Tag Archives: hard

#437673 Can AI and Automation Deliver a COVID-19 ...

Illustration: Marysia Machulska

Within moments of meeting each other at a conference last year, Nathan Collins and Yann Gaston-Mathé began devising a plan to work together. Gaston-Mathé runs a startup that applies automated software to the design of new drug candidates. Collins leads a team that uses an automated chemistry platform to synthesize new drug candidates.

“There was an obvious synergy between their technology and ours,” recalls Gaston-Mathé, CEO and cofounder of Paris-based Iktos.

In late 2019, the pair launched a project to create a brand-new antiviral drug that would block a specific protein exploited by influenza viruses. Then the COVID-19 pandemic erupted across the world stage, and Gaston-Mathé and Collins learned that the viral culprit, SARS-CoV-2, relied on a protein that was 97 percent similar to their influenza protein. The partners pivoted.

Their companies are just two of hundreds of biotech firms eager to overhaul the drug-discovery process, often with the aid of artificial intelligence (AI) tools. The first set of antiviral drugs to treat COVID-19 will likely come from sifting through existing drugs. Remdesivir, for example, was originally developed to treat Ebola, and it has been shown to speed the recovery of hospitalized COVID-19 patients. But a drug made for one condition often has side effects and limited potency when applied to another. If researchers can produce an ­antiviral that specifically targets SARS-CoV-2, the drug would likely be safer and more effective than a repurposed drug.

There’s one big problem: Traditional drug discovery is far too slow to react to a pandemic. Designing a drug from scratch typically takes three to five years—and that’s before human clinical trials. “Our goal, with the combination of AI and automation, is to reduce that down to six months or less,” says Collins, who is chief strategy officer at SRI Biosciences, a division of the Silicon Valley research nonprofit SRI International. “We want to get this to be very, very fast.”

That sentiment is shared by small biotech firms and big pharmaceutical companies alike, many of which are now ramping up automated technologies backed by supercomputing power to predict, design, and test new antivirals—for this pandemic as well as the next—with unprecedented speed and scope.

“The entire industry is embracing these tools,” says Kara Carter, president of the International Society for Antiviral Research and executive vice president of infectious disease at Evotec, a drug-discovery company in Hamburg. “Not only do we need [new antivirals] to treat the SARS-CoV-2 infection in the population, which is probably here to stay, but we’ll also need them to treat future agents that arrive.”

There are currentlyabout 200 known viruses that infect humans. Although viruses represent less than 14 percent of all known human pathogens, they make up two-thirds of all new human pathogens discovered since 1980.

Antiviral drugs are fundamentally different from vaccines, which teach a person’s immune system to mount a defense against a viral invader, and antibody treatments, which enhance the body’s immune response. By contrast, anti­virals are chemical compounds that directly block a virus after a person has become infected. They do this by binding to specific proteins and preventing them from functioning, so that the virus cannot copy itself or enter or exit a cell.

The SARS-CoV-2 virus has an estimated 25 to 29 proteins, but not all of them are suitable drug targets. Researchers are investigating, among other targets, the virus’s exterior spike protein, which binds to a receptor on a human cell; two scissorlike enzymes, called proteases, that cut up long strings of viral proteins into functional pieces inside the cell; and a polymerase complex that makes the cell churn out copies of the virus’s genetic material, in the form of single-stranded RNA.

But it’s not enough for a drug candidate to simply attach to a target protein. Chemists also consider how tightly the compound binds to its target, whether it binds to other things as well, how quickly it metabolizes in the body, and so on. A drug candidate may have 10 to 20 such objectives. “Very often those objectives can appear to be anticorrelated or contradictory with each other,” says Gaston-Mathé.

Compared with antibiotics, antiviral drug discovery has proceeded at a snail’s pace. Scientists advanced from isolating the first antibacterial molecules in 1910 to developing an arsenal of powerful antibiotics by 1944. By contrast, it took until 1951 for researchers to be able to routinely grow large amounts of virus particles in cells in a dish, a breakthrough that earned the inventors a Nobel Prize in Medicine in 1954.

And the lag between the discovery of a virus and the creation of a treatment can be heartbreaking. According to the World Health Organization, 71 million people worldwide have chronic hepatitis C, a major cause of liver cancer. The virus that causes the infection was discovered in 1989, but effective antiviral drugs didn’t hit the market until 2014.

While many antibiotics work on a range of microbes, most antivirals are highly specific to a single virus—what those in the business call “one bug, one drug.” It takes a detailed understanding of a virus to develop an antiviral against it, says Che Colpitts, a virologist at Queen’s University, in Canada, who works on antivirals against RNA viruses. “When a new virus emerges, like SARS-CoV-2, we’re at a big disadvantage.”

Making drugs to stop viruses is hard for three main reasons. First, viruses are the Spartans of the pathogen world: They’re frugal, brutal, and expert at evading the human immune system. About 20 to 250 nanometers in diameter, viruses rely on just a few parts to operate, hijacking host cells to reproduce and often destroying those cells upon departure. They employ tricks to camouflage their presence from the host’s immune system, including preventing infected cells from sending out molecular distress beacons. “Viruses are really small, so they only have a few components, so there’s not that many drug targets available to start with,” says Colpitts.

