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#431559 Drug Discovery AI to Scour a Universe of ...

On a dark night, away from city lights, the stars of the Milky Way can seem uncountable. Yet from any given location no more than 4,500 are visible to the naked eye. Meanwhile, our galaxy has 100–400 billion stars, and there are even more galaxies in the universe.
The numbers of the night sky are humbling. And they give us a deep perspective…on drugs.
Yes, this includes wow-the-stars-are-freaking-amazing-tonight drugs, but also the kinds of drugs that make us well again when we’re sick. The number of possible organic compounds with “drug-like” properties dwarfs the number of stars in the universe by over 30 orders of magnitude.
Next to this multiverse of possibility, the chemical configurations scientists have made into actual medicines are like the smattering of stars you’d glimpse downtown.
But for good reason.
Exploring all that potential drug-space is as humanly impossible as exploring all of physical space, and even if we could, most of what we’d find wouldn’t fit our purposes. Still, the idea that wonder drugs must surely lurk amid the multitudes is too tantalizing to ignore.
Which is why, Alex Zhavoronkov said at Singularity University’s Exponential Medicine in San Diego last week, we should use artificial intelligence to do more of the legwork and speed discovery. This, he said, could be one of the next big medical applications for AI.
Dogs, Diagnosis, and Drugs
Zhavoronkov is CEO of Insilico Medicine and CSO of the Biogerontology Research Foundation. Insilico is one of a number of AI startups aiming to accelerate drug discovery with AI.
In recent years, Zhavoronkov said, the now-famous machine learning technique, deep learning, has made progress on a number of fronts. Algorithms that can teach themselves to play games—like DeepMind’s AlphaGo Zero or Carnegie Mellon’s poker playing AI—are perhaps the most headline-grabbing of the bunch. But pattern recognition was the thing that kicked deep learning into overdrive early on, when machine learning algorithms went from struggling to tell dogs and cats apart to outperforming their peers and then their makers in quick succession.
[Watch this video for an AI update from Neil Jacobstein, chair of Artificial Intelligence and Robotics at Singularity University.]

In medicine, deep learning algorithms trained on databases of medical images can spot life-threatening disease with equal or greater accuracy than human professionals. There’s even speculation that AI, if we learn to trust it, could be invaluable in diagnosing disease. And, as Zhavoronkov noted, with more applications and a longer track record that trust is coming.
“Tesla is already putting cars on the street,” Zhavoronkov said. “Three-year, four-year-old technology is already carrying passengers from point A to point B, at 100 miles an hour, and one mistake and you’re dead. But people are trusting their lives to this technology.”
“So, why don’t we do it in pharma?”
Trial and Error and Try Again
AI wouldn’t drive the car in pharmaceutical research. It’d be an assistant that, when paired with a chemist or two, could fast-track discovery by screening more possibilities for better candidates.
There’s plenty of room to make things more efficient, according to Zhavoronkov.
Drug discovery is arduous and expensive. Chemists sift tens of thousands of candidate compounds for the most promising to synthesize. Of these, a handful will go on to further research, fewer will make it to human clinical trials, and a fraction of those will be approved.
The whole process can take many years and cost hundreds of millions of dollars.
This is a big data problem if ever there was one, and deep learning thrives on big data. Early applications have shown their worth unearthing subtle patterns in huge training databases. Although drug-makers already use software to sift compounds, such software requires explicit rules written by chemists. AI’s allure is its ability to learn and improve on its own.
“There are two strategies for AI-driven innovation in pharma to ensure you get better molecules and much faster approvals,” Zhavoronkov said. “One is looking for the needle in the haystack, and another one is creating a new needle.”
To find the needle in the haystack, algorithms are trained on large databases of molecules. Then they go looking for molecules with attractive properties. But creating a new needle? That’s a possibility enabled by the generative adversarial networks Zhavoronkov specializes in.
Such algorithms pit two neural networks against each other. One generates meaningful output while the other judges whether this output is true or false, Zhavoronkov said. Together, the networks generate new objects like text, images, or in this case, molecular structures.
“We started employing this particular technology to make deep neural networks imagine new molecules, to make it perfect right from the start. So, to come up with really perfect needles,” Zhavoronkov said. “[You] can essentially go to this [generative adversarial network] and ask it to create molecules that inhibit protein X at concentration Y, with the highest viability, specific characteristics, and minimal side effects.”
Zhavoronkov believes AI can find or fabricate more needles from the array of molecular possibilities, freeing human chemists to focus on synthesizing only the most promising. If it works, he hopes we can increase hits, minimize misses, and generally speed the process up.
