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#432891 This Week’s Awesome Stories From ...

TRANSPORTATION
Elon Musk Presents His Tunnel Vision to the People of LA
Jack Stewart and Aarian Marshall | Wired
“Now, Musk wants to build this new, 2.1-mile tunnel, near LA’s Sepulveda pass. It’s all part of his broader vision of a sprawling network that could take riders from Sherman Oaks in the north to Long Beach Airport in the south, Santa Monica in the west to Dodger Stadium in the east—without all that troublesome traffic.”

ROBOTICS
Feel What This Robot Feels Through Tactile Expressions
Evan Ackerman | IEEE Spectrum
“Guy Hoffman’s Human-Robot Collaboration & Companionship (HRC2) Lab at Cornell University is working on a new robot that’s designed to investigate this concept of textural communication, which really hasn’t been explored in robotics all that much. The robot uses a pneumatically powered elastomer skin that can be dynamically textured with either goosebumps or spikes, which should help it communicate more effectively, especially if what it’s trying to communicate is, ‘Don’t touch me!’”

VIRTUAL REALITY
In Virtual Reality, How Much Body Do You Need?
Steph Yin | The New York Times
“In a paper published Tuesday in Scientific Reports, they showed that animating virtual hands and feet alone is enough to make people feel their sense of body drift toward an invisible avatar. Their work fits into a corpus of research on illusory body ownership, which has challenged understandings of perception and contributed to therapies like treating pain for amputees who experience phantom limb.”

MEDICINE
How Graphene and Gold Could Help Us Test Drugs and Monitor Cancer
Angela Chen | The Verge
“In today’s study, scientists learned to precisely control the amount of electricity graphene generates by changing how much light they shine on the material. When they grew heart cells on the graphene, they could manipulate the cells too, says study co-author Alex Savtchenko, a physicist at the University of California, San Diego. They could make it beat 1.5 times faster, three times faster, 10 times faster, or whatever they needed.”

DISASTER RELIEF
Robotic Noses Could Be the Future of Disaster Rescue—If They Can Outsniff Search Dogs
Eleanor Cummins | Popular Science
“While canine units are a tried and fairly true method for identifying people trapped in the wreckage of a disaster, analytical chemists have for years been working in the lab to create a robotic alternative. A synthetic sniffer, they argue, could potentially prove to be just as or even more reliable than a dog, more resilient in the face of external pressures like heat and humidity, and infinitely more portable.”

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#432691 Is the Secret to Significantly Longer ...

Once upon a time, a powerful Sumerian king named Gilgamesh went on a quest, as such characters often do in these stories of myth and legend. Gilgamesh had witnessed the death of his best friend, Enkidu, and, fearing a similar fate, went in search of immortality. The great king failed to find the secret of eternal life but took solace that his deeds would live well beyond his mortal years.

Fast-forward four thousand years, give or take a century, and Gilgamesh (as famous as any B-list celebrity today, despite the passage of time) would probably be heartened to learn that many others have taken up his search for longevity. Today, though, instead of battling epic monsters and the machinations of fickle gods, those seeking to enhance and extend life are cutting-edge scientists and visionary entrepreneurs who are helping unlock the secrets of human biology.

Chief among them is Aubrey de Grey, a biomedical gerontologist who founded the SENS Research Foundation, a Silicon Valley-based research organization that seeks to advance the application of regenerative medicine to age-related diseases. SENS stands for Strategies for Engineered Negligible Senescence, a term coined by de Grey to describe a broad array (seven, to be precise) of medical interventions that attempt to repair or prevent different types of molecular and cellular damage that eventually lead to age-related diseases like cancer and Alzheimer’s.

Many of the strategies focus on senescent cells, which accumulate in tissues and organs as people age. Not quite dead, senescent cells stop dividing but are still metabolically active, spewing out all sorts of proteins and other molecules that can cause inflammation and other problems. In a young body, that’s usually not a problem (and probably part of general biological maintenance), as a healthy immune system can go to work to put out most fires.

However, as we age, senescent cells continue to accumulate, and at some point the immune system retires from fire watch. Welcome to old age.

Of Mice and Men
Researchers like de Grey believe that treating the cellular underpinnings of aging could not only prevent disease but significantly extend human lifespans. How long? Well, if you’re talking to de Grey, Biblical proportions—on the order of centuries.

De Grey says that science has made great strides toward that end in the last 15 years, such as the ability to copy mitochondrial DNA to the nucleus. Mitochondria serve as the power plant of the cell but are highly susceptible to mutations that lead to cellular degeneration. Copying the mitochondrial DNA into the nucleus would help protect it from damage.

