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#437103 How to Make Sense of Uncertainty in a ...

As the internet churns with information about Covid-19, about the virus that causes the disease, and about what we’re supposed to do to fight it, it can be difficult to see the forest for the trees. What can we realistically expect for the rest of 2020? And how do we even know what’s realistic?

Today, humanity’s primary, ideal goal is to eliminate the virus, SARS-CoV-2, and Covid-19. Our second-choice goal is to control virus transmission. Either way, we have three big aims: to save lives, to return to public life, and to keep the economy functioning.

To hit our second-choice goal—and maybe even our primary goal—countries are pursuing five major public health strategies. Note that many of these advances cross-fertilize: for example, advances in virus testing and antibody testing will drive data-based prevention efforts.

Five major public health strategies are underway to bring Covid-19 under control and to contain the spread of SARS-CoV-2.
These strategies arise from things we can control based on the things that we know at any given moment. But what about the things we can’t control and don’t yet know?

The biology of the virus and how it interacts with our bodies is what it is, so we should seek to understand it as thoroughly as possible. How long any immunity gained from prior infection lasts—and indeed whether people develop meaningful immunity at all after infection—are open questions urgently in need of greater clarity. Similarly, right now it’s important to focus on understanding rather than making assumptions about environmental factors like seasonality.

But the biggest question on everyone’s lips is, “When?” When will we see therapeutic progress against Covid-19? And when will life get “back to normal”? There are lots of models out there on the internet; which of those models are right? The simple answer is “none of them.” That’s right—it’s almost certain that every model you’ve seen is wrong in at least one detail, if not all of them. But modeling is meant to be a tool for deeper thinking, a way to run mental (and computational) experiments before—and while—taking action. As George E. P. Box famously wrote in 1976, “All models are wrong, but some are useful.”

Here, we’re seeking useful insights, as opposed to exact predictions, which is why we’re pulling back from quantitative details to get at the mindsets that will support agency and hope. To that end, I’ve been putting together timelines that I believe will yield useful expectations for the next year or two—and asking how optimistic I need to be in order to believe a particular timeline.

For a moderately optimistic scenario to be relevant, breakthroughs in science and technology come at paces expected based on previous efforts and assumptions that turn out to be basically correct; accessibility of those breakthroughs increases at a reasonable pace; regulation achieves its desired effects, without major surprises; and compliance with regulations is reasonably high.

In contrast, if I’m being highly optimistic, breakthroughs in science and technology and their accessibility come more quickly than they ever have before; regulation is evidence-based and successful in the first try or two; and compliance with those regulations is high and uniform. If I’m feeling not-so-optimistic, then I anticipate serious setbacks to breakthroughs and accessibility (with the overturning of many important assumptions), repeated failure of regulations to achieve their desired outcomes, and low compliance with those regulations.

The following scenarios outline the things that need to happen in the fight against Covid-19, when I expect to see them, and how confident I feel in those expectations. They focus on North America and Europe because there are data missing about China’s 2019 outbreak and other regions are still early in their outbreaks. Perhaps the most important thing to keep in mind throughout: We know more today than we did yesterday, but we still have much to learn. New knowledge derived from greater study and debate will almost certainly inspire ongoing course corrections.

As you dive into the scenarios below, practice these three mindset shifts. First, defeating Covid-19 will be a marathon, not a sprint. We shouldn’t expect life to look like 2019 for the next year or two—if ever. As Ed Yong wrote recently in The Atlantic, “There won’t be an obvious moment when everything is under control and regular life can safely resume.” Second, remember that you have important things to do for at least a year. And third, we are all in this together. There is no “us” and “them.” We must all be alert, responsive, generous, and strong throughout 2020 and 2021—and willing to throw away our assumptions when scientific evidence invalidates them.

The Middle Way: Moderate Optimism
Let’s start with the case in which I have the most confidence: moderate optimism.

This timeline considers milestones through late 2021, the earliest that I believe vaccines will become available. The “normal” timeline for developing a vaccine for diseases like seasonal flu is 18 months, which leads to my projection that we could potentially have vaccines as soon as 18 months from the first quarter of 2020. While Melinda Gates agrees with that projection, others (including AI) believe that 3 to 5 years is far more realistic, based on past vaccine development and the need to test safety and efficacy in humans. However, repurposing existing vaccines against other diseases—or piggybacking off clever synthetic platforms—could lead to vaccines being available sooner. I tried to balance these considerations for this moderately optimistic scenario. Either way, deploying vaccines at the end of 2021 is probably much later than you may have been led to believe by the hype engine. Again, if you take away only one message from this article, remember that the fight against Covid-19 is a marathon, not a sprint.

Here, I’ve visualized a moderately optimistic scenario as a baseline. Think of these timelines as living guides, as opposed to exact predictions. There are still many unknowns. More or less optimistic views (see below) and new information could shift these timelines forward or back and change the details of the strategies.
Based on current data, I expect that the first wave of Covid-19 cases (where we are now) will continue to subside in many areas, leading governments to ease restrictions in an effort to get people back to work. We’re already seeing movement in that direction, with a variety of benchmarks and changes at state and country levels around the world. But depending on the details of the changes, easing restrictions will probably cause a second wave of sickness (see Germany and Singapore), which should lead governments to reimpose at least some restrictions.

In tandem, therapeutic efforts will be transitioning from emergency treatments to treatments that have been approved based on safety and efficacy data in clinical trials. In a moderately optimistic scenario, assuming clinical trials currently underway yield at least a few positive results, this shift to mostly approved therapies could happen as early as the third or fourth quarter of this year and continue from there. One approval that should come rather quickly is for plasma therapies, in which the blood from people who have recovered from Covid-19 is used as a source of antibodies for people who are currently sick.

Companies around the world are working on both viral and antibody testing, focusing on speed, accuracy, reliability, and wide accessibility. While these tests are currently being run in hospitals and research laboratories, at-home testing is a critical component of the mass testing we’ll need to keep viral spread in check. These are needed to minimize the impact of asymptomatic cases, test the assumption that infection yields resistance to subsequent infection (and whether it lasts), and construct potential immunity passports if this assumption holds. Testing is also needed for contact tracing efforts to prevent further spread and get people back to public life. Finally, it’s crucial to our fundamental understanding of the biology of SARS-CoV-2 and Covid-19.

We need tests that are very reliable, both in the clinic and at home. So, don’t go buying any at-home test kits just yet, even if you find them online. Wait for reliable test kits and deeper understanding of how a test result translates to everyday realities. If we’re moderately optimistic, in-clinic testing will rapidly expand this quarter and/or next, with the possibility of broadly available, high-quality at-home sampling (and perhaps even analysis) thereafter.

Note that testing is not likely to be a “one-and-done” endeavor, as a person’s infection and immunity status change over time. Expect to be testing yourself—and your family—often as we move later into 2020.

Testing data are also going to inform distancing requirements at the country and local levels. In this scenario, restrictions—at some level of stringency—could persist at least through the end of 2020, as most countries are way behind the curve on testing (Iceland is an informative exception). Governments will likely continue to ask citizens to work from home if at all possible; to wear masks or face coverings in public; to employ heightened hygiene and social distancing in workplaces; and to restrict travel and social gatherings. So while it’s likely we’ll be eating in local restaurants again in 2020 in this scenario, at least for a little while, it’s not likely we’ll be heading to big concerts any time soon.

The Extremes: High and Low Optimism
How would high and low levels of optimism change our moderately optimistic timeline? The milestones are the same, but the time required to achieve them is shorter or longer, respectively. Quantifying these shifts is less important than acknowledging and incorporating a range of possibilities into our view. It pays to pay attention to our bias. Here are a few examples of reasonable possibilities that could shift the moderately optimistic timeline.