Proof’s in the Pudding
Insilico isn’t alone on its drug-discovery quest, nor is it a brand new area of interest.
Last year, a Harvard group published a paper on an AI that similarly suggests drug candidates. The software trained on 250,000 drug-like molecules and used its experience to generate new molecules that blended existing drugs and made suggestions based on desired properties.
An MIT Technology Review article on the subject highlighted a few of the challenges such systems may still face. The results returned aren’t always meaningful or easy to synthesize in the lab, and the quality of these results, as always, is only as good as the data dined upon.
Stanford chemistry professor and Andreesen Horowitz partner, Vijay Pande, said that images, speech, and text—three of the areas deep learning’s made quick strides in—have better, cleaner data. Chemical data, on the other hand, is still being optimized for deep learning. Also, while there are public databases, much data still lives behind closed doors at private companies.
To overcome the challenges and prove their worth, Zhavoronkov said, his company is very focused on validating the tech. But this year, skepticism in the pharmaceutical industry seems to be easing into interest and investment.
AI drug discovery startup Exscientia inked a deal with Sanofi for $280 million and GlaxoSmithKline for $42 million. Insilico is also partnering with GlaxoSmithKline, and Numerate is working with Takeda Pharmaceutical. Even Google may jump in. According to an article in Nature outlining the field, the firm’s deep learning project, Google Brain, is growing its biosciences team, and industry watchers wouldn’t be surprised to see them target drug discovery.
With AI and the hardware running it advancing rapidly, the greatest potential may yet be ahead. Perhaps, one day, all 1060 molecules in drug-space will be at our disposal. “You should take all the data you have, build n new models, and search as much of that 1060 as possible” before every decision you make, Brandon Allgood, CTO at Numerate, told Nature.
Today’s projects need to live up to their promises, of course, but Zhavoronkov believes AI will have a big impact in the coming years, and now’s the time to integrate it. “If you are working for a pharma company, and you’re still thinking, ‘Okay, where is the proof?’ Once there is a proof, and once you can see it to believe it—it’s going to be too late,” he said.
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#431389 Tech Is Becoming Emotionally ...

Many people get frustrated with technology when it malfunctions or is counterintuitive. The last thing people might expect is for that same technology to pick up on their emotions and engage with them differently as a result.
All of that is now changing. Computers are increasingly able to figure out what we’re feeling—and it’s big business.
A recent report predicts that the global affective computing market will grow from $12.2 billion in 2016 to $53.98 billion by 2021. The report by research and consultancy firm MarketsandMarkets observed that enabling technologies have already been adopted in a wide range of industries and noted a rising demand for facial feature extraction software.
Affective computing is also referred to as emotion AI or artificial emotional intelligence. Although many people are still unfamiliar with the category, researchers in academia have already discovered a multitude of uses for it.
At the University of Tokyo, Professor Toshihiko Yamasaki decided to develop a machine learning system that evaluates the quality of TED Talk videos. Of course, a TED Talk is only considered to be good if it resonates with a human audience. On the surface, this would seem too qualitatively abstract for computer analysis. But Yamasaki wanted his system to watch videos of presentations and predict user impressions. Could a machine learning system accurately evaluate the emotional persuasiveness of a speaker?
Yamasaki and his colleagues came up with a method that analyzed correlations and “multimodal features including linguistic as well as acoustic features” in a dataset of 1,646 TED Talk videos. The experiment was successful. The method obtained “a statistically significant macro-average accuracy of 93.3 percent, outperforming several competitive baseline methods.”
A machine was able to predict whether or not a person would emotionally connect with other people. In their report, the authors noted that these findings could be used for recommendation purposes and also as feedback to the presenters, in order to improve the quality of their public presentation. However, the usefulness of affective computing goes far beyond the way people present content. It may also transform the way they learn it.
Researchers from North Carolina State University explored the connection between students’ affective states and their ability to learn. Their software was able to accurately predict the effectiveness of online tutoring sessions by analyzing the facial expressions of participating students. The software tracked fine-grained facial movements such as eyebrow raising, eyelid tightening, and mouth dimpling to determine engagement, frustration, and learning. The authors concluded that “analysis of facial expressions has great potential for educational data mining.”
This type of technology is increasingly being used within the private sector. Affectiva is a Boston-based company that makes emotion recognition software. When asked to comment on this emerging technology, Gabi Zijderveld, chief marketing officer at Affectiva, explained in an interview for this article, “Our software measures facial expressions of emotion. So basically all you need is our software running and then access to a camera so you can basically record a face and analyze it. We can do that in real time or we can do this by looking at a video and then analyzing data and sending it back to folks.”
The technology has particular relevance for the advertising industry.
