Tag Archives: inverse

#439077 How Scientists Grew Human Muscles in Pig ...

The little pigs bouncing around the lab looked exceedingly normal. Yet their adorable exterior hid a remarkable secret: each piglet carried two different sets of genes. For now, both sets came from their own species. But one day, one of those sets may be human.

The piglets are chimeras—creatures with intermingled sets of genes, as if multiple entities were seamlessly mashed together. Named after the Greek lion-goat-serpent monsters, chimeras may hold the key to an endless supply of human organs and tissues for transplant. The crux is growing these human parts in another animal—one close enough in size and function to our own.

Last week, a team from the University of Minnesota unveiled two mind-bending chimeras. One was joyous little piglets, each propelled by muscles grown from a different pig. Another was pig embryos, transplanted into surrogate pigs, that developed human muscles for more than 20 days.

The study, led by Drs. Mary and Daniel Garry at the University of Minnesota, had a therapeutic point: engineering a brilliant way to replace muscle loss, especially for the muscles around our skeletons that allow us to move and navigate the world. Trauma and injury, such as from firearm wounds or car crashes, can damage muscle tissue beyond the point of repair. Unfortunately, muscles are also stubborn in that donor tissue from cadavers doesn’t usually “take” at the injury site. For now, there are no effective treatments for severe muscle death, called volumetric muscle loss.

The new human-pig hybrids are designed to tackle this problem. Muscle wasting aside, the study also points to a clever “hack” that increases the amount of human tissue inside a growing pig embryo.

If further improved, the technology could “provide an unlimited supply of organs for transplantation,” said Dr. Mary Garry to Inverse. What’s more, because the human tissue can be sourced from patients themselves, the risk of rejection by the immune system is relatively low—even when grown inside a pig.

“The shortage of organs for heart transplantation, vascular grafting, and skeletal muscle is staggering,” said Garry. Human-animal chimeras could have a “seismic impact” that transforms organ transplantation and helps solve the organ shortage crisis.

That is, if society accepts the idea of a semi-humanoid pig.

Wait…But How?
The new study took a page from previous chimera recipes.

The main ingredients and steps go like this: first, you need an embryo that lacks the ability to develop a tissue or organ. This leaves an “empty slot” of sorts that you can fill with another set of genes—pig, human, or even monkey.

Second, you need to fine-tune the recipe so that the embryos “take” the new genes, incorporating them into their bodies as if they were their own. Third, the new genes activate to instruct the growing embryo to make the necessary tissue or organs without harming the overall animal. Finally, the foreign genes need to stay put, without cells migrating to another body part—say, the brain.

Not exactly straightforward, eh? The piglets are technological wonders that mix cutting-edge gene editing with cloning technologies.

The team went for two chimeras: one with two sets of pig genes, the other with a pig and human mix. Both started with a pig embryo that can’t make its own skeletal muscles (those are the muscles surrounding your bones). Using CRISPR, the gene-editing Swiss Army Knife, they snipped out three genes that are absolutely necessary for those muscles to develop. Like hitting a bullseye with three arrows simultaneously, it’s already a technological feat.

Here’s the really clever part: the muscles around your bones have a slightly different genetic makeup than the ones that line your blood vessels or the ones that pump your heart. While the resulting pig embryos had severe muscle deformities as they developed, their hearts beat as normal. This means the gene editing cut only impacted skeletal muscles.

Then came step two: replacing the missing genes. Using a microneedle, the team injected a fertilized and slightly developed pig egg—called a blastomere—into the embryo. If left on its natural course, a blastomere eventually develops into another embryo. This step “smashes” the two sets of genes together, with the newcomer filling the muscle void. The hybrid embryo was then placed into a surrogate, and roughly four months later, chimeric piglets were born.

Equipped with foreign DNA, the little guys nevertheless seemed totally normal, nosing around the lab and running everywhere without obvious clumsy stumbles. Under the microscope, their “xenomorph” muscles were indistinguishable from run-of-the-mill average muscle tissue—no signs of damage or inflammation, and as stretchy and tough as muscles usually are. What’s more, the foreign DNA seemed to have only developed into muscles, even though they were prevalent across the body. Extensive fishing experiments found no trace of the injected set of genes inside blood vessels or the brain.

A Better Human-Pig Hybrid
Confident in their recipe, the team next repeated the experiment with human cells, with a twist. Instead of using controversial human embryonic stem cells, which are obtained from aborted fetuses, they relied on induced pluripotent stem cells (iPSCs). These are skin cells that have been reverted back into a stem cell state.