When vaccines become available
Vaccine repurposing could shorten the time for vaccines to become available; today, many vaccine candidates are in various stages of testing. On the other hand, difficulties in manufacture and distribution, or faster-than-expected mutation of SARS-CoV-2, could slow vaccine development. Given what we know now, I am not strongly concerned about either of these possibilities—drug companies are rapidly expanding their capabilities, and viral mutation isn’t an urgent concern at this time based on sequencing data—but they could happen.

At first, governments will likely supply vaccines to essential workers such as healthcare workers, but it is essential that vaccines become widely available around the world as quickly and as safely as possible. Overall, I suggest a dose of skepticism when reading highly optimistic claims about a vaccine (or multiple vaccines) being available in 2020. Remember, a vaccine is a knockout punch, not a first line of defense for an outbreak.

When testing hits its stride
While I am confident that testing is a critical component of our response to Covid-19, reliability is incredibly important to testing for SARS-CoV-2 and for immunity to the disease, particularly at home. For an individual, a false negative (being told you don’t have antibodies when you really do) could be just as bad as a false positive (being told you do have antibodies when you really don’t). Those errors are compounded when governments are trying to make evidence-based policies for social and physical distancing.

If you’re highly optimistic, high-quality testing will ramp up quickly as companies and scientists innovate rapidly by cleverly combining multiple test modalities, digital signals, and cutting-edge tech like CRISPR. Pop-up testing labs could also take some pressure off hospitals and clinics.

If things don’t go well, reliability issues could hinder testing, manufacturing bottlenecks could limit availability, and both could hamstring efforts to control spread and ease restrictions. And if it turns out that immunity to Covid-19 isn’t working the way we assumed, then we must revisit our assumptions about our path(s) back to public life, as well as our vaccine-development strategies.

How quickly safe and effective treatments appear
Drug development is known to be long, costly, and fraught with failure. It’s not uncommon to see hope in a drug spike early only to be dashed later on down the road. With that in mind, the number of treatments currently under investigation is astonishing, as is the speed through which they’re proceeding through testing. Breakthroughs in a therapeutic area—for example in treating the seriously ill or in reducing viral spread after an infection takes hold—could motivate changes in the focus of distancing regulations.

While speed will save lives, we cannot overlook the importance of knowing a treatment’s efficacy (does it work against Covid-19?) and safety (does it make you sick in a different, or worse, way?). Repurposing drugs that have already been tested for other diseases is speeding innovation here, as is artificial intelligence.

Remarkable collaborations among governments and companies, large and small, are driving innovation in therapeutics and devices such as ventilators for treating the sick.

Whether government policies are effective and responsive
Those of us who have experienced lockdown are eager for it to be over. Businesses, economists, and governments are also eager to relieve the terrible pressure that is being exerted on the global economy. However, lifting restrictions will almost certainly lead to a resurgence in sickness.

Here, the future is hard to model because there are many, many factors at play, and at play differently in different places—including the extent to which individuals actually comply with regulations.

Reliable testing—both in the clinic and at home—is crucial to designing and implementing restrictions, monitoring their effectiveness, and updating them; delays in reliable testing could seriously hamper this design cycle. Lack of trust in governments and/or companies could also suppress uptake. That said, systems are already in place for contact tracing in East Asia. Other governments could learn important lessons, but must also earn—and keep—their citizens’ trust.

Expect to see restrictions descend and then lift in response to changes in the number of Covid-19 cases and in the effectiveness of our prevention strategies. Also expect country-specific and perhaps even area-specific responses that differ from each other. The benefit of this approach? Governments around the world are running perhaps hundreds of real-time experiments and design cycles in balancing health and the economy, and we can learn from the results.

A Way Out
As Jeremy Farrar, head of the Wellcome Trust, told Science magazine, “Science is the exit strategy.” Some of our greatest technological assistance is coming from artificial intelligence, digital tools for collaboration, and advances in biotechnology.

Our exit strategy also needs to include empathy and future visioning—because in the midst of this crisis, we are breaking ground for a new, post-Covid future.

What do we want that future to look like? How will the hard choices we make now about data ethics impact the future of surveillance? Will we continue to embrace inclusiveness and mass collaboration? Perhaps most importantly, will we lay the foundation for successfully confronting future challenges? Whether we’re thinking about the next pandemic (and there will be others) or the cascade of catastrophes that climate change is bringing ever closer—it’s important to remember that we all have the power to become agents of that change.

Special thanks to Ola Kowalewski and Jason Dorrier for significant conversations.

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Posted in Human Robots

#436977 The Top 100 AI Startups Out There Now, ...

New drug therapies for a range of chronic diseases. Defenses against various cyber attacks. Technologies to make cities work smarter. Weather and wildfire forecasts that boost safety and reduce risk. And commercial efforts to monetize so-called deepfakes.

What do all these disparate efforts have in common? They’re some of the solutions that the world’s most promising artificial intelligence startups are pursuing.

Data research firm CB Insights released its much-anticipated fourth annual list of the top 100 AI startups earlier this month. The New York-based company has become one of the go-to sources for emerging technology trends, especially in the startup scene.

About 10 years ago, it developed its own algorithm to assess the health of private companies using publicly-available information and non-traditional signals (think social media sentiment, for example) thanks to more than $1 million in grants from the National Science Foundation.

It uses that algorithm-generated data from what it calls a company’s Mosaic score—pulling together information on market trends, money, and momentum—along with other details ranging from patent activity to the latest news analysis to identify the best of the best.

“Our final list of companies is a mix of startups at various stages of R&D and product commercialization,” said Deepashri Varadharajanis, a lead analyst at CB Insights, during a recent presentation on the most prominent trends among the 2020 AI 100 startups.

About 10 companies on the list are among the world’s most valuable AI startups. For instance, there’s San Francisco-based Faire, which has raised at least $266 million since it was founded just three years ago. The company offers a wholesale marketplace that uses machine learning to match local retailers with goods that are predicted to sell well in their specific location.

Image courtesy of CB Insights
Funding for AI in Healthcare
Another startup valued at more than $1 billion, referred to as a unicorn in venture capital speak, is Butterfly Network, a company on the East Coast that has figured out a way to turn a smartphone phone into an ultrasound machine. Backed by $350 million in private investments, Butterfly Network uses AI to power the platform’s diagnostics. A more modestly funded San Francisco startup called Eko is doing something similar for stethoscopes.

In fact, there are more than a dozen AI healthcare startups on this year’s AI 100 list, representing the most companies of any industry on the list. In total, investors poured about $4 billion into AI healthcare startups last year, according to CB Insights, out of a record $26.6 billion raised by all private AI companies in 2019. Since 2014, more than 4,300 AI startups in 80 countries have raised about $83 billion.

One of the most intensive areas remains drug discovery, where companies unleash algorithms to screen potential drug candidates at an unprecedented speed and breadth that was impossible just a few years ago. It has led to the discovery of a new antibiotic to fight superbugs. There’s even a chance AI could help fight the coronavirus pandemic.

There are several AI drug discovery startups among the AI 100: San Francisco-based Atomwise claims its deep convolutional neural network, AtomNet, screens more than 100 million compounds each day. Cyclica is an AI drug discovery company in Toronto that just announced it would apply its platform to identify and develop novel cannabinoid-inspired drugs for neuropsychiatric conditions such as bipolar disorder and anxiety.

And then there’s OWKIN out of New York City, a startup that uses a type of machine learning called federated learning. Backed by Google, the company’s AI platform helps train algorithms without sharing the necessary patient data required to provide the sort of valuable insights researchers need for designing new drugs or even selecting the right populations for clinical trials.

Keeping Cyber Networks Healthy
Privacy and data security are the focus of a number of AI cybersecurity startups, as hackers attempt to leverage artificial intelligence to launch sophisticated attacks while also trying to fool the AI-powered systems rapidly coming online.

