Tag Archives: interest
#436962 Scientists Engineered Neurons to Make ...
Electricity plays a surprisingly powerful role in our bodies. While most people are aware that it plays a crucial role in carrying signals to and from our nerves, our bodies produce electric fields that can do everything from helping heal wounds to triggering the release of hormones.
Electric fields can influence a host of important cellular behavior, like directional migration, proliferation, division, or even differentiation into different cell types. The work of Michael Levin at Tufts University even suggests that electrical fields may play a crucial role in the way our bodies organize themselves.
This has prompted considerable interest in exploiting our body’s receptiveness to electrical stimulation for therapeutic means, but given the diffuse nature of electrical fields a key challenge is finding a way to localize these effects. Conductive polymers have proven a useful tool in this regard thanks to their good electrical properties and biocompatibility, and have been used in everything from neural implants to biosensors.
But now, a team at Stanford University has developed a way to genetically engineer neurons to build the materials into their own cell membranes. The approach could make it possible to target highly specific groups of cells, providing unprecedented control over the body’s response to electrical stimulation.
In a paper in Science, the team explained how they used re-engineered viruses to deliver DNA that hijacks cells’ biosynthesis machinery to create an enzyme that assembles electroactive polymers onto their membranes. This changes the electrical properties of the cells, which the team demonstrated could be used to control their behavior.
They used the approach to modulate neuronal firing in cultures of rat hippocampal neurons, mouse brain slices, and even human cortical spheroids. Most impressively, they showed that they could coax the neurons of living C. elegans worms to produce the polymers in large enough quantities to alter their behavior without impairing the cells’ natural function.
Translating the idea to humans poses major challenges, not least because the viruses used to deliver the genetic changes are still a long way from being approved for clinical use. But the ability to precisely target specific cells using a genetic approach holds enormous promise for bioelectronic medicine, Kevin Otto and Christine Schmidt from the University of Florida say in an accompanying perspective.
Interest is booming in therapies that use electrical stimulation of neural circuits as an alternative to drugs for diseases as varied as arthritis, Alzheimer’s, diabetes, and cardiovascular disease, and hundreds of clinical trials are currently underway.
At present these approaches rely on electrodes that can provide some level of localization, but because different kinds of nerve cells are often packed closely together it’s proven hard to stimulate exactly the right nerves, say Otto and Schmidt. This new approach makes it possible to boost the conductivity of specific cell types, which could make these kinds of interventions dramatically more targeted.
Besides disease-focused bioelectronic interventions, Otto and Schmidt say the approach could prove invaluable for helping to interface advanced prosthetics with patients’ nervous systems by making it possible to excite sensory neurons without accidentally triggering motor neurons, or vice versa.
More speculatively, the approach could one day help create far more efficient bridges between our minds and machines. One of the major challenges for brain-machine interfaces is recording from specific neurons, something that a genetically targeted approach might be able to help greatly with.
If the researchers can replicate the ability to build electronic-tissue “composites” in humans, we may be well on our way to the cyborg future predicted by science fiction.
Image Credit: Gerd Altmann from Pixabay Continue reading
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#436403 Why Your 5G Phone Connection Could Mean ...
Will getting full bars on your 5G connection mean getting caught out by sudden weather changes?
The question may strike you as hypothetical, nonsensical even, but it is at the core of ongoing disputes between meteorologists and telecommunications companies. Everyone else, including you and I, are caught in the middle, wanting both 5G’s faster connection speeds and precise information about our increasingly unpredictable weather. So why can’t we have both?
Perhaps we can, but because of the way 5G networks function, it may take some special technology—specifically, artificial intelligence.
The Bandwidth Worries
Around the world, the first 5G networks are already being rolled out. The networks use a variety of frequencies to transmit data to and from devices at speeds up to 100 times faster than existing 4G networks.
One of the bandwidths used is between 24.25 and 24.45 gigahertz (GHz). In a recent FCC auction, telecommunications companies paid a combined $2 billion for the 5G usage rights for this spectrum in the US.