Another achievement occurred about six years ago when scientists first figured out how to kill senescent cells. That discovery led to a spate of new experiments in mice indicating that removing these ticking-time-bomb cells prevented disease and even extended their lifespans. Now the anti-aging therapy is about to be tested in humans.

“As for the next few years, I think the stream of advances is likely to become a flood—once the first steps are made, things get progressively easier and faster,” de Grey tells Singularity Hub. “I think there’s a good chance that we will achieve really dramatic rejuvenation of mice within only six to eight years: maybe taking middle-aged mice and doubling their remaining lifespan, which is an order of magnitude more than can be done today.”

Not Horsing Around
Richard G.A. Faragher, a professor of biogerontology at the University of Brighton in the United Kingdom, recently made discoveries in the lab regarding the rejuvenation of senescent cells with chemical compounds found in foods like chocolate and red wine. He hopes to apply his findings to an animal model in the future—in this case,horses.

“We have been very fortunate in receiving some funding from an animal welfare charity to look at potential treatments for older horses,” he explains to Singularity Hub in an email. “I think this is a great idea. Many aspects of the physiology we are studying are common between horses and humans.”

What Faragher and his colleagues demonstrated in a paper published in BMC Cell Biology last year was that resveralogues, chemicals based on resveratrol, were able to reactivate a protein called a splicing factor that is involved in gene regulation. Within hours, the chemicals caused the cells to rejuvenate and start dividing like younger cells.

“If treatments work in our old pony systems, then I am sure they could be translated into clinical trials in humans,” Faragher says. “How long is purely a matter of money. Given suitable funding, I would hope to see a trial within five years.”

Show Them the Money
Faragher argues that the recent breakthroughs aren’t because a result of emerging technologies like artificial intelligence or the gene-editing tool CRISPR, but a paradigm shift in how scientists understand the underpinnings of cellular aging. Solving the “aging problem” isn’t a question of technology but of money, he says.

“Frankly, when AI and CRISPR have removed cystic fibrosis, Duchenne muscular dystrophy or Gaucher syndrome, I’ll be much more willing to hear tales of amazing progress. Go fix a single, highly penetrant genetic disease in the population using this flashy stuff and then we’ll talk,” he says. “My faith resides in the most potent technological development of all: money.”

De Grey is less flippant about the role that technology will play in the quest to defeat aging. AI, CRISPR, protein engineering, advances in stem cell therapies, and immune system engineering—all will have a part.

“There is not really anything distinctive about the ways in which these technologies will contribute,” he says. “What’s distinctive is that we will need all of these technologies, because there are so many different types of damage to repair and they each require different tricks.”

It’s in the Blood
A startup in the San Francisco Bay Area believes machines can play a big role in discovering the right combination of factors that lead to longer and healthier lives—and then develop drugs that exploit those findings.

BioAge Labs raised nearly $11 million last year for its machine learning platform that crunches big data sets to find blood factors, such as proteins or metabolites, that are tied to a person’s underlying biological age. The startup claims that these factors can predict how long a person will live.

“Our interest in this comes out of research into parabiosis, where joining the circulatory systems of old and young mice—so that they share the same blood—has been demonstrated to make old mice healthier and more robust,” Dr. Eric Morgen, chief medical officer at BioAge, tells Singularity Hub.

Based on that idea, he explains, it should be possible to alter those good or bad factors to produce a rejuvenating effect.

“Our main focus at BioAge is to identify these types of factors in our human cohort data, characterize the important molecular pathways they are involved in, and then drug those pathways,” he says. “This is a really hard problem, and we use machine learning to mine these complex datasets to determine which individual factors and molecular pathways best reflect biological age.”

Saving for the Future
Of course, there’s no telling when any of these anti-aging therapies will come to market. That’s why Forever Labs, a biotechnology startup out of Ann Arbor, Michigan, wants your stem cells now. The company offers a service to cryogenically freeze stem cells taken from bone marrow.

The theory behind the procedure, according to Forever Labs CEO Steven Clausnitzer, is based on research showing that stem cells may be a key component for repairing cellular damage. That’s because stem cells can develop into many different cell types and can divide endlessly to replenish other cells. Clausnitzer notes that there are upwards of a thousand clinical studies looking at using stem cells to treat age-related conditions such as cardiovascular disease.

