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#437236 Why We Need Mass Automation to ...

The scale of goods moving around the planet at any moment is staggering. Raw materials are dug up in one country, spun into parts and pieces in another, and assembled into products in a third. Crossing oceans and continents, they find their way to a local store or direct to your door.

Magically, a roll of toilet paper, power tool, or tube of toothpaste is there just when you need it.

Even more staggering is that this whole system, the global supply chain, works so well that it’s effectively invisible most of the time. Until now, that is. The pandemic has thrown a floodlight on the inner workings of this modern wonder—and it’s exposed massive vulnerabilities.

The e-commerce supply chain is an instructive example. As the world went into lockdown, and everything non-essential went online, demand for digital fulfillment skyrocketed.

Even under “normal” conditions, most e-commerce warehouses were struggling to meet demand. But Covid-19 has further strained the ability to cope with shifting supply, an unprecedented tidal wave of orders, and labor shortages. Local stores are running out of key products. Online grocers and e-commerce platforms are suspending some home deliveries, restricting online purchases of certain items, and limiting new customers. The whole system is being severely tested.

Why? Despite an abundance of 21st century technology, we’re stuck in the 20th century.

Today’s supply chain consists of fleets of ships, trucks, warehouses, and importantly, people scattered around the world. While there are some notable instances of advanced automation, the overwhelming majority of work is still manual, resembling a sort of human-powered bucket brigade, with people wandering around warehouses or standing alongside conveyor belts. Each package of diapers or bottle of detergent ordered by an online customer might be touched dozens of times by warehouse workers before finding its way into a box delivered to a home.

The pandemic has proven the critical need for innovation due to increased demand, concerns about the health and safety of workers, and traceability and safety of products and services.

At the 2020 World Economic Forum, there was much discussion about the ongoing societal transformation in which humans and machines work in tandem, automating and augmenting the way we get things done. At the time, pre-pandemic, debate trended toward skepticism and fear of job losses, with some even questioning the ethics and need for these technologies.

Now, we see things differently. To make the global supply chain more resilient to shocks like Covid-19, we must look to technology.

Perfecting the Global Supply Chain: The Massive ‘Matter Router’
Technology has faced and overcome similar challenges in the past.

World War II, for example, drove innovation in techniques for rapid production of many products on a large scale, including penicillin. We went from the availability of one dose of the drug in 1941, to four million sterile packages of the drug every month four years later.

Similarly, today’s companies, big and small, are looking to automation, robotics, and AI to meet the pandemic head on. These technologies are crucial to scaling the infrastructure that will fulfill most of the world’s e-commerce and food distribution needs.

You can think of this new infrastructure as a rapidly evolving “matter router” that will employ increasingly complex robotic systems to move products more freely and efficiently.

Robots powered by specialized AI software, for example, are already learning to adapt to changes in the environment, using the most recent advances in industrial robotics and machine learning. When customers suddenly need to order dramatically new items, these robots don’t need to stop or be reprogrammed. They can perform new tasks by learning from experience using low-cost camera systems and deep learning for visual and image recognition.

These more flexible robots can work around the clock, helping make facilities less sensitive to sudden changes in workforce and customer demand and strengthening the supply chain.

Today, e-commerce is roughly 12% of retail sales in the US and is expected to rise well beyond 25% within the decade, fueled by changes in buying habits. However, analysts have begun to consider whether the current crisis might cause permanent jumps in those numbers, as it has in the past (for instance with the SARS epidemic in China in 2003). Whatever happens, the larger supply chain will benefit from greater, more flexible automation, especially during global crises.

We must create what Hamza Mudassire of the University of Cambridge calls a “resilient ecosystem that links multiple buyers with multiple vendors, across a mesh of supply chains.” This ecosystem must be backed by robust, efficient, and scalable automation that uses robotics, autonomous vehicles, and the Internet of Things to help track the flow of goods through the supply chain.

The good news? We can accomplish this with technologies we have today.

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Posted in Human Robots

#437209 A Renaissance of Genomics and Drugs Is ...

The causes of aging are extremely complex and unclear. But with longevity clinical trials increasing, more answers—and questions—are emerging than ever before.

With the dramatic demonetization of genome reading and editing over the past decade, and Big Pharma, startups, and the FDA starting to face aging as a disease, we are starting to turn those answers into practical ways to extend our healthspan.

In this article, I’ll explore how genome sequencing and editing, along with new classes of anti-aging drugs, are augmenting our biology to further extend our healthy lives.

Genome Sequencing and Editing
Your genome is the software that runs your body. A sequence of 3.2 billion letters makes you “you.” These base pairs of A’s, T’s, C’s, and G’s determine your hair color, your height, your personality, your propensity for disease, your lifespan, and so on.

Until recently, it’s been very difficult to rapidly and cheaply “read” these letters—and even more difficult to understand what they mean. Since 2001, the cost to sequence a whole human genome has plummeted exponentially, outpacing Moore’s Law threefold. From an initial cost of $3.7 billion, it dropped to $10 million in 2006, and to $1,500 in 2015.