Second, viruses replicate quickly, typically doubling in number in hours or days. This constant copying of their genetic material enables viruses to evolve quickly, producing mutations able to sidestep drug effects. The virus that causes AIDS soon develops resistance when exposed to a single drug. That’s why a cocktail of antiviral drugs is used to treat HIV infection.

Finally, unlike bacteria, which can exist independently outside human cells, viruses invade human cells to propagate, so any drug designed to eliminate a virus needs to spare the host cell. A drug that fails to distinguish between a virus and a cell can cause serious side effects. “Discriminating between the two is really quite difficult,” says Evotec’s Carter, who has worked in antiviral drug discovery for over three decades.

And then there’s the money barrier. Developing antivirals is rarely profitable. Health-policy researchers at the London School of Economics recently estimated that the average cost of developing a new drug is US $1 billion, and up to $2.8 billion for cancer and other specialty drugs. Because antivirals are usually taken for only short periods of time or during short outbreaks of disease, companies rarely recoup what they spent developing the drug, much less turn a profit, says Carter.

To change the status quo, drug discovery needs fresh approaches that leverage new technologies, rather than incremental improvements, says Christian Tidona, managing director of BioMed X, an independent research institute in Heidelberg, Germany. “We need breakthroughs.”

Putting Drug Development on Autopilot
Earlier this year, SRI Biosciences and Iktos began collaborating on a way to use artificial intelligence and automated chemistry to rapidly identify new drugs to target the COVID-19 virus. Within four months, they had designed and synthesized a first round of antiviral candidates. Here’s how they’re doing it.

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STEP 1: Iktos’s AI platform uses deep-learning algorithms in an iterative process to come up with new molecular structures likely to bind to and disable a specific coronavirus protein. Illustrations: Chris Philpot

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STEP 2: SRI Biosciences’s SynFini system is a three-part automated chemistry suite for producing new compounds. Starting with a target compound from Iktos, SynRoute uses machine learning to analyze and optimize routes for creating that compound, with results in about 10 seconds. It prioritizes routes based on cost, likelihood of success, and ease of implementation.

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STEP 3: SynJet, an automated inkjet printer platform, tests the routes by printing out tiny quantities of chemical ingredients to see how they react. If the right compound is produced, the platform tests it.

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STEP 4: AutoSyn, an automated tabletop chemical plant, synthesizes milligrams to grams of the desired compound for further testing. Computer-selected “maps” dictate paths through the plant’s modular components.

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STEP 5: The most promising compounds are tested against live virus samples.

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Iktos’s AI platform was created by a medicinal chemist and an AI expert. To tackle SARS-CoV-2, the company used generative models—deep-learning algorithms that generate new data—to “imagine” molecular structures with a good chance of disabling a key coronavirus protein.

For a new drug target, the software proposes and evaluates roughly 1 million compounds, says Gaston-Mathé. It’s an iterative process: At each step, the system generates 100 virtual compounds, which are tested in silico with predictive models to see how closely they meet the objectives. The test results are then used to design the next batch of compounds. “It’s like we have a very, very fast chemist who is designing compounds, testing compounds, getting back the data, then designing another batch of compounds,” he says.

The computer isn’t as smart as a human chemist, Gaston-Mathé notes, but it’s much faster, so it can explore far more of what people in the field call “chemical space”—the set of all possible organic compounds. Unexplored chemical space is huge: Biochemists estimate that there are at least 1063 possible druglike molecules, and that 99.9 percent of all possible small molecules or compounds have never been synthesized.

Still, designing a chemical compound isn’t the hardest part of creating a new drug. After a drug candidate is designed, it must be synthesized, and the highly manual process for synthesizing a new chemical hasn’t changed much in 200 years. It can take days to plan a synthesis process and then months to years to optimize it for manufacture.

That’s why Gaston-Mathé was eager to send Iktos’s AI-generated designs to Collins’s team at SRI Biosciences. With $13.8 million from the Defense Advanced Research Projects Agency, SRI Biosciences spent the last four years automating the synthesis process. The company’s automated suite of three technologies, called SynFini, can produce new chemical compounds in just hours or days, says Collins.

First, machine-learning software devises possible routes for making a desired molecule. Next, an inkjet printer platform tests the routes by printing out and mixing tiny quantities of chemical ingredients to see how they react with one another; if the right compound is produced, the platform runs tests on it. Finally, a tabletop chemical plant synthesizes milligrams to grams of the desired compound.

Less than four months after Iktos and SRI Biosciences announced their collaboration, they had designed and synthesized a first round of antiviral candidates for SARS-CoV-2. Now they’re testing how well the compounds work on actual samples of the virus.

Out of 10
63 possible druglike molecules, 99.9 percent have never been synthesized.

Theirs isn’t the only collaborationapplying new tools to drug discovery. In late March, Alex Zhavoronkov, CEO of Hong Kong–based Insilico Medicine, came across a YouTube video showing three virtual-reality avatars positioning colorful, sticklike fragments in the side of a bulbous blue protein. The three researchers were using VR to explore how compounds might bind to a SARS-CoV-2 enzyme. Zhavoronkov contacted the startup that created the simulation—Nanome, in San Diego—and invited it to examine Insilico’s ­AI-generated molecules in virtual reality.