“I think this is an interesting field because it’s a bit of a cat and mouse game,” noted Varadharajanis. “As your cyber defenses get smarter, your cyber attacks get even smarter, and so it’s a constant game of who’s going to match the other in terms of tech capabilities.”

Few AI cybersecurity startups match Silicon Valley-based SentinelOne in terms of private capital. The company has raised more than $400 million, with a valuation of $1.1 billion following a $200 million Series E earlier this year. The company’s platform automates what’s called endpoint security, referring to laptops, phones, and other devices at the “end” of a centralized network.

Fellow AI 100 cybersecurity companies include Blue Hexagon, which protects the “edge” of the network against malware, and Abnormal Security, which stops targeted email attacks, both out of San Francisco. Just down the coast in Los Angeles is Obsidian Security, a startup offering cybersecurity for cloud services.

Deepfakes Get a Friendly Makeover
Deepfakes of videos and other types of AI-manipulated media where faces or voices are synthesized in order to fool viewers or listeners has been a different type of ongoing cybersecurity risk. However, some firms are swapping malicious intent for benign marketing and entertainment purposes.

Now anyone can be a supermodel thanks to Superpersonal, a London-based AI startup that has figured out a way to seamlessly swap a user’s face onto a fashionista modeling the latest threads on the catwalk. The most obvious use case is for shoppers to see how they will look in a particular outfit before taking the plunge on a plunging neckline.

Another British company called Synthesia helps users create videos where a talking head will deliver a customized speech or even talk in a different language. The startup’s claim to fame was releasing a campaign video for the NGO Malaria Must Die showing soccer star David Becham speak in nine different languages.

There’s also a Seattle-based company, Wellsaid Labs, which uses AI to produce voice-over narration where users can choose from a library of digital voices with human pitch, emphasis, and intonation. Because every narrator sounds just a little bit smarter with a British accent.

AI Helps Make Smart Cities Smarter
Speaking of smarter: A handful of AI 100 startups are helping create the smart city of the future, where a digital web of sensors, devices, and cloud-based analytics ensure that nobody is ever stuck in traffic again or without an umbrella at the wrong time. At least that’s the dream.

A couple of them are directly connected to Google subsidiary Sidewalk Labs, which focuses on tech solutions to improve urban design. A company called Replica was spun out just last year. It’s sort of SimCity for urban planning. The San Francisco startup uses location data from mobile phones to understand how people behave and travel throughout a typical day in the city. Those insights can then help city governments, for example, make better decisions about infrastructure development.

Denver-area startup AMP Robotics gets into the nitty gritty details of recycling by training robots on how to recycle trash, since humans have largely failed to do the job. The U.S. Environmental Protection Agency estimates that only about 30 percent of waste is recycled.

Some people might complain that weather forecasters don’t even do that well when trying to predict the weather. An Israeli AI startup, ClimaCell, claims it can forecast rain block by block. While the company taps the usual satellite and ground-based sources to create weather models, it has developed algorithms to analyze how precipitation and other conditions affect signals in cellular networks. By analyzing changes in microwave signals between cellular towers, the platform can predict the type and intensity of the precipitation down to street level.

And those are just some of the highlights of what some of the world’s most promising AI startups are doing.

“You have companies optimizing mining operations, warehouse logistics, insurance, workflows, and even working on bringing AI solutions to designing printed circuit boards,” Varadharajanis said. “So a lot of creative ways in which companies are applying AI to solve different issues in different industries.”

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Posted in Human Robots

#436526 Not Bot, Not Beast: Scientists Create ...

A remarkable combination of artificial intelligence (AI) and biology has produced the world’s first “living robots.”

This week, a research team of roboticists and scientists published their recipe for making a new lifeform called xenobots from stem cells. The term “xeno” comes from the frog cells (Xenopus laevis) used to make them.

One of the researchers described the creation as “neither a traditional robot nor a known species of animal,” but a “new class of artifact: a living, programmable organism.”

Xenobots are less than 1 millimeter long and made of 500-1,000 living cells. They have various simple shapes, including some with squat “legs.” They can propel themselves in linear or circular directions, join together to act collectively, and move small objects. Using their own cellular energy, they can live up to 10 days.

While these “reconfigurable biomachines” could vastly improve human, animal, and environmental health, they raise legal and ethical concerns.

Strange New ‘Creature’
To make xenobots, the research team used a supercomputer to test thousands of random designs of simple living things that could perform certain tasks.

The computer was programmed with an AI “evolutionary algorithm” to predict which organisms would likely display useful tasks, such as moving towards a target.

After the selection of the most promising designs, the scientists attempted to replicate the virtual models with frog skin or heart cells, which were manually joined using microsurgery tools. The heart cells in these bespoke assemblies contract and relax, giving the organisms motion.

The creation of xenobots is groundbreaking. Despite being described as “programmable living robots,” they are actually completely organic and made of living tissue. The term “robot” has been used because xenobots can be configured into different forms and shapes, and “programmed” to target certain objects, which they then unwittingly seek. They can also repair themselves after being damaged.

Possible Applications
Xenobots may have great value. Some speculate they could be used to clean our polluted oceans by collecting microplastics. Similarly, they may be used to enter confined or dangerous areas to scavenge toxins or radioactive materials. Xenobots designed with carefully shaped “pouches” might be able to carry drugs into human bodies.

Future versions may be built from a patient’s own cells to repair tissue or target cancers. Being biodegradable, xenobots would have an edge on technologies made of plastic or metal.

Further development of biological “robots” could accelerate our understanding of living and robotic systems. Life is incredibly complex, so manipulating living things could reveal some of life’s mysteries—and improve our use of AI.

Legal and Ethical Questions
Conversely, xenobots raise legal and ethical concerns. In the same way they could help target cancers, they could also be used to hijack life functions for malevolent purposes.

Some argue artificially making living things is unnatural, hubristic, or involves “playing God.” A more compelling concern is that of unintended or malicious use, as we have seen with technologies in fields including nuclear physics, chemistry, biology and AI. For instance, xenobots might be used for hostile biological purposes prohibited under international law.

More advanced future xenobots, especially ones that live longer and reproduce, could potentially “malfunction” and go rogue, and out-compete other species.

For complex tasks, xenobots may need sensory and nervous systems, possibly resulting in their sentience. A sentient programmed organism would raise additional ethical questions. Last year, the revival of a disembodied pig brain elicited concerns about different species’ suffering.

Managing Risks
The xenobot’s creators have rightly acknowledged the need for discussion around the ethics of their creation. The 2018 scandal over using CRISPR (which allows the introduction of genes into an organism) may provide an instructive lesson here. While the experiment’s goal was to reduce the susceptibility of twin baby girls to HIV-AIDS, associated risks caused ethical dismay. The scientist in question is in prison.

When CRISPR became widely available, some experts called for a moratorium on heritable genome editing. Others argued the benefits outweighed the risks.

While each new technology should be considered impartially and based on its merits, giving life to xenobots raises certain significant questions:

Should xenobots have biological kill-switches in case they go rogue?
Who should decide who can access and control them?
What if “homemade” xenobots become possible? Should there be a moratorium until regulatory frameworks are established? How much regulation is required?

Lessons learned in the past from advances in other areas of science could help manage future risks, while reaping the possible benefits.

Long Road Here, Long Road Ahead
The creation of xenobots had various biological and robotic precedents. Genetic engineering has created genetically modified mice that become fluorescent in UV light.

Designer microbes can produce drugs and food ingredients that may eventually replace animal agriculture. In 2012, scientists created an artificial jellyfish called a “medusoid” from rat cells.

Robotics is also flourishing. Nanobots can monitor people’s blood sugar levels and may eventually be able to clear clogged arteries. Robots can incorporate living matter, which we witnessed when engineers and biologists created a sting-ray robot powered by light-activated cells.