Zijderveld said, “We have products that allow you to measure how consumers or viewers respond to digital content…you could have a number of people looking at an ad, you measure their emotional response so you aggregate the data and it gives you insight into how well your content is performing. And then you can adapt and adjust accordingly.”
Zijderveld explained that this is the first market where the company got traction. However, they have since packaged up their core technology in software development kits or SDKs. This allows other companies to integrate emotion detection into whatever they are building.
By licensing its technology to others, Affectiva is now rapidly expanding into a wide variety of markets, including gaming, education, robotics, and healthcare. The core technology is also used in human resources for the purposes of video recruitment. The software analyzes the emotional responses of interviewees, and that data is factored into hiring decisions.
Richard Yonck is founder and president of Intelligent Future Consulting and the author of a book about our relationship with technology. “One area I discuss in Heart of the Machine is the idea of an emotional economy that will arise as an ecosystem of emotionally aware businesses, systems, and services are developed. This will rapidly expand into a multi-billion-dollar industry, leading to an infrastructure that will be both emotionally responsive and potentially exploitive at personal, commercial, and political levels,” said Yonck, in an interview for this article.
According to Yonck, these emotionally-aware systems will “better anticipate needs, improve efficiency, and reduce stress and misunderstandings.”
Affectiva is uniquely positioned to profit from this “emotional economy.” The company has already created the world’s largest emotion database. “We’ve analyzed a little bit over 4.7 million faces in 75 countries,” said Zijderveld. “This is data first and foremost, it’s data gathered with consent. So everyone has opted in to have their faces analyzed.”
The vastness of that database is essential for deep learning approaches. The software would be inaccurate if the data was inadequate. According to Zijderveld, “If you don’t have massive amounts of data of people of all ages, genders, and ethnicities, then your algorithms are going to be pretty biased.”
This massive database has already revealed cultural insights into how people express emotion. Zijderveld explained, “Obviously everyone knows that women are more expressive than men. But our data confirms that, but not only that, it can also show that women smile longer. They tend to smile more often. There’s also regional differences.”
Yonck believes that affective computing will inspire unimaginable forms of innovation and that change will happen at a fast pace.
He explained, “As businesses, software, systems, and services develop, they’ll support and make possible all sorts of other emotionally aware technologies that couldn’t previously exist. This leads to a spiral of increasingly sophisticated products, just as happened in the early days of computing.”
Those who are curious about affective technology will soon be able to interact with it.
Hubble Connected unveiled the Hubble Hugo at multiple trade shows this year. Hugo is billed as “the world’s first smart camera,” with emotion AI video analytics powered by Affectiva. The product can identify individuals, figure out how they’re feeling, receive voice commands, video monitor your home, and act as a photographer and videographer of events. Media can then be transmitted to the cloud. The company’s website describes Hugo as “a fun pal to have in the house.”
Although he sees the potential for improved efficiencies and expanding markets, Richard Yonck cautions that AI technology is not without its pitfalls.
“It’s critical that we understand we are headed into very unknown territory as we develop these systems, creating problems unlike any we’ve faced before,” said Yonck. “We should put our focus on ensuring AI develops in a way that represents our human values and ideals.”
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#431385 Here’s How to Get to Conscious ...

“We cannot be conscious of what we are not conscious of.” – Julian Jaynes, The Origin of Consciousness in the Breakdown of the Bicameral Mind
Unlike the director leads you to believe, the protagonist of Ex Machina, Andrew Garland’s 2015 masterpiece, isn’t Caleb, a young programmer tasked with evaluating machine consciousness. Rather, it’s his target Ava, a breathtaking humanoid AI with a seemingly child-like naïveté and an enigmatic mind.
Like most cerebral movies, Ex Machina leaves the conclusion up to the viewer: was Ava actually conscious? In doing so, it also cleverly avoids a thorny question that has challenged most AI-centric movies to date: what is consciousness, and can machines have it?
Hollywood producers aren’t the only people stumped. As machine intelligence barrels forward at breakneck speed—not only exceeding human performance on games such as DOTA and Go, but doing so without the need for human expertise—the question has once more entered the scientific mainstream.
Are machines on the verge of consciousness?
This week, in a review published in the prestigious journal Science, cognitive scientists Drs. Stanislas Dehaene, Hakwan Lau and Sid Kouider of the Collège de France, University of California, Los Angeles and PSL Research University, respectively, argue: not yet, but there is a clear path forward.
The reason? Consciousness is “resolutely computational,” the authors say, in that it results from specific types of information processing, made possible by the hardware of the brain.
There is no magic juice, no extra spark—in fact, an experiential component (“what is it like to be conscious?”) isn’t even necessary to implement consciousness.
