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#434534 To Extend Our Longevity, First We Must ...

Healthcare today is reactive, retrospective, bureaucratic, and expensive. It’s sick care, not healthcare.

But that is radically changing at an exponential rate.

Through this multi-part blog series on longevity, I’ll take a deep dive into aging, longevity, and healthcare technologies that are working together to dramatically extend the human lifespan, disrupting the $3 trillion healthcare system in the process.

I’ll begin the series by explaining the nine hallmarks of aging, as explained in this journal article. Next, I’ll break down the emerging technologies and initiatives working to combat these nine hallmarks. Finally, I’ll explore the transformative implications of dramatically extending the human health span.

In this blog I’ll cover:

Why the healthcare system is broken
Why, despite this, we live in the healthiest time in human history
The nine mechanisms of aging

Let’s dive in.

The System is Broken—Here’s the Data:

Doctors spend $210 billion per year on procedures that aren’t based on patient need, but fear of liability.
Americans spend, on average, $8,915 per person on healthcare—more than any other country on Earth.
Prescription drugs cost around 50 percent more in the US than in other industrialized countries.
At current rates, by 2025, nearly 25 percent of the US GDP will be spent on healthcare.
It takes 12 years and $359 million, on average, to take a new drug from the lab to a patient.
Only 5 in 5,000 of these new drugs proceed to human testing. From there, only 1 of those 5 is actually approved for human use.

And Yet, We Live in the Healthiest Time in Human History
Consider these insights, which I adapted from Max Roser’s excellent database Our World in Data:

Right now, the countries with the lowest life expectancy in the world still have higher life expectancies than the countries with the highest life expectancy did in 1800.
In 1841, a 5-year-old had a life expectancy of 55 years. Today, a 5-year-old can expect to live 82 years—an increase of 27 years.
We’re seeing a dramatic increase in healthspan. In 1845, a newborn would expect to live to 40 years old. For a 70-year-old, that number became 79. Now, people of all ages can expect to live to be 81 to 86 years old.
100 years ago, 1 of 3 children would die before the age of 5. As of 2015, the child mortality rate fell to just 4.3 percent.
The cancer mortality rate has declined 27 percent over the past 25 years.

Figure: Around the globe, life expectancy has doubled since the 1800s. | Image from Life Expectancy by Max Roser – Our World in Data / CC BY SA
Figure: A dramatic reduction in child mortality in 1800 vs. in 2015. | Image from Child Mortality by Max Roser – Our World in Data / CC BY SA
The 9 Mechanisms of Aging
*This section was adapted from CB INSIGHTS: The Future Of Aging.

Longevity, healthcare, and aging are intimately linked.

With better healthcare, we can better treat some of the leading causes of death, impacting how long we live.

By investigating how to treat diseases, we’ll inevitably better understand what causes these diseases in the first place, which directly correlates to why we age.

Following are the nine hallmarks of aging. I’ll share examples of health and longevity technologies addressing each of these later in this blog series.

Genomic instability: As we age, the environment and normal cellular processes cause damage to our genes. Activities like flying at high altitude, for example, expose us to increased radiation or free radicals. This damage compounds over the course of life and is known to accelerate aging.
Telomere attrition: Each strand of DNA in the body (known as chromosomes) is capped by telomeres. These short snippets of DNA repeated thousands of times are designed to protect the bulk of the chromosome. Telomeres shorten as our DNA replicates; if a telomere reaches a certain critical shortness, a cell will stop dividing, resulting in increased incidence of disease.
Epigenetic alterations: Over time, environmental factors will change how genes are expressed, i.e., how certain sequences of DNA are read and the instruction set implemented.
Loss of proteostasis: Over time, different proteins in our body will no longer fold and function as they are supposed to, resulting in diseases ranging from cancer to neurological disorders.
Deregulated nutrient-sensing: Nutrient levels in the body can influence various metabolic pathways. Among the affected parts of these pathways are proteins like IGF-1, mTOR, sirtuins, and AMPK. Changing levels of these proteins’ pathways has implications on longevity.
Mitochondrial dysfunction: Mitochondria (our cellular power plants) begin to decline in performance as we age. Decreased performance results in excess fatigue and other symptoms of chronic illnesses associated with aging.
Cellular senescence: As cells age, they stop dividing and cannot be removed from the body. They build up and typically cause increased inflammation.
Stem cell exhaustion: As we age, our supply of stem cells begins to diminish as much as 100 to 10,000-fold in different tissues and organs. In addition, stem cells undergo genetic mutations, which reduce their quality and effectiveness at renovating and repairing the body.
Altered intercellular communication: The communication mechanisms that cells use are disrupted as cells age, resulting in decreased ability to transmit information between cells.

Conclusion
Over the past 200 years, we have seen an abundance of healthcare technologies enable a massive lifespan boom.