Insilico runs an AI platform that uses biological data to train deep-learning algorithms, then uses those algorithms to identify molecules with druglike features that will likely bind to a protein target. A four-day training sprint in late January yielded 100 molecules that appear to bind to an important SARS-CoV-2 protease. The company recently began synthesizing some of those molecules for laboratory testing.

Nanome’s VR software, meanwhile, allows researchers to import a molecular structure, then view and manipulate it on the scale of individual atoms. Like human chess players who use computer programs to explore potential moves, chemists can use VR to predict how to make molecules more druglike, says Nanome CEO Steve McCloskey. “The tighter the interface between the human and the computer, the more information goes both ways,” he says.

Zhavoronkov sent data about several of Insilico’s compounds to Nanome, which re-created them in VR. Nanome’s chemist demonstrated chemical tweaks to potentially improve each compound. “It was a very good experience,” says Zhavoronkov.

Meanwhile, in March, Takeda Pharmaceutical Co., of Japan, invited Schrödinger, a New York–based company that develops chemical-simulation software, to join an alliance working on antivirals. Schrödinger’s AI focuses on the physics of how proteins interact with small molecules and one another.

The software sifts through billions of molecules per week to predict a compound’s properties, and it optimizes for multiple desired properties simultaneously, says Karen Akinsanya, chief biomedical scientist and head of discovery R&D at Schrödinger. “There’s a huge sense of urgency here to come up with a potent molecule, but also to come up with molecules that are going to be well tolerated” by the body, she says. Drug developers are seeking compounds that can be broadly used and easily administered, such as an oral drug rather than an intravenous drug, she adds.

Schrödinger evaluated four protein targets and performed virtual screens for two of them, a computing-intensive process. In June, Google Cloud donated the equivalent of 16 million hours of Nvidia GPU time for the company’s calculations. Next, the alliance’s drug companies will synthesize and test the most promising compounds identified by the virtual screens.

Other companies, including Amazon Web Services, IBM, and Intel, as well as several U.S. national labs are also donating time and resources to the Covid-19 High Performance Computing Consortium. The consortium is supporting 87 projects, which now have access to 6.8 million CPU cores, 50,000 GPUs, and 600 petaflops of computational resources.

While advanced technologies could transform early drug discovery, any new drug candidate still has a long road after that. It must be tested in animals, manufactured in large batches for clinical trials, then tested in a series of trials that, for antivirals, lasts an average of seven years.

In May, the BioMed X Institute in Germany launched a five-year project to build a Rapid Antiviral Response Platform, which would speed drug discovery all the way through manufacturing for clinical trials. The €40 million ($47 million) project, backed by drug companies, will identify ­outside-the-box proposals from young scientists, then provide space and funding to develop their ideas.

“We’ll focus on technologies that allow us to go from identification of a new virus to 10,000 doses of a novel potential therapeutic ready for trials in less than six months,” says BioMed X’s Tidona, who leads the project.

While a vaccine will likely arrive long before a bespoke antiviral does, experts expect COVID-19 to be with us for a long time, so the effort to develop a direct-acting, potent antiviral continues. Plus, having new antivirals—and tools to rapidly create more—can only help us prepare for the next pandemic, whether it comes next month or in another 102 years.

“We’ve got to start thinking differently about how to be more responsive to these kinds of threats,” says Collins. “It’s pushing us out of our comfort zones.”

This article appears in the October 2020 print issue as “Automating Antivirals.” Continue reading

Posted in Human Robots

#437643 Video Friday: Matternet Launches Urban ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

IROS 2020 – October 25-25, 2020 – [Online]
Bay Area Robotics Symposium – November 20, 2020 – [Online]
ACRA 2020 – December 8-10, 2020 – [Online]
Let us know if you have suggestions for next week, and enjoy today's videos.

Sixteen teams chose their roster of virtual robots and sensor payloads, some based on real-life subterranean robots, and submitted autonomy and mapping algorithms that SubT Challenge officials then tested across eight cave courses in the cloud-based SubT Simulator. Their robots traversed the cave environments autonomously, without any input or adjustments from human operators. The Cave Circuit Virtual Competition teams earned points by correctly finding, identifying, and localizing up to 20 artifacts hidden in the cave courses within five-meter accuracy.

[ SubT ]

This year, the KUKA Innovation Award’s international jury of experts received a total of more than 40 ideas. The five finalist teams had time until November to implement their ideas. A KUKA LBR Med lightweight robot – the first robotic component to be certified for integration into a medical device – has been made available to them for this purpose. Beyond this, the teams have received a training for the hardware and coaching from KUKA experts throughout the competition. At virtual.MEDICA from 16-19.11.2020, the finalists presented their concepts to an international audience of experts and to the Innovation Award jury.

The winner of the KUKA Innovation Award 2020, worth 20,000 euros, is Team HIFUSK from the Scuola Superiore Sant'Anna in Italy.

[ KUKA Innovation Award ]

Like everything else the in-person Cybathlon event was cancelled, but the competition itself took place, just a little more distributed than it would have been otherwise.