If consciousness results purely from the computations within our three-pound organ, then endowing machines with a similar quality is just a matter of translating biology to code.
Much like the way current powerful machine learning techniques heavily borrow from neurobiology, the authors write, we may be able to achieve artificial consciousness by studying the structures in our own brains that generate consciousness and implementing those insights as computer algorithms.
From Brain to Bot
Without doubt, the field of AI has greatly benefited from insights into our own minds, both in form and function.
For example, deep neural networks, the architecture of algorithms that underlie AlphaGo’s breathtaking sweep against its human competitors, are loosely based on the multi-layered biological neural networks that our brain cells self-organize into.
Reinforcement learning, a type of “training” that teaches AIs to learn from millions of examples, has roots in a centuries-old technique familiar to anyone with a dog: if it moves toward the right response (or result), give a reward; otherwise ask it to try again.
In this sense, translating the architecture of human consciousness to machines seems like a no-brainer towards artificial consciousness. There’s just one big problem.
“Nobody in AI is working on building conscious machines because we just have nothing to go on. We just don’t have a clue about what to do,” said Dr. Stuart Russell, the author of Artificial Intelligence: A Modern Approach in a 2015 interview with Science.
Multilayered consciousness
The hard part, long before we can consider coding machine consciousness, is figuring out what consciousness actually is.
To Dehaene and colleagues, consciousness is a multilayered construct with two “dimensions:” C1, the information readily in mind, and C2, the ability to obtain and monitor information about oneself. Both are essential to consciousness, but one can exist without the other.
Say you’re driving a car and the low fuel light comes on. Here, the perception of the fuel-tank light is C1—a mental representation that we can play with: we notice it, act upon it (refill the gas tank) and recall and speak about it at a later date (“I ran out of gas in the boonies!”).
“The first meaning we want to separate (from consciousness) is the notion of global availability,” explains Dehaene in an interview with Science. When you’re conscious of a word, your whole brain is aware of it, in a sense that you can use the information across modalities, he adds.
But C1 is not just a “mental sketchpad.” It represents an entire architecture that allows the brain to draw multiple modalities of information from our senses or from memories of related events, for example.
Unlike subconscious processing, which often relies on specific “modules” competent at a defined set of tasks, C1 is a global workspace that allows the brain to integrate information, decide on an action, and follow through until the end.
Like The Hunger Games, what we call “conscious” is whatever representation, at one point in time, wins the competition to access this mental workspace. The winners are shared among different brain computation circuits and are kept in the spotlight for the duration of decision-making to guide behavior.
Because of these features, C1 consciousness is highly stable and global—all related brain circuits are triggered, the authors explain.
For a complex machine such as an intelligent car, C1 is a first step towards addressing an impending problem, such as a low fuel light. In this example, the light itself is a type of subconscious signal: when it flashes, all of the other processes in the machine remain uninformed, and the car—even if equipped with state-of-the-art visual processing networks—passes by gas stations without hesitation.
With C1 in place, the fuel tank would alert the car computer (allowing the light to enter the car’s “conscious mind”), which in turn checks the built-in GPS to search for the next gas station.
“We think in a machine this would translate into a system that takes information out of whatever processing module it’s encapsulated in, and make it available to any of the other processing modules so they can use the information,” says Dehaene. “It’s a first sense of consciousness.”
Meta-cognition
In a way, C1 reflects the mind’s capacity to access outside information. C2 goes introspective.
The authors define the second facet of consciousness, C2, as “meta-cognition:” reflecting on whether you know or perceive something, or whether you just made an error (“I think I may have filled my tank at the last gas station, but I forgot to keep a receipt to make sure”). This dimension reflects the link between consciousness and sense of self.
C2 is the level of consciousness that allows you to feel more or less confident about a decision when making a choice. In computational terms, it’s an algorithm that spews out the probability that a decision (or computation) is correct, even if it’s often experienced as a “gut feeling.”
C2 also has its claws in memory and curiosity. These self-monitoring algorithms allow us to know what we know or don’t know—so-called “meta-memory,” responsible for that feeling of having something at the tip of your tongue. Monitoring what we know (or don’t know) is particularly important for children, says Dehaene.
“Young children absolutely need to monitor what they know in order to…inquire and become curious and learn more,” he explains.
The two aspects of consciousness synergize to our benefit: C1 pulls relevant information into our mental workspace (while discarding other “probable” ideas or solutions), while C2 helps with long-term reflection on whether the conscious thought led to a helpful response.
Going back to the low fuel light example, C1 allows the car to solve the problem in the moment—these algorithms globalize the information, so that the car becomes aware of the problem.