Now, exponential technologies like artificial intelligence, 3D printing and sensors, as well as tremendous advancements in genomics, stem cell research, chemistry, and many other fields, are beginning to tackle the fundamental issues of why we age.

In the next blog in this series, we will dive into how genome sequencing and editing, along with new classes of drugs, are augmenting our biology to further extend our healthy lives.

What will you be able to achieve with an extra 30 to 50 healthy years (or longer) in your lifespan? Personally, I’m excited for a near-infinite lifespan to take on moonshots.

Join Me
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Posted in Human Robots

#434297 How Can Leaders Ensure Humanity in a ...

It’s hard to avoid the prominence of AI in our lives, and there is a plethora of predictions about how it will influence our future. In their new book Solomon’s Code: Humanity in a World of Thinking Machines, co-authors Olaf Groth, Professor of Strategy, Innovation and Economics at HULT International Business School and CEO of advisory network Cambrian.ai, and Mark Nitzberg, Executive Director of UC Berkeley’s Center for Human-Compatible AI, believe that the shift in balance of power between intelligent machines and humans is already here.

I caught up with the authors about how the continued integration between technology and humans, and their call for a “Digital Magna Carta,” a broadly-accepted charter developed by a multi-stakeholder congress that would help guide the development of advanced technologies to harness their power for the benefit of all humanity.

Lisa Kay Solomon: Your new book, Solomon’s Code, explores artificial intelligence and its broader human, ethical, and societal implications that all leaders need to consider. AI is a technology that’s been in development for decades. Why is it so urgent to focus on these topics now?

Olaf Groth and Mark Nitzberg: Popular perception always thinks of AI in terms of game-changing narratives—for instance, Deep Blue beating Gary Kasparov at chess. But it’s the way these AI applications are “getting into our heads” and making decisions for us that really influences our lives. That’s not to say the big, headline-grabbing breakthroughs aren’t important; they are.

But it’s the proliferation of prosaic apps and bots that changes our lives the most, by either empowering or counteracting who we are and what we do. Today, we turn a rapidly growing number of our decisions over to these machines, often without knowing it—and even more often without understanding the second- and third-order effects of both the technologies and our decisions to rely on them.

There is genuine power in what we call a “symbio-intelligent” partnership between human, machine, and natural intelligences. These relationships can optimize not just economic interests, but help improve human well-being, create a more purposeful workplace, and bring more fulfillment to our lives.

However, mitigating the risks while taking advantage of the opportunities will require a serious, multidisciplinary consideration of how AI influences human values, trust, and power relationships. Whether or not we acknowledge their existence in our everyday life, these questions are no longer just thought exercises or fodder for science fiction.

In many ways, these technologies can challenge what it means to be human, and their ramifications already affect us in real and often subtle ways. We need to understand how

LKS: There is a lot of hype and misconceptions about AI. In your book, you provide a useful distinction between the cognitive capability that we often associate with AI processes, and the more human elements of consciousness and conscience. Why are these distinctions so important to understand?

OG & MN: Could machines take over consciousness some day as they become more powerful and complex? It’s hard to say. But there’s little doubt that, as machines become more capable, humans will start to think of them as something conscious—if for no other reason than our natural inclination to anthropomorphize.

Machines are already learning to recognize our emotional states and our physical health. Once they start talking that back to us and adjusting their behavior accordingly, we will be tempted to develop a certain rapport with them, potentially more trusting or more intimate because the machine recognizes us in our various states.

Consciousness is hard to define and may well be an emergent property, rather than something you can easily create or—in turn—deduce to its parts. So, could it happen as we put more and more elements together, from the realms of AI, quantum computing, or brain-computer interfaces? We can’t exclude that possibility.

Either way, we need to make sure we’re charting out a clear path and guardrails for this development through the Three Cs in machines: cognition (where AI is today); consciousness (where AI could go); and conscience (what we need to instill in AI before we get there). The real concern is that we reach machine consciousness—or what humans decide to grant as consciousness—without a conscience. If that happens, we will have created an artificial sociopath.

LKS: We have been seeing major developments in how AI is influencing product development and industry shifts. How is the rise of AI changing power at the global level?

OG & MN: Both in the public and private sectors, the data holder has the power. We’ve already seen the ascendance of about 10 “digital barons” in the US and China who sit on huge troves of data, massive computing power, and the resources and money to attract the world’s top AI talent. With these gaps already open between the haves and the have-nots on the technological and corporate side, we’re becoming increasingly aware that similar inequalities are forming at a societal level as well.

Economic power flows with data, leaving few options for socio-economically underprivileged populations and their corrupt, biased, or sparse digital footprints. By concentrating power and overlooking values, we fracture trust.

We can already see this tension emerging between the two dominant geopolitical models of AI. China and the US have emerged as the most powerful in both technological and economic terms, and both remain eager to drive that influence around the world. The EU countries are more contained on these economic and geopolitical measures, but they’ve leaped ahead on privacy and social concerns.