Today, the cost of genome sequencing has dropped below $600, and according to Illumina, the world’s leading sequencing company, the process will soon cost about $100 and take about an hour to complete.

This represents one of the most powerful and transformative technology revolutions in healthcare. When we understand your genome, we’ll be able to understand how to optimize “you.”

We’ll know the perfect foods, the perfect drugs, the perfect exercise regimen, and the perfect supplements, just for you.
We’ll understand what microbiome types, or gut flora, are ideal for you (more on this in a later article).
We’ll accurately predict how specific sedatives and medicines will impact you.
We’ll learn which diseases and illnesses you’re most likely to develop and, more importantly, how to best prevent them from developing in the first place (rather than trying to cure them after the fact).

CRISPR Gene Editing
In addition to reading the human genome, scientists can now edit a genome using a naturally occurring biological system discovered in 1987 called CRISPR/Cas9.

Short for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9, the editing system was adapted from a naturally-occurring defense system found in bacteria.

Here’s how it works. The bacteria capture snippets of DNA from invading viruses (or bacteriophage) and use them to create DNA segments known as CRISPR arrays. The CRISPR arrays allow the bacteria to “remember” the viruses (or closely related ones), and defend against future invasions. If the viruses attack again, the bacteria produce RNA segments from the CRISPR arrays to target the viruses’ DNA. The bacteria then use Cas9 to cut the DNA apart, which disables the virus.

Most importantly, CRISPR is cheap, quick, easy to use, and more accurate than all previous gene editing methods. As a result, CRISPR/Cas9 has swept through labs around the world as the way to edit a genome. A short search in the literature will show an exponential rise in the number of CRISPR-related publications and patents.

2018: Filled With CRISPR Breakthroughs
Early results are impressive. Researchers have used CRISPR to genetically engineer cocaine resistance into mice, reverse the gene defect causing Duchenne muscular dystrophy (DMD) in dogs, and reduce genetic deafness in mice.

Already this year, CRISPR-edited immune cells have been shown to successfully kill cancer cells in human patients. Researchers have discovered ways to activate CRISPR with light and use the gene-editing technology to better understand Alzheimer’s disease progression.

With great power comes great responsibility, and the opportunity for moral and ethical dilemmas. In 2015, Chinese scientists sparked global controversy when they first edited human embryo cells in the lab with the goal of modifying genes that would make the child resistant to smallpox, HIV, and cholera. Three years later, in November 2018, researcher He Jiankui informed the world that the first set of CRISPR-engineered female twins had been delivered.

To accomplish his goal, Jiankui deleted a region of a receptor on the surface of white blood cells known as CCR5, introducing a rare, natural genetic variation that makes it more difficult for HIV to infect its favorite target, white blood cells. Because Jiankui forged ethical review documents and misled doctors in the process, he was sentenced to three years in prison and fined $429,000 last December.

Coupled with significant ethical conversations necessary for progress, CRISPR will soon provide us the tools to eliminate diseases, create hardier offspring, produce new environmentally resistant crops, and even wipe out pathogens.

Senolytics, Nutraceuticals, and Pharmaceuticals
Over the arc of your life, the cells in your body divide until they reach what is known as the Hayflick limit, or the number of times a normal human cell population will divide before cell division stops, which is typically about 50 divisions.

What normally follows next is programmed cell death or destruction by the immune system. A very small fraction of cells, however, become senescent cells and evade this fate to linger indefinitely. These lingering cells secrete a potent mix of molecules that triggers chronic inflammation, damages the surrounding tissue structures, and changes the behavior of nearby cells for the worse. Senescent cells appear to be one of the root causes of aging, causing everything from fibrosis and blood vessel calcification to localized inflammatory conditions such as osteoarthritis to diminished lung function.

Fortunately, both the scientific and entrepreneurial communities have begun to work on senolytic therapies, moving the technology for selectively destroying senescent cells out of the laboratory and into a half-dozen startup companies.

Prominent companies in the field include the following:

Unity Biotechnology is developing senolytic medicines to selectively eliminate senescent cells with an initial focus on delivering localized therapy in osteoarthritis, ophthalmology, and pulmonary disease.

Oisin Biotechnologies is pioneering a programmable gene therapy that can destroy cells based on their internal biochemistry.

SIWA Therapeutics is working on an immunotherapy approach to the problem of senescent cells.

In recent years, researchers have identified or designed a handful of senolytic compounds that can curb aging by regulating senescent cells. Two of these drugs that have gained mainstay research traction are rapamycin and metformin.

(1) Rapamycin

Originally extracted from bacteria found on Easter Island, rapamycin acts on the m-TOR (mechanistic target of rapamycin) pathway to selectively block a key protein that facilitates cell division. Currently, rapamycin derivatives are widely used for immunosuppression in organ and bone marrow transplants. Research now suggests that use results in prolonged lifespan and enhanced cognitive and immune function.