But to solve the problem, the car would need a “catalog of its cognitive abilities”—a self-awareness of what resources it has readily available, for example, a GPS map of gas stations.
“A car with this sort of self-knowledge is what we call having C2,” says Dehaene. Because the signal is globally available and because it’s being monitored in a way that the machine is looking at itself, the car would care about the low gas light and behave like humans do—lower fuel consumption and find a gas station.
“Most present-day machine learning systems are devoid of any self-monitoring,” the authors note.
But their theory seems to be on the right track. The few examples whereby a self-monitoring system was implemented—either within the structure of the algorithm or as a separate network—the AI has generated “internal models that are meta-cognitive in nature, making it possible for an agent to develop a (limited, implicit, practical) understanding of itself.”
Towards conscious machines
Would a machine endowed with C1 and C2 behave as if it were conscious? Very likely: a smartcar would “know” that it’s seeing something, express confidence in it, report it to others, and find the best solutions for problems. If its self-monitoring mechanisms break down, it may also suffer “hallucinations” or even experience visual illusions similar to humans.
Thanks to C1 it would be able to use the information it has and use it flexibly, and because of C2 it would know the limit of what it knows, says Dehaene. “I think (the machine) would be conscious,” and not just merely appearing so to humans.
If you’re left with a feeling that consciousness is far more than global information sharing and self-monitoring, you’re not alone.
“Such a purely functional definition of consciousness may leave some readers unsatisfied,” the authors acknowledge.
“But we’re trying to take a radical stance, maybe simplifying the problem. Consciousness is a functional property, and when we keep adding functions to machines, at some point these properties will characterize what we mean by consciousness,” Dehaene concludes.
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#431371 Amazon Is Quietly Building the Robots of ...

Science fiction is the siren song of hard science. How many innocent young students have been lured into complex, abstract science, technology, engineering, or mathematics because of a reckless and irresponsible exposure to Arthur C. Clarke at a tender age? Yet Arthur C. Clarke has a very famous quote: “Any sufficiently advanced technology is indistinguishable from magic.”
It’s the prospect of making that… ahem… magic leap that entices so many people into STEM in the first place. A magic leap that would change the world. How about, for example, having humanoid robots? They could match us in dexterity and speed, perceive the world around them as we do, and be programmed to do, well, more or less anything we can do.
Such a technology would change the world forever.
But how will it arrive? While true sci-fi robots won’t get here right away—the pieces are coming together, and the company best developing them at the moment is Amazon. Where others have struggled to succeed, Amazon has been quietly progressing. Notably, Amazon has more than just a dream, it has the most practical of reasons driving it into robotics.
This practicality matters. Technological development rarely proceeds by magic; it’s a process filled with twists, turns, dead-ends, and financial constraints. New technologies often have to answer questions like “What is this good for, are you being realistic?” A good strategy, then, can be to build something more limited than your initial ambition, but useful for a niche market. That way, you can produce a prototype, have a reasonable business plan, and turn a profit within a decade. You might call these “stepping stone” applications that allow for new technologies to be developed in an economically viable way.
You need something you can sell to someone, soon: that’s how you get investment in your idea. It’s this model that iRobot, developers of the Roomba, used: migrating from military prototypes to robotic vacuum cleaners to become the “boring, successful robot company.” Compare this to Willow Garage, a genius factory if ever there was one: they clearly had ambitions towards a general-purpose, multi-functional robot. They built an impressive device—PR2—and programmed the operating system, ROS, that is still the industry and academic standard to this day.
But since they were unable to sell their robot for much less than $250,000, it was never likely to be a profitable business. This is why Willow Garage is no more, and many workers at the company went into telepresence robotics. Telepresence is essentially videoconferencing with a fancy robot attached to move the camera around. It uses some of the same software (for example, navigation and mapping) without requiring you to solve difficult problems of full autonomy for the robot, or manipulating its environment. It’s certainly one of the stepping-stone areas that various companies are investigating.
Another approach is to go to the people with very high research budgets: the military.
This was the Boston Dynamics approach, and their incredible achievements in bipedal locomotion saw them getting snapped up by Google. There was a great deal of excitement and speculation about Google’s “nightmare factory” whenever a new slick video of a futuristic militarized robot surfaced. But Google broadly backed away from Replicant, their robotics program, and Boston Dynamics was sold. This was partly due to PR concerns over the Terminator-esque designs, but partly because they didn’t see the robotics division turning a profit. They hadn’t found their stepping stones.
This is where Amazon comes in. Why Amazon? First off, they just announced that their profits are up by 30 percent, and yet the company is well-known for their constantly-moving Day One philosophy where a great deal of the profits are reinvested back into the business. But lots of companies have ambition.