The problem is, no one has yet combined leadership on all three critical elements of values, trust, and power. The nations and organizations that foster all three of these elements in their AI systems and strategies will lead the future. Some are starting to recognize the need for the combination, but we found just 13 countries that have created significant AI strategies. Countries that wait too long to join them risk subjecting themselves to a new “data colonialism” that could change their economies and societies from the outside.

LKS: Solomon’s Code looks at AI from a variety of perspectives, considering both positive and potentially dangerous effects. You caution against the rising global threat and weaponization of AI and data, suggesting that “biased or dirty data is more threatening than nuclear arms or a pandemic.” For global leaders, entrepreneurs, technologists, policy makers and social change agents reading this, what specific strategies do you recommend to ensure ethical development and application of AI?

OG & MN: We’ve surrendered many of our most critical decisions to the Cult of Data. In most cases, that’s a great thing, as we rely more on scientific evidence to understand our world and our way through it. But we swing too far in other instances, assuming that datasets and algorithms produce a complete story that’s unsullied by human biases or intellectual shortcomings. We might choose to ignore it, but no one is blind to the dangers of nuclear war or pandemic disease. Yet, we willfully blind ourselves to the threat of dirty data, instead believing it to be pristine.

So, what do we do about it? On an individual level, it’s a matter of awareness, knowing who controls your data and how outsourcing of decisions to thinking machines can present opportunities and threats alike.

For business, government, and political leaders, we need to see a much broader expansion of ethics committees with transparent criteria with which to evaluate new products and services. We might consider something akin to clinical trials for pharmaceuticals—a sort of testing scheme that can transparently and independently measure the effects on humans of algorithms, bots, and the like. All of this needs to be multidisciplinary, bringing in expertise from across technology, social systems, ethics, anthropology, psychology, and so on.

Finally, on a global level, we need a new charter of rights—a Digital Magna Carta—that formalizes these protections and guides the development of new AI technologies toward all of humanity’s benefit. We’ve suggested the creation of a multi-stakeholder Cambrian Congress (harkening back to the explosion of life during the Cambrian period) that can not only begin to frame benefits for humanity, but build the global consensus around principles for a basic code-of-conduct, and ideas for evaluation and enforcement mechanisms, so we can get there without any large-scale failures or backlash in society. So, it’s not one or the other—it’s both.

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Posted in Human Robots

#434260 The Most Surprising Tech Breakthroughs ...

Development across the entire information technology landscape certainly didn’t slow down this year. From CRISPR babies, to the rapid decline of the crypto markets, to a new robot on Mars, and discovery of subatomic particles that could change modern physics as we know it, there was no shortage of headline-grabbing breakthroughs and discoveries.

As 2018 comes to a close, we can pause and reflect on some of the biggest technology breakthroughs and scientific discoveries that occurred this year.

I reached out to a few Singularity University speakers and faculty across the various technology domains we cover asking what they thought the biggest breakthrough was in their area of expertise. The question posed was:

“What, in your opinion, was the biggest development in your area of focus this year? Or, what was the breakthrough you were most surprised by in 2018?”

I can share that for me, hands down, the most surprising development I came across in 2018 was learning that a publicly-traded company that was briefly valued at over $1 billion, and has over 12,000 employees and contractors spread around the world, has no physical office space and the entire business is run and operated from inside an online virtual world. This is Ready Player One stuff happening now.

For the rest, here’s what our experts had to say.

DIGITAL BIOLOGY
Dr. Tiffany Vora | Faculty Director and Vice Chair, Digital Biology and Medicine, Singularity University

“That’s easy: CRISPR babies. I knew it was technically possible, and I’ve spent two years predicting it would happen first in China. I knew it was just a matter of time but I failed to predict the lack of oversight, the dubious consent process, the paucity of publicly-available data, and the targeting of a disease that we already know how to prevent and treat and that the children were at low risk of anyway.

I’m not convinced that this counts as a technical breakthrough, since one of the girls probably isn’t immune to HIV, but it sure was a surprise.”

For more, read Dr. Vora’s summary of this recent stunning news from China regarding CRISPR-editing human embryos.

QUANTUM COMPUTING
Andrew Fursman | Co-Founder/CEO 1Qbit, Faculty, Quantum Computing, Singularity University

“There were two last-minute holiday season surprise quantum computing funding and technology breakthroughs:

First, right before the government shutdown, one priority legislative accomplishment will provide $1.2 billion in quantum computing research over the next five years. Second, there’s the rise of ions as a truly viable, scalable quantum computing architecture.”