However, stem cells come with their own expiration date, which usually coincides with the age that most people start experiencing serious health problems. Stem cells harvested from bone marrow at a younger age can potentially provide a therapeutic resource in the future.

“We believe strongly that by having access to your own best possible selves, you’re going to be well positioned to lead healthier, longer lives,” he tells Singularity Hub.

“There’s a compelling argument to be made that if you started to maintain the bone marrow population, the amount of nuclear cells in your bone marrow, and to re-up them so that they aren’t declining with age, it stands to reason that you could absolutely mitigate things like cardiovascular disease and stroke and Alzheimer’s,” he adds.

Clausnitzer notes that the stored stem cells can be used today in developing therapies to treat chronic conditions such as osteoarthritis. However, the more exciting prospect—and the reason he put his own 38-year-old stem cells on ice—is that he believes future stem cell therapies can help stave off the ravages of age-related disease.

“I can start reintroducing them not to treat age-related disease but to treat the decline in the stem-cell niche itself, so that I don’t ever get an age-related disease,” he says. “I don’t think that it equates to immortality, but it certainly is a step in that direction.”

Indecisive on Immortality
The societal implications of a longer-living human species are a guessing game at this point. We do know that by mid-century, the global population of those aged 65 and older will reach 1.6 billion, while those older than 80 will hit nearly 450 million, according to the National Academies of Science. If many of those people could enjoy healthy lives in their twilight years, an enormous medical cost could be avoided.

Faragher is certainly working toward a future where human health is ubiquitous. Human immortality is another question entirely.

“The longer lifespans become, the more heavily we may need to control birth rates and thus we may have fewer new minds. This could have a heavy ‘opportunity cost’ in terms of progress,” he says.

And does anyone truly want to live forever?

“There have been happy moments in my life but I have also suffered some traumatic disappointments. No [drug] will wash those experiences out of me,” Faragher says. “I no longer view my future with unqualified enthusiasm, and I do not think I am the only middle-aged man to feel that way. I don’t think it is an accident that so many ‘immortalists’ are young.

“They should be careful what they wish for.”

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#432646 How Fukushima Changed Japanese Robotics ...

In March 2011, Japan was hit by a catastrophic earthquake that triggered a terrible tsunami. Thousands were killed and billions of dollars of damage was done in one of the worst disasters of modern times. For a few perilous weeks, though, the eyes of the world were focused on the Fukushima Daiichi nuclear power plant. Its safety systems were unable to cope with the tsunami damage, and there were widespread fears of another catastrophic meltdown that could spread radiation over several countries, like the Chernobyl disaster in the 1980s. A heroic effort that included dumping seawater into the reactor core prevented an even bigger catastrophe. As it is, a hundred thousand people are still evacuated from the area, and it will likely take many years and hundreds of billions of dollars before the region is safe.

Because radiation is so dangerous to humans, the natural solution to the Fukushima disaster was to send in robots to monitor levels of radiation and attempt to begin the clean-up process. The techno-optimists in Japan had discovered a challenge, deep in the heart of that reactor core, that even their optimism could not solve. The radiation fried the circuits of the robots that were sent in, even those specifically designed and built to deal with the Fukushima catastrophe. The power plant slowly became a vast robot graveyard. While some robots initially saw success in measuring radiation levels around the plant—and, recently, a robot was able to identify the melted uranium fuel at the heart of the disaster—hopes of them playing a substantial role in the clean-up are starting to diminish.



In Tokyo’s neon Shibuya district, it can sometimes seem like it’s brighter at night than it is during the daytime. In karaoke booths on the twelfth floor—because everything is on the twelfth floor—overlooking the brightly-lit streets, businessmen unwind by blasting out pop hits. It can feel like the most artificial place on Earth; your senses are dazzled by the futuristic techno-optimism. Stock footage of the area has become symbolic of futurism and modernity.

Japan has had a reputation for being a nation of futurists for a long time. We’ve already described how tech giant Softbank, headed by visionary founder Masayoshi Son, is investing billions in a technological future, including plans for the world’s largest solar farm.

When Google sold pioneering robotics company Boston Dynamics in 2017, Softbank added it to their portfolio, alongside the famous Nao and Pepper robots. Some may think that Son is taking a gamble in pursuing a robotics project even Google couldn’t succeed in, but this is a man who lost nearly everything in the dot-com crash of 2000. The fact that even this reversal didn’t dent his optimism and faith in technology is telling. But how long can it last?