One thing Amazon has that few other corporations have, as well as big financial resources, is viable stepping stones for developing the technologies needed for this sort of robotics to become a reality. They already employ 100,000 robots: these are of the “pragmatic, boring, useful” kind that we’ve profiled, which move around the shelves in warehouses. These robots are allowing Amazon to develop localization and mapping software for robots that can autonomously navigate in the simple warehouse environment.
But their ambitions don’t end there. The Amazon Robotics Challenge is a multi-million dollar competition, open to university teams, to produce a robot that can pick and package items in warehouses. The problem of grasping and manipulating a range of objects is not a solved one in robotics, so this work is still done by humans—yet it’s absolutely fundamental for any sci-fi dream robot.
Google, for example, attempted to solve this problem by hooking up 14 robot hands to machine learning algorithms and having them grasp thousands of objects. Although results were promising, the 10 to 20 percent failure rate for grasps is too high for warehouse use. This is a perfect stepping stone for Amazon; should they crack the problem, they will likely save millions in logistics.
Another area where humanoid robotics—especially bipedal locomotion, or walking, has been seriously suggested—is in the last mile delivery problem. Amazon has shown willingness to be creative in this department with their notorious drone delivery service. In other words, it’s all very well to have your self-driving car or van deliver packages to people’s doors, but who puts the package on the doorstep? It’s difficult for wheeled robots to navigate the full range of built environments that exist. That’s why bipedal robots like CASSIE, developed by Oregon State, may one day be used to deliver parcels.
Again: no one more than Amazon stands to profit from cracking this technology. The line from robotics research to profit is very clear.
So, perhaps one day Amazon will have robots that can move around and manipulate their environments. But they’re also working on intelligence that will guide those robots and make them truly useful for a variety of tasks. Amazon has an AI, or at least the framework for an AI: it’s called Alexa, and it’s in tens of millions of homes. The Alexa Prize, another multi-million-dollar competition, is attempting to make Alexa more social.
To develop a conversational AI, at least using the current methods of machine learning, you need data on tens of millions of conversations. You need to understand how people will try to interact with the AI. Amazon has access to this in Alexa, and they’re using it. As owners of the leading voice-activated personal assistant, they have an ecosystem of developers creating apps for Alexa. It will be integrated with the smart home and the Internet of Things. It is a very marketable product, a stepping stone for robot intelligence.
What’s more, the company can benefit from its huge sales infrastructure. For Amazon, having an AI in your home is ideal, because it can persuade you to buy more products through its website. Unlike companies like Google, Amazon has an easy way to make a direct profit from IoT devices, which could fuel funding.
For a humanoid robot to be truly useful, though, it will need vision and intelligence. It will have to understand and interpret its environment, and react accordingly. The way humans learn about our environment is by getting out and seeing it. This is something that, for example, an Alexa coupled to smart glasses would be very capable of doing. There are rumors that Alexa’s AI will soon be used in security cameras, which is an ideal stepping stone task to train an AI to process images from its environment, truly perceiving the world and any threats it might contain.
It’s a slight exaggeration to say that Amazon is in the process of building a secret robot army. The gulf between our sci-fi vision of robots that can intelligently serve us, rather than mindlessly assemble cars, is still vast. But in quietly assembling many of the technologies needed for intelligent, multi-purpose robotics—and with the unique stepping stones they have along the way—Amazon might just be poised to leap that gulf. As if by magic.
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#431343 How Technology Is Driving Us Toward Peak ...

At some point in the future—and in some ways we are already seeing this—the amount of physical stuff moving around the world will peak and begin to decline. By “stuff,” I am referring to liquid fuels, coal, containers on ships, food, raw materials, products, etc.
New technologies are moving us toward “production-at-the-point-of-consumption” of energy, food, and products with reduced reliance on a global supply chain.
The trade of physical stuff has been central to globalization as we’ve known it. So, this declining movement of stuff may signal we are approaching “peak globalization.”
To be clear, even as the movement of stuff may slow, if not decline, the movement of people, information, data, and ideas around the world is growing exponentially and is likely to continue doing so for the foreseeable future.
Peak globalization may provide a pathway to preserving the best of globalization and global interconnectedness, enhancing economic and environmental sustainability, and empowering individuals and communities to strengthen democracy.
At the same time, some of the most troublesome aspects of globalization may be eased, including massive financial transfers to energy producers and loss of jobs to manufacturing platforms like China. This shift could bring relief to the “losers” of globalization and ease populist, nationalist political pressures that are roiling the developed countries.
That is quite a claim, I realize. But let me explain the vision.