*Read this Gizmodo profile on an exciting startup in the space to learn more about this type of quantum computing

ENERGY
Ramez Naam | Chair, Energy and Environmental Systems, Singularity University

“2018 had plenty of energy surprises. In solar, we saw unsubsidized prices in the sunny parts of the world at just over two cents per kwh, or less than half the price of new coal or gas electricity. In the US southwest and Texas, new solar is also now cheaper than new coal or gas. But even more shockingly, in Germany, which is one of the least sunny countries on earth (it gets less sunlight than Canada) the average bid for new solar in a 2018 auction was less than 5 US cents per kwh. That’s as cheap as new natural gas in the US, and far cheaper than coal, gas, or any other new electricity source in most of Europe.

In fact, it’s now cheaper in some parts of the world to build new solar or wind than to run existing coal plants. Think tank Carbon Tracker calculates that, over the next 10 years, it will become cheaper to build new wind or solar than to operate coal power in most of the world, including specifically the US, most of Europe, and—most importantly—India and the world’s dominant burner of coal, China.

Here comes the sun.”

GLOBAL GRAND CHALLENGES
Darlene Damm | Vice Chair, Faculty, Global Grand Challenges, Singularity University

“In 2018 we saw a lot of areas in the Global Grand Challenges move forward—advancements in robotic farming technology and cultured meat, low-cost 3D printed housing, more sophisticated types of online education expanding to every corner of the world, and governments creating new policies to deal with the ethics of the digital world. These were the areas we were watching and had predicted there would be change.

What most surprised me was to see young people, especially teenagers, start to harness technology in powerful ways and use it as a platform to make their voices heard and drive meaningful change in the world. In 2018 we saw teenagers speak out on a number of issues related to their well-being and launch digital movements around issues such as gun and school safety, global warming and environmental issues. We often talk about the harm technology can cause to young people, but on the flip side, it can be a very powerful tool for youth to start changing the world today and something I hope we see more of in the future.”

BUSINESS STRATEGY
Pascal Finette | Chair, Entrepreneurship and Open Innovation, Singularity University

“Without a doubt the rapid and massive adoption of AI, specifically deep learning, across industries, sectors, and organizations. What was a curiosity for most companies at the beginning of the year has quickly made its way into the boardroom and leadership meetings, and all the way down into the innovation and IT department’s agenda. You are hard-pressed to find a mid- to large-sized company today that is not experimenting or implementing AI in various aspects of its business.

On the slightly snarkier side of answering this question: The very rapid decline in interest in blockchain (and cryptocurrencies). The blockchain party was short, ferocious, and ended earlier than most would have anticipated, with a huge hangover for some. The good news—with the hot air dissipated, we can now focus on exploring the unique use cases where blockchain does indeed offer real advantages over centralized approaches.”

*Author note: snark is welcome and appreciated

ROBOTICS
Hod Lipson | Director, Creative Machines Lab, Columbia University

“The biggest surprise for me this year in robotics was learning dexterity. For decades, roboticists have been trying to understand and imitate dexterous manipulation. We humans seem to be able to manipulate objects with our fingers with incredible ease—imagine sifting through a bunch of keys in the dark, or tossing and catching a cube. And while there has been much progress in machine perception, dexterous manipulation remained elusive.

There seemed to be something almost magical in how we humans can physically manipulate the physical world around us. Decades of research in grasping and manipulation, and millions of dollars spent on robot-hand hardware development, has brought us little progress. But in late 2018, the Berkley OpenAI group demonstrated that this hurdle may finally succumb to machine learning as well. Given 200 years worth of practice, machines learned to manipulate a physical object with amazing fluidity. This might be the beginning of a new age for dexterous robotics.”

MACHINE LEARNING
Jeremy Howard | Founding Researcher, fast.ai, Founder/CEO, Enlitic, Faculty Data Science, Singularity University

“The biggest development in machine learning this year has been the development of effective natural language processing (NLP).

The New York Times published an article last month titled “Finally, a Machine That Can Finish Your Sentence,” which argued that NLP neural networks have reached a significant milestone in capability and speed of development. The “finishing your sentence” capability mentioned in the title refers to a type of neural network called a “language model,” which is literally a model that learns how to finish your sentences.

Earlier this year, two systems (one, called ELMO, is from the Allen Institute for AI, and the other, called ULMFiT, was developed by me and Sebastian Ruder) showed that such a model could be fine-tuned to dramatically improve the state-of-the-art in nearly every NLP task that researchers study. This work was further developed by OpenAI, which in turn was greatly scaled up by Google Brain, who created a system called BERT which reached human-level performance on some of NLP’s toughest challenges.

Over the next year, expect to see fine-tuned language models used for everything from understanding medical texts to building disruptive social media troll armies.”

DIGITAL MANUFACTURING
Andre Wegner | Founder/CEO Authentise, Chair, Digital Manufacturing, Singularity University

“Most surprising to me was the extent and speed at which the industry finally opened up.

While previously, only few 3D printing suppliers had APIs and knew what to do with them, 2018 saw nearly every OEM (or original equipment manufacturer) enabling data access and, even more surprisingly, shying away from proprietary standards and adopting MTConnect, as stalwarts such as 3D Systems and Stratasys have been. This means that in two to three years, data access to machines will be easy, commonplace, and free. The value will be in what is being done with that data.