PureTech Health subsidiary resTORbio (which went public in 2018) is working on a rapamycin-based drug intended to enhance immunity and reduce infection. Their clinical-stage RTB101 drug works by inhibiting part of the mTOR pathway.

Results of the drug’s recent clinical trial include decreased incidence of infection, improved influenza vaccination response, and a 30.6 percent decrease in respiratory tract infection.

Impressive, to say the least.

(2) Metformin

Metformin is a widely-used generic drug for mitigating liver sugar production in Type 2 diabetes patients. Researchers have found that metformin also reduces oxidative stress and inflammation, which otherwise increase as we age. There is strong evidence that metformin can augment cellular regeneration and dramatically mitigate cellular senescence by reducing both oxidative stress and inflammation.

Over 100 studies registered on ClinicalTrials.gov are currently following up on strong evidence of metformin’s protective effect against cancer.

(3) Nutraceuticals and NAD+

Beyond cellular senescence, certain critical nutrients and proteins tend to decline as a function of age. Nutraceuticals combat aging by supplementing and replenishing these declining nutrient levels.

NAD+ exists in every cell, participating in every process from DNA repair to creating the energy vital for cellular processes. It’s been shown that NAD+ levels decline as we age.

The Elysium Health Basis supplement aims to elevate NAD+ levels in the body to extend one’s lifespan. Elysium’s first clinical study reports that Basis increases NAD+ levels consistently by a sustained 40 percent.

Conclusion
These are just a taste of the tremendous momentum that longevity and aging technology has right now. As artificial intelligence and quantum computing transform how we decode our DNA and how we discover drugs, genetics and pharmaceuticals will become truly personalized.

The next article in this series will demonstrate how artificial intelligence is converging with genetics and pharmaceuticals to transform how we approach longevity, aging, and vitality.

We are edging closer toward a dramatically extended healthspan—where 100 is the new 60. What will you create, where will you explore, and how will you spend your time if you are able to add an additional 40 healthy years to your life?

Join Me
(1) A360 Executive Mastermind: If you’re an exponentially and abundance-minded entrepreneur who would like coaching directly from me, consider joining my Abundance 360 Mastermind, a highly selective community of 360 CEOs and entrepreneurs who I coach for 3 days every January in Beverly Hills, Ca. Through A360, I provide my members with context and clarity about how converging exponential technologies will transform every industry. I’m committed to running A360 for the course of an ongoing 25-year journey as a “countdown to the Singularity.”

If you’d like to learn more and consider joining our 2021 membership, apply here.

(2) Abundance-Digital Online Community: I’ve also created a Digital/Online community of bold, abundance-minded entrepreneurs called Abundance-Digital. Abundance-Digital is Singularity University’s ‘onramp’ for exponential entrepreneurs—those who want to get involved and play at a higher level. Click here to learn more.

(Both A360 and Abundance-Digital are part of Singularity University—your participation opens you to a global community.)

This article originally appeared on diamandis.com. Read the original article here.

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Posted in Human Robots

#437202 Scientists Used Dopamine to Seamlessly ...

In just half a decade, neuromorphic devices—or brain-inspired computing—already seem quaint. The current darling? Artificial-biological hybrid computing, uniting both man-made computer chips and biological neurons seamlessly into semi-living circuits.

It sounds crazy, but a new study in Nature Materials shows that it’s possible to get an artificial neuron to communicate directly with a biological one using not just electricity, but dopamine—a chemical the brain naturally uses to change how neural circuits behave, most known for signaling reward.

Because these chemicals, known as “neurotransmitters,” are how biological neurons functionally link up in the brain, the study is a dramatic demonstration that it’s possible to connect artificial components with biological brain cells into a functional circuit.

The team isn’t the first to pursue hybrid neural circuits. Previously, a different team hooked up two silicon-based artificial neurons with a biological one into a circuit using electrical protocols alone. Although a powerful demonstration of hybrid computing, the study relied on only one-half of the brain’s computational ability: electrical computing.

The new study now tackles the other half: chemical computing. It adds a layer of compatibility that lays the groundwork not just for brain-inspired computers, but also for brain-machine interfaces and—perhaps—a sort of “cyborg” future. After all, if your brain can’t tell the difference between an artificial neuron and your own, could you? And even if you did, would you care?

Of course, that scenario is far in the future—if ever. For now, the team, led by Dr. Alberto Salleo, professor of materials science and engineering at Stanford University, collectively breathed a sigh of relief that the hybrid circuit worked.

“It’s a demonstration that this communication melding chemistry and electricity is possible,” said Salleo. “You could say it’s a first step toward a brain-machine interface, but it’s a tiny, tiny very first step.”

Neuromorphic Computing
The study grew from years of work into neuromorphic computing, or data processing inspired by the brain.

The blue-sky idea was inspired by the brain’s massive parallel computing capabilities, along with vast energy savings. By mimicking these properties, scientists reasoned, we could potentially turbo-charge computing. Neuromorphic devices basically embody artificial neural networks in physical form—wouldn’t hardware that mimics how the brain processes information be even more efficient and powerful?