[ Cybathlon ]

Matternet, developer of the world's leading urban drone logistics platform, today announced the launch of operations at Labor Berlin Charité Vivantes in Germany. The program kicked-off November 17, 2020 with permanent operations expected to take flight next year, creating the first urban BVLOS [Beyond Visual Line of Sight] medical drone delivery network in the European Union. The drone network expects to significantly improve the timeliness and efficiency of Labor Berlin’s diagnostics services by providing an option to avoid roadway delays, which will improve patient experience with potentially life-saving benefits and lower costs.

Routine BVLOS over an urban area? Impressive.

[ Matternet ]

Robots playing diabolo!

Thanks Thilo!

[ OMRON Sinic X]

Anki's tech has been repackaged into this robot that serves butter:

[ Butter Robot ]

Berkshire Grey just announced our Picking With Purpose Program in which we’ve partnered our robotic automation solutions with food rescue organizations City Harvest and The Greater Boston Food Bank to pick, pack, and distribute food to families in need in time for Thanksgiving. Berkshire Grey donated about 40,000 pounds of food, used one of our robotic automation systems to pick and pack that food into meal boxes for families in need, and our team members volunteered to run the system. City Harvest and The Greater Boston Food Bank are distributing the 4,000 meal boxes we produced. This is just the beginning. We are building a sponsorship program to make Picking With Purpose an ongoing initiative.

[ Berkshire Grey ]

Thanks Peter!

We posted a video previously of Cassie learning to skip, but here's a much more detailed look (accompanying an ICRA submission) that includes some very impressive stair descending.

[ DRL ]

From garage inventors to university students and entrepreneurs, NASA is looking for ideas on how to excavate the Moon’s icy regolith, or dirt, and deliver it to a hypothetical processing plant at the lunar South Pole. The NASA Break the Ice Lunar Challenge, a NASA Centennial Challenge, is now open for registration. The competition will take place over two phases and will reward new ideas and approaches for a system architecture capable of excavating and moving icy regolith and water on the lunar surface.

[ NASA ]

Adaptation to various scene configurations and object properties, stability and dexterity in robotic grasping manipulation is far from explored. This work presents an origami-based shape morphing fingertip design to actively tackle the grasping stability and dexterity problems. The proposed fingertip utilizes origami as its skeleton providing degrees of freedom at desired positions and motor-driven four-bar-linkages as its transmission components to achieve a compact size of the fingertip.

[ Paper ]

“If Roboy crashes… you die.”

[ Roboy ]

Traditionally lunar landers, as well as other large space exploration vehicles, are powered by solar arrays or small nuclear reactors. Rovers and small robots, however, are not big enough to carry their own dedicated power supplies and must be tethered to their larger counterparts via electrical cables. Tethering severely restricts mobility, and cables are prone to failure due to lunar dust (regolith) interfering with electrical contact points. Additionally, as robots become smaller and more complex, they are fitted with additional sensors that require more power, further exacerbating the problem. Lastly, solar arrays are not viable for charging during the lunar night. WiBotic is developing rapid charging systems and energy monitoring base stations for lunar robots, including the CubeRover – a shoebox-sized robot designed by Astrobotic – that will operate autonomously and charge wirelessly on the Moon.

[ WiBotic ]

Watching pick and place robots is my therapy.

[ Soft Robotics ]

It's really, really hard to beat liquid fuel for energy storage, as Quaternium demonstrates with their hybrid drone.

[ Quaternium ]

Thanks Gregorio!

State-of-the-art quadrotor simulators have a rigid and highly-specialized structure: either are they really fast, physically accurate, or photo-realistic. In this work, we propose a novel quadrotor simulator: Flightmare.

[ Flightmare ]

Drones that chuck fire-fighting balls into burning buildings, sure!

[ LARICS ]

If you missed ROS World, that's okay, because all of the talks are now online. Here's the opening keynote from Vivian Chu and Diligent robotics, along with a couple fun lightning talks.

[ ROS World 2020 ]

This week's CMU RI Seminar is by Chelsea Finn from Stanford University, on Data Scalability for Robot Learning.

Recent progress in robot learning has demonstrated how robots can acquire complex manipulation skills from perceptual inputs through trial and error, particularly with the use of deep neural networks. Despite these successes, the generalization and versatility of robots across environment conditions, tasks, and objects remains a major challenge. And, unfortunately, our existing algorithms and training set-ups are not prepared to tackle such challenges, which demand large and diverse sets of tasks and experiences. In this talk, I will discuss two central challenges that pertain to data scalability: first, acquiring large datasets of diverse and useful interactions with the world, and second, developing algorithms that can learn from such datasets. Then, I will describe multiple approaches that we might take to rethink our algorithms and data pipelines to serve these goals. This will include algorithms that allow a real robot to explore its environment in a targeted manner with minimal supervision, approaches that can perform robot reinforcement learning with videos of human trial-and-error experience, and visual model-based RL approaches that are not bottlenecked by their capacity to model everything about the world.

[ CMU RI ] Continue reading

Posted in Human Robots

#437630 How Toyota Research Envisions the Future ...

Yesterday, the Toyota Research Institute (TRI) showed off some of the projects that it’s been working on recently, including a ceiling-mounted robot that could one day help us with household chores. That system is just one example of how TRI envisions the future of robotics and artificial intelligence. As TRI CEO Gill Pratt told us, the company is focusing on robotics and AI technology for “amplifying, rather than replacing, human beings.” In other words, Toyota wants to develop robots not for convenience or to do our jobs for us, but rather to allow people to continue to live and work independently even as we age.