The failure of Japan’s robots to deal with the immense challenge of Fukushima has sparked something of a crisis of conscience within the industry. Disaster response is an obvious stepping-stone technology for robots. Initially, producing a humanoid robot will be very costly, and the robot will be less capable than a human; building a robot to wait tables might not be particularly economical yet. Building a robot to do jobs that are too dangerous for humans is far more viable. Yet, at Fukushima, in one of the most advanced nations in the world, many of the robots weren’t up to the task.

Nowhere was this crisis more felt than Honda; the company had developed ASIMO, which stunned the world in 2000 and continues to fascinate as an iconic humanoid robot. Despite all this technological advancement, however, Honda knew that ASIMO was still too unreliable for the real world.

It was Fukushima that triggered a sea-change in Honda’s approach to robotics. Two years after the disaster, there were rumblings that Honda was developing a disaster robot, and in October 2017, the prototype was revealed to the public for the first time. It’s not yet ready for deployment in disaster zones, however. Interestingly, the creators chose not to give it dexterous hands but instead to assume that remotely-operated tools fitted to the robot would be a better solution for the range of circumstances it might encounter.

This shift in focus for humanoid robots away from entertainment and amusement like ASIMO, and towards being practically useful, has been mirrored across the world.

In 2015, also inspired by the Fukushima disaster and the lack of disaster-ready robots, the DARPA Robotics Challenge tested humanoid robots with a range of tasks that might be needed in emergency response, such as driving cars, opening doors, and climbing stairs. The Terminator-like ATLAS robot from Boston Dynamics, alongside Korean robot HUBO, took many of the plaudits, and CHIMP also put in an impressive display by being able to right itself after falling.

Yet the DARPA Robotics Challenge showed us just how far the robots are from truly being as useful as we’d like, or maybe even as we would imagine. Many robots took hours to complete the tasks, which were highly idealized to suit them. Climbing stairs proved a particular challenge. Those who watched were more likely to see a robot that had fallen over, struggling to get up, rather than heroic superbots striding in to save the day. The “striding” proved a particular problem, with the fastest robot HUBO managing this by resorting to wheels in its knees when the legs weren’t necessary.

Fukushima may have brought a sea-change over futuristic Japan, but before robots will really begin to enter our everyday lives, they will need to prove their worth. In the interim, aerial drone robots designed to examine infrastructure damage after disasters may well see earlier deployment and more success.

It’s a considerable challenge.

Building a humanoid robot is expensive; if these multi-million-dollar machines can’t help in a crisis, people may begin to question the worth of investing in them in the first place (unless your aim is just to make viral videos). This could lead to a further crisis of confidence among the Japanese, who are starting to rely on humanoid robotics as a solution to the crisis of the aging population. The Japanese government, as part of its robots strategy, has already invested $44 million in their development.

But if they continue to fail when put to the test, that will raise serious concerns. In Tokyo’s Akihabara district, you can see all kinds of flash robotic toys for sale in the neon-lit superstores, and dancing, acting robots like Robothespian can entertain crowds all over the world. But if we want these machines to be anything more than toys—partners, helpers, even saviors—more work needs to be done.

At the same time, those who participated in the DARPA Robotics Challenge in 2015 won’t be too concerned if people were underwhelmed by the performance of their disaster relief robots. Back in 2004, nearly every participant in the DARPA Grand Challenge crashed, caught fire, or failed on the starting line. To an outside observer, the whole thing would have seemed like an unmitigated disaster, and a pointless investment. What was the task in 2004? Developing a self-driving car. A lot can change in a decade.

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#432572 Robots Can Swim, Fetch, Lift, and Dance. ...

Robotics has come a long way in the past few years. Robots can now fetch items from specific spots in massive warehouses, swim through the ocean to study marine life, and lift 200 times their own weight. They can even perform synchronized dance routines.

But the really big question is—can robots put together an Ikea chair?

A team of engineers from Nanyang Technological University in Singapore decided to find out, detailing their work in a paper published last week in the journal Science Robotics. The team took industrial robot arms and equipped them with parallel grippers, force-detecting sensors, and 3D cameras, and wrote software enabling the souped-up bots to tackle chair assembly. The robots’ starting point was a set of chair parts randomly scattered within reach.

As impressive as the above-mentioned robotic capabilities are, it’s worth noting that they’re mostly limited to a single skill. Putting together furniture, on the other hand, requires using and precisely coordinating multiple skills, including force control, visual localization, hand-eye coordination, and the patience to read each step of the manual without rushing through it and messing everything up.

