Tag Archives: rockefeller
#435822 The Internet Is Coming to the Rest of ...
People surf it. Spiders crawl it. Gophers navigate it.
Now, a leading group of cognitive biologists and computer scientists want to make the tools of the Internet accessible to the rest of the animal kingdom.
Dubbed the Interspecies Internet, the project aims to provide intelligent animals such as elephants, dolphins, magpies, and great apes with a means to communicate among each other and with people online.
And through artificial intelligence, virtual reality, and other digital technologies, researchers hope to crack the code of all the chirps, yips, growls, and whistles that underpin animal communication.
Oh, and musician Peter Gabriel is involved.
“We can use data analysis and technology tools to give non-humans a lot more choice and control,” the former Genesis frontman, dressed in his signature Nehru-style collar shirt and loose, open waistcoat, told IEEE Spectrum at the inaugural Interspecies Internet Workshop, held Monday in Cambridge, Mass. “This will be integral to changing our relationship with the natural world.”
The workshop was a long time in the making.
Eighteen years ago, Gabriel visited a primate research center in Atlanta, Georgia, where he jammed with two bonobos, a male named Kanzi and his half-sister Panbanisha. It was the first time either bonobo had sat at a piano before, and both displayed an exquisite sense of musical timing and melody.
Gabriel seemed to be speaking to the great apes through his synthesizer. It was a shock to the man who once sang “Shock the Monkey.”
“It blew me away,” he says.
Add in the bonobos’ ability to communicate by pointing to abstract symbols, Gabriel notes, and “you’d have to be deaf, dumb, and very blind not to notice language being used.”
Gabriel eventually teamed up with Internet protocol co-inventor Vint Cerf, cognitive psychologist Diana Reiss, and IoT pioneer Neil Gershenfeld to propose building an Interspecies Internet. Presented in a 2013 TED Talk as an “idea in progress,” the concept proved to be ahead of the technology.
“It wasn’t ready,” says Gershenfeld, director of MIT’s Center for Bits and Atoms. “It needed to incubate.”
So, for the past six years, the architects of the Dolittlesque initiative embarked on two small pilot projects, one for dolphins and one for chimpanzees.
At her Hunter College lab in New York City, Reiss developed what she calls the D-Pad—a touchpad for dolphins.
Reiss had been trying for years to create an underwater touchscreen with which to probe the cognition and communication skills of bottlenose dolphins. But “it was a nightmare coming up with something that was dolphin-safe and would work,” she says.
Her first attempt emitted too much heat. A Wii-like system of gesture recognition proved too difficult to install in the dolphin tanks.
Eventually, she joined forces with Rockefeller University biophysicist Marcelo Magnasco and invented an optical detection system in which images and infrared sensors are projected through an underwater viewing window onto a glass panel, allowing the dolphins to play specially designed apps, including one dubbed Whack-a-Fish.
Meanwhile, in the United Kingdom, Gabriel worked with Alison Cronin, director of the ape rescue center Monkey World, to test the feasibility of using FaceTime with chimpanzees.
The chimps engaged with the technology, Cronin reported at this week’s workshop. However, our hominid cousins proved as adept at videotelephonic discourse as my three-year-old son is at video chatting with his grandparents—which is to say, there was a lot of pass-the-banana-through-the-screen and other silly games, and not much meaningful conversation.
“We can use data analysis and technology tools to give non-humans a lot more choice and control.”
—Peter Gabriel
The buggy, rudimentary attempt at interspecies online communication—what Cronin calls her “Max Headroom experiment”—shows that building the Interspecies Internet will not be as simple as giving out Skype-enabled tablets to smart animals.
“There are all sorts of problems with creating a human-centered experience for another animal,” says Gabriel Miller, director of research and development at the San Diego Zoo.
Miller has been working on animal-focused sensory tools such as an “Elephone” (for elephants) and a “Joybranch” (for birds), but it’s not easy to design efficient interactive systems for other creatures—and for the Interspecies Internet to be successful, Miller points out, “that will be super-foundational.”
Researchers are making progress on natural language processing of animal tongues. Through a non-profit organization called the Earth Species Project, former Firefox designer Aza Raskin and early Twitter engineer Britt Selvitelle are applying deep learning algorithms developed for unsupervised machine translation of human languages to fashion a Rosetta Stone–like tool capable of interpreting the vocalizations of whales, primates, and other animals.
Inspired by the scientists who first documented the complex sonic arrangements of humpback whales in the 1960s—a discovery that ushered in the modern marine conservation movement—Selvitelle hopes that an AI-powered animal translator can have a similar effect on environmentalism today.
“A lot of shifts happen when someone who doesn’t have a voice gains a voice,” he says.