To better understand Toyota’s vision of robotics 15 to 20 years from now, it’s worth watching the 20-minute video below, which depicts various scenarios “where the application of robotic capabilities is enabling members of an aging society to live full and independent lives in spite of the challenges that getting older brings.” It’s a long video, but it helps explains TRI’s perspective on how robots will collaborate with humans in our daily lives over the next couple of decades.

Those are some interesting conceptual telepresence-controlled bipeds they’ve got running around in that video, right?

For more details, we sent TRI some questions on how it plans to go from concepts like the ones shown in the video to real products that can be deployed in human environments. Below are answers from TRI CEO Gill Pratt, who is also chief scientist for Toyota Motor Corp.; Steffi Paepcke, senior UX designer at TRI; and Max Bajracharya, VP of robotics at TRI.

IEEE Spectrum: TRI seems to have a more explicit focus on eventual commercialization than most of the robotics research that we cover. At what point TRI starts to think about things like reliability and cost?

Photo: TRI

Toyota is exploring robots capable of manipulating dishes in a sink and a dishwasher, performing experiments and simulations to make sure that the robots can handle a wide range of conditions.

Gill Pratt: It’s a really interesting question, because the normal way to think about this would be to say, well, both reliability and cost are product development tasks. But actually, we need to think about it at the earliest possible stage with research as well. The hardware that we use in the laboratory for doing experiments, we don’t worry about cost there, or not nearly as much as you’d worry about for a product. However, in terms of what research we do, we very much have to think about, is it possible (if the research is successful) for it to end up in a product that has a reasonable cost. Because if a customer can’t afford what we come up with, maybe it has some academic value but it’s not actually going to make a difference in their quality of life in the real world. So we think about cost very much from the beginning.

The same is true with reliability. Right now, we’re working very hard to make our control techniques robust to wide variations in the environment. For instance, in work that Russ Tedrake is doing with manipulating dishes in a sink and a dishwasher, both in physical testing and in simulation, we’re doing thousands and now millions of different experiments to make sure that we can handle the edge cases and it works over a very wide range of conditions.

A tremendous amount of work that we do is trying to bring robotics out of the age of doing demonstrations. There’s been a history of robotics where for some time, things have not been reliable, so we’d catch the robot succeeding just once and then show that video to the world, and people would get the mis-impression that it worked all of the time. Some researchers have been very good about showing the blooper reel too, to show that some of the time, robots don’t work.

“A tremendous amount of work that we do is trying to bring robotics out of the age of doing demonstrations. There’s been a history of robotics where for some time, things have not been reliable, so we’d catch the robot succeeding just once and then show that video to the world, and people would get the mis-impression that it worked all of the time.”
—Gill Pratt, TRI

In the spirit of sharing things that didn’t work, can you tell us a bit about some of the robots that TRI has had under development that didn’t make it into the demo yesterday because they were abandoned along the way?

Steffi Paepcke: We’re really looking at how we can connect people; it can be hard to stay in touch and see our loved ones as much as we would like to. There have been a few prototypes that we’ve worked on that had to be put on the shelf, at least for the time being. We were exploring how to use light so that people could be ambiently aware of one another across distances. I was very excited about that—the internal name was “glowing orb.” For a variety of reasons, it didn’t work out, but it was really fascinating to investigate different modalities for keeping in touch.

Another prototype we worked on—we found through our research that grocery shopping is obviously an important part of life, and for a lot of older adults, it’s not necessarily the right answer to always have groceries delivered. Getting up and getting out of the house keeps you physically active, and a lot of people prefer to continue doing it themselves. But it can be challenging, especially if you’re purchasing heavy items that you need to transport. We had a prototype that assisted with grocery shopping, but when we pivoted our focus to Japan, we found that the inside of a Japanese home really needs to stay inside, and the outside needs to stay outside, so a robot that traverses both domains is probably not the right fit for a Japanese audience, and those were some really valuable lessons for us.

Photo: TRI

Toyota recently demonstrated a gantry robot that would hang from the ceiling to perform tasks like wiping surfaces and clearing clutter.

I love that TRI is exploring things like the gantry robot both in terms of near-term research and as part of its long-term vision, but is a robot like this actually worth pursuing? Or more generally, what’s the right way to compromise between making an environment robot friendly, and asking humans to make changes to their homes?

Max Bajracharya: We think a lot about the problems that we’re trying to address in a holistic way. We don’t want to just give people a robot, and assume that they’re not going to change anything about their lifestyle. We have a lot of evidence from people who use automated vacuum cleaners that people will adapt to the tools you give them, and they’ll change their lifestyle. So we want to think about what is that trade between changing the environment, and giving people robotic assistance and tools.

We certainly think that there are ways to make the gantry system plausible. The one you saw today is obviously a prototype and does require significant infrastructure. If we’re going to retrofit a home, that isn’t going to be the way to do it. But we still feel like we’re very much in the prototype phase, where we’re trying to understand whether this is worth it to be able to bypass navigation challenges, and coming up with the pros and cons of the gantry system. We’re evaluating whether we think this is the right approach to solving the problem.