New Technologies and Businesses: Digital, Democratized, Decentralized
The key factors moving us toward peak globalization and making it economically viable are new technologies and innovative businesses and business models allowing for “production-at-the-point-of-consumption” of energy, food, and products.
Exponential technologies are enabling these trends by sharply reducing the “cost of entry” for creating businesses. Driven by Moore’s Law, powerful technologies have become available to almost anyone, anywhere.
Beginning with the microchip, which has had a 100-billion-fold improvement in 40 years—10,000 times faster and 10 million times cheaper—the marginal cost of producing almost everything that can be digitized has fallen toward zero.
A hard copy of a book, for example, will always entail the cost of materials, printing, shipping, etc., even if the marginal cost falls as more copies are produced. But the marginal cost of a second digital copy, such as an e-book, streaming video, or song, is nearly zero as it is simply a digital file sent over the Internet, the world’s largest copy machine.* Books are one product, but there are literally hundreds of thousands of dollars in once-physical, separate products jammed into our devices at little to no cost.
A smartphone alone provides half the human population access to artificial intelligence—from SIRI, search, and translation to cloud computing—geolocation, free global video calls, digital photography and free uploads to social network sites, free access to global knowledge, a million apps for a huge variety of purposes, and many other capabilities that were unavailable to most people only a few years ago.
As powerful as dematerialization and demonetization are for private individuals, they’re having a stronger effect on businesses. A small team can access expensive, advanced tools that before were only available to the biggest organizations. Foundational digital platforms, such as the internet and GPS, and the platforms built on top of them by the likes of Google, Apple, Amazon, and others provide the connectivity and services democratizing business tools and driving the next generation of new startups.

“As these trends gain steam in coming decades, they’ll bleed into and fundamentally transform global supply chains.”

An AI startup, for example, doesn’t need its own server farm to train its software and provide service to customers. The team can rent computing power from Amazon Web Services. This platform model enables small teams to do big things on the cheap. And it isn’t just in software. Similar trends are happening in hardware too. Makers can 3D print or mill industrial grade prototypes of physical stuff in a garage or local maker space and send or sell designs to anyone with a laptop and 3D printer via online platforms.
These are early examples of trends that are likely to gain steam in coming decades, and as they do, they’ll bleed into and fundamentally transform global supply chains.
The old model is a series of large, connected bits of centralized infrastructure. It makes sense to mine, farm, or manufacture in bulk when the conditions, resources, machines, and expertise to do so exist in particular places and are specialized and expensive. The new model, however, enables smaller-scale production that is local and decentralized.
To see this more clearly, let’s take a look at the technological trends at work in the three biggest contributors to the global trade of physical stuff—products, energy, and food.
Products
3D printing (additive manufacturing) allows for distributed manufacturing near the point of consumption, eliminating or reducing supply chains and factory production lines.
This is possible because product designs are no longer made manifest in assembly line parts like molds or specialized mechanical tools. Rather, designs are digital and can be called up at will to guide printers. Every time a 3D printer prints, it can print a different item, so no assembly line needs to be set up for every different product. 3D printers can also print an entire finished product in one piece or reduce the number of parts of larger products, such as engines. This further lessens the need for assembly.
Because each item can be customized and printed on demand, there is no cost benefit from scaling production. No inventories. No shipping items across oceans. No carbon emissions transporting not only the final product but also all the parts in that product shipped from suppliers to manufacturer. Moreover, 3D printing builds items layer by layer with almost no waste, unlike “subtractive manufacturing” in which an item is carved out of a piece of metal, and much or even most of the material can be waste.
Finally, 3D printing is also highly scalable, from inexpensive 3D printers (several hundred dollars) for home and school use to increasingly capable and expensive printers for industrial production. There are also 3D printers being developed for printing buildings, including houses and office buildings, and other infrastructure.
The technology for finished products is only now getting underway, and there are still challenges to overcome, such as speed, quality, and range of materials. But as methods and materials advance, it will likely creep into more manufactured goods.
Ultimately, 3D printing will be a general purpose technology that involves many different types of printers and materials—such as plastics, metals, and even human cells—to produce a huge range of items, from human tissue and potentially human organs to household items and a range of industrial items for planes, trains, and automobiles.
Energy
Renewable energy production is located at or relatively near the source of consumption.
Although electricity generated by solar, wind, geothermal, and other renewable sources can of course be transmitted over longer distances, it is mostly generated and consumed locally or regionally. It is not transported around the world in tankers, ships, and pipelines like petroleum, coal, and natural gas.
Moreover, the fuel itself is free—forever. There is no global price on sun or wind. The people relying on solar and wind power need not worry about price volatility and potential disruption of fuel supplies as a result of political, market, or natural causes.
