or anti-materiel weapons
Non-lethal anti-personnel weapons
Research on ways of improving autonomous weapon technology to reduce non-combatant harm in future anti-personnel lethal autonomous weapon systems
Weapons that find, track, and engage specific individuals whom a human has decided should be engaged within a limited predetermined period of time and geographic region

Motivation:

This moratorium would pause development and deployment of anti-personnel lethal autonomous weapons systems to allow states to better understand the systemic risks of their use and to perform research that improves their safety, understandability, and effectiveness. Particular objectives could be to:

ensure that, prior to deployment, anti-personnel lethal autonomous weapons can be used in ways that are equal to or outperform humans in their compliance with IHL (other conditions may also apply prior to deployment being acceptable);
lay the groundwork for a potentially legally binding diplomatic instrument; and
decrease the geopolitical pressure on countries to deploy anti-personnel lethal autonomous weapons before they are reliable and well-understood.

Compliance Verification:

As part of a moratorium, states could consider various approaches to compliance verification. Potential approaches include:

Developing an industry cooperation regime analogous to that mandated under the Chemical Weapons Convention, whereby manufacturers must know their customers and report suspicious purchases of significant quantities of items such as fixed-wing drones, quadcopters, and other weaponizable robots.
Encouraging states to declare inventories of autonomous weapons for the purposes of transparency and confidence-building.
Facilitating scientific exchanges and military-to-military contacts to increase trust, transparency, and mutual understanding on topics such as compliance verification and safe operation of autonomous systems.
Designing control systems to require operator identity authentication and unalterable records of operation; enabling post-hoc compliance checks in case of plausible evidence of non-compliant autonomous weapon attacks.
Relating the quantity of weapons to corresponding capacities for human-in-the-loop operation of those weapons.
Designing weapons with air-gapped firing authorization circuits that are connected to the remote human operator but not to the on-board automated control system.
More generally, avoiding weapon designs that enable conversion from compliant to non-compliant categories or missions solely by software updates.
Designing weapons with formal proofs of relevant properties—e.g., the property that the weapon is unable to initiate an attack without human authorization. Proofs can, in principle, be provided using cryptographic techniques that allow the proofs to be checked by a third party without revealing any details of the underlying software.
Facilitate access to (non-classified) AI resources (software, data, methods for ensuring safe operation) to all states that remain in compliance and participate in transparency activities.

Component 2:

Define and universalize guiding principles for human involvement in the use of force.

Humans, not machines, are legal and moral agents in military operations.
It is a human responsibility to ensure that any attack, including one involving autonomous weapons, complies with the laws of war.
Humans responsible for initiating an attack must have sufficient understanding of the weapons, the targets, the environment and the context for use to determine whether that particular attack is lawful.
The attack must be bounded in space, time, target class, and means of attack in order for the determination about the lawfulness of that attack to be meaningful.
Militaries must invest in training, education, doctrine, policies, system design, and human-machine interfaces to ensure that humans remain responsible for attacks.

Component 3:

Develop protocols and/or technological means to mitigate the risk of unintentional escalation due to autonomous systems.

Specific potential measures include:

Developing safe rules for autonomous system behavior when in proximity to adversarial forces to avoid unintentional escalation or signaling. Examples include:

No-first-fire policy, so that autonomous weapons do not initiate hostilities without explicit human authorization.
A human must always be responsible for providing the mission for an autonomous system.
Taking steps to clearly distinguish exercises, patrols, reconnaissance, or other peacetime military operations from attacks in order to limit the possibility of reactions from adversary autonomous systems, such as autonomous air or coastal defenses.

Developing resilient communications links to ensure recallability of autonomous systems. Additionally, militaries should refrain from jamming others’ ability to recall their autonomous systems in order to afford the possibility of human correction in the event of unauthorized behavior.

Component 4:

Develop strategies for preventing proliferation to illicit uses, such as by criminals, terrorists, or rogue states:

Targeted multilateral controls to prevent large-scale sale and transfer of weaponizable robots and related military-specific components for illicit use.
Employ measures to render weaponizable robots less harmful (e.g., geofencing; hard-wired kill switch; onboard control systems largely implemented in unalterable, non-reprogrammable hardware such as application-specific integrated circuits).

Component 5:

Conduct research to improve technologies and human-machine systems to reduce non-combatant harm and ensure IHL-compliance in the use of future weapons, including:

Strategies to promote human moral engagement in decisions about the use of force
Risk assessment for autonomous weapon systems, including the potential for large-scale effects, geopolitical destabilization, accidental escalation, increased instability due to uncertainty about the relative military balance of power, and lowering thresholds to initiating conflict and for violence within conflict
Methodologies for ensuring the reliability and security of autonomous weapon systems
New techniques for verification, validation, explainability, characterization of failure conditions, and behavioral specifications.

About the Authors (in alphabetical order)

Ronald Arkin directs the Mobile Robot Laboratory at Georgia Tech.