To what extent do you think humans should be either directly or indirectly in the loop with home and service robots?

Bajracharya: Our goal is to amplify people, so achieving this is going to require robots to be in a loop with people in some form. One thing we have learned is that using people in a slow loop with robots, such as teaching them or helping them when they make mistakes, gives a robot an important advantage over one that has to do everything perfectly 100 percent of the time. In unstructured human environments, robots are going to encounter corner cases, and are going to need to learn to adapt. People will likely play an important role in helping the robots learn. Continue reading

Posted in Human Robots

#437614 Video Friday: Poimo Is a Portable ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here's what we have so far (send us your events!):

IROS 2020 – October 25-29, 2020 – [Online]
ROS World 2020 – November 12, 2020 – [Online]
CYBATHLON 2020 – November 13-14, 2020 – [Online]
ICSR 2020 – November 14-16, 2020 – Golden, Colo., USA
Let us know if you have suggestions for next week, and enjoy today's videos.

Engineers at the University of California San Diego have built a squid-like robot that can swim untethered, propelling itself by generating jets of water. The robot carries its own power source inside its body. It can also carry a sensor, such as a camera, for underwater exploration.

[ UCSD ]

Thanks Ioana!

Shark Robotics, French and European leader in Unmanned Ground Vehicles, is announcing today a disinfection add-on for Boston Dynamics Spot robot, designed to fight the COVID-19 pandemic. The Spot robot with Shark’s purpose-built disinfection payload can decontaminate up to 2,000 m2 in 15 minutes, in any space that needs to be sanitized – such as hospitals, metro stations, offices, warehouses or facilities.

[ Shark Robotics ]

Here’s an update on the Poimo portable inflatable mobility project we wrote about a little while ago; while not strictly robotics, it seems like it holds some promise for rapidly developing different soft structures that robotics might find useful.

[ University of Tokyo ]

Thanks Ryuma!

Pretty cool that you can do useful force feedback teleop while video chatting through a “regular broadband Internet connection.” Although, what “regular” means to you is a bit subjective, right?

[ HEBI Robotics ]

Thanks Dave!

While NASA's Mars rover Perseverance travels through space toward the Red Planet, its nearly identical rover twin is hard at work on Earth. The vehicle system test bed (VSTB) rover named OPTIMISM is a full-scale engineering version of the Mars-bound rover. It is used to test hardware and software before the commands are sent up to the Perseverance rover.

[ NASA ]

Jacquard takes ordinary, familiar objects and enhances them with new digital abilities and experiences, while remaining true to their original purpose — like being your favorite jacket, backpack or a pair of shoes that you love to wear.

Our ambition is simple: to make life easier. By staying connected to your digital world, your things can do so much more. Skip a song by brushing your sleeve. Take a picture by tapping on a shoulder strap. Get reminded about the phone you left behind with a blink of light or a haptic buzz on your cuff.

[ Google ATAP ]

Should you attend the IROS 2020 workshop on “Planetary Exploration Robots: Challenges and Opportunities”? Of course you should!

[ Workshop ]

Kuka makes a lot of these videos where I can’t help but think that if they put as much effort into programming the robot as they did into producing the video, the result would be much more impressive.

[ Kuka ]

The Colorado School of Mines is one of the first customers to buy a Spot robot from Boston Dynamics to help with robotics research. Watch as scientists take Spot into the school's mine for the first time.

[ HCR ] via [ CNET ]

A very interesting soft(ish) actuator from Ayato Kanada at Kyushu University's Control Engineering Lab.

A flexible ultrasonic motor (FUSM), which generates linear motion as a novel soft actuator. This motor consists of a single metal cube stator with a hole and an elastic elongated coil spring inserted into the hole. When voltages are applied to piezoelectric plates on the stator, the coil spring moves back and forward as a linear slider. In the FUSM that uses the friction drive as the principle, the most important parameter for optimizing its output is the preload between the stator and slider. The coil spring has a slightly larger diameter than the stator hole and generates the preload by expanding in a radial direction. The coil springs act not only as a flexible slider but also as a resistive positional sensor. Changes in the resistance between the stator and the coil spring end are converted to a voltage and used for position detection.

[ Control Engineering Lab ]

Thanks Ayato!

We show how to use the limbs of a quadruped robot to identify fine-grained soil, representative for Martian regolith.

[ Paper ] via [ ANYmal Research ]

PR2 is serving breakfast and cleaning up afterwards. It’s slow, but all you have to do is eat and leave.

That poor PR2 is a little more naked than it's probably comfortable with.

[ EASE ]

NVIDIA researchers present a hierarchical framework that combines model-based control and reinforcement learning (RL) to synthesize robust controllers for a quadruped robot (the Unitree Laikago).

[ NVIDIA ]

What's interesting about this assembly task is that the robot is using its arm only for positioning, and doing the actual assembly with just fingers.

[ RC2L ]

In this electronics assembly application, Kawasaki's cobot duAro2 uses a tool changing station to tackle a multitude of tasks and assemble different CPU models.

Okay but can it apply thermal paste to a CPU in the right way? Personally, I find that impossible.