A challenge with this sort of AI software remains verification and validation. Normally, machine-learning algorithms are benchmarked against a human expert, but who is to say if a cybernetic translation of a sperm whale’s clicks is accurate or not?
One could back-translate an English expression into sperm whale-ese and then into English again. But with the great apes, there might be a better option.
According to primatologist Sue Savage-Rumbaugh, expertly trained bonobos could serve as bilingual interpreters, translating the argot of apes into the parlance of people, and vice versa.
Not just any trained ape will do, though. They have to grow up in a mixed Pan/Homo environment, as Kanzi and Panbanisha were.
“If I can have a chat with a cow, maybe I can have more compassion for it.”
—Jeremy Coller
Those bonobos were raised effectively from birth both by Savage-Rumbaugh, who taught the animals to understand spoken English and to communicate via hundreds of different pictographic “lexigrams,” and a bonobo mother named Matata that had lived for six years in the Congolese rainforests before her capture.
Unlike all other research primates—which are brought into captivity as infants, reared by human caretakers, and have limited exposure to their natural cultures or languages—those apes thus grew up fluent in both bonobo and human.
Panbanisha died in 2012, but Kanzi, aged 38, is still going strong, living at an ape sanctuary in Des Moines, Iowa. Researchers continue to study his cognitive abilities—Francine Dolins, a primatologist at the University of Michigan-Dearborn, is running one study in which Kanzi and other apes hunt rabbits and forage for fruit through avatars on a touchscreen. Kanzi could, in theory, be recruited to check the accuracy of any Google Translate–like app for bonobo hoots, barks, grunts, and cries.
Alternatively, Kanzi could simply provide Internet-based interpreting services for our two species. He’s already proficient at video chatting with humans, notes Emily Walco, a PhD student at Harvard University who has personally Skyped with Kanzi. “He was super into it,” Walco says.
And if wild bonobos in Central Africa can be coaxed to gather around a computer screen, Savage-Rumbaugh is confident Kanzi could communicate with them that way. “It can all be put together,” she says. “We can have an Interspecies Internet.”
“Both the technology and the knowledge had to advance,” Savage-Rumbaugh notes. However, now, “the techniques that we learned could really be extended to a cow or a pig.”
That’s music to the ears of Jeremy Coller, a private equity specialist whose foundation partially funded the Interspecies Internet Workshop. Coller is passionate about animal welfare and has devoted much of his philanthropic efforts toward the goal of ending factory farming.
At the workshop, his foundation announced the creation of the Coller Doolittle Prize, a US $100,000 award to help fund further research related to the Interspecies Internet. (A working group also formed to synthesize plans for the emerging field, to facilitate future event planning, and to guide testing of shared technology platforms.)
Why would a multi-millionaire with no background in digital communication systems or cognitive psychology research want to back the initiative? For Coller, the motivation boils to interspecies empathy.
“If I can have a chat with a cow,” he says, “maybe I can have more compassion for it.”
An abridged version of this post appears in the September 2019 print issue as “Elephants, Dolphins, and Chimps Need the Internet, Too.” Continue reading
Posted in Human Robots
#431189 Researchers Develop New Tech to Predict ...
It is one of the top 10 deadliest diseases in the United States, and it cannot be cured or prevented. But new studies are finding ways to diagnose Alzheimer’s disease in its earliest stages, while some of the latest research says technologies like artificial intelligence can detect dementia years before the first symptoms occur.
These advances, in turn, will help bolster clinical trials seeking a cure or therapies to slow or prevent the disease. Catching Alzheimer’s disease or other forms of dementia early in their progression can help ease symptoms in some cases.
“Often neurodegeneration is diagnosed late when massive brain damage has already occurred,” says professor Francis L Martin at the University of Central Lancashire in the UK, in an email to Singularity Hub. “As we know more about the molecular basis of the disease, there is the possibility of clinical interventions that might slow or halt the progress of the disease, i.e., before brain damage. Extending cognitive ability for even a number of years would have huge benefit.”
Blood Diamond
Martin is the principal investigator on a project that has developed a technique to analyze blood samples to diagnose Alzheimer’s disease and distinguish between other forms of dementia.
The researchers used sensor-based technology with a diamond core to analyze about 550 blood samples. They identified specific chemical bonds within the blood after passing light through the diamond core and recording its interaction with the sample. The results were then compared against blood samples from cases of Alzheimer’s disease and other neurodegenerative diseases, along with those from healthy individuals.
“From a small drop of blood, we derive a fingerprint spectrum. That fingerprint spectrum contains numerical data, which can be inputted into a computational algorithm we have developed,” Martin explains. “This algorithm is validated for prediction of unknown samples. From this we determine sensitivity and specificity. Although not perfect, my clinical colleagues reliably tell me our results are far better than anything else they have seen.”