Leslie Kaelbling is co-director of the Learning and Intelligent Systems Group at MIT.

Stuart Russell is a professor of computer science and engineering at UC Berkeley.

Dorsa Sadigh is an assistant professor of computer science and of electrical engineering at Stanford.

Paul Scharre directs the Technology and National Security Program at the Center for a New American Security (CNAS).

Bart Selman is a professor of computer science at Cornell.

Toby Walsh is a professor of artificial intelligence at the University of New South Wales (UNSW) Sydney.

The authors would like to thank Max Tegmark for organizing the three-day meeting from which this document was produced.

1 Autonomous Weapons System (AWS): A weapon system that, once activated, can select and engage targets without further intervention by a human operator. BACK TO TEXT↑

2 There is no implication that some authors would not personally support stronger recommendations. BACK TO TEXT↑

3 For ease of use, this working paper will frequently shorten “autonomous weapon system” to “autonomous weapon.” The terms should be treated as synonymous, with the understanding that “weapon” refers to the entire system: sensor, decision-making element, and munition. BACK TO TEXT↑

4 Anti-personnel lethal autonomous weapon system: A weapon system that, once activated, can select and engage dismounted human targets with lethal force and without further intervention by a human operator. BACK TO TEXT↑

5 The authors are not unanimous about this item because of concerns about ease of repurposing for mass-casualty missions targeting unarmed humans. The purpose of the lower limit on explosive payload weight would be to minimize the risk of such repurposing. There is precedent for using explosive weight limit as a mechanism of delineating between anti-personnel and anti-materiel weapons, such as the 1868 St. Petersburg Declaration Renouncing the Use, in Time of War, of Explosive Projectiles Under 400 Grammes Weight. BACK TO TEXT↑ Continue reading

Posted in Human Robots

#430830 Biocomputers Made From Cells Can Now ...

When it comes to biomolecules, RNA doesn’t get a lot of love.
Maybe you haven’t even heard of the silent workhorse. RNA is the cell’s de facto translator: like a game of telephone, RNA takes DNA’s genetic code to a cellular factory called ribosomes. There, the cell makes proteins based on RNA’s message.
But RNA isn’t just a middleman. It controls what proteins are formed. Because proteins wiz around the cell completing all sorts of important processes, you can say that RNA is the gatekeeper: no RNA message, no proteins, no life.
In a new study published in Nature, RNA finally took center stage. By adding bits of genetic material to the E. Coli bacteria, a team of biohackers at the Wyss Institute hijacked the organism’s RNA messengers so that they only spring into action following certain inputs.
The result? A bacterial biocomputer capable of performing 12-input logic operations—AND, OR, and NOT—following specific inputs. Rather than outputting 0s and 1s, these biocircuits produce results based on the presence or absence of proteins and other molecules.
“It’s the greatest number of inputs in a circuit that a cell has been able to process,” says study author Dr. Alexander Green at Arizona State University. “To be able to analyze those signals and make a decision is the big advance here.”
When given a specific set of inputs, the bacteria spit out a protein that made them glow neon green under fluorescent light.
But synthetic biology promises far more than just a party trick—by tinkering with a cell’s RNA repertoire, scientists may one day coax them to photosynthesize, produce expensive drugs on the fly, or diagnose and hunt down rogue tumor cells.
Illustration of an RNA-based ‘ribocomputing’ device that makes logic-based decisions in living cells. The long gate RNA (blue) detects the binding of an input RNA (red). The ribosome (purple/mauve) reads the gate RNA to produce an output protein. Image Credit: Alexander Green / Arizona State University
The software of life
This isn’t the first time that scientists hijacked life’s algorithms to reprogram cells into nanocomputing systems. Previous work has already introduced to the world yeast cells that can make anti-malaria drugs from sugar or mammalian cells that can perform Boolean logic.
Yet circuits with multiple inputs and outputs remain hard to program. The reason is this: synthetic biologists have traditionally focused on snipping, fusing, or otherwise arranging a cell’s DNA to produce the outcomes they want.
But DNA is two steps removed from proteins, and tinkering with life’s code often leads to unexpected consequences. For one, the cell may not even accept and produce the extra bits of DNA code. For another, the added code, when transformed into proteins, may not act accordingly in the crowded and ever-changing environment of the cell.
What’s more, tinkering with one gene is often not enough to program an entirely new circuit. Scientists often need to amp up or shut down the activity of multiple genes, or multiple biological “modules” each made up of tens or hundreds of genes.
It’s like trying to fit new Lego pieces in a specific order into a room full of Lego constructions. Each new piece has the potential to wander off track and click onto something it’s not supposed to touch.
Getting every moving component to work in sync—as you might have guessed—is a giant headache.
The RNA way
With “ribocomputing,” Green and colleagues set off to tackle a main problem in synthetic biology: predictability.
Named after the “R (ribo)” in “RNA,” the method grew out of an idea that first struck Green back in 2012.
“The synthetic biological circuits to date have relied heavily on protein-based regulators that are difficult to scale up,” Green wrote at the time. We only have a limited handful of “designable parts” that work well, and these circuits require significant resources to encode and operate, he explains.
RNA, in comparison, is a lot more predictable. Like its more famous sibling DNA, RNA is composed of units that come in four different flavors: A, G, C, and U. Although RNA is only single-stranded, rather than the double helix for which DNA is known for, it can bind short DNA-like sequences in a very predictable manner: Gs always match up with Cs and As always with Us.
Because of this predictability, it’s possible to design RNA components that bind together perfectly. In other words, it reduces the chance that added RNA bits might go rogue in an unsuspecting cell.
Normally, once RNA is produced it immediately rushes to the ribosome—the cell’s protein-building factory. Think of it as a constantly “on” system.
However, Green and his team found a clever mechanism to slow them down. Dubbed the “toehold switch,” it works like this: the artificial RNA component is first incorporated into a chain of A, G, C, and U folded into a paperclip-like structure.
This blocks the RNA from accessing the ribosome. Because one RNA strand generally maps to one protein, the switch prevents that protein from ever getting made.
In this way, the switch is set to “off” by default—a “NOT” gate, in Boolean logic.
To activate the switch, the cell needs another component: a “trigger RNA,” which binds to the RNA toehold switch. This flips it on: the RNA grabs onto the ribosome, and bam—proteins.
BioLogic gates
String a few RNA switches together, with the activity of each one relying on the one before, and it forms an “AND” gate. Alternatively, if the activity of each switch is independent, that’s an “OR” gate.
“Basically, the toehold switches performed so well that we wanted to find a way to best exploit them for cellular applications,” says Green. They’re “kind of the equivalent of your first transistors,” he adds.
Once the team optimized the designs for different logic gates, they carefully condensed the switches into “gate RNA” molecules. These gate RNAs contain both codes for proteins and the logic operations needed to kickstart the process—a molecular logic circuit, so to speak.
If you’ve ever played around with an Arduino-controlled electrical circuit, you probably know the easiest way to test its function is with a light bulb.
That’s what the team did here, though with a biological bulb: green fluorescent protein, a light-sensing protein not normally present in bacteria that—when turned on—makes the microbugs glow neon green.
In a series of experiments, Green and his team genetically inserted gate RNAs into bacteria. Then, depending on the type of logical function, they added different combinations of trigger RNAs—the inputs.
When the input RNA matched up with its corresponding gate RNA, it flipped on the switch, causing the cell to light up.