Indeed, Ikea furniture, while meant to be simple and user-friendly, has left even the best of us scratching our heads and holding a spare oddly-shaped piece of wood as we stare at the desk or bed frame we just put together—or, for the less even-tempered among us, throwing said piece of wood across the room.

It’s a good thing robots don’t have tempers, because it took a few tries for the bots to get the chair assembly right.

Practice makes perfect, though (or in this case, rewriting code makes perfect), and these bots didn’t give up so easily. They had to hone three different skills: identifying which part was which among the scattered, differently-shaped pieces of wood, coordinating their movements to put those pieces in the right place, and knowing how much force to use in various steps of the process (i.e., more force is needed to connect two pieces than to pick up one piece).

A few tries later, the bots were able to assemble the chair from start to finish in about nine minutes.

On the whole, nicely done. But before we applaud the robots’ success too loudly, it’s important to note that they didn’t autonomously assemble the chair. Rather, each step of the process was planned and coded by engineers, down to the millimeter.

However, the team believes this closely-guided chair assembly was just a first step, and they see a not-so-distant future where combining artificial intelligence with advanced robotic capabilities could produce smart bots that would learn to assemble furniture and do other complex tasks on their own.

Future applications mentioned in the paper include electronics and aircraft manufacturing, logistics, and other high-mix, low-volume sectors.

Image Credit: Francisco Suárez-Ruiz and Quang-Cuong Pham/Nanyang Technological University Continue reading

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#432563 This Week’s Awesome Stories From ...

ARTIFICIAL INTELLIGENCE
Pedro Domingos on the Arms Race in Artificial Intelligence
Christoph Scheuermann and Bernhard Zand | Spiegel Online
“AI lowers the cost of knowledge by orders of magnitude. One good, effective machine learning system can do the work of a million people, whether it’s for commercial purposes or for cyberespionage. Imagine a country that produces a thousand times more knowledge than another. This is the challenge we are facing.”

BIOTECHNOLOGY
Gene Therapy Could Free Some People From a Lifetime of Blood Transfusions
Emily Mullin | MIT Technology Review
“A one-time, experimental treatment for an inherited blood disorder has shown dramatic results in a small study. …[Lead author Alexis Thompson] says the effect on patients has been remarkable. ‘They have been tied to this ongoing medical therapy that is burdensome and expensive for their whole lives,’ she says. ‘Gene therapy has allowed people to have aspirations and really pursue them.’ ”

ENVIRONMENT
The Revolutionary Giant Ocean Cleanup Machine Is About to Set Sail
Adele Peters | Fast Company
“By the end of 2018, the nonprofit says it will bring back its first harvest of ocean plastic from the North Pacific Gyre, along with concrete proof that the design works. The organization expects to bring 5,000 kilograms of plastic ashore per month with its first system. With a full fleet of systems deployed, it believes that it can collect half of the plastic trash in the Great Pacific Garbage Patch—around 40,000 metric tons—within five years.”

ROBOTICS
Autonomous Boats Will Be on the Market Sooner Than Self-Driving Cars
Tracey Lindeman | Motherboard
“Some unmanned watercraft…may be at sea commercially before 2020. That’s partly because automating all ships could generate a ridiculous amount of revenue. According to the United Nations, 90 percent of the world’s trade is carried by sea and 10.3 billion tons of products were shipped in 2016.”

DIGITAL CULTURE
Style Is an Algorithm
Kyle Chayka | Racked
“Confronting the Echo Look’s opaque statements on my fashion sense, I realize that all of these algorithmic experiences are matters of taste: the question of what we like and why we like it, and what it means that taste is increasingly dictated by black-box robots like the camera on my shelf.”

COMPUTING
How Apple Will Use AR to Reinvent the Human-Computer Interface
Tim Bajarin | Fast Company
“It’s in Apple’s DNA to continually deliver the ‘next’ major advancement to the personal computing experience. Its innovation in man-machine interfaces started with the Mac and then extended to the iPod, the iPhone, the iPad, and most recently, the Apple Watch. Now, get ready for the next chapter, as Apple tackles augmented reality, in a way that could fundamentally transform the human-computer interface.”

SCIENCE
Advanced Microscope Shows Cells at Work in Incredible Detail
Steve Dent | Engadget
“For the first time, scientists have peered into living cells and created videos showing how they function with unprecedented 3D detail. Using a special microscope and new lighting techniques, a team from Harvard and the Howard Hughes Medical Institute captured zebrafish immune cell interactions with unheard-of 3D detail and resolution.”

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