Renewables have their problems, of course, including intermittency and storage, and currently they work best if complementary to other sources, especially natural gas power plants that, unlike coal plants, can be turned on or off and modulated like a gas stove, and are half the carbon emissions of coal.
Within the next decades or so, it is likely the intermittency and storage problems will be solved or greatly mitigated. In addition, unlike coal and natural gas power plants, solar is scalable, from solar panels on individual homes or even cars and other devices, to large-scale solar farms. Solar can be connected with microgrids and even allow for autonomous electricity generation by homes, commercial buildings, and communities.
It may be several decades before fossil fuel power plants can be phased out, but the development cost of renewables has been falling exponentially and, in places, is beginning to compete with coal and gas. Solar especially is expected to continue to increase in efficiency and decline in cost.
Given these trends in cost and efficiency, renewables should become obviously cheaper over time—if the fuel is free for solar and has to be continually purchased for coal and gas, at some point the former is cheaper than the latter. Renewables are already cheaper if externalities such as carbon emissions and environmental degradation involved in obtaining and transporting the fuel are included.
Food
Food can be increasingly produced near the point of consumption with vertical farms and eventually with printed food and even printed or cultured meat.
These sources bring production of food very near the consumer, so transportation costs, which can be a significant portion of the cost of food to consumers, are greatly reduced. The use of land and water are reduced by 95% or more, and energy use is cut by nearly 50%. In addition, fertilizers and pesticides are not required and crops can be grown 365 days a year whatever the weather and in more climates and latitudes than is possible today.
While it may not be practical to grow grains, corn, and other such crops in vertical farms, many vegetables and fruits can flourish in such facilities. In addition, cultured or printed meat is being developed—the big challenge is scaling up and reducing cost—that is based on cells from real animals without slaughtering the animals themselves.
There are currently some 70 billion animals being raised for food around the world [PDF] and livestock alone counts for about 15% of global emissions. Moreover, livestock places huge demands on land, water, and energy. Like vertical farms, cultured or printed meat could be produced with no more land use than a brewery and with far less water and energy.
A More Democratic Economy Goes Bottom Up
This is a very brief introduction to the technologies that can bring “production-at-the-point-of-consumption” of products, energy, and food to cities and regions.
What does this future look like? Here’s a simplified example.
Imagine a universal manufacturing facility with hundreds of 3D printers printing tens of thousands of different products on demand for the local community—rather than assembly lines in China making tens of thousands of the same product that have to be shipped all over the world since no local market can absorb all of the same product.
Nearby, a vertical farm and cultured meat facility produce much of tomorrow night’s dinner. These facilities would be powered by local or regional wind and solar. Depending on need and quality, some infrastructure and machinery, like solar panels and 3D printers, would live in these facilities and some in homes and businesses.
The facilities could be owned by a large global corporation—but still locally produce goods—or they could be franchised or even owned and operated independently by the local population. Upkeep and management at each would provide jobs for communities nearby. Eventually, not only would global trade of parts and products diminish, but even required supplies of raw materials and feed stock would decline since there would be less waste in production, and many materials would be recycled once acquired.

“Peak globalization could be a viable pathway to an economic foundation that puts people first while building a more economically and environmentally sustainable future.”

This model suggests a shift toward a “bottom up” economy that is more democratic, locally controlled, and likely to generate more local jobs.
The global trends in democratization of technology make the vision technologically plausible. Much of this technology already exists and is improving and scaling while exponentially decreasing in cost to become available to almost anyone, anywhere.
This includes not only access to key technologies, but also to education through digital platforms available globally. Online courses are available for free, ranging from advanced physics, math, and engineering to skills training in 3D printing, solar installations, and building vertical farms. Social media platforms can enable local and global collaboration and sharing of knowledge and best practices.
These new communities of producers can be the foundation for new forms of democratic governance as they recognize and “capitalize” on the reality that control of the means of production can translate to political power. More jobs and local control could weaken populist, anti-globalization political forces as people recognize they could benefit from the positive aspects of globalization and international cooperation and connectedness while diminishing the impact of globalization’s downsides.
There are powerful vested interests that stand to lose in such a global structural shift. But this vision builds on trends that are already underway and are gaining momentum. Peak globalization could be a viable pathway to an economic foundation that puts people first while building a more economically and environmentally sustainable future.
This article was originally posted on Open Democracy (CC BY-NC 4.0). The version above was edited with the author for length and includes additions. Read the original article on Open Democracy.
* See Jeremy Rifkin, The Zero Marginal Cost Society, (New York: Palgrave Macmillan, 2014), Part II, pp. 69-154.
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