In the coming years, we are sure to see more creations like xenobots that evoke both wonder and due concern. And when we do, it is important we remain both open-minded and critical.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Posted in Human Robots

#436504 20 Technology Metatrends That Will ...

In the decade ahead, waves of exponential technological advancements are stacking atop one another, eclipsing decades of breakthroughs in scale and impact.

Emerging from these waves are 20 “metatrends” likely to revolutionize entire industries (old and new), redefine tomorrow’s generation of businesses and contemporary challenges, and transform our livelihoods from the bottom up.

Among these metatrends are augmented human longevity, the surging smart economy, AI-human collaboration, urbanized cellular agriculture, and high-bandwidth brain-computer interfaces, just to name a few.

It is here that master entrepreneurs and their teams must see beyond the immediate implications of a given technology, capturing second-order, Google-sized business opportunities on the horizon.

Welcome to a new decade of runaway technological booms, historic watershed moments, and extraordinary abundance.

Let’s dive in.

20 Metatrends for the 2020s
(1) Continued increase in global abundance: The number of individuals in extreme poverty continues to drop, as the middle-income population continues to rise. This metatrend is driven by the convergence of high-bandwidth and low-cost communication, ubiquitous AI on the cloud, and growing access to AI-aided education and AI-driven healthcare. Everyday goods and services (finance, insurance, education, and entertainment) are being digitized and becoming fully demonetized, available to the rising billion on mobile devices.

(2) Global gigabit connectivity will connect everyone and everything, everywhere, at ultra-low cost: The deployment of both licensed and unlicensed 5G, plus the launch of a multitude of global satellite networks (OneWeb, Starlink, etc.), allow for ubiquitous, low-cost communications for everyone, everywhere, not to mention the connection of trillions of devices. And today’s skyrocketing connectivity is bringing online an additional three billion individuals, driving tens of trillions of dollars into the global economy. This metatrend is driven by the convergence of low-cost space launches, hardware advancements, 5G networks, artificial intelligence, materials science, and surging computing power.

(3) The average human healthspan will increase by 10+ years: A dozen game-changing biotech and pharmaceutical solutions (currently in Phase 1, 2, or 3 clinical trials) will reach consumers this decade, adding an additional decade to the human healthspan. Technologies include stem cell supply restoration, wnt pathway manipulation, senolytic medicines, a new generation of endo-vaccines, GDF-11, and supplementation of NMD/NAD+, among several others. And as machine learning continues to mature, AI is set to unleash countless new drug candidates, ready for clinical trials. This metatrend is driven by the convergence of genome sequencing, CRISPR technologies, AI, quantum computing, and cellular medicine.

(4) An age of capital abundance will see increasing access to capital everywhere: From 2016 – 2018 (and likely in 2019), humanity hit all-time highs in the global flow of seed capital, venture capital, and sovereign wealth fund investments. While this trend will witness some ups and downs in the wake of future recessions, it is expected to continue its overall upward trajectory. Capital abundance leads to the funding and testing of ‘crazy’ entrepreneurial ideas, which in turn accelerate innovation. Already, $300 billion in crowdfunding is anticipated by 2025, democratizing capital access for entrepreneurs worldwide. This metatrend is driven by the convergence of global connectivity, dematerialization, demonetization, and democratization.

(5) Augmented reality and the spatial web will achieve ubiquitous deployment: The combination of augmented reality (yielding Web 3.0, or the spatial web) and 5G networks (offering 100Mb/s – 10Gb/s connection speeds) will transform how we live our everyday lives, impacting every industry from retail and advertising to education and entertainment. Consumers will play, learn, and shop throughout the day in a newly intelligent, virtually overlaid world. This metatrend will be driven by the convergence of hardware advancements, 5G networks, artificial intelligence, materials science, and surging computing power.

(6) Everything is smart, embedded with intelligence: The price of specialized machine learning chips is dropping rapidly with a rise in global demand. Combined with the explosion of low-cost microscopic sensors and the deployment of high-bandwidth networks, we’re heading into a decade wherein every device becomes intelligent. Your child’s toy remembers her face and name. Your kids’ drone safely and diligently follows and videos all the children at the birthday party. Appliances respond to voice commands and anticipate your needs.

(7) AI will achieve human-level intelligence: As predicted by technologist and futurist Ray Kurzweil, artificial intelligence will reach human-level performance this decade (by 2030). Through the 2020s, AI algorithms and machine learning tools will be increasingly made open source, available on the cloud, allowing any individual with an internet connection to supplement their cognitive ability, augment their problem-solving capacity, and build new ventures at a fraction of the current cost. This metatrend will be driven by the convergence of global high-bandwidth connectivity, neural networks, and cloud computing. Every industry, spanning industrial design, healthcare, education, and entertainment, will be impacted.

(8) AI-human collaboration will skyrocket across all professions: The rise of “AI as a Service” (AIaaS) platforms will enable humans to partner with AI in every aspect of their work, at every level, in every industry. AIs will become entrenched in everyday business operations, serving as cognitive collaborators to employees—supporting creative tasks, generating new ideas, and tackling previously unattainable innovations. In some fields, partnership with AI will even become a requirement. For example: in the future, making certain diagnoses without the consultation of AI may be deemed malpractice.

(9) Most individuals adapt a JARVIS-like “software shell” to improve their quality of life: As services like Alexa, Google Home, and Apple Homepod expand in functionality, such services will eventually travel beyond the home and become your cognitive prosthetic 24/7. Imagine a secure JARVIS-like software shell that you give permission to listen to all your conversations, read your email, monitor your blood chemistry, etc. With access to such data, these AI-enabled software shells will learn your preferences, anticipate your needs and behavior, shop for you, monitor your health, and help you problem-solve in support of your mid- and long-term goals.

(10) Globally abundant, cheap renewable energy: Continued advancements in solar, wind, geothermal, hydroelectric, nuclear, and localized grids will drive humanity towards cheap, abundant, and ubiquitous renewable energy. The price per kilowatt-hour will drop below one cent per kilowatt-hour for renewables, just as storage drops below a mere three cents per kilowatt-hour, resulting in the majority displacement of fossil fuels globally. And as the world’s poorest countries are also the world’s sunniest, the democratization of both new and traditional storage technologies will grant energy abundance to those already bathed in sunlight.

(11) The insurance industry transforms from “recovery after risk” to “prevention of risk”: Today, fire insurance pays you after your house burns down; life insurance pays your next-of-kin after you die; and health insurance (which is really sick insurance) pays only after you get sick. This next decade, a new generation of insurance providers will leverage the convergence of machine learning, ubiquitous sensors, low-cost genome sequencing, and robotics to detect risk, prevent disaster, and guarantee safety before any costs are incurred.

(12) Autonomous vehicles and flying cars will redefine human travel (soon to be far faster and cheaper): Fully autonomous vehicles, car-as-a-service fleets, and aerial ride-sharing (flying cars) will be fully operational in most major metropolitan cities in the coming decade. The cost of transportation will plummet 3-4X, transforming real estate, finance, insurance, the materials economy, and urban planning. Where you live and work, and how you spend your time, will all be fundamentally reshaped by this future of human travel. Your kids and elderly parents will never drive. This metatrend will be driven by the convergence of machine learning, sensors, materials science, battery storage improvements, and ubiquitous gigabit connections.

(13) On-demand production and on-demand delivery will birth an “instant economy of things”: Urban dwellers will learn to expect “instant fulfillment” of their retail orders as drone and robotic last-mile delivery services carry products from local supply depots directly to your doorstep. Further riding the deployment of regional on-demand digital manufacturing (3D printing farms), individualized products can be obtained within hours, anywhere, anytime. This metatrend is driven by the convergence of networks, 3D printing, robotics, and artificial intelligence.