Unlike previous attempts at making human chimeras, the team then scoured the genetic landscape of how pig and human embryos develop to find any genetic “brakes” that could derail the process. One gene, TP53, stood out, which was then promptly eliminated with CRISPR.

This approach provides a way for future studies to similarly increase the efficiency of interspecies chimeras, the team said.

The human-pig embryos were then carefully grown inside surrogate pigs for less than a month, and extensively analyzed. By day 20, the hybrids had already grown detectable human skeletal muscle. Similar to the pig-pig chimeras, the team didn’t detect any signs that the human genes had sprouted cells that would eventually become neurons or other non-muscle cells.

For now, human-animal chimeras are not allowed to grow to term, in part to stem the theoretical possibility of engineering humanoid hybrid animals (shudder). However, a sentient human-pig chimera is something that the team specifically addressed. Through multiple experiments, they found no trace of human genes in the embryos’ brain stem cells 20 and 27 days into development. Similarly, human donor genes were absent in cells that would become the hybrid embryos’ reproductive cells.

Despite bioethical quandaries and legal restrictions, human-animal chimeras have taken off, both as a source of insight into human brain development and a well of personalized organs and tissues for transplant. In 2019, Japan lifted its ban on developing human brain cells inside animal embryos, as well as the term limit—to global controversy. There’s also the question of animal welfare, given that hybrid clones will essentially become involuntary organ donors.

As the debates rage on, scientists are nevertheless pushing the limits of human-animal chimeras, while treading as carefully as possible.

“Our data…support the feasibility of the generation of these interspecies chimeras, which will serve as a model for translational research or, one day, as a source for xenotransplantation,” the team said.

Image Credit: Christopher Carson on Unsplash Continue reading

Posted in Human Robots

#438613 Video Friday: Digit Takes a Hike

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

HRI 2021 – March 8-11, 2021 – [Online Conference]
RoboSoft 2021 – April 12-16, 2021 – [Online Conference]
ICRA 2021 – May 30-5, 2021 – Xi'an, China
Let us know if you have suggestions for next week, and enjoy today's videos.

It's winter in Oregon, so everything is damp, all the time. No problem for Digit!

Also the case for summer in Oregon.

[ Agility Robotics ]

While other organisms form collective flocks, schools, or swarms for such purposes as mating, predation, and protection, the Lumbriculus variegatus worms are unusual in their ability to braid themselves together to accomplish tasks that unconnected individuals cannot. A new study reported by researchers at the Georgia Institute of Technology describes how the worms self-organize to act as entangled “active matter,” creating surprising collective behaviors whose principles have been applied to help blobs of simple robots evolve their own locomotion.

No, this doesn't squick me out at all, why would it.

[ Georgia Tech ]

A few years ago, we wrote about Zhifeng Huang's jet-foot equipped bipedal robot, and he's been continuing to work on it to the point where it can now step over gaps that are an absolutely astonishing 147% of its leg length.

[ Paper ]

Thanks Zhifeng!

The Inception Drive is a novel, ultra-compact design for an Infinitely Variable Transmission (IVT) that uses nested-pulleys to adjust the gear ratio between input and output shafts. This video shows the first proof-of-concept prototype for a “Fully Balanced” design, where the spinning masses within the drive are completely balanced to reduce vibration, thereby allowing the drive to operate more efficiently and at higher speeds than achievable on an unbalanced design.

As shown in this video, the Inception Drive can change both the speed and direction of rotation of the output shaft while keeping the direction and speed of the input shaft constant. This ability to adjust speed and direction within such a compact package makes the Inception Drive a compelling choice for machine designers in a wide variety of fields, including robotics, automotive, and renewable-energy generation.

[ SRI ]

Robots with kinematic loops are known to have superior mechanical performance. However, due to these loops, their modeling and control is challenging, and prevents a more widespread use. In this paper, we describe a versatile Inverse Kinematics (IK) formulation for the retargeting of expressive motions onto mechanical systems with loops.

[ Disney Research ]

Watch Engineered Arts put together one of its Mesmer robots in a not at all uncanny way.

[ Engineered Arts ]

There's been a bunch of interesting research into vision-based tactile sensing recently; here's some from Van Ho at JAIST:

[ Paper ]

Thanks Van!

This is really more of an automated system than a robot, but these little levitating pucks are very very slick.

ACOPOS 6D is based on the principle of magnetic levitation: Shuttles with integrated permanent magnets float over the surface of electromagnetic motor segments. The modular motor segments are 240 x 240 millimeters in size and can be arranged freely in any shape. A variety of shuttle sizes carry payloads of 0.6 to 14 kilograms and reach speeds of up to 2 meters per second. They can move freely in two-dimensional space, rotate and tilt along three axes and offer precise control over the height of levitation. All together, that gives them six degrees of motion control freedom.