Another example of this openness are the seemingly endless announcements of integrated workflows: GE’s announcement with most major software players to enable integrated solutions, EOS’s announcement with Siemens, and many more. It’s clear that all actors in the additive ecosystem have taken a step forward in terms of openness. The result is a faster pace of innovation, particularly in the software and data domains that are crucial to enabling comprehensive digital workflow to drive agile and resilient manufacturing.

I’m more optimistic we’ll achieve that now than I was at the end of 2017.”

SCIENCE AND DISCOVERY
Paul Saffo | Chair, Future Studies, Singularity University, Distinguished Visiting Scholar, Stanford Media-X Research Network

“The most important development in technology this year isn’t a technology, but rather the astonishing science surprises made possible by recent technology innovations. My short list includes the discovery of the “neptmoon”, a Neptune-scale moon circling a Jupiter-scale planet 8,000 lightyears from us; the successful deployment of the Mars InSight Lander a month ago; and the tantalizing ANITA detection (what could be a new subatomic particle which would in turn blow the standard model wide open). The highest use of invention is to support science discovery, because those discoveries in turn lead us to the future innovations that will improve the state of the world—and fire up our imaginations.”

ROBOTICS
Pablos Holman | Inventor, Hacker, Faculty, Singularity University

“Just five or ten years ago, if you’d asked any of us technologists “What is harder for robots? Eyes, or fingers?” We’d have all said eyes. Robots have extraordinary eyes now, but even in a surgical robot, the fingers are numb and don’t feel anything. Stanford robotics researchers have invented fingertips that can feel, and this will be a kingpin that allows robots to go everywhere they haven’t been yet.”

BLOCKCHAIN
Nathana Sharma | Blockchain, Policy, Law, and Ethics, Faculty, Singularity University

“2017 was the year of peak blockchain hype. 2018 has been a year of resetting expectations and technological development, even as the broader cryptocurrency markets have faced a winter. It’s now about seeing adoption and applications that people want and need to use rise. An incredible piece of news from December 2018 is that Facebook is developing a cryptocurrency for users to make payments through Whatsapp. That’s surprisingly fast mainstream adoption of this new technology, and indicates how powerful it is.”

ARTIFICIAL INTELLIGENCE
Neil Jacobstein | Chair, Artificial Intelligence and Robotics, Singularity University

“I think one of the most visible improvements in AI was illustrated by the Boston Dynamics Parkour video. This was not due to an improvement in brushless motors, accelerometers, or gears. It was due to improvements in AI algorithms and training data. To be fair, the video released was cherry-picked from numerous attempts, many of which ended with a crash. However, the fact that it could be accomplished at all in 2018 was a real win for both AI and robotics.”

NEUROSCIENCE
Divya Chander | Chair, Neuroscience, Singularity University

“2018 ushered in a new era of exponential trends in non-invasive brain modulation. Changing behavior or restoring function takes on a new meaning when invasive interfaces are no longer needed to manipulate neural circuitry. The end of 2018 saw two amazing announcements: the ability to grow neural organoids (mini-brains) in a dish from neural stem cells that started expressing electrical activity, mimicking the brain function of premature babies, and the first (known) application of CRISPR to genetically alter two fetuses grown through IVF. Although this was ostensibly to provide genetic resilience against HIV infections, imagine what would happen if we started tinkering with neural circuitry and intelligence.”

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Posted in Human Robots

#433928 The Surprising Parallels Between ...

The human mind can be a confusing and overwhelming place. Despite incredible leaps in human progress, many of us still struggle to make our peace with our thoughts. The roots of this are complex and multifaceted. To find explanations for the global mental health epidemic, one can tap into neuroscience, psychology, evolutionary biology, or simply observe the meaningless systems that dominate our modern-day world.

This is not only the context of our reality but also that of the critically-acclaimed Netflix series, Maniac. Psychological dark comedy meets science fiction, Maniac is a retro, futuristic, and hallucinatory trip that is filled with hidden symbols. Directed by Cary Joji Fukunaga, the series tells the story of two strangers who decide to participate in the final stage of a “groundbreaking” pharmaceutical trial—one that combines novel pharmaceuticals with artificial intelligence, and promises to make their emotional pain go away.

Naturally, things don’t go according to plan.

From exams used for testing defense mechanisms to techniques such as cognitive behavioral therapy, the narrative infuses genuine psychological science. As perplexing as the series may be to some viewers, many of the tools depicted actually have a strong grounding in current technological advancements.

Catalysts for Alleviating Suffering
In the therapy of Maniac, participants undergo a three-day trial wherein they ingest three pills and appear to connect their consciousness to a superintelligent AI. Each participant is hurled into the traumatic experiences imprinted in their subconscious and forced to cope with them in a series of hallucinatory and dream-like experiences.