(14) Ability to sense and know anything, anytime, anywhere: We’re rapidly approaching the era wherein 100 billion sensors (the Internet of Everything) is monitoring and sensing (imaging, listening, measuring) every facet of our environments, all the time. Global imaging satellites, drones, autonomous car LIDARs, and forward-looking augmented reality (AR) headset cameras are all part of a global sensor matrix, together allowing us to know anything, anytime, anywhere. This metatrend is driven by the convergence of terrestrial, atmospheric and space-based sensors, vast data networks, and machine learning. In this future, it’s not “what you know,” but rather “the quality of the questions you ask” that will be most important.

(15) Disruption of advertising: As AI becomes increasingly embedded in everyday life, your custom AI will soon understand what you want better than you do. In turn, we will begin to both trust and rely upon our AIs to make most of our buying decisions, turning over shopping to AI-enabled personal assistants. Your AI might make purchases based upon your past desires, current shortages, conversations you’ve allowed your AI to listen to, or by tracking where your pupils focus on a virtual interface (i.e. what catches your attention). As a result, the advertising industry—which normally competes for your attention (whether at the Superbowl or through search engines)—will have a hard time influencing your AI. This metatrend is driven by the convergence of machine learning, sensors, augmented reality, and 5G/networks.

(16) Cellular agriculture moves from the lab into inner cities, providing high-quality protein that is cheaper and healthier: This next decade will witness the birth of the most ethical, nutritious, and environmentally sustainable protein production system devised by humankind. Stem cell-based ‘cellular agriculture’ will allow the production of beef, chicken, and fish anywhere, on-demand, with far higher nutritional content, and a vastly lower environmental footprint than traditional livestock options. This metatrend is enabled by the convergence of biotechnology, materials science, machine learning, and AgTech.

(17) High-bandwidth brain-computer interfaces (BCIs) will come online for public use: Technologist and futurist Ray Kurzweil has predicted that in the mid-2030s, we will begin connecting the human neocortex to the cloud. This next decade will see tremendous progress in that direction, first serving those with spinal cord injuries, whereby patients will regain both sensory capacity and motor control. Yet beyond assisting those with motor function loss, several BCI pioneers are now attempting to supplement their baseline cognitive abilities, a pursuit with the potential to increase their sensorium, memory, and even intelligence. This metatrend is fueled by the convergence of materials science, machine learning, and robotics.

(18) High-resolution VR will transform both retail and real estate shopping: High-resolution, lightweight virtual reality headsets will allow individuals at home to shop for everything from clothing to real estate from the convenience of their living room. Need a new outfit? Your AI knows your detailed body measurements and can whip up a fashion show featuring your avatar wearing the latest 20 designs on a runway. Want to see how your furniture might look inside a house you’re viewing online? No problem! Your AI can populate the property with your virtualized inventory and give you a guided tour. This metatrend is enabled by the convergence of: VR, machine learning, and high-bandwidth networks.

(19) Increased focus on sustainability and the environment: An increase in global environmental awareness and concern over global warming will drive companies to invest in sustainability, both from a necessity standpoint and for marketing purposes. Breakthroughs in materials science, enabled by AI, will allow companies to drive tremendous reductions in waste and environmental contamination. One company’s waste will become another company’s profit center. This metatrend is enabled by the convergence of materials science, artificial intelligence, and broadband networks.

(20) CRISPR and gene therapies will minimize disease: A vast range of infectious diseases, ranging from AIDS to Ebola, are now curable. In addition, gene-editing technologies continue to advance in precision and ease of use, allowing families to treat and ultimately cure hundreds of inheritable genetic diseases. This metatrend is driven by the convergence of various biotechnologies (CRISPR, gene therapy), genome sequencing, and artificial intelligence.

Join Me
(1) A360 Executive Mastermind: If you’re an exponentially and abundance-minded entrepreneur who would like coaching directly from me, consider joining my Abundance 360 Mastermind, a highly selective community of 360 CEOs and entrepreneurs who I coach for 3 days every January in Beverly Hills, Ca. Through A360, I provide my members with context and clarity about how converging exponential technologies will transform every industry. I’m committed to running A360 for the course of an ongoing 25-year journey as a “countdown to the Singularity.”

If you’d like to learn more and consider joining our 2020 membership, apply here.

(2) Abundance-Digital Online Community: I’ve also created a Digital/Online community of bold, abundance-minded entrepreneurs called Abundance-Digital. Abundance-Digital is Singularity University’s ‘onramp’ for exponential entrepreneurs — those who want to get involved and play at a higher level. Click here to learn more.

(Both A360 and Abundance-Digital are part of Singularity University — your participation opens you to a global community.)

This article originally appeared on diamandis.com. Read the original article here.

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Posted in Human Robots

#436263 Skydio 2 Review: This Is the Drone You ...

Let me begin this review by saying that the Skydio 2 is one of the most impressive robots that I have ever seen. Over the last decade, I’ve spent enough time around robots to have a very good sense of what kinds of things are particularly challenging for them, and to set my expectations accordingly. Those expectations include things like “unstructured environments are basically impossible” and “full autonomy is impractically expensive” and “robot videos rarely reflect reality.”

Skydio’s newest drone is an exception to all of this. It’s able to fly autonomously at speed through complex environments in challenging real-world conditions in a way that’s completely effortless and stress-free for the end user, allowing you to capture the kind of video that would be otherwise impossible, even (I’m guessing) for professional drone pilots. When you see this technology in action, it’s (almost) indistinguishable from magic.

Skydio 2 Price
To be clear, the Skydio 2 is not without compromises, and the price of $999 (on pre-order with delivery of the next batch expected in spring of 2020) requires some justification. But the week I’ve had with this drone has left me feeling like its fundamental autonomous capability is so far beyond just about anything that I’ve ever experienced that I’m questioning why I would every fly anything else ever again.

We’ve written extensively about Skydio, beginning in early 2016 when the company posted a video of a prototype drone dodging trees while following a dude on a bike. Even three years ago, Skydio’s tech was way better than anything we’d seen outside of a research lab, and in early 2018, they introduced their first consumer product, the Skydio R1. A little over a year later, Skydio has introduced the Skydio 2, which is smaller, smarter, and much more affordable. Here’s an overview video just to get you caught up:

Skydio sent me a Skydio 2 review unit last week, and while I’m reasonably experienced with drones in general, this is the first time I’ve tried a Skydio drone in person. I had a pretty good idea what to expect, and I was absolutely blown away. Like, I was giggling to myself while running through the woods as the drone zoomed around, deftly avoiding trees and keeping me in sight. Robots aren’t supposed to be this good.

A week is really not enough time to explore everything that the Skydio can do, especially Thanksgiving week in Washington, D.C. (a no-fly zone) in early winter. But I found a nearby state park in which I could legally and safely fly the drone, and I did my best to put the Skydio 2 through its paces.

Note: Throughout this review, we’ve got a bunch of GIFs to help illustrate different features of the drone. To fit them all in, these GIFs had to be heavily compressed. Underneath each GIF is a timestamped link to this YouTube video (also available at the bottom of the post), which you can click on to see the an extended cut of the original 4K 30 fps footage. And there’s a bunch of interesting extra video in there as well.

Skydio 2 Specs

Photo: Evan Ackerman/IEEE Spectrum

The Skydio 2 is primarily made out of magnesium, which (while light) is both heavier and more rigid and durable than plastic. The offset props (the back pair are above the body, and the front pair are below) are necessary to maintain the field of view of the navigation cameras.

The Skydio 2 both looks and feels like a well-designed and carefully thought-out drone. It’s solid, and a little on the heavy side as far as drones go—it’s primarily made out of magnesium, which (while light) is both heavier and more rigid and durable than plastic. The blue and black color scheme is far more attractive than you typically see with drones.

Photo: Evan Ackerman/IEEE Spectrum

To detect and avoid obstacles, the Skydio 2 uses an array of six 4K hemispherical cameras that feed data into an NVIDIA Jetson TX2 at 30 fps, with the drone processing a million points in 3D space per second to plan the safest path.