[ ACOPOS ]

Navigation and motion control of a robot to a destination are tasks that have historically been performed with the assumption that contact with the environment is harmful. This makes sense for rigid-bodied robots where obstacle collisions are fundamentally dangerous. However, because many soft robots have bodies that are low-inertia and compliant, obstacle contact is inherently safe. We find that a planner that takes into account and capitalizes on environmental contact produces paths that are more robust to uncertainty than a planner that avoids all obstacle contact.

[ CHARM Lab ]

The quadrotor experts at UZH have been really cranking it up recently.

Aerodynamic forces render accurate high-speed trajectory tracking with quadrotors extremely challenging. These complex aerodynamic effects become a significant disturbance at high speeds, introducing large positional tracking errors, and are extremely difficult to model. To fly at high speeds, feedback control must be able to account for these aerodynamic effects in real-time. This necessitates a modelling procedure that is both accurate and efficient to evaluate. Therefore, we present an approach to model aerodynamic effects using Gaussian Processes, which we incorporate into a Model Predictive Controller to achieve efficient and precise real-time feedback control, leading to up to 70% reduction in trajectory tracking error at high speeds. We verify our method by extensive comparison to a state-of-the-art linear drag model in synthetic and real-world experiments at speeds of up to 14m/s and accelerations beyond 4g.

[ Paper ]

I have not heard much from Harvest Automation over the last couple years and their website was last updated in 2016, but I guess they're selling robots in France, so that's good?

[ Harvest Automation ]

Last year, Clearpath Robotics introduced a ROS package for Spot which enables robotics developers to leverage ROS capabilities out-of-the-box. Here at OTTO Motors, we thought it would be a compelling test case to see just how easy it would be to integrate Spot into our test fleet of OTTO materials handling robots.

[ OTTO Motors ]

Video showcasing recent robotics activities at PRISMA Lab, coordinated by Prof. Bruno Siciliano, at Università di Napoli Federico II.

[ PRISMA Lab ]

Thanks Fan!

State estimation framework developed by the team CoSTAR for the DARPA Subterranean Challenge, where the team achieved 2nd and 1st places in the Tunnel and Urban circuits.

[ Paper ]

Highlights from the 2020 ROS Industrial conference.

[ ROS Industrial ]

Thanks Thilo!

Not robotics, but entertaining anyway. From the CHI 1995 Technical Video Program, “The Tablet Newspaper: a Vision for the Future.”

[ CHI 1995 ]

This week's GRASP on Robotics seminar comes from Allison Okamura at Stanford, on “Wearable Haptic Devices for Ubiquitous Communication.”

Haptic devices allow touch-based information transfer between humans and intelligent systems, enabling communication in a salient but private manner that frees other sensory channels. For such devices to become ubiquitous, their physical and computational aspects must be intuitive and unobtrusive. We explore the design of a wide array of haptic feedback mechanisms, ranging from devices that can be actively touched by the fingertips to multi-modal haptic actuation mounted on the arm. We demonstrate how these devices are effective in virtual reality, human-machine communication, and human-human communication.

[ UPenn ] Continue reading

Posted in Human Robots

#437800 Malleable Structure Makes Robot Arm More ...

The majority of robot arms are built out of some combination of long straight tubes and actuated joints. This isn’t surprising, since our limbs are built the same way, which was a clever and efficient bit of design. By adding more tubes and joints (or degrees of freedom), you can increase the versatility of your robot arm, but the tradeoff is that complexity, weight, and cost will increase, too.

At ICRA, researchers from Imperial College London’s REDS Lab, headed by Nicolas Rojas, introduced a design for a robot that’s built around a malleable structure rather than a rigid one, allowing you to improve how versatile the arm is without having to add extra degrees of freedom. The idea is that you’re no longer constrained to static tubes and joints but can instead reconfigure your robot to set it up exactly the way you want and easily change it whenever you feel like.

Inside of that bendable section of arm are layers and layers of mylar sheets, cut into flaps and stacked on top of one another so that each flap is overlapping or overlapped by at least 11 other flaps. The mylar is slippery enough that under most circumstances, the flaps can move smoothly against each other, letting you adjust the shape of the arm. The flaps are sealed up between latex membranes, and when air is pumped out from between the membranes, they press down on each other and turn the whole structure rigid, locking itself in whatever shape you’ve put it in.