However, meteorologists are concerned that transmissions near the lower end of that range can interfere with their ability to accurately measure water vapor in the atmosphere. Wired reported that acting chief of the National Oceanic and Atmospheric Administration (NOAA), Neil Jacobs, told the US House Subcommittee on the Environment that 5G interference could substantially cut the amount of weather data satellites can gather. As a result, forecast accuracy could drop by as much as 30 percent.
Among the consequences could be less time to prepare for hurricanes, and it may become harder to predict storms’ paths. Due to the interconnectedness of weather patterns, measurement issues in one location can affect other areas too. Lack of accurate atmospheric data from the US could, for example, lead to less accurate forecasts for weather patterns over Europe.
The Numbers Game
Water vapor emits a faint signal at 23.8 GHz. Weather satellites measure the signals, and the data is used to gauge atmospheric humidity levels. Meteorologists have expressed concern that 5G signals in the same range can disturb those readings. The issue is that it would be nigh on impossible to tell whether a signal is water vapor or an errant 5G signal.
Furthermore, 5G disturbances in other frequency bands could make forecasting even more difficult. Rain and snow emit frequencies around 36-37 GHz. 50.2-50.4 GHz is used to measure atmospheric temperatures, and 86-92 GHz clouds and ice. All of the above are under consideration for international 5G signals. Some have warned that the wider consequences could set weather forecasts back to the 1980s.
Telecommunications companies and interest organizations have argued back, saying that weather sensors aren’t as susceptible to interference as meteorologists fear. Furthermore, 5G devices and signals will produce much less interference with weather forecasts than organizations like NOAA predict. Since very little scientific research has been carried out to examine the claims of either party, we seem stuck in a ‘wait and see’ situation.
To offset some of the possible effects, the two groups have tried to reach a consensus on a noise buffer between the 5G transmissions and water-vapor signals. It could be likened to limiting the noise from busy roads or loud sound systems to avoid bothering neighboring buildings.
The World Meteorological Organization was looking to establish a -55 decibel watts buffer. In Europe, regulators are locked in on a -42 decibel watts buffer for 5G base stations. For comparison, the US Federal Communications Commission has advocated for a -20 decibel watts buffer, which would, in reality, allow more than 150 times more noise than the European proposal.
How AI Could Help
Much of the conversation about 5G’s possible influence on future weather predictions is centered around mobile phones. However, the phones are far from the only systems that will be receiving and transmitting signals on 5G. Self-driving cars and the Internet of Things are two other technologies that could soon be heavily reliant on faster wireless signals.
Densely populated areas are likely going to be the biggest emitters of 5G signals, leading to a suggestion to only gather water-vapor data over oceans.
Another option is to develop artificial intelligence (AI) approaches to clean or process weather data. AI is playing an increasing role in weather forecasting. For example, in 2016 IBM bought The Weather Company for $2 billion. The goal was to combine the two companies’ models and data in IBM’s Watson to create more accurate forecasts. AI would also be able to predict increases or drops in business revenues due to weather changes. Monsanto has also been investing in AI for forecasting, in this case to provide agriculturally-related weather predictions.
Smartphones may also provide a piece of the weather forecasting puzzle. Studies have shown how data from thousands of smartphones can help to increase the accuracy of storm predictions, as well as the force of storms.
“Weather stations cost a lot of money,” Cliff Mass, an atmospheric scientist at the University of Washington in Seattle, told Inside Science, adding, “If there are already 20 million smartphones, you might as well take advantage of the observation system that’s already in place.”
Smartphones may not be the solution when it comes to finding new ways of gathering the atmospheric data on water vapor that 5G could disrupt. But it does go to show that some technologies open new doors, while at the same time, others shut them.
Image Credit: Image by Free-Photos from Pixabay Continue reading
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#436200 AI and the Future of Work: The Economic ...