The Skydio 2 is built around an array of six hemispherical obstacle-avoidance cameras and the NVIDIA Jetson TX2 computing module that they’re connected to. This defines the placement of the gimbal, the motors and props, and the battery, since all of this stuff has to be as much as possible out of the view of the cameras in order for the drone to effectively avoid obstacles in any direction.

Without the bottom-mounted battery attached, the drone is quite flat. The offset props (the back pair are above the body, and the front pair are below) are necessary to maintain the field of view of the obstacle-avoidance cameras. These hemispherical cameras are on the end of each of the prop arms as well as above and below the body of the drone. They look awfully exposed, even though each is protected from ground contact by a little fin. You need to make sure these cameras are clean and smudge-free, and Skydio includes a cleaning cloth for this purpose. Underneath the drone there are slots for microSD cards, one for recording from the camera and a second one that the drone uses to store data. The attention to detail extends to the SD card insertion, which has a sloped channel that guides the card securely into its slot.

Once you snap the battery in, the drone goes from looking streamlined to looking a little chubby. Relative to other drones, the battery almost seems like an afterthought, like Skydio designed the drone and then remembered, “oops we have to add a battery somewhere, let’s just kludge it onto the bottom.” But again, the reason for this is to leave room inside the body for the NVIDIA TX2, while making sure that the battery stays out of view of the obstacle avoidance cameras.

The magnetic latching system for the battery is both solid and satisfying. I’m not sure why it’s necessary, strictly speaking, but I do like it, and it doesn’t seem like the battery will fly off even during the most aggressive maneuvers. Each battery includes an LED array that will display its charge level in 25 percent increments, as well as a button that you push to turn the drone on and off. Charging takes place via a USB-C port in the top of the drone, which I don’t like, because it means that the batteries can’t be charged on their own (like the Parrot Anafi’s battery), and that you can’t charge one battery while flying with another, like basically every other drone ever. A separate battery charger that will charge two at once is available from Skydio for an eyebrow-raising $129.

I appreciate that all of Skydio’s stuff (batteries, controller, and beacon) charges via USB-C, though. The included USB-C adapter with its beefy cable will output at up to 65 watts, which’ll charge a mostly depleted battery in under an hour. The drone turns itself on while charging, which seems unnecessary.

Photo: Evan Ackerman/IEEE Spectrum

The Skydio 2 is not foldable, making it not nearly as easy to transport as some other drones. But it does come with a nice case that mitigates this issue somewhat, and the drone plus two batteries end up as a passably flat package about the size of a laptop case.

The most obvious compromise that Skydio made with the Skydio 2 is that the drone is not foldable. Skydio CEO Adam Bry told us that adding folding joints to the arms of the Skydio 2 would have made calibrating all six cameras a nightmare and significantly impacted performance. This makes complete sense, of course, but it does mean that the Skydio 2 is not nearly as easy to transport as some other drones.

Photo: Evan Ackerman/IEEE Spectrum

Folded and unfolded: The Skydio 2 compared to the Parrot Anafi (upper left) and the DJI Mavic Pro (upper right).

The Skydio 2 does come with a very nice case that mitigates this issue somewhat, and the drone plus two batteries end up as a passably flat package about the size of a laptop case. Still, it’s just not as convenient to toss into a backpack as my Anafi, although the Mavic Mini might be even more portable.

Photo: Evan Ackerman/IEEE Spectrum

While the Skydio 2’s case is relatively compact, the non-foldable drone is overall a significantly larger package than the Parrot Anafi.

The design of the drone leads to some other compromises as well. Since landing gear would, I assume, occlude the camera system, the drone lands directly on the bottom of its battery pack, which has a slightly rubberized pad about the size of a playing card. This does’t feel particularly stable unless you end up on a very flat surface, and made me concerned for the exposed cameras underneath the drone as well as the lower set of props. I’d recommend hand takeoffs and landings—more on those later.

Skydio 2 Camera System

Photo: Evan Ackerman/IEEE Spectrum

The Skydio 2’s primary camera is a Sony IMX577 1/2.3″ 12.3-megapixel CMOS sensor. It’s mounted to a three-axis gimbal and records 4K video at 60 fps, or 1080p video at 120 fps.

The Skydio 2 comes with a three-axis gimbal supporting a 12-megapixel camera, just enough to record 4K video at 60 fps, or 1080p video at 120 fps. Skydio has provided plenty of evidence that its imaging system is at least as good if not better than other drone cameras. Tested against my Mavic Pro and Parrot Anafi, I found no reason to doubt that. To be clear, I didn’t do exhaustive pixel-peeping comparisons between them, you’re just getting my subjective opinion that the Skydio 2 has a totally decent camera that you won’t be disappointed with. I will say that I found the HDR photo function to be not all that great under the few situations in which I tested it—after looking at a few muddy sunset shots, I turned it off and was much happier.

Photo: Evan Ackerman/IEEE Spectrum

The Skydio 2’s 12-megapixel camera is solid, although we weren’t impressed with the HDR option.

The video stabilization is fantastic, to the point where watching the video footage can be underwhelming because it doesn’t reflect the motion of the drone. I almost wish there was a way to change to unstabilized (or less-stabilized) video so that the viewer could get a little more of a wild ride. Or, ideally, there’d be a way for the drone to provide you with a visualization of what it was doing using the data collected by its cameras. That’s probably wishful thinking, though. The drone itself doesn’t record audio because all you’d get would be an annoying buzz, but the app does record audio, so the audio from your phone gets combined with the drone video. Don’t expect great quality, but it’s better than nothing.

Skydio 2 App
The app is very simple compared to every other drone app I’ve tried, and that’s a good thing. Here’s what it looks like:

Image: Skydio

Trackable subjects get a blue “+” sign over them, and if you tap them, the “+” turns into a spinny blue circle. Once you’ve got a subject selected, you can choose from a variety of cinematic skills that the drone will execute while following you.

You get the controls that you need and the information that you need, and nothing else. Manual flight with the on-screen buttons works adequately, and the double-tap to fly function on the phone works surprisingly well, making it easy to direct the drone to a particular spot above the ground.

The settings menus are limited but functional, allowing you to change settings for the camera and a few basic tweaks for controlling the drone. One unique setting to the Skydio 2 is the height floor—since the drone only avoids static obstacles, you can set it to maintain a height of at least 8 feet above the ground while flying autonomously to make sure that if you’re flying around other people, it won’t run into anyone who isn’t absurdly tall and therefore asking for it.

Trackable subjects get a blue “+” sign over them in the app, and if you tap them, the “+” turns into a spinny blue circle. Once you’ve got a subject selected, you can choose from a variety of cinematic skills that the drone will execute while following you, and in addition, you can select “one-shot” skills that involve the drone performing a specific maneuver before returning to the previously selected cinematic skill. For example, you can tell the drone to orbit around you, and then do a “rocket” one-shot where it’ll fly straight up above you (recording the whole time, of course), before returning to its orbiting.

After you’re done flying, you can scroll through your videos and easily clip out excerpts from them and save them to your phone for sharing. Again, it’s a fairly simple interface without a lot of options. You could call it limited, I guess, but I appreciate that it just does a few things that you care about and otherwise doesn’t clutter itself up.

The real limitation of the app is that it uses Wi-Fi to connect to the Skydio 2, which restricts the range. To fly much beyond a hundred meters or so, you’ll need to use the controller or beacon instead.

Skydio 2 Controller and Beacon

Photo: Evan Ackerman/IEEE Spectrum

While the Skydio 2 controller provides a better hands-on flight experience than with the phone, plus an extended range of up to 3.5 km, more experienced pilots may find manual control a bit frustrating, because the underlying autonomy will supersede your maneuvers when you start getting close to objects.