[ Kawasaki ]

You only need to watch this video long enough to appreciate the concept of putting a robot on a robot.

[ Impress ]

In this lecture, we’ll hear from the man behind one of the biggest robotics companies in the world, Boston Dynamics, whose robotic dog, Spot, has been used to encourage social distancing in Singapore and is now getting ready for FDA approval to be able to measure patients’ vital signs in hospitals.

[ Alan Turing Institute ]

Greg Kahn from UC Berkeley wrote in to share his recent dissertation talk on “Mobile Robot Learning.”

In order to create mobile robots that can autonomously navigate real-world environments, we need generalizable perception and control systems that can reason about the outcomes of navigational decisions. Learning-based methods, in which the robot learns to navigate by observing the outcomes of navigational decisions in the real world, offer considerable promise for obtaining these intelligent navigation systems. However, there are many challenges impeding mobile robots from autonomously learning to act in the real-world, in particular (1) sample-efficiency–how to learn using a limited amount of data? (2) supervision–how to tell the robot what to do? and (3) safety–how to ensure the robot and environment are not damaged or destroyed during learning? In this talk, I will present deep reinforcement learning methods for addressing these real world mobile robot learning challenges and show results which enable ground and aerial robots to navigate in complex indoor and outdoor environments.

[ UC Berkeley ]

Thanks Greg!

Leila Takayama from UC Santa Cruz (and previously Google X and Willow Garage) gives a talk entitled “Toward a more human-centered future of robotics.”

Robots are no longer only in outer space, in factory cages, or in our imaginations. We interact with robotic agents when withdrawing cash from bank ATMs, driving cars with adaptive cruise control, and tuning our smart home thermostats. In the moment of those interactions with robotic agents, we behave in ways that do not necessarily align with the rational belief that robots are just plain machines. Through a combination of controlled experiments and field studies, we use theories and concepts from the social sciences to explore ways that human and robotic agents come together, including how people interact with personal robots and how people interact through telepresence robots. Together, we will explore topics and raise questions about the psychology of human-robot interaction and how we could invent a future of a more human-centered robotics that we actually want to live in.

[ Leila Takayama ]

Roboticist and stand-up comedian Naomi Fitter from Oregon State University gives a talk on “Everything I Know about Telepresence.”

Telepresence robots hold promise to connect people by providing videoconferencing and navigation abilities in far-away environments. At the same time, the impacts of current commercial telepresence robots are not well understood, and circumstances of robot use including internet connection stability, odd personalizations, and interpersonal relationship between a robot operator and people co-located with the robot can overshadow the benefit of the robot itself. And although the idea of telepresence robots has been around for over two decades, available nonverbal expressive abilities through telepresence robots are limited, and suitable operator user interfaces for the robot (for example, controls that allow for the operator to hold a conversation and move the robot simultaneously) remain elusive. So where should we be using telepresence robots? Are there any pitfalls to watch out for? What do we know about potential robot expressivity and user interfaces? This talk will cover my attempts to address these questions and ways in which the robotics research community can build off of this work

[ Talking Robotics ] Continue reading

Posted in Human Robots

#437608 Video Friday: Agility Robotics Raises ...

Video Friday is your weekly selection of awesome robotics videos, collected by your Automaton bloggers. We’ll also be posting a weekly calendar of upcoming robotics events for the next few months; here’s what we have so far (send us your events!):

IROS 2020 – October 25-29, 2020 – [Online]
ROS World 2020 – November 12, 2020 – [Online]
CYBATHLON 2020 – November 13-14, 2020 – [Online]
ICSR 2020 – November 14-16, 2020 – Golden, Colo., USA
Let us know if you have suggestions for next week, and enjoy today’s videos.

Digit is now in full commercial production and we’re excited to announce a $20M funding rounding round co-led by DCVC and Playground Global!

Digits for everyone!

[ Agility Robotics ]

A flexible rover that has both ability to travel long distances and rappel down hard-to-reach areas of scientific interest has undergone a field test in the Mojave Desert in California to showcase its versatility. Composed of two Axel robots, DuAxel is designed to explore crater walls, pits, scarps, vents and other extreme terrain on the moon, Mars and beyond.

This technology demonstration developed at NASA’s Jet Propulsion Laboratory in Southern California showcases the robot’s ability to split in two and send one of its halves — a two-wheeled Axle robot — over an otherwise inaccessible slope, using a tether as support and to supply power.

The rappelling Axel can then autonomously seek out areas to study, safely overcome slopes and rocky obstacles, and then return to dock with its other half before driving to another destination. Although the rover doesn’t yet have a mission, key technologies are being developed that might, one day, help us explore the rocky planets and moons throughout the solar system.

[ JPL ]

A rectangular robot as tiny as a few human hairs can travel throughout a colon by doing back flips, Purdue University engineers have demonstrated in live animal models. Why the back flips? Because the goal is to use these robots to transport drugs in humans, whose colons and other organs have rough terrain. Side flips work, too. Why a back-flipping robot to transport drugs? Getting a drug directly to its target site could remove side effects, such as hair loss or stomach bleeding, that the drug may otherwise cause by interacting with other organs along the way.