Image: Imperial College London

The malleable part of the robot consists of layers of mylar sheets, cut into flaps that can move smoothly against each other, letting you adjust the shape of the arm. The flaps are sealed up between latex membranes, and when air is pumped out from between the membranes, they press down on each other and turn the whole structure rigid, locking itself in whatever shape you’ve put it in.

The nice thing about this system is that it’s a sort of combination of a soft robot and a rigid robot—you get the flexibility (both physical and metaphorical) of a soft system, without necessarily having to deal with all of the control problems. It’s more mechanically complex than either (as hybrid systems tend to be), but you save on cost, size, and weight, and reduce the number of actuators you need, which tend to be points of failure. You do need to deal with creating and maintaining a vacuum, and the fact that the malleable arm is not totally rigid, but depending on your application, those tradeoffs could easily be worth it.

For more details, we spoke with first author Angus B. Clark via email.

IEEE Spectrum: Where did this idea come from?

Angus Clark: The idea of malleable robots came from the realization that the majority of serial robot arms have 6 or more degrees of freedom (DoF)—usually rotary joints—yet are typically performing tasks that only require 2 or 3 DoF. The idea of a robot arm that achieves flexibility and adaptation to tasks but maintains the simplicity of a low DoF system, along with the rapid development of variable stiffness continuum robots for medical applications, inspired us to develop the malleable robot concept.

What are some ways in which a malleable robot arm could provide unique advantages, and what are some potential applications that could leverage these advantages?

Malleable robots have the ability to complete multiple traditional tasks, such as pick and place or bin picking operations, without the added bulk of extra joints that are not directly used within each task, as the flexibility of the robot arm is provided by ​a malleable link instead. This results in an overall smaller form factor, including weight and footprint of the robot, as well as a lower power requirement and cost of the robot as fewer joints are needed, without sacrificing adaptability. This makes the robot ideal for scenarios where any of these factors are critical, such as in space robotics—where every kilogram saved is vital—or in rehabilitation robotics, where cost reduction may facilitate adoption, to name two examples. Moreover, the collaborative soft-robot-esque nature of malleable robots also tends towards collaborative robots in factories working safely alongside and with humans.

“The idea of malleable robots came from the realization that the majority of serial robot arms have 6 or more degrees of freedom (DoF), yet are typically performing tasks that only require 2 or 3 DoF”
—Angus B. Clark, Imperial College London

Compared to a conventional rigid link between joints, what are the disadvantages of using a malleable link?

Currently the maximum stiffness of a malleable link is considerably weaker than that of an equivalent solid steel rigid link, and this is one of the key areas we are focusing research on improving as motion precision and accuracy are impacted. We have created the largest existing variable stiffness link at roughly 800 mm length and 50 mm diameter, which suits malleable robots towards small and medium size workspaces. Our current results evaluating this accuracy are good, however achieving a uniform stiffness across the entire malleable link can be problematic due to the production of wrinkles under bending in the encapsulating membrane. As demonstrated by our SCARA topology results, this can produce slight structural variations resulting in reduced accuracy.

Does the robot have any way of knowing its own shape? Potentially, could this system reconfigure itself somehow?

Currently we compute the robot topology using motion tracking, with markers placed on the joints of the robot. Using distance geometry, we are then able to obtain the forward and inverse kinematics of the robot, of which we can use to control the end effector (the gripper) of the robot. Ideally, in the future we would love to develop a system that no longer requires the use of motion tracking cameras.

As for the robot reconfiguring itself, which we call an “intrinsic malleable link,” there are many methods that have been demonstrated for controlling a continuum structure, such as using positive pressure or via tendon wires, however the ability to in real-time determine the curvature of the link, not just the joint positions, is a significant hurdle to solve. However, we hope to see future development on malleable robots work towards solving this problem.

What are you working on next?

For us, refining the kinematics of the robot to enable a robust and complete system for allowing a user to collaboratively reshape the robot, while still achieving the accuracy expected from robotic systems, is our current main goal. Malleable robots are a brand new field we have introduced, and as such provide many opportunities for development and optimization. Over the coming years, we hope to see other researchers work alongside us to solve these problems.

“Design and Workspace Characterization of Malleable Robots,” by Angus B. Clark and Nicolas Rojas from Imperial College London, was presented at ICRA 2020.

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Posted in Human Robots

#428053 Omnidirectional Mobile Robot Has Just ...