These explorations led to novel neuromorphic chips, or artificial neurons that “fire” like biological ones. Additional work found that it’s possible to link these chips up into powerful circuits that run deep learning with ease, with bioengineered communication nodes called artificial synapses.

As a potential computing hardware replacement, these systems have proven to be incredibly promising. Yet scientists soon wondered: given their similarity to biological brains, can we use them as “replacement parts” for brains that suffer from traumatic injuries, aging, or degeneration? Can we hook up neuromorphic components to the brain to restore its capabilities?

Buzz & Chemistry
Theoretically, the answer’s yes.

But there’s a huge problem: current brain-machine interfaces only use electrical signals to mimic neural computation. The brain, in contrast, has two tricks up its sleeve: electricity and chemicals, or electrochemical.

Within a neuron, electricity travels up its incoming branches, through the bulbous body, then down the output branches. When electrical signals reach the neuron’s outgoing “piers,” dotted along the output branch, however, they hit a snag. A small gap exists between neurons, so to get to the other side, the electrical signals generally need to be converted into little bubble ships, packed with chemicals, and set sail to the other neuronal shore.

In other words, without chemical signals, the brain can’t function normally. These neurotransmitters don’t just passively carry information. Dopamine, for example, can dramatically change how a neural circuit functions. For an artificial-biological hybrid neural system, the absence of chemistry is like nixing international cargo vessels and only sticking with land-based trains and highways.

“To emulate biological synaptic behavior, the connectivity of the neuromorphic device must be dynamically regulated by the local neurotransmitter activity,” the team said.

Let’s Get Electro-Chemical
The new study started with two neurons: the upstream, an immortalized biological cell that releases dopamine; and the downstream, an artificial neuron that the team previously introduced in 2017, made of a mix of biocompatible and electrical-conducting materials.

Rather than the classic neuron shape, picture more of a sandwich with a chunk bitten out in the middle (yup, I’m totally serious). Each of the remaining parts of the sandwich is a soft electrode, made of biological polymers. The “bitten out” part has a conductive solution that can pass on electrical signals.

The biological cell sits close to the first electrode. When activated, it dumps out boats of dopamine, which drift to the electrode and chemically react with it—mimicking the process of dopamine docking onto a biological neuron. This, in turn, generates a current that’s passed on to the second electrode through the conductive solution channel. When this current reaches the second electrode, it changes the electrode’s conductance—that is, how well it can pass on electrical information. This second step is analogous to docked dopamine “ships” changing how likely it is that a biological neuron will fire in the future.

In other words, dopamine release from the biological neuron interacts with the artificial one, so that the chemicals change how the downstream neuron behaves in a somewhat lasting way—a loose mimic of what happens inside the brain during learning.

But that’s not all. Chemical signaling is especially powerful in the brain because it’s flexible. Dopamine, for example, only grabs onto the downstream neurons for a bit before it returns back to its upstream neuron—that is, recycled or destroyed. This means that its effect is temporary, giving the neural circuit breathing room to readjust its activity.

The Stanford team also tried reconstructing this quirk in their hybrid circuit. They crafted a microfluidic channel that shuttles both dopamine and its byproduct away from the artificial neurons after they’ve done their job for recycling.

Putting It All Together
After confirming that biological cells can survive happily on top of the artificial one, the team performed a few tests to see if the hybrid circuit could “learn.”

They used electrical methods to first activate the biological dopamine neuron, and watched the artificial one. Before the experiment, the team wasn’t quite sure what to expect. Theoretically, it made sense that dopamine would change the artificial neuron’s conductance, similar to learning. But “it was hard to know whether we’d achieve the outcome we predicted on paper until we saw it happen in the lab,” said study author Scott Keene.

On the first try, however, the team found that the burst of chemical signaling was able to change the artificial neuron’s conductance long-term, similar to the neuroscience dogma “neurons that fire together, wire together.” Activating the upstream biological neuron with chemicals also changed the artificial neuron’s conductance in a way that mimicked learning.

“That’s when we realized the potential this has for emulating the long-term learning process of a synapse,” said Keene.

Visualizing under an electron microscope, the team found that, similar to its biological counterpart, the hybrid synapse was able to efficiently recycle dopamine with timescales similar to the brain after some calibration. By playing with how much dopamine accumulates at the artificial neuron, the team found that they loosely mimic a learning rule called spike learning—a darling of machine learning inspired by the brain’s computation.

A Hybrid Future?
Unfortunately for cyborg enthusiasts, the work is still in its infancy.

For one, the artificial neurons are still rather bulky compared to biological ones. This means that they can’t capture and translate information from a single “boat” of dopamine. It’s also unclear if, and how, a hybrid synapse can work inside a living brain. Given the billions of synapses firing away in our heads, it’ll be a challenge to find-and-replace those that need replacement, and be able to control our memories and behaviors similar to natural ones.