Martin says the breakthrough is the result of more than 10 years developing sensor-based technologies for routine screening, monitoring, or diagnosing neurodegenerative diseases and cancers.
“My vision was to develop something low-cost that could be readily applied in a typical clinical setting to handle thousands of samples potentially per day or per week,” he says, adding that the technology also has applications in environmental science and food security.
The new test can also distinguish accurately between Alzheimer’s disease and other forms of neurodegeneration, such as Lewy body dementia, which is one of the most common causes of dementia after Alzheimer’s.
“To this point, other than at post-mortem, there has been no single approach towards classifying these pathologies,” Martin notes. “MRI scanning is often used but is labor-intensive, costly, difficult to apply to dementia patients, and not a routine point-of-care test.”
Crystal Ball
Canadian researchers at McGill University believe they can predict Alzheimer’s disease up to two years before its onset using big data and artificial intelligence. They developed an algorithm capable of recognizing the signatures of dementia using a single amyloid PET scan of the brain of patients at risk of developing the disease.
Alzheimer’s is caused by the accumulation of two proteins—amyloid beta and tau. The latest research suggests that amyloid beta leads to the buildup of tau, which is responsible for damaging nerve cells and connections between cells called synapses.
The work was recently published in the journal Neurobiology of Aging.
“Despite the availability of biomarkers capable of identifying the proteins causative of Alzheimer’s disease in living individuals, the current technologies cannot predict whether carriers of AD pathology in the brain will progress to dementia,” Sulantha Mathotaarachchi, lead author on the paper and an expert in artificial neural networks, tells Singularity Hub by email.
The algorithm, trained on a population with amnestic mild cognitive impairment observed over 24 months, proved accurate 84.5 percent of the time. Mathotaarachchi says the algorithm can be trained on different populations for different observational periods, meaning the system can grow more comprehensive with more data.
“The more biomarkers we incorporate, the more accurate the prediction could be,” Mathotaarachchi adds. “However, right now, acquiring [the] required amount of training data is the biggest challenge. … In Alzheimer’s disease, it is known that the amyloid protein deposition occurs decades before symptoms onset.”
Unfortunately, the same process occurs in normal aging as well. “The challenge is to identify the abnormal patterns of deposition that lead to the disease later on,” he says
One of the key goals of the project is to improve the research in Alzheimer’s disease by ensuring those patients with the highest probability to develop dementia are enrolled in clinical trials. That will increase the efficiency of clinical programs, according to Mathotaarachchi.
“One of the most important outcomes from our study was the pilot, online, real-time prediction tool,” he says. “This can be used as a framework for patient screening before recruiting for clinical trials. … If a disease-modifying therapy becomes available for patients, a predictive tool might have clinical applications as well, by providing to the physician information regarding clinical progression.”
Pixel by Pixel Prediction
Private industry is also working toward improving science’s predictive powers when it comes to detecting dementia early. One startup called Darmiyan out of San Francisco claims its proprietary software can pick up signals before the onset of Alzheimer’s disease by up to 15 years.
Darmiyan didn’t respond to a request for comment for this article. Venture Beat reported that the company’s MRI-analyzing software “detects cell abnormalities at a microscopic level to reveal what a standard MRI scan cannot” and that the “software measures and highlights subtle microscopic changes in the brain tissue represented in every pixel of the MRI image long before any symptoms arise.”
Darmiyan claims to have a 90 percent accuracy rate and says its software has been vetted by top academic institutions like New York University, Rockefeller University, and Stanford, according to Venture Beat. The startup is awaiting FDA approval to proceed further but is reportedly working with pharmaceutical companies like Amgen, Johnson & Johnson, and Pfizer on pilot programs.
“Our technology enables smarter drug selection in preclinical animal studies, better patient selection for clinical trials, and much better drug-effect monitoring,” Darmiyan cofounder and CEO Padideh Kamali-Zare told Venture Beat.
Conclusions
An estimated 5.5 million Americans have Alzheimer’s, and one in 10 people over age 65 have been diagnosed with the disease. By mid-century, the number of Alzheimer’s patients could rise to 16 million. Health care costs in 2017 alone are estimated to be $259 billion, and by 2050 the annual price tag could be more than $1 trillion.
In sum, it’s a disease that cripples people and the economy.
Researchers are always after more data as they look to improve outcomes, with the hope of one day developing a cure or preventing the onset of neurodegeneration altogether. If interested in seeing this medical research progress, you can help by signing up on the Brain Health Registry to improve the quality of clinical trials.
Image Credit: rudall30 / Shutterstock.com Continue reading
Posted in Human Robots