I was looking forward to using the controller, because with every other drone I’ve had, the precision that a physically controller provides is, I find, mandatory for a good flying experience and to get the photos and videos that you want. With Skydio 2, that’s all out the window. It’s not that the controller is useless or anything, it’s just that because the drone tracks you and avoids obstacles on its own, that level of control precision becomes largely unnecessary.

The controller itself is perfectly fine. It’s a rebranded Parrot Skycontroller3, which is the same as the one that you get with a Parrot Anafi. It’s too bad that the sticks don’t unscrew to make it a little more portable, and overall it’s functional rather than fancy, but it feels good to use and includes a sizeable antenna that makes a significant difference to the range that you get (up to 3.5 kilometers).

You definitely get a better hands-on flight experience with the controller than with the phone, so if you want to (say) zip the drone around some big open space for fun, it’s good for that. And it’s nice to be able to hand the controller to someone who’s never flown a drone before and let them take it for a spin without freaking out about them crashing it the whole time. For more experienced pilots, though, the controller is ultimately just a bit frustrating, because the underlying autonomy will supersede your control when you start getting close to objects, which (again) limits how useful the controller is relative to your phone.

I do still prefer the controller over the phone, but I’m not sure that it’s worth the extra $150, unless you plan to fly the Skydio 2 at very long distances or primarily in manual mode. And honestly, if either of those two things are your top priority, the Skydio 2 is probably not the drone for you.

Photo: Evan Ackerman/IEEE Spectrum

The Skydio 2 beacon uses GPS tracking to help the drone follow you, extending range up to 1.5 km. You can also fly the with the beacon alone, no phone necessary.

The purpose of the beacon, according to Skydio, is to give the drone a way of tracking you if it can’t see you, which can happen, albeit infrequently. My initial impression of the beacon was that it was primarily useful as a range-extending bridge between my phone and the drone. But I accidentally left my phone at home one day (oops) and had to fly the drone with only the beacon, and it was a surprisingly decent experience. The beacon allows for full manual control of a sort—you can tap different buttons to rotate, fly forward, and ascend or descend. This is sufficient for takeoff, landing, to make sure that the drone is looking at you when you engage visual tracking, and to rescue it if it gets trapped somewhere.

The rest of the beacon’s control functions are centered around a few different tracking modes, and with these, it works just about as well as your phone. You have fewer options overall, but all the basic stuff is there with just a few intuitive button clicks, including tracking range and angle. If you’re willing to deal with this relatively minor compromise, it’s nice to not have your phone available for other things rather than being monopolized by the drone.

Skydio 2 In Flight

GIF: Evan Ackerman/IEEE Spectrum

Hand takeoffs are simple and reliable.
Click here for a full resolution clip.

Starting up the Skydio 2 doesn’t require any kind of unusual calibration steps or anything like that. It prefers to be kept still, but you can start it up while holding it, it’ll just take a few seconds longer to tell you that it’s ready to go. While the drone will launch from any flat surface with significant clearance around it (it’ll tell you if it needs more room), the small footprint of the battery means that I was more comfortable hand launching it. This is not a “throw” launch; you just let the drone rest on your palm, tell it to take off, and then stay still while it gets its motors going and then gently lifts off. The lift off is so gentle that you have to be careful not to pull your hand away too soon—I did that once and the drone, being not quite ready, dropped towards the ground, but managed to recover without much drama.

GIF: Evan Ackerman/IEEE Spectrum

Hand landings always look scary, but the Skydio 2 is incredibly gentle. After trying this once, it became the only way I ever landed the drone.
Click here for a full resolution clip.

Catching the drone for landing is perhaps very slightly more dangerous, but not any more difficult. You put the drone above and in front of you facing away, tell it to land in the app or with the beacon, and then put your hand underneath it to grasp it as it slowly descends. It settles delicately and promptly turns itself off. Every drone should land this way. The battery pack provides a good place to grip, although you do have to be mindful of the forward set of props, which (since they’re the pair that are beneath the body of drone) are quite close to your fingers. You’ll certainly be mindful after you catch a blade with your fingers once. Which I did. For the purposes of this review and totally not by accident. No damage, for the record.

Photo: Evan Ackerman/IEEE Spectrum

You won’t be disappointed with the Skydio 2’s in-flight performance, unless you’re looking for a dedicated racing drone.

In normal flight, the Skydio 2 performs as well as you’d expect. It’s stable and manages light to moderate wind without any problems, although I did notice some occasional lateral drifting when the drone should have been in a stationary hover. While the controller gains are adjustable, the Skydio 2 isn’t quite as aggressive in flight as my Mavic Pro on Sport Mode, but again, if you’re looking for a high-speed drone, that’s really not what the Skydio is all about.

The Skydio 2 is substantially louder than my Anafi, although the Anafi is notably quiet for a drone. It’s not annoying to hear (not a high-pitched whine), but you can hear it from a ways away, and farther away than my Mavic Pro. I’m not sure whether that’s because of the absolute volume or the volume plus the pitch. In some ways, this is a feature, since you can hear the drone following you even if you’re not looking at it, you just need to be aware of the noise it makes when you’re flying it around people.

Obstacle Avoidance
The primary reason Skydio 2 is the drone that you want to fly is because of its autonomous subject tracking and obstacle avoidance. Skydio’s PR videos make this capability look almost too good, and since I hadn’t tried out one of their drones before, the first thing I did with it was exactly what you’d expect: attempt to fly it directly into the nearest tree.

GIF: Evan Ackerman/IEEE Spectrum

The Skydio 2 deftly slides around trees and branches. The control inputs here were simple “forward” or “turn,” all obstacle avoidance is autonomous.
Click here for a full resolution clip.

And it just won’t do it. It slows down a bit, and then slides right around one tree after another, going over and under and around branches. I pointed the drone into a forest and just held down “forward” and away it went, without any fuss, effortlessly ducking and weaving its way around. Of course, it wasn’t effortless at all—six 4K cameras were feeding data into the NVIDIA TX2 at 30 fps, and the drone was processing a million points in 3D space per second to plan the safest path while simultaneously taking into account where I wanted it to go. I spent about 10 more minutes doing my level best to crash the drone into anything at all using a flying technique probably best described as “reckless,” but the drone was utterly unfazed. It’s incredible.

What knocked my socks off was telling the drone to pass through treetops—in the clip below, I’m just telling the drone to fly straight down. Watch as it weaves its way through gaps between the branches:

GIF: Evan Ackerman/IEEE Spectrum

The result of parking the Skydio 2 above some trees and holding “down” on the controller is this impressive fully autonomous descent through the branches.
Click here for a full resolution clip.

Here’s one more example, where I sent the drone across a lake and started poking around in a tree. Sometimes the Skydio 2 isn’t sure where you want it to go, and you have to give it a little bit of a nudge in a clear direction, but that’s it.

GIF: Evan Ackerman/IEEE Spectrum

In obstacle-heavy environments, the Skydio 2 prudently slows down, but it can pick its way through almost anything that it can see.
Click here for a full resolution clip.

It’s important to keep in mind that all of the Skydio 2’s intelligence is based on vision. It uses cameras to see the world, which means that it has similar challenges as your eyes do. Specifically, Skydio warns against flying in the following conditions:

Skydio 2 can’t see certain visually challenging obstacles. Do not fly around thin branches, telephone or power lines, ropes, netting, wires, chain link fencing or other objects less than ½ inch in diameter.
Do not fly around transparent surfaces like windows or reflective surfaces like mirrors greater than 60 cm wide.
When the sun is low on the horizon, it can temporarily blind Skydio 2’s cameras depending on the angle of flight. Your drone may be cautious or jerky when flying directly toward the sun.