That said, we’re inching ever closer to full-capability artificial-biological hybrid circuits.

“The neurotransmitter-mediated neuromorphic device presented in this work constitutes a fundamental building block for artificial neural networks that can be directly modulated based on biological feedback from live neurons,” the authors concluded. “[It] is a crucial first step in realizing next-generation adaptive biohybrid interfaces.”

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Posted in Human Robots

#436946 Coronavirus May Mean Automation Is ...

We’re in the midst of a public health emergency, and life as we know it has ground to a halt. The places we usually go are closed, the events we were looking forward to are canceled, and some of us have lost our jobs or fear losing them soon.

But although it may not seem like it, there are some silver linings; this crisis is bringing out the worst in some (I’m looking at you, toilet paper hoarders), but the best in many. Italians on lockdown are singing together, Spaniards on lockdown are exercising together, this entrepreneur made a DIY ventilator and put it on YouTube, and volunteers in Italy 3D printed medical valves for virus treatment at a fraction of their usual cost.

Indeed, if you want to feel like there’s still hope for humanity instead of feeling like we’re about to snowball into terribleness as a species, just look at these examples—and I’m sure there are many more out there. There’s plenty of hope and opportunity to be found in this crisis.

Peter Xing, a keynote speaker and writer on emerging technologies and associate director in technology and growth initiatives at KPMG, would agree. Xing believes the coronavirus epidemic is presenting us with ample opportunities for increased automation and remote delivery of goods and services. “The upside right now is the burgeoning platform of the digital transformation ecosystem,” he said.

In a thought-provoking talk at Singularity University’s COVID-19 virtual summit this week, Xing explained how the outbreak is accelerating our transition to a highly-automated society—and painted a picture of what the future may look like.

Confronting Scarcity
You’ve probably seen them by now—the barren shelves at your local grocery store. Whether you were in the paper goods aisle, the frozen food section, or the fresh produce area, it was clear something was amiss; the shelves were empty. One of the most inexplicable items people have been panic-bulk-buying is toilet paper.

Xing described this toilet paper scarcity as a prisoner’s dilemma, pointing out that we have a scarcity problem right now in terms of our mindset, not in terms of actual supply shortages. “It’s a prisoner’s dilemma in that we’re all prisoners in our homes right now, and we can either hoard or not hoard, and the outcomes depend on how we collaborate with each other,” he said. “But it’s not a zero-sum game.”

Xing referenced a CNN article about why toilet paper, of all things, is one of the items people have been panic-buying most (I, too, have been utterly baffled by this phenomenon). But maybe there’d be less panic if we knew more about the production methods and supply chain involved in manufacturing toilet paper. It turns out it’s a highly automated process (you can learn more about it in this documentary by National Geographic) and requires very few people (though it does require about 27,000 trees a day—so stop bulk-buying it! Just stop!).

The supply chain limitation here is in the raw material; we certainly can’t keep cutting down this many trees a day forever. But—somewhat ironically, given the Costco cartloads of TP people have been stuffing into their trunks and backseats—thanks to automation, toilet paper isn’t something stores are going to stop receiving anytime soon.

Automation For All
Now we have a reason to apply this level of automation to, well, pretty much everything.

Though our current situation may force us into using more robots and automated systems sooner than we’d planned, it will end up saving us money and creating opportunity, Xing believes. He cited “fast-casual” restaurants (Chipotle, Panera, etc.) as a prime example.

Currently, people in the US spend much more to eat at home than we do to eat in fast-casual restaurants if you take into account the cost of the food we’re preparing plus the value of the time we’re spending on cooking, grocery shopping, and cleaning up after meals. According to research from investment management firm ARK Invest, taking all these costs into account makes for about $12 per meal for food cooked at home.

That’s the same as or more than the cost of grabbing a burrito or a sandwich at the joint around the corner. As more of the repetitive, low-skill tasks involved in preparing fast casual meals are automated, their cost will drop even more, giving us more incentive to forego home cooking. (But, it’s worth noting that these figures don’t take into account that eating at home is, in most cases, better for you since you’re less likely to fill your food with sugar, oil, or various other taste-enhancing but health-destroying ingredients—plus, there are those of us who get a nearly incomparable amount of joy from laboring over then savoring a homemade meal).

Now that we’re not supposed to be touching each other or touching anything anyone else has touched, but we still need to eat, automating food preparation sounds appealing (and maybe necessary). Multiple food delivery services have already implemented a contactless delivery option, where customers can choose to have their food left on their doorstep.

Besides the opportunities for in-restaurant automation, “This is an opportunity for automation to happen at the last mile,” said Xing. Delivery drones, robots, and autonomous trucks and vans could all play a part. In fact, use of delivery drones has ramped up in China since the outbreak.

Speaking of deliveries, service robots have steadily increased in numbers at Amazon; as of late 2019, the company employed around 650,000 humans and 200,000 robots—and costs have gone down as robots have gone up.