Perhaps the most recognizable parallel that can be drawn is with the latest advancements in psychedelic therapy. Psychedelics are a class of drugs that alter the experience of consciousness, and often cause radical changes in perception and cognitive processes.

Through a process known as transient hypofrontality, the executive “over-thinking” parts of our brains get a rest, and deeper areas become more active. This experience, combined with the breakdown of the ego, is often correlated with feelings of timelessness, peacefulness, presence, unity, and above all, transcendence.

Despite being not addictive and extremely difficult to overdose on, regulators looked down on the use of psychedelics for decades and many continue to dismiss them as “party drugs.” But in the last few years, all of this began to change.

Earlier this summer, the FDA granted breakthrough therapy designation to MDMA for the treatment of PTSD, after several phases of successful trails. Similar research has discovered that Psilocybin (also known as magic mushrooms) combined with therapy is far more effective than traditional forms of treatment to treat depression and anxiety. Today, there is a growing and overwhelming body of research that proves that not only are psychedelics such as LSD, MDMA, or Psylicybin effective catalysts to alleviate suffering and enhance the human condition, but they are potentially the most effective tools out there.

It’s important to realize that these substances are not solutions on their own, but rather catalysts for more effective therapy. They can be groundbreaking, but only in the right context and setting.

Brain-Machine Interfaces
In Maniac, the medication-assisted therapy is guided by what appears to be a super-intelligent form of artificial intelligence called the GRTA, nicknamed Gertie. Gertie, who is a “guide” in machine form, accesses the minds of the participants through what appears to be a futuristic brain-scanning technology and curates customized hallucinatory experiences with the goal of accelerating the healing process.

Such a powerful form of brain-scanning technology is not unheard of. Current levels of scanning technology are already allowing us to decipher dreams and connect three human brains, and are only growing exponentially. Though they are nowhere as advanced as Gertie (we have a long way to go before we get to this kind of general AI), we are also seeing early signs of AI therapy bots, chatbots that listen, think, and communicate with users like a therapist would.

The parallels between current advancements in mental health therapy and the methods in Maniac can be startling, and are a testament to how science fiction and the arts can be used to explore the existential implications of technology.

Not Necessarily a Dystopia
While there are many ingenious similarities between the technology in Maniac and the state of mental health therapy, it’s important to recognize the stark differences. Like many other blockbuster science fiction productions, Maniac tells a fundamentally dystopian tale.

The series tells the story of the 73rd iteration of a controversial drug trial, one that has experienced many failures and even led to various participants being braindead. The scientists appear to be evil, secretive, and driven by their own superficial agendas and deep unresolved emotional issues.

In contrast, clinicians and researchers are not only required to file an “investigational new drug application” with the FDA (and get approval) but also update the agency with safety and progress reports throughout the trial.

Furthermore, many of today’s researchers are driven by a strong desire to contribute to the well-being and progress of our species. Even more, the results of decades of research by organizations like MAPS have been exceptionally promising and aligned with positive values. While Maniac is entertaining and thought-provoking, viewers must not forget the positive potential of such advancements in mental health therapy.

Science, technology, and psychology aside, Maniac is a deep commentary on the human condition and the often disorienting states that pain us all. Within any human lifetime, suffering is inevitable. It is the disproportionate, debilitating, and unjust levels of suffering that we ought to tackle as a society. Ultimately, Maniac explores whether advancements in science and technology can help us live not a life devoid of suffering, but one where it is balanced with fulfillment.

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Posted in Human Robots

#433892 The Spatial Web Will Map Our 3D ...

The boundaries between digital and physical space are disappearing at a breakneck pace. What was once static and boring is becoming dynamic and magical.

For all of human history, looking at the world through our eyes was the same experience for everyone. Beyond the bounds of an over-active imagination, what you see is the same as what I see.

But all of this is about to change. Over the next two to five years, the world around us is about to light up with layer upon layer of rich, fun, meaningful, engaging, and dynamic data. Data you can see and interact with.

This magical future ahead is called the Spatial Web and will transform every aspect of our lives, from retail and advertising, to work and education, to entertainment and social interaction.

Massive change is underway as a result of a series of converging technologies, from 5G global networks and ubiquitous artificial intelligence, to 30+ billion connected devices (known as the IoT), each of which will generate scores of real-world data every second, everywhere.

The current AI explosion will make everything smart, autonomous, and self-programming. Blockchain and cloud-enabled services will support a secure data layer, putting data back in the hands of users and allowing us to build complex rule-based infrastructure in tomorrow’s virtual worlds.

And with the rise of online-merge-offline (OMO) environments, two-dimensional screens will no longer serve as our exclusive portal to the web. Instead, virtual and augmented reality eyewear will allow us to interface with a digitally-mapped world, richly layered with visual data.