Spherical Induction Motor Eliminates Robot’s Mechanical Drive System
PITTSBURGH— More than a decade ago, Ralph Hollis invented the ballbot, an elegantly simple robot whose tall, thin body glides atop a sphere slightly smaller than a bowling ball. The latest version, called SIMbot, has an equally elegant motor with just one moving part: the ball.
The only other active moving part of the robot is the body itself.
The spherical induction motor (SIM) invented by Hollis, a research professor in Carnegie Mellon University’s Robotics Institute, and Masaaki Kumagai, a professor of engineering at Tohoku Gakuin University in Tagajo, Japan, eliminates the mechanical drive systems that each used on previous ballbots. Because of this extreme mechanical simplicity, SIMbot requires less routine maintenance and is less likely to suffer mechanical failures.
The new motor can move the ball in any direction using only electronic controls. These movements keep SIMbot’s body balanced atop the ball.
Early comparisons between SIMbot and a mechanically driven ballbot suggest the new robot is capable of similar speed — about 1.9 meters per second, or the equivalent of a very fast walk — but is not yet as efficient, said Greg Seyfarth, a former member of Hollis’ lab who recently completed his master’s degree in robotics.
Induction motors are nothing new; they use magnetic fields to induce electric current in the motor’s rotor, rather than through an electrical connection. What is new here is that the rotor is spherical and, thanks to some fancy math and advanced software, can move in any combination of three axes, giving it omnidirectional capability. In contrast to other attempts to build a SIM, the design by Hollis and Kumagai enables the ball to turn all the way around, not just move back and forth a few degrees.
Though Hollis said it is too soon to compare the cost of the experimental motor with conventional motors, he said long-range trends favor the technologies at its heart.
“This motor relies on a lot of electronics and software,” he explained. “Electronics and software are getting cheaper. Mechanical systems are not getting cheaper, or at least not as fast as electronics and software are.”
SIMbot’s mechanical simplicity is a significant advance for ballbots, a type of robot that Hollis maintains is ideally suited for working with people in human environments. Because the robot’s body dynamically balances atop the motor’s ball, a ballbot can be as tall as a person, but remain thin enough to move through doorways and in between furniture. This type of robot is inherently compliant, so people can simply push it out of the way when necessary. Ballbots also can perform tasks such as helping a person out of a chair, helping to carry parcels and physically guiding a person.
Until now, moving the ball to maintain the robot’s balance has relied on mechanical means. Hollis’ ballbots, for instance, have used an “inverse mouse ball” method, in which four motors actuate rollers that press against the ball so that it can move in any direction across a floor, while a fifth motor controls the yaw motion of the robot itself.
“But the belts that drive the rollers wear out and need to be replaced,” said Michael Shomin, a Ph.D. student in robotics. “And when the belts are replaced, the system needs to be recalibrated.” He said the new motor’s solid-state system would eliminate that time-consuming process.
The rotor of the spherical induction motor is a precisely machined hollow iron ball with a copper shell. Current is induced in the ball with six laminated steel stators, each with three-phase wire windings. The stators are positioned just next to the ball and are oriented slightly off vertical.
The six stators generate travelling magnetic waves in the ball, causing the ball to move in the direction of the wave. The direction of the magnetic waves can be steered by altering the currents in the stators.
Hollis and Kumagai jointly designed the motor. Ankit Bhatia, a Ph.D. student in robotics, and Olaf Sassnick, a visiting scientist from Salzburg University of Applied Sciences, adapted it for use in ballbots.
Getting rid of the mechanical drive eliminates a lot of the friction of previous ballbot models, but virtually all friction could be eliminated by eventually installing an air bearing, Hollis said. The robot body would then be separated from the motor ball with a cushion of air, rather than passive rollers.
“Even without optimizing the motor’s performance, SIMbot has demonstrated impressive performance,” Hollis said. “We expect SIMbot technology will make ballbots more accessible and more practical for wide adoption.”
The National Science Foundation and, in Japan, Grants-in-Aid for Scientific Research (KAKENHI) supported this research. A report on the work was presented at the May IEEE International Conference on Robotics and Automation in Stockholm, Sweden.

Video by: Carnegie Mellon University
###
About Carnegie Mellon University: Carnegie Mellon (www.cmu.edu) is a private, internationally ranked research university with programs in areas ranging from science, technology and business, to public policy, the humanities and the arts. More than 13,000 students in the university’s seven schools and colleges benefit from a small student-to-faculty ratio and an education characterized by its focus on creating and implementing solutions for real problems, interdisciplinary collaboration and innovation.

Communications Department
Carnegie Mellon University
5000 Forbes Ave.
Pittsburgh, PA 15213
412-268-2900
Fax: 412-268-6929

Contact: Byron Spice For immediate release:
412-268-9068 October 4, 2016
bspice@cs.cmu.edu
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Posted in Human Robots