[ Purdue ]

This video shows the latest results in the whole-body locomotion control of the humanoid robot iCub achieved by the Dynamic Interaction Control line at IIT-Istituto Italiano di Tecnologia in Genova (Italy). In particular, the iCub now keeps the balance while walking and receiving pushes from an external user. The implemented control algorithms also ensure the robot to remain compliant during locomotion and human-robot interaction, a fundamental property to lower the possibility to harm humans that share the robot surrounding environment.

This is super impressive, considering that iCub was only able to crawl and was still tethered not too long ago. Also, it seems to be blinking properly now, so it doesn’t look like it’s always sleepy.

[ IIT ]

This video shows a set of new tests we performed on Bolt. We conducted tests on 5 different scenarios, 1) walking forward/backward 2) uneven surface 3) soft surface 4) push recovery 5) slippage recovery. Thanks to our feedback control based on Model Predictive Control, the robot can perform walking in the presence of all these uncertainties. We will open-source all the codes in a near future.

[ ODRI ]

The title of this video is “Can you throw your robot into a lake?” The title of this video should be, “Can you throw your robot into a lake and drive it out again?”

[ Norlab ]

AeroVironment Successfully Completes Sunglider Solar HAPS Stratospheric Test Flight, Surpassing 60,000 Feet Altitude and Demonstrating Broadband Mobile Connectivity.

[ AeroVironment ]

We present CoVR, a novel robotic interface providing strong kinesthetic feedback (100 N) in a room-scale VR arena. It consists of a physical column mounted on a 2D Cartesian ceiling robot (XY displacements) with the capacity of (1) resisting to body-scaled users actions such as pushing or leaning; (2) acting on the users by pulling or transporting them as well as (3) carrying multiple potentially heavy objects (up to 80kg) that users can freely manipulate or make interact with each other.

[ DeepAI ]

In a new video, personnel from Swiss energy supply company Kraftwerke Oberhasli AG (KWO) explain how they were able to keep employees out of harm’s way by using Flyability’s Elios 2 to collect visual data while building a new dam.

[ Flyability ]

Enjoy our Ascento robot fail compilation! With every failure we experience, we learn more and we can improve our robot for its next iteration, which will come soon… Stay tuned for more!

FYI posting a robot fails video will pretty much guarantee you a spot in Video Friday!

[ Ascento ]

Humans are remarkably good at using chopsticks. The Guinness World Record witnessed a person using chopsticks to pick up 65 M&Ms in just a minute. We aim to collect demonstrations from humans and to teach robot to use chopsticks.

[ UW Personal Robotics Lab ]

A surprising amount of personality from these Yaskawa assembly robots.

[ Yaskawa ]

This paper presents the system design, modeling, and control of the Aerial Robotic Chain Manipulator. This new robot design offers the potential to exert strong forces and moments to the environment, carry and lift significant payloads, and simultaneously navigate through narrow corridors. The presented experimental studies include a valve rotation task, a pick-and-release task, and the verification of load oscillation suppression to demonstrate the stability and performance of the system.

[ ARL ]

Whether animals or plants, whether in the water, on land or in the air, nature provides the model for many technical innovations and inventions. This is summed up in the term bionics, which is a combination of the words ‘biology‘ and ‘electronics’. At Festo, learning from nature has a long history, as our Bionic Learning Network is based on using nature as the source for future technologies like robots, assistance systems or drive solutions.

[ Festo ]

Dogs! Selfies! Thousands of LEGO bricks! This video has it all.

[ LEGO ]

An IROS workshop talk on “Cassie and Mini Cheetah Autonomy” by Maani Ghaffari and Jessy Grizzle from the University of Michigan.

[ Michigan Robotics ]

David Schaefer’s Cozmo robots are back with this mind-blowing dance-off!

What you just saw represents hundreds of hours of work, David tells us: “I wrote over 10,000 lines of code to create the dance performance as I had to translate the beats per minute of the song into motor rotations in order to get the right precision needed to make the moves look sharp. The most challenging move was the SpongeBob SquareDance as any misstep would send the Cozmos crashing into each other. LOL! Fortunately for me, Cozmo robots are pretty resilient.”

[ Life with Cozmo ]

Thanks David!

This week’s GRASP on Robotics seminar is by Sangbae Kim from MIT, on “Robots with Physical Intelligence.”

While industrial robots are effective in repetitive, precise kinematic tasks in factories, the design and control of these robots are not suited for physically interactive performance that humans do easily. These tasks require ‘physical intelligence’ through complex dynamic interactions with environments whereas conventional robots are designed primarily for position control. In order to develop a robot with ‘physical intelligence’, we first need a new type of machines that allow dynamic interactions. This talk will discuss how the new design paradigm allows dynamic interactive tasks. As an embodiment of such a robot design paradigm, the latest version of the MIT Cheetah robots and force-feedback teleoperation arms will be presented.

[ GRASP ]

This week’s CMU Ri Seminar is by Kevin Lynch from Northwestern, on “Robotics and Biosystems.”

Research at the Center for Robotics and Biosystems at Northwestern University encompasses bio-inspiration, neuromechanics, human-machine systems, and swarm robotics, among other topics. In this talk I will give an overview of some of our recent work on in-hand manipulation, robot locomotion on yielding ground, and human-robot systems.

[ CMU RI ] Continue reading

Posted in Human Robots