Welcome to the Spatial Web. Over the next few months, I’ll be doing a deep dive into the Spatial Web (a.k.a. Web 3.0), covering what it is, how it works, and its vast implications across industries, from real estate and healthcare to entertainment and the future of work. In this blog, I’ll discuss the what, how, and why of Web 3.0—humanity’s first major foray into our virtual-physical hybrid selves (BTW, this year at Abundance360, we’ll be doing a deep dive into the Spatial Web with the leaders of HTC, Magic Leap, and High-Fidelity).

Let’s dive in.

What is the Spatial Web?
While we humans exist in three dimensions, our web today is flat.

The web was designed for shared information, absorbed through a flat screen. But as proliferating sensors, ubiquitous AI, and interconnected networks blur the lines between our physical and online worlds, we need a spatial web to help us digitally map a three-dimensional world.

To put Web 3.0 in context, let’s take a trip down memory lane. In the late 1980s, the newly-birthed world wide web consisted of static web pages and one-way information—a monumental system of publishing and linking information unlike any unified data system before it. To connect, we had to dial up through unstable modems and struggle through insufferably slow connection speeds.

But emerging from this revolutionary (albeit non-interactive) infodump, Web 2.0 has connected the planet more in one decade than empires did in millennia.

Granting democratized participation through newly interactive sites and applications, today’s web era has turbocharged information-sharing and created ripple effects of scientific discovery, economic growth, and technological progress on an unprecedented scale.

We’ve seen the explosion of social networking sites, wikis, and online collaboration platforms. Consumers have become creators; physically isolated users have been handed a global microphone; and entrepreneurs can now access billions of potential customers.

But if Web 2.0 took the world by storm, the Spatial Web emerging today will leave it in the dust.

While there’s no clear consensus about its definition, the Spatial Web refers to a computing environment that exists in three-dimensional space—a twinning of real and virtual realities—enabled via billions of connected devices and accessed through the interfaces of virtual and augmented reality.

In this way, the Spatial Web will enable us to both build a twin of our physical reality in the virtual realm and bring the digital into our real environments.

It’s the next era of web-like technologies:

Spatial computing technologies, like augmented and virtual reality;
Physical computing technologies, like IoT and robotic sensors;
And decentralized computing: both blockchain—which enables greater security and data authentication—and edge computing, which pushes computing power to where it’s most needed, speeding everything up.

Geared with natural language search, data mining, machine learning, and AI recommendation agents, the Spatial Web is a growing expanse of services and information, navigable with the use of ever-more-sophisticated AI assistants and revolutionary new interfaces.

Where Web 1.0 consisted of static documents and read-only data, Web 2.0 introduced multimedia content, interactive web applications, and social media on two-dimensional screens. But converging technologies are quickly transcending the laptop, and will even disrupt the smartphone in the next decade.

With the rise of wearables, smart glasses, AR / VR interfaces, and the IoT, the Spatial Web will integrate seamlessly into our physical environment, overlaying every conversation, every road, every object, conference room, and classroom with intuitively-presented data and AI-aided interaction.

Think: the Oasis in Ready Player One, where anyone can create digital personas, build and invest in smart assets, do business, complete effortless peer-to-peer transactions, and collect real estate in a virtual world.

Or imagine a virtual replica or “digital twin” of your office, each conference room authenticated on the blockchain, requiring a cryptographic key for entry.

As I’ve discussed with my good friend and “VR guru” Philip Rosedale, I’m absolutely clear that in the not-too-distant future, every physical element of every building in the world is going to be fully digitized, existing as a virtual incarnation or even as N number of these. “Meet me at the top of the Empire State Building?” “Sure, which one?”

This digitization of life means that suddenly every piece of information can become spatial, every environment can be smarter by virtue of AI, and every data point about me and my assets—both virtual and physical—can be reliably stored, secured, enhanced, and monetized.

In essence, the Spatial Web lets us interface with digitally-enhanced versions of our physical environment and build out entirely fictional virtual worlds—capable of running simulations, supporting entire economies, and even birthing new political systems.

But while I’ll get into the weeds of different use cases next week, let’s first concretize.

How Does It Work?
Let’s start with the stack. In the PC days, we had a database accompanied by a program that could ingest that data and present it to us as digestible information on a screen.

Then, in the early days of the web, data migrated to servers. Information was fed through a website, with which you would interface via a browser—whether Mosaic or Mozilla.

And then came the cloud.

Resident at either the edge of the cloud or on your phone, today’s rapidly proliferating apps now allow us to interact with previously read-only data, interfacing through a smartphone. But as Siri and Alexa have brought us verbal interfaces, AI-geared phone cameras can now determine your identity, and sensors are beginning to read our gestures.

And now we’re not only looking at our screens but through them, as the convergence of AI and AR begins to digitally populate our physical worlds.