ARK Invest’s research predicts automation could add $800 billion to US GDP over the next 5 years and $12 trillion during the next 15 years. On this trajectory, GDP would end up being 40 percent higher with automation than without it.

Automating Ourselves?
This is all well and good, but what do these numbers and percentages mean for the average consumer, worker, or citizen?

“The benefits of automation aren’t being passed on to the average citizen,” said Xing. “They’re going to the shareholders of the companies creating the automation.” This is where policies like universal basic income and universal healthcare come in; in the not-too-distant future, we may see more movement toward measures like these (depending how the election goes) that spread the benefit of automation out rather than concentrating it in a few wealthy hands.

In the meantime, though, some people are benefiting from automation in ways that maybe weren’t expected. We’re in the midst of what’s probably the biggest remote-work experiment in US history, not to mention remote learning. Tools that let us digitally communicate and collaborate, like Slack, Zoom, Dropbox, and Gsuite, are enabling remote work in a way that wouldn’t have been possible 20 or even 10 years ago.

In addition, Xing said, tools like DataRobot and H2O.ai are democratizing artificial intelligence by allowing almost anyone, not just data scientists or computer engineers, to run machine learning algorithms. People are codifying the steps in their own repetitive work processes and having their computers take over tasks for them.

As 3D printing gets cheaper and more accessible, it’s also being more widely adopted, and people are finding more applications (case in point: the Italians mentioned above who figured out how to cheaply print a medical valve for coronavirus treatment).

The Mother of Invention
This movement towards a more automated society has some positives: it will help us stay healthy during times like the present, it will drive down the cost of goods and services, and it will grow our GDP in the long run. But by leaning into automation, will we be enabling a future that keeps us more physically, psychologically, and emotionally distant from each other?

We’re in a crisis, and desperate times call for desperate measures. We’re sheltering in place, practicing social distancing, and trying not to touch each other. And for most of us, this is really unpleasant and difficult. We can’t wait for it to be over.

For better or worse, this pandemic will likely make us pick up the pace on our path to automation, across many sectors and processes. The solutions people implement during this crisis won’t disappear when things go back to normal (and, depending who you talk to, they may never really do so).

But let’s make sure to remember something. Even once robots are making our food and drones are delivering it, and our computers are doing data entry and email replies on our behalf, and we all have 3D printers to make anything we want at home—we’re still going to be human. And humans like being around each other. We like seeing one another’s faces, hearing one another’s voices, and feeling one another’s touch—in person, not on a screen or in an app.

No amount of automation is going to change that, and beyond lowering costs or increasing GDP, our greatest and most crucial responsibility will always be to take care of each other.

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Posted in Human Robots

#436482 50+ Reasons Our Favorite Emerging ...

For most of history, technology was about atoms, the manipulation of physical stuff to extend humankind’s reach. But in the last five or six decades, atoms have partnered with bits, the elemental “particles” of the digital world as we know it today. As computing has advanced at the accelerating pace described by Moore’s Law, technological progress has become increasingly digitized.

SpaceX lands and reuses rockets and self-driving cars do away with drivers thanks to automation, sensors, and software. Businesses find and hire talent from anywhere in the world, and for better and worse, a notable fraction of the world learns and socializes online. From the sequencing of DNA to artificial intelligence and from 3D printing to robotics, more and more new technologies are moving at a digital pace and quickly emerging to reshape the world around us.

In 2019, stories charting the advances of some of these digital technologies consistently made headlines. Below is, what is at best, an incomplete list of some of the big stories that caught our eye this year. With so much happening, it’s likely we’ve missed some notable headlines and advances—as well as some of your personal favorites. In either instance, share your thoughts and candidates for the biggest stories and breakthroughs on Facebook and Twitter.

With that said, let’s dive straight into the year.

Artificial Intelligence
No technology garnered as much attention as AI in 2019. With good reason. Intelligent computer systems are transitioning from research labs to everyday life. Healthcare, weather forecasting, business process automation, traffic congestion—you name it, and machine learning algorithms are likely beginning to work on it. Yet, AI has also been hyped up and overmarketed, and the latest round of AI technology, deep learning, is likely only one piece of the AI puzzle.

This year, Open AI’s game-playing algorithms beat some of the world’s best Dota 2 players, DeepMind notched impressive wins in Starcraft, and Carnegie Mellon University’s Libratus “crushed” pros at six-player Texas Hold‘em.
Speaking of games, AI’s mastery of the incredibly complex game of Go prompted a former world champion to quit, stating that AI ‘”cannot be defeated.”
But it isn’t just fun and games. Practical, powerful applications that make the best of AI’s pattern recognition abilities are on the way. Insilico Medicine, for example, used machine learning to help discover and design a new drug in just 46 days, and DeepMind is focused on using AI to crack protein folding.
Of course, AI can be a double-edged sword. When it comes to deepfakes and fake news, for example, AI makes both easier to create and detect, and early in the year, OpenAI created and announced a powerful AI text generator but delayed releasing it for fear of malicious use.
Recognizing AI’s power for good and ill, the OECD, EU, World Economic Forum, and China all took a stab at defining an ethical framework for the development and deployment of AI.