This week at MIT, academics and industry officials compared notes, studies, and predictions about AI and the future of work. During the discussions, an insurance company executive shared details about one AI program that rolled out at his firm earlier this year. A chatbot the company introduced, the executive said, now handles 150,000 calls per month.
Later in the day, a panelist—David Fanning, founder of PBS’s Frontline—remarked that this statistic is emblematic of broader fears he saw when reporting a new Frontline documentary about AI. “People are scared,” Fanning said of the public’s AI anxiety.
Fanning was part of a daylong symposium about AI’s economic consequences—good, bad, and otherwise—convened by MIT’s Task Force on the Work of the Future.
“Dig into every industry, and you’ll find AI changing the nature of work,” said Daniela Rus, director of MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL). She cited recent McKinsey research that found 45 percent of the work people are paid to do today can be automated with currently available technologies. Those activities, McKinsey found, represent some US $2 trillion in wages.
However, the threat of automation—whether by AI or other technologies—isn’t as new as technologists on America’s coasts seem to believe, said panelist Fred Goff, CEO of Jobcase, Inc.
“If you live in Detroit or Toledo, where I come from, technology has been displacing jobs for the last half-century,” Goff said. “I don’t think that most people in this country have the increased anxiety that the coasts do, because they’ve been living this.”
Goff added that the challenge AI poses for the workforce is not, as he put it, “getting coal miners to code.” Rather, he said, as AI automates some jobs, it will also open opportunities for “reskilling” that may have nothing to do with AI or automation. He touted trade schools—teaching skills like welding, plumbing, and electrical work—and certification programs for sales industry software packages like Salesforce.
On the other hand, a documentarian who reported another recent program on AI—Krishna Andavolu, senior correspondent for Vice Media—said “reskilling” may not be an easy answer.
“People in rooms like this … don’t realize that a lot of people don’t want to work that much,” Andavolu said. “They’re not driven by passion for their career, they’re driven by passion for life. We’re telling a lot of these workers that they need to reskill. But to a lot of people that sounds like, ‘I’ve got to work twice as hard for what I have now.’ That sounds scary. We underestimate that at our peril.”
Part of the problem with “reskilling,” Andavolu said, is that some high-growth industries involve caregiving for seniors and in medical facilities—roles which are traditionally considered “feminized” careers. Destigmatizing these jobs, and increasing the pay to match the salaries of displaced jobs like long-haul truck drivers, is another challenge.
Daron Acemoglu, MIT Institute Professor of Economics, faulted the comparably slim funding of academic research into AI.
“There is nothing preordained about the progress of technology,” he said. Computers, the Internet, antibiotics, and sensors all grew out of government and academic research programs. What he called the “blue-sky thinking” of non-corporate AI research can also develop applications that are not purely focused on maximizing profits.
American companies, Acemoglu said, get tax breaks for capital R&D—but not for developing new technologies for their employees. “We turn around and [tell companies], ‘Use your technologies to empower workers,’” he said. “But why should they do that? Hiring workers is expensive in many ways. And we’re subsidizing capital.”
Said Sarita Gupta, director of the Ford Foundation’s Future of Work(ers) Program, “Low and middle income workers have for over 30 years been experiencing stagnant and declining pay, shrinking benefits, and less power on the job. Now technology is brilliant at enabling scale. But the question we sit with is—how do we make sure that we’re not scaling these longstanding problems?”
Andrew McAfee, co-director of MIT’s Initiative on the Digital Economy, said AI may not reduce the number of jobs available in the workplace today. But the quality of those jobs is another story. He cited the Dutch economist Jan Tinbergen who decades ago said that “Inequality is a race between technology and education.”
McAfee said, ultimately, the time to solve the economic problems AI poses for workers in the United States is when the U.S. economy is doing well—like right now.
“We do have the wind at our backs,” said Elisabeth Reynolds, executive director of MIT’s Task Force on the Work of the Future.
“We have some breathing room right now,” McAfee agreed. “Economic growth has been pretty good. Unemployment is pretty low. Interest rates are very, very low. We might not have that war chest in the future.” Continue reading
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