While Pokémon Go sent millions of mobile game-players on virtual treasure hunts, IKEA is just one of the many companies letting you map virtual furniture within your physical home—simulating everything from cabinets to entire kitchens. No longer the one-sided recipients, we’re beginning to see through sensors, creatively inserting digital content in our everyday environments.

Let’s take a look at how the latest incarnation might work. In this new Web 3.0 stack, my personal AI would act as an intermediary, accessing public or privately-authorized data through the blockchain on my behalf, and then feed it through an interface layer composed of everything from my VR headset, to numerous wearables, to my smart environment (IoT-connected devices or even in-home robots).

But as we attempt to build a smart world with smart infrastructure, smart supply chains and smart everything else, we need a set of basic standards with addresses for people, places, and things. Just like our web today relies on the Internet Protocol (TCP/IP) and other infrastructure, by which your computer is addressed and data packets are transferred, we need infrastructure for the Spatial Web.

And a select group of players is already stepping in to fill this void. Proposing new structural designs for Web 3.0, some are attempting to evolve today’s web model from text-based web pages in 2D to three-dimensional AR and VR web experiences located in both digitally-mapped physical worlds and newly-created virtual ones.

With a spatial programming language analogous to HTML, imagine building a linkable address for any physical or virtual space, granting it a format that then makes it interchangeable and interoperable with all other spaces.

But it doesn’t stop there.

As soon as we populate a virtual room with content, we then need to encode who sees it, who can buy it, who can move it…

And the Spatial Web’s eventual governing system (for posting content on a centralized grid) would allow us to address everything from the room you’re sitting in, to the chair on the other side of the table, to the building across the street.

Just as we have a DNS for the web and the purchasing of web domains, once we give addresses to spaces (akin to granting URLs), we then have the ability to identify and visit addressable locations, physical objects, individuals, or pieces of digital content in cyberspace.

And these not only apply to virtual worlds, but to the real world itself. As new mapping technologies emerge, we can now map rooms, objects, and large-scale environments into virtual space with increasing accuracy.

We might then dictate who gets to move your coffee mug in a virtual conference room, or when a team gets to use the room itself. Rules and permissions would be set in the grid, decentralized governance systems, or in the application layer.

Taken one step further, imagine then monetizing smart spaces and smart assets. If you have booked the virtual conference room, perhaps you’ll let me pay you 0.25 BTC to let me use it instead?

But given the Spatial Web’s enormous technological complexity, what’s allowing it to emerge now?

Why Is It Happening Now?
While countless entrepreneurs have already started harnessing blockchain technologies to build decentralized apps (or dApps), two major developments are allowing today’s birth of Web 3.0:

High-resolution wireless VR/AR headsets are finally catapulting virtual and augmented reality out of a prolonged winter.

The International Data Corporation (IDC) predicts the VR and AR headset market will reach 65.9 million units by 2022. Already in the next 18 months, 2 billion devices will be enabled with AR. And tech giants across the board have long begun investing heavy sums.

In early 2019, HTC is releasing the VIVE Focus, a wireless self-contained VR headset. At the same time, Facebook is charging ahead with its Project Santa Cruz—the Oculus division’s next-generation standalone, wireless VR headset. And Magic Leap has finally rolled out its long-awaited Magic Leap One mixed reality headset.

Mass deployment of 5G will drive 10 to 100-gigabit connection speeds in the next 6 years, matching hardware progress with the needed speed to create virtual worlds.

We’ve already seen tremendous leaps in display technology. But as connectivity speeds converge with accelerating GPUs, we’ll start to experience seamless VR and AR interfaces with ever-expanding virtual worlds.

And with such democratizing speeds, every user will be able to develop in VR.

But accompanying these two catalysts is also an important shift towards the decentralized web and a demand for user-controlled data.

Converging technologies, from immutable ledgers and blockchain to machine learning, are now enabling the more direct, decentralized use of web applications and creation of user content. With no central point of control, middlemen are removed from the equation and anyone can create an address, independently interacting with the network.

Enabled by a permission-less blockchain, any user—regardless of birthplace, gender, ethnicity, wealth, or citizenship—would thus be able to establish digital assets and transfer them seamlessly, granting us a more democratized Internet.

And with data stored on distributed nodes, this also means no single point of failure. One could have multiple backups, accessible only with digital authorization, leaving users immune to any single server failure.

Implications Abound–What’s Next…
With a newly-built stack and an interface built from numerous converging technologies, the Spatial Web will transform every facet of our everyday lives—from the way we organize and access our data, to our social and business interactions, to the way we train employees and educate our children.

We’re about to start spending more time in the virtual world than ever before. Beyond entertainment or gameplay, our livelihoods, work, and even personal decisions are already becoming mediated by a web electrified with AI and newly-emerging interfaces.

In our next blog on the Spatial Web, I’ll do a deep dive into the myriad industry implications of Web 3.0, offering tangible use cases across sectors.

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