Computing Systems
Processors and chips kickstarted the digital boom and are still the bedrock of continued growth. While progress in traditional silicon-based chips continues, it’s slowing and getting more expensive. Some say we’re reaching the end of Moore’s Law. While that may be the case for traditional chips, specialized chips and entirely new kinds of computing are waiting in the wings.

In fall 2019, Google confirmed its quantum computer had achieved “quantum supremacy,” a term that means a quantum computer can perform a calculation a normal computer cannot. IBM pushed back on the claim, and it should be noted the calculation was highly specialized. But while it’s still early days, there does appear to be some real progress (and more to come).
Should quantum computing become truly practical, “the implications are staggering.” It could impact machine learning, medicine, chemistry, and materials science, just to name a few areas.
Specialized chips continue to take aim at machine learning—a giant new chip with over a trillion transistors, for example, may make machine learning algorithms significantly more efficient.
Cellular computers also saw advances in 2019 thanks to CRISPR. And the year witnessed the emergence of the first reprogrammable DNA computer and new chips inspired by the brain.
The development of hardware computing platforms is intrinsically linked to software. 2019 saw a continued move from big technology companies towards open sourcing (at least parts of) their software, potentially democratizing the use of advanced systems.

Networks
Increasing interconnectedness has, in many ways, defined the 21st century so far. Your phone is no longer just a phone. It’s access to the world’s population and accumulated knowledge—and it fits in your pocket. Pretty neat. This is all thanks to networks, which had some notable advances in 2019.

The biggest network development of the year may well be the arrival of the first 5G networks.
5G’s faster speeds promise advances across many emerging technologies.
Self-driving vehicles, for example, may become both smarter and safer thanks to 5G C-V2X networks. (Don’t worry with trying to remember that. If they catch on, they’ll hopefully get a better name.)
Wi-Fi may have heard the news and said “hold my beer,” as 2019 saw the introduction of Wi-Fi 6. Perhaps the most important upgrade, among others, is that Wi-Fi 6 ensures that the ever-growing number of network connected devices get higher data rates.
Networks also went to space in 2019, as SpaceX began launching its Starlink constellation of broadband satellites. In typical fashion, Elon Musk showed off the network’s ability to bounce data around the world by sending a Tweet.

Augmented Reality and Virtual Reality
Forget Pokemon Go (unless you want to add me as a friend in the game—in which case don’t forget Pokemon Go). 2019 saw AR and VR advance, even as Magic Leap, the most hyped of the lot, struggled to live up to outsized expectations and sell headsets.

Mixed reality AR and VR technologies, along with the explosive growth of sensor-based data about the world around us, is creating a one-to-one “Mirror World” of our physical reality—a digital world you can overlay on our own or dive into immersively thanks to AR and VR.
Facebook launched Replica, for example, which is a photorealistic virtual twin of the real world that, among other things, will help train AIs to better navigate their physical surroundings.
Our other senses (beyond eyes) may also become part of the Mirror World through the use of peripherals like a newly developed synthetic skin that aim to bring a sense of touch to VR.
AR and VR equipment is also becoming cheaper—with more producers entering the space—and more user-friendly. Instead of a wired headset requiring an expensive gaming PC, the new Oculus Quest is a wireless, self-contained step toward the mainstream.
Niche uses also continue to gain traction, from Google Glass’s Enterprise edition to the growth of AR and VR in professional education—including on-the-job-training and roleplaying emotionally difficult work encounters, like firing an employee.

Digital Biology and Biotech
The digitization of biology is happening at an incredible rate. With wild new research coming to light every year and just about every tech giant pouring money into new solutions and startups, we’re likely to see amazing advances in 2020 added to those we saw in 2019.

None were, perhaps, more visible than the success of protein-rich, plant-based substitutes for various meats. This was the year Beyond Meat was the top IPO on the NASDAQ stock exchange and people stood in line for the plant-based Impossible Whopper and KFC’s Beyond Chicken.
In the healthcare space, a report about three people with HIV who became virus free thanks to a bone marrow transplants of stem cells caused a huge stir. The research is still in relatively early stages, and isn’t suitable for most people, but it does provides a glimmer of hope.
CRISPR technology, which almost deserves its own section, progressed by leaps and bounds. One tweak made CRISPR up to 50 times more accurate, while the latest new CRISPR-based system, CRISPR prime, was described as a “word processor” for gene editing.
Many areas of healthcare stand to gain from CRISPR. For instance, cancer treatment, were a first safety test showed ‘promising’ results.
CRISPR’s many potential uses, however, also include some weird/morally questionable areas, which was exemplified by one the year’s stranger CRISPR-related stories about a human-monkey hybrid embryo in China.
Incidentally, China could be poised to take the lead on CRISPR thanks to massive investments and research programs.
As a consequence of quick advances in gene editing, we are approaching a point where we will be able to design our own biology—but first we need to have a serious conversation as a society about the ethics of gene editing and what lines should be drawn.