Their most complex circuit contained five AND gates, five OR gates, and two NOTs—a 12-input ribocomputer that functioned exactly as designed.
That’s quite the achievement. “Everything is interacting with everything else and there are a million ways those interactions could flip the switch on accident,” says RNA researcher Dr. Julies Lucks at Northwestern University.
The specificity is thanks to RNA, the authors explain. Because RNAs bind to others so predictably, we can now design massive libraries of gate and trigger units to mix-and-match into all types of nano-biocomputers.
RNA BioNanobots
Although the technology doesn’t have any immediate applications, the team has high hopes.
For the first time, it’s now possible to massively scale up the process of programming new circuits into living cells. We’ve expanded the library of available biocomponents that can be used to reprogram life’s basic code, the authors say.
What’s more, when freeze-dried onto a piece of tissue paper, RNA keeps very well. We could potentially print RNA toehold switches onto paper that respond to viruses or to tumor cells, the authors say, essentially transforming the technology into highly accurate diagnostic platforms.
But Green’s hopes are even wilder for his RNA-based circuits.
“Because we’re using RNA, a universal molecule of life, we know these interactions can also work in other cells, so our method provides a general strategy that could be ported to other organisms,” he says.
Ultimately, the hope is to program neural network-like capabilities into the body’s other cells.
Imagine cells endowed with circuits capable of performing the kinds of computation the brain does, the authors say.
Perhaps one day, synthetic biology will transform our own cells into fully programmable entities, turning us all into biological cyborgs from the inside. How wild would that be?
Image Credit: Wyss Institute at Harvard University Continue reading

Posted in Human Robots

#428130 Autonomous – A Sci-Fi Short movie

AUTONOMOUS is an award-winning Sci-Fi short film that unofficially premiered at the 35th SGAI International Conference on Artificial Intelligence at the University of Cambridge. It recently won the Silver Award at The Box Film Festival 2016 (UK) and is an official selection in ten more film festivals around the world.
Featured Photo Credit: George VarotsisPremise: When a mistrustful rogue, who earns a living by sending “obsolete” humanoid robots to the scrap heap, has a change of heart and decides it’s time to call it quits, he stumbles upon a conspiracy that will reveal his life’s darkest secret.

You can watch the film here: https://www.youtube.com/watch?v=Dj92Mh2l8kk

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Posted in Human Robots