Basically, if you’d have trouble seeing a thing, or seeing under some specific flight conditions, then the Skydio 2 almost certainly will also. It gets even more problematic when challenging obstacles are combined with challenging flight conditions, which is what I’m pretty sure led to the only near-crash I had with the drone. Here’s a video:

GIF: Evan Ackerman/IEEE Spectrum

Flying around very thin branches and into the sun can cause problems for the Skydio 2’s obstacle avoidance.
Click here for a full resolution clip.

I had the Skydio 2 set to follow me on my bike (more about following and tracking in a bit). It was mid afternoon, but since it’s late fall here in Washington, D.C., the sun doesn’t get much higher than 30 degrees above the horizon. Late fall also means that most of the deciduous trees have lost their leaves, and so there are a bunch of skinny branches all over the place. The drone was doing a pretty good job of following me along the road at a relatively slow speed, and then it clipped the branch that you can just barely see in the video above. It recovered in an acrobatic maneuver that has been mostly video-stabilized out, and resumed tracking me before I freaked and told it to land. You can see another example here, where the drone (again) clips a branch that has the sun behind it, and this clip shows me stopping my bike before the drone runs into another branch in a similar orientation. As the video shows, it’s very hard to see the branches until it’s too late.

As far as I can tell, the drone is no worse for wear from any of this, apart from a small nick in one of the props. But, this is a good illustration of a problematic situation for the Skydio 2: flying into a low sun angle around small bare branches. Should I not have been flying the drone in this situation? It’s hard to say. These probably qualify as “thin branches,” although there was plenty of room along with middle of the road. There is an open question with the Skydio 2 as to exactly how much responsibility the user should have about when and where it’s safe to fly—for branches, how thin is too thin? How low can the sun be? What if the branches are only kinda thin and the sun is only kinda low, but it’s also a little windy? Better to be safe than sorry, of course, but there’s really no way for the user (or the drone) to know what it can’t handle until it can’t handle it.

Edge cases like these aside, the obstacle avoidance just works. Even if you’re not deliberately trying to fly into branches, it’s keeping a lookout for you all the time, which means that flying the drone goes from somewhat stressful to just pure fun. I can’t emphasize enough how amazing it is to be able to fly without worrying about running into things, and how great it feels to be able to hand the controller to someone who’s never flown a drone before and say, with complete confidence, “go ahead, fly it around!”

Skydio 2 vs. DJI Mavic

Photo: Evan Ackerman/IEEE Spectrum

Both the Skydio 2 and many models of DJI’s Mavic use visual obstacle avoidance, but the Skydio 2 is so much more advanced that you can’t really compare the two systems.

It’s important to note that there’s a huge difference between the sort of obstacle avoidance that you get with a DJI Mavic, and the sort of obstacle avoidance that you get with the Skydio 2. The objective of the Mavic’s obstacle avoidance is really there to prevent you from accidentally running into things, and in that capacity, it usually works. But there are two things to keep in mind here—first, not running into things is not the same as avoiding things, because avoiding things means planning several steps ahead, not just one step.

Second, there’s the fact that the Mavic’s obstacle detection only works most of the time. Fundamentally, I don’t trust my Mavic Pro, because sometimes the safety system doesn’t kick in for whatever reason and the drone ends up alarmingly close to something. And that’s actually fine, because with the Mavic, I expect to be piloting it. It’s for this same reason that I don’t care that my Parrot Anafi doesn’t have obstacle avoidance at all: I’m piloting it anyway, and I’m a careful pilot, so it just doesn’t matter. The Skydio 2 is totally and completely different. It’s in a class by itself, and you can’t compare what it can do to what anything else out there right now. Period.

Skydio 2 Tracking
Skydio’s big selling point on the Skydio 2 is that it’ll autonomously track you while avoiding obstacles. It does this visually, by watching where you go, predicting your future motion, and then planning its own motion to keep you in frame. The works better than you might expect, in that it’s really very good at not losing you. Obviously, the drone prioritizes not running into stuff over tracking you, which means that it may not always be where you feel like it should be. It’s probably trying to get there, but in obstacle dense environments, it can take some creative paths.

Having said that, I found it to be very consistent with keeping me in the frame, and I only managed to lose it when changing direction while fully occluded by an obstacle, or while it was executing an avoidance maneuver that was more dynamic than normal. If you deliberately try to hide from the drone it’s not that hard to do so if there are enough obstacles around, but I didn’t find the tracking to be something that I had to worry about it most cases. When tracking does fail and you’re not using the beacon, the drone will come to a hover. It won’t try and find you, but it will reacquire you if you get back into its field of view.

The Skydio 2 had no problem tracking me running through fairly dense trees:

GIF: Evan Ackerman/IEEE Spectrum

The Skydio 2 had no problem chasing me around through these trees, even while I was asking it to continually change its tracking angle.
Click here for a full resolution clip.

It also managed to keep up with me as I rode my bike along a tree-lined road:

GIF: Evan Ackerman/IEEE Spectrum

The Skydio 2 is easily fast enough to keep up with me on a bike, even while avoiding tree branches.
Click here for a full resolution clip.

It lost me when I asked it to follow very close behind me as I wove through some particularly branch-y trees, but it fails more or less gracefully by just sort of nope-ing out of situations when they start to get bad and coming to a hover somewhere safe.

GIF: Evan Ackerman/IEEE Spectrum

The Skydio 2 knows better than to put itself into situations that it can’t handle, and will bail to a safe spot if things get too complicated.
Click here for a full resolution clip.

After a few days of playing with the drone, I started to get to the point where I could set it to track me and then just forget about it while I rode my bike or whatever, as opposed to constantly turning around to make sure it was still behind me, which is what I was doing initially. It’s a level of trust that I don’t think would be possible with any other drone.

Should You Buy a Skydio 2?

Photo: Evan Ackerman/IEEE Spectrum

We think the Skydio 2 is fun and relaxing to fly, with unique autonomous intelligence that makes it worth the cost.

In case I haven’t said it often enough in this review, the Skydio 2 is an incredible piece of technology. As far as I know (as a robotics journalist, mind you), this represents the state of the art in commercial drone autonomy, and quite possibly the state of the art in drone autonomy, period. And it’s available for $999, which is expensive, but less money than a Mavic Pro 2. If you’re interested in a new drone, you should absolutely consider the Skydio 2.

There are some things to keep in mind—battery life is a solid but not stellar 20 minutes. Extra batteries are expensive at $99 each (the base kit includes just one). The controller and the beacon are also expensive, at $150 each. And while I think the Skydio 2 is definitely the drone you want to fly, it may not be the drone you want to travel with, since it’s bulky compared to other options.

But there’s no denying the fact that the experience is uniquely magical. Once you’ve flown the Skydio 2, you won’t want to fly anything else. This drone makes it possible to get pictures and videos that would be otherwise impossible, and you can do it completely on your own. You can trust the drone to do what it promises, as long as you’re mindful of some basic and common sense safety guidelines. And we’ve been told that the drone is only going to get smarter and more capable over time.

If you buy a Skydio 2, it comes with the following warranty from Skydio:

“If you’re operating your Skydio 2 within our Safe Flight guidelines, and it crashes, we’ll repair or replace it for free.”

Skydio trusts their drone to go out into a chaotic and unstructured world and dodge just about anything that comes its way. And after a week with this drone, I can see how they’re able to offer this kind of guarantee. This is the kind of autonomy that robots have been promising for years, and the Skydio 2 makes it real.

Detailed technical specifications are available on Skydio’s website, and if you have any questions, post a comment—we’ve got this drone for a little while longer, and I’d be happy to try out (nearly) anything with it.

Skydio 2 Review Video Highlights
This video is about 7 minutes of 4K, 30 fps footage directly from the Skydio 2. The only editing I did was cutting clips together, no stabilization or color correcting or anything like that. The drone will record in 4K 60 fps, so it gets smoother than this, but I, er, forgot to change the setting.

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