3D Printing
3D printing has quietly been growing both market size and the objects the printers are capable of producing. While both are impressive, perhaps the biggest story of 2019 is their increased speed.

One example was a boat that was printed in just three days, which also set three new world records for 3D printing.
3D printing is also spreading in the construction industry. In Mexico, the technology is being used to construct 50 new homes with subsidized mortgages of just $20/month.
3D printers also took care of all parts of a 640 square-meter home in Dubai.
Generally speaking, the use of 3D printing to make parts for everything from rocket engines (even entire rockets) to trains to cars illustrates the sturdiness of the technology, anno 2019.
In healthcare, 3D printing is also advancing the cause of bio-printed organs and, in one example, was used to print vascularized parts of a human heart.

Robotics
Living in Japan, I get to see Pepper, Aibo, and other robots on pretty much a daily basis. The novelty of that experience is spreading to other countries, and robots are becoming a more visible addition to both our professional and private lives.

We can’t talk about robots and 2019 without mentioning Boston Dynamics’ Spot robot, which went on sale for the general public.
Meanwhile, Google, Boston Dynamics’ former owner, rebooted their robotics division with a more down-to-earth focus on everyday uses they hope to commercialize.
SoftBank’s Pepper robot is working as a concierge and receptionist in various countries. It is also being used as a home companion. Not satisfied, Pepper rounded off 2019 by heading to the gym—to coach runners.
Indeed, there’s a growing list of sports where robots perform as well—or better—than humans.
2019 also saw robots launch an assault on the kitchen, including the likes of Samsung’s robot chef, and invade the front yard, with iRobot’s Terra robotic lawnmower.
In the borderlands of robotics, full-body robotic exoskeletons got a bit more practical, as the (by all accounts) user-friendly, battery-powered Sarcos Robotics Guardian XO went commercial.

Autonomous Vehicles
Self-driving cars did not—if you will forgive the play on words—stay quite on track during 2019. The fallout from Uber’s 2018 fatal crash marred part of the year, while some big players ratcheted back expectations on a quick shift to the driverless future. Still, self-driving cars, trucks, and other autonomous systems did make progress this year.

Winner of my unofficial award for best name in self-driving goes to Optimus Ride. The company also illustrates that self-driving may not be about creating a one-size-fits-all solution but catering to specific markets.
Self-driving trucks had a good year, with tests across many countries and states. One of the year’s odder stories was a self-driving truck traversing the US with a delivery of butter.
A step above the competition may be the future slogan (or perhaps not) of Boeing’s self-piloted air taxi that saw its maiden test flight in 2019. It joins a growing list of companies looking to create autonomous, flying passenger vehicles.
2019 was also the year where companies seemed to go all in on last-mile autonomous vehicles. Who wins that particular competition could well emerge during 2020.

Blockchain and Digital Currencies
Bitcoin continues to be the cryptocurrency equivalent of a rollercoaster, but the underlying blockchain technology is progressing more steadily. Together, they may turn parts of our financial systems cashless and digital—though how and when remains a slightly open question.

One indication of this was Facebook’s hugely controversial announcement of Libra, its proposed cryptocurrency. The company faced immediate pushback and saw a host of partners jump ship. Still, it brought the tech into mainstream conversations as never before and is putting the pressure on governments and central banks to explore their own digital currencies.
Deloitte’s in-depth survey of the state of blockchain highlighted how the technology has moved from fintech into just about any industry you can think of.
One of the biggest issues facing the spread of many digital currencies—Bitcoin in particular, you could argue—is how much energy it consumes to mine them. 2019 saw the emergence of several new digital currencies with a much smaller energy footprint.
2019 was also a year where we saw a new kind of digital currency, stablecoins, rise to prominence. As the name indicates, stablecoins are a group of digital currencies whose price fluctuations are more stable than the likes of Bitcoin.
In a geopolitical sense, 2019 was a year of China playing catch-up. Having initially banned blockchain, the country turned 180 degrees and announced that it was “quite close” to releasing a digital currency and a wave of blockchain-programs.

Renewable Energy and Energy Storage
While not every government on the planet seems to be a fan of renewable energy, it keeps on outperforming fossil fuel after fossil fuel in places well suited to it—even without support from some of said governments.

One of the reasons for renewable energy’s continued growth is that energy efficiency levels keep on improving.
As a result, an increased number of coal plants are being forced to close due to an inability to compete, and the UK went coal-free for a record two weeks.
We are also seeing more and more financial institutions refusing to fund fossil fuel projects. One such example is the European Investment Bank.
Renewable energy’s advance is tied at the hip to the rise of energy storage, which also had a breakout 2019, in part thanks to investments from the likes of Bill Gates.
The size and capabilities of energy storage also grew in 2019. The best illustration came from Australia were Tesla’s mega-battery proved that energy storage has reached a stage where it can prop up